Gene

KWMTBOMO13117  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000381

Annotation

PREDICTED:_nuclear_migration_protein_nudC_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr22(-):8585887-8613945      View in EpiBrowser

Full name

Nuclear migration protein nudC      

Alternative Name

Nuclear distribution protein C homolog
Silica-induced gene 92 protein
c15

Location in the cell

Nuclear   Reliability : 2.823

CDS

ATGGCAAACGATCCTGAAAGATTTGATTCCATGCTCCTAGCTATGGCACAACAGCACGAAGGCGGCGTAAAAGATCTGCTGAACACAATAGTTAGCTTTTTGTCTAGAAAAACTGACTTTTTCACTGGTGGCCGTGAAGGGGAATGGGAGCAGGTAGTCAAAGATACTTTCTACACCCATGCTAAAAAAGCATGTGATGAAGCTAATAGGATTAAAAAAGAAAAAGAAGAAGCAGACAAGAGATTAAAAGAGATTCAACAAAGAAAAGAACAAGAGAGACTTGCAAATGATTTTGAACCTGCTACTGTAACTGAACTCACTGATCAGGAAGCAGAGAAGTTAAAGGAAGATATTGAAAAGGACAAAAATGAAAAGAATGCAGAAGTTGGCAGTGGTGATAGCAGTGATGTTACTGAGCCTGCAACGCCCGAAGAAGATGACGATCCCAAAGAAAAGGGGAAGTTGAAACCTAATGCTGGAAATGGATGTGATCTGGAGCACTACAAATGGACACAGACGTTGGAAGAAGTAGAGATTCGAGTGCCGCTGCGACAGATTCTGCGGCCACGCGATCTGACAGTGGTCATCAATAAGAAACACCTCAAGGTTGGCATCAAAGGTCAACCTCTTATAATCGACGGCGAGCTAGATGCCGACGTCAAGATTGAGGAGTCCACGTGGGTGTTGCAGGATGGACGCAATCTACTTATCAACTTAGAAAAGGTGAACAAAATGAACTGGTGGGGTCGGCTTGTTACAACGGACCCAGAAATATCTACAAGGAAAATTAATCCAGAACCATCGAAGCTGTCGGATCTTGATGGTGAAACACGTGGTCTAGTTGAAAAGATGATGTACGATCAGAGACAGAAAGAAATGGGACTACCTACAAGTGATGAACAAAAGAAACAAGAAGTACTCAAGAAATTCATGGAACAGCATCCAGAGATGGACTTCTCCAAATGCAAATTCAACTAA

Protein

MANDPERFDSMLLAMAQQHEGGVKDLLNTIVSFLSRKTDFFTGGREGEWEQVVKDTFYTHAKKACDEANRIKKEKEEADKRLKEIQQRKEQERLANDFEPATVTELTDQEAEKLKEDIEKDKNEKNAEVGSGDSSDVTEPATPEEDDDPKEKGKLKPNAGNGCDLEHYKWTQTLEEVEIRVPLRQILRPRDLTVVINKKHLKVGIKGQPLIIDGELDADVKIEESTWVLQDGRNLLINLEKVNKMNWWGRLVTTDPEISTRKINPEPSKLSDLDGETRGLVEKMMYDQRQKEMGLPTSDEQKKQEVLKKFMEQHPEMDFSKCKFN

Description

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).

Subunit

Interacts with PLK1 (By similarity). Interacts with PAFAH1B1 (PubMed:9601647). Part of a complex containing PLK1, NUDC, dynein and dynactin (PubMed:11734602). Interacts with DCDC1 (By similarity).
Interacts with PAFAH1B1 (PubMed:9601647). Interacts with PLK1 and DCDC1. Part of a complex containing PLK1, NUDC, dynein and dynactin (By similarity).

Similarity

Belongs to the nudC family.

Keywords

3D-structure   Acetylation   Cell cycle   Cell division   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Microtubule   Mitosis   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  Nuclear migration protein nudC

Uniprot

Q2F5N8   A0A212F9D6   S4P8K9   A0A1E1WIP4   A0A3S2NXJ4   A0A0C9RI57   + More
A0A1L8DME6   A0A139WHS7   A0A0P5GJ43   A0A162RKR0   K7J0S6   A0A0P5M778   A0A0P5HYJ0   E9H4M9   A0A195EUF6   A0A0P5WGQ6   A0A1B6E9Q9   V5IAR9   A0A1L8DMN4   A0A0P6BC11   L7M6J3   A0A195CKM0   B4LG60   Q29EX0   B4H5M5   A0A0P6CVD6   J3JZL2   A0A1B6L247   A0A067QP89   A0A182J913   A0A2A3EGC0   V9ILC6   J9K0W5   A0A2H8TXV8   Q9VVA6   A0A0M4EXH1   A0A2S2P9V2   A0A1Y1LXM3   B4QMY9   A0A154PCI1   B4KY02   A0A158NK14   B7QH59   U5EVG8   B3NDH2   B4HK70   B4IXG3   A0A131Y236   A0A2S2PVR4   B4N3A7   A0A0K8RPN4   A0A026VV86   A0A3L8DSN6   A0A224XRW0   G3MQQ8   A0A3P8VVJ8   B4PK95   A0A182I1F7   A0A2K5DKP6   A0A1W4WFX2   Q7Q5Z9   A0A182XP68   A0A182KP18   A0A182TJ59   A0A2K6V384   H0WK00   A0A023GIF0   A0A1E1XAL0   A0A0A9X5K3   F7F437   A0A0V0G543   A0A2U3ZA42   G1TEZ4   I3N9X7   A0A096MM99   A0A0D9S835   H9Z4J0   A0A1S3ABV9   A0A2K5RRH3   G1RE19   A0A1S3JUH0   A0A3Q7MWP3   O35685   Q63525   A0A3Q4HX13   A0A250XYI6   B4FBE4   G3RH24   M3YW43   A0A1A6GCZ0   A0A2R8Z5V8   H2PYE7   A0A2K5ZCC5   M3WHP3   A0A2U3VIQ5   A0A061IEW1   A0A3Q4I440   H2N8E2   H9FNY2   A0A2K6GML8  

Pubmed

22118469    23622113    18362917    19820115    20075255    21292972    + More
25576852    17994087    15632085    22516182    24845553    9376324    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28004739    22936249    21347285    24508170    30249741    22216098    24487278    17550304    12364791    14747013    17210077    20966253    28503490    25401762    26823975    25243066    21993624    25319552    7868905    9601647    16141072    15489334    11734602    21183079    7776977    25186727    28087693    19936069    22398555    22722832    16136131    17975172    23929341    29704459   

EMBL

DQ311385    ABD36329.1    AGBW02009593    OWR50365.1    GAIX01004154    JAA88406.1    + More
GDQN01004323    JAT86731.1    RSAL01000111    RVE47076.1    GBYB01012887    JAG82654.1    GFDF01006448    JAV07636.1    KQ971343    KYB27439.1    GDIQ01239808    JAK11917.1    LRGB01000146    KZS20595.1    GDIQ01159736    JAK91989.1    GDIQ01220913    JAK30812.1    GL732592    EFX73173.1    KQ981979    KYN31532.1    GDIP01086561    JAM17154.1    GEDC01002629    JAS34669.1    GALX01000705    JAB67761.1    GFDF01006413    JAV07671.1    GDIP01017413    JAM86302.1    GACK01005552    JAA59482.1    KQ977642    KYN01002.1    CH940647    EDW69368.1    CH379070    EAL29939.1    CH479211    EDW33077.1    GDIQ01087959    JAN06778.1    BT128288    AEE65523.1    GEBQ01022247    JAT17730.1    KK853097    KDR11435.1    KZ288263    PBC30342.1    JR053182    AEY61870.1    ABLF02024134    ABLF02024135    GFXV01006193    MBW17998.1    AE014296    AY071485    AY328470    AAF49407.2    AAL49107.1    AAP93640.1    AFH04476.1    CP012525    ALC43000.1    GGMR01013349    MBY25968.1    GEZM01045228    JAV77851.1    CM000363    CM002912    EDX10781.1    KMZ00116.1    KQ434870    KZC09605.1    CH933809    EDW18704.1    ADTU01018620    ADTU01018621    ADTU01018622    ADTU01018623    ADTU01018624    ADTU01018625    ADTU01018626    ADTU01018627    ADTU01018628    ADTU01018629    ABJB010242016    ABJB010293257    ABJB010431635    ABJB010582604    ABJB010641009    ABJB010650853    ABJB010826137    ABJB010899687    ABJB010926867    DS937308    EEC18181.1    GANO01001868    JAB58003.1    CH954178    EDV52034.1    CH480815    EDW41811.1    CH916366    EDV96400.1    GEFM01003261    JAP72535.1    GGMS01000231    MBY69434.1    CH964062    EDW78846.1    GADI01000802    JAA73006.1    KK107847    EZA47451.1    QOIP01000005    RLU23183.1    GFTR01005154    JAW11272.1    JO844209    AEO35826.1    CM000159    EDW94793.1    APCN01000055    AAAB01008960    EAA10911.2    AAQR03155822    AAQR03155823    AAQR03155824    AAQR03155825    AAQR03155826    GBBM01001739    JAC33679.1    GFAC01002898    JAT96290.1    GBHO01027607    GBRD01008206    GDHC01000469    JAG15997.1    JAG57615.1    JAQ18160.1    GAMT01006044    GAMR01009208    GAMQ01000006    GAMP01008302    JAB05817.1    JAB24724.1    JAB41845.1    JAB44453.1    GECL01002940    JAP03184.1    AAGW02062843    AAGW02062844    AGTP01007829    AHZZ02015549    AHZZ02015550    AHZZ02015551    AHZZ02015552    AQIB01147820    AQIB01147821    AQIB01147822    JU474052    JV045971    AFH30856.1    AFI36042.1    ADFV01067364    ADFV01067365    ADFV01067366    ADFV01067367    ADFV01067368    X81443    Y15522    AK032673    AK146323    BC011253    X82445    BC065581    GFFV01003488    JAV36457.1    BT034432    ACF79437.1    CABD030001868    AEYP01008124    LZPO01099511    OBS63635.1    AJFE02029023    AJFE02029024    AJFE02029025    AJFE02029026    AJFE02029027    AJFE02029028    AJFE02029029    AACZ04072232    AACZ04072233    AACZ04072234    GABC01000566    GABF01004862    GABD01009136    GABE01009751    NBAG03000438    JAA10772.1    JAA17283.1    JAA23964.1    JAA34988.1    PNI24457.1    AANG04003369    KE668164    RAZU01000087    ERE84178.1    RLQ74456.1    ABGA01131575    ABGA01131576    ABGA01131577    ABGA01131578    ABGA01131579    NDHI03003565    PNJ20494.1    JU332586    AFE76341.1   

Proteomes

UP000007151    UP000283053    UP000007266    UP000076858    UP000002358    UP000000305    + More
UP000078541    UP000078542    UP000008792    UP000001819    UP000008744    UP000027135    UP000075880    UP000242457    UP000007819    UP000000803    UP000092553    UP000000304    UP000076502    UP000009192    UP000005205    UP000001555    UP000008711    UP000001292    UP000001070    UP000007798    UP000053097    UP000279307    UP000265120    UP000002282    UP000075840    UP000233020    UP000192223    UP000007062    UP000076407    UP000075882    UP000075902    UP000233220    UP000005225    UP000008225    UP000245340    UP000001811    UP000005215    UP000028761    UP000029965    UP000079721    UP000233040    UP000001073    UP000085678    UP000286641    UP000000589    UP000002494    UP000261580    UP000001519    UP000000715    UP000092124    UP000240080    UP000002277    UP000233140    UP000011712    UP000030759    UP000273346    UP000001595    UP000233160   

PRIDE

Q2F5N8    Q9VVA6    O35685    Q63525   

Pfam

PF14050   Nudc_N        + More
PF04969   CS
PF16273   NuDC

Interpro

IPR025934   NudC_N_dom        + More
IPR008978   HSP20-like_chaperone       
IPR037898   NudC_fam       
IPR007052   CS_dom       
IPR032572   NuDC       

SUPFAM

SSF49764   SSF49764       

Gene 3D

2.60.40.790    

ProteinModelPortal

Q2F5N8   A0A212F9D6   S4P8K9   A0A1E1WIP4   A0A3S2NXJ4   A0A0C9RI57   + More
A0A1L8DME6   A0A139WHS7   A0A0P5GJ43   A0A162RKR0   K7J0S6   A0A0P5M778   A0A0P5HYJ0   E9H4M9   A0A195EUF6   A0A0P5WGQ6   A0A1B6E9Q9   V5IAR9   A0A1L8DMN4   A0A0P6BC11   L7M6J3   A0A195CKM0   B4LG60   Q29EX0   B4H5M5   A0A0P6CVD6   J3JZL2   A0A1B6L247   A0A067QP89   A0A182J913   A0A2A3EGC0   V9ILC6   J9K0W5   A0A2H8TXV8   Q9VVA6   A0A0M4EXH1   A0A2S2P9V2   A0A1Y1LXM3   B4QMY9   A0A154PCI1   B4KY02   A0A158NK14   B7QH59   U5EVG8   B3NDH2   B4HK70   B4IXG3   A0A131Y236   A0A2S2PVR4   B4N3A7   A0A0K8RPN4   A0A026VV86   A0A3L8DSN6   A0A224XRW0   G3MQQ8   A0A3P8VVJ8   B4PK95   A0A182I1F7   A0A2K5DKP6   A0A1W4WFX2   Q7Q5Z9   A0A182XP68   A0A182KP18   A0A182TJ59   A0A2K6V384   H0WK00   A0A023GIF0   A0A1E1XAL0   A0A0A9X5K3   F7F437   A0A0V0G543   A0A2U3ZA42   G1TEZ4   I3N9X7   A0A096MM99   A0A0D9S835   H9Z4J0   A0A1S3ABV9   A0A2K5RRH3   G1RE19   A0A1S3JUH0   A0A3Q7MWP3   O35685   Q63525   A0A3Q4HX13   A0A250XYI6   B4FBE4   G3RH24   M3YW43   A0A1A6GCZ0   A0A2R8Z5V8   H2PYE7   A0A2K5ZCC5   M3WHP3   A0A2U3VIQ5   A0A061IEW1   A0A3Q4I440   H2N8E2   H9FNY2   A0A2K6GML8  

PDB

1WFI     E-value=1.79454e-33,     Score=356

KEGG

692957    no KO assigned | (RefSeq) nuclear migration protein nudC

GO

GO:0032502   GO:0005737   GO:0051082   GO:0006457   GO:0016021   GO:0051647   GO:0050775   GO:0007097   GO:0005829   GO:0005874   GO:0007049   GO:0051301   GO:0005634   GO:0005794   GO:0043434  

PANTHER

PTHR12356  

Subcellular location

Cytoplasm   A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity).   With evidence from 3 publications.
Cytoskeleton   A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity).   With evidence from 3 publications.
Nucleus   A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity).   With evidence from 3 publications.

Length:

325

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00059

Exp number, first 60 AAs:

0.00059

Total prob of N-in:

0.02071

outside

1  -  325

 

 

Pi

226.033396

Theta

191.908687

Tajima's D

0.557334

CLR

0.066139

CSRT

0.531923403829809

Interpretation

Uncertain