Gene

KWMTBOMO13095  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000390

Annotation

PREDICTED:_phosphoribosylformylglycinamidine_synthase_[Amyelois_transitella]

Location

Bomo_Chr22(-):8262034-8271584      View in EpiBrowser

Full name

Phosphoribosylformylglycinamidine synthase      

Alternative Name

Formylglycinamide ribonucleotide amidotransferase
Formylglycinamide ribotide amidotransferase
Protein adenosine-2

Location in the cell

Cytoplasmic   Reliability : 2.512

CDS

ATGTCTATCGTACGATTCTTTTCTACCGAAGCATTTAGTTTACATAAAACAAATGAAATTTTACAAAAACTGAAGTTTGTGGATAGTGATATAAAAGATTTGTCTACTGAGCTGTGTTACCATGTAGAGCTGGCTGAAGGCTGTGAATATCTCAATATAAATCAGATCAAAGTGTTAAAATGGCTGTTGAGTTCACCACTACAGCCTCAAGCTGTTAGAAATGAAACTATCTTCAAAAGTAATGATAACAGTCAGCTTTTAATAGAAATTGGTCCTAGGTTTAATTTCTCAACAGCAGACTCCAGTAACTCTGTGCAGATTTGTGAAAGCGTGGGTCTACGCGATGTTGTTCGTCTTGAAGTGTCTACAAGATACCTAATTACATTTGGAAAACAAAAAAATGTTACTGAAAAACATTTTGAGAATTTAGCTGCAGTGTTACATGATAGGATGACGCAATGTGTTTATACAAAGGATAATCTACCCCGTAAAAGTTTTAATGAAGGCCTGCCAAAAGATTTAGAACCATGGTTTGTTGTTCCCTTGCAAGAGCAAGGCATTTCTGCTATGAGAAAGGTTAATGATAAATTAGGTTTGGCATTTGATACATGGGACATGGAATTTTACATGGATTTATTTGTGAACAAACTGAAAAGGGATCCTACGAGTGTAGAACTATTTGACCTCGCCCAGAGCAACAGTGAACATTCACGTCATTGGTTTTTCAAGGGTAAGTTAGTATTGGATGGTAAAGAGATAAATGAATCTTTAATTGATATGGTTGCTTCAACACAAAAAACTTCGAATAATAACAATGTTATTAAATTTGGTGATAACAGTAGTGCAATCAAAGGCTTCCAACATACAATATTGCGTCCTACCAATGTTAGAGGACCATCGCAAGTTATCCAGAAGAAAACAGAATCTGATATAATATTCACGGCAGAAACTCACAATATGCCAACCGCAGTAGCCCCTTTTAGCGGGGCTACAACTGGTACGGGGGGACGTATTAGGGACGTTCAAGGAGTTGGTCGTGGTGGACACACAGTTGCTGGCACAGCTGGGTATAGTGTGGGCAACCTACATATACCAGGGTACGATCTACCGTGGGAGGAAAAAGGTTGGGAATATCCAAGTAATTTTGCAACACCTCTACAAATTATAATAGAAGCCAGCAATGGAGCTTCAGACTATGGAAACAAGTTTGGTGAACCAGTAATATCTGGATTTGTCCAATCGTATGGATTGAAAAATGCGGACAATACAAGAGAAGAATTTGTGAAACCGATAATGTTTAGTGGTGGTATCGGCTACATGCCACATTCGATGATTAAAAAAAACAAACCCGACAAAGGTATGCTGCTAGTGAAGATCGGTGGTCCCGTATATCGTATCGGCGTCGGTGGTGGGGCCGCTTCCTCCGTAGCCGTGCAGGGCGGCGACGCTAGAGACCACGCCCTTGACTTTGGAGCTGTGCAGAGAGGTGATGCGGAAATGGGTAATCGTCTGAACCGCGTGGTTCGTGGATGTCTGGAATCCGATGTTAATCCAGTTGAATGTGAGTATTTTTTCAATCATGTTATTTTTTGA

Protein

MSIVRFFSTEAFSLHKTNEILQKLKFVDSDIKDLSTELCYHVELAEGCEYLNINQIKVLKWLLSSPLQPQAVRNETIFKSNDNSQLLIEIGPRFNFSTADSSNSVQICESVGLRDVVRLEVSTRYLITFGKQKNVTEKHFENLAAVLHDRMTQCVYTKDNLPRKSFNEGLPKDLEPWFVVPLQEQGISAMRKVNDKLGLAFDTWDMEFYMDLFVNKLKRDPTSVELFDLAQSNSEHSRHWFFKGKLVLDGKEINESLIDMVASTQKTSNNNNVIKFGDNSSAIKGFQHTILRPTNVRGPSQVIQKKTESDIIFTAETHNMPTAVAPFSGATTGTGGRIRDVQGVGRGGHTVAGTAGYSVGNLHIPGYDLPWEEKGWEYPSNFATPLQIIIEASNGASDYGNKFGEPVISGFVQSYGLKNADNTREEFVKPIMFSGGIGYMPHSMIKKNKPDKGMLLVKIGGPVYRIGVGGGAASSVAVQGGDARDHALDFGAVQRGDAEMGNRLNRVVRGCLESDVNPVECEYFFNHVIF

Description

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).

Catalytic Activity

ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate

Similarity

In the N-terminal section; belongs to the FGAMS family.

Keywords

ATP-binding   Complete proteome   Glutamine amidotransferase   Ligase   Magnesium   Metal-binding   Nucleotide-binding   Purine biosynthesis   Reference proteome  

Feature

chain  Phosphoribosylformylglycinamidine synthase

Uniprot

H9IT11   A0A2H1VMD1   A0A2A4IX63   A0A2W1BTP0   A0A194PX17   A0A194R136   + More
A0A212EZS4   A0A336M968   A0A336MBE0   A0A1J1HEV2   A0A0K8VSR0   A0A0K8V3V5   A0A034W2Y8   A0A1L8DXU7   A0A0K8TXD6   V5I8P4   A0A1W4X6B4   A0A1I8NMG1   A0A1B0FM81   A0A1A9YDW6   A0A1B0C4Y6   A0A0A1X5F9   A0A1B6DZ99   A0A0M4ENV9   A0A1B0A5L8   U4U6Q1   W4VRR3   A0A1A9UNK4   A0A1B0CYC3   B4MUY2   K7J2R4   A0A0T6B804   A0A232F240   A0A1B6MKA9   B4I1Q0   B4LRK9   A0A3B0KLY5   W5JJV4   A0A1B0D1U8   A0A182FRW1   A0A2M3ZZG9   A0A2M3ZZ22   A0A0L7QQW1   B4JB83   W8C4W9   A0A182NFP0   A0A310SK93   Q17A67   A0A2P8XHT0   A0A0L0BT40   A0A2A3E8W2   Q29PN1   P35421   A0A2M3ZZU5   A0A0R3NQR5   A0A088A349   A0A182PE24   B4G6J9   B3N9S0   D2A2F6   T1PHX9   B4NZR4   A0A1I8N5A6   A0A182UMY3   A0A182RX40   A0A1Y1MYP2   A0A1W4VW44   B4Q468   A0A182TPE8   A0A182MGH3   A0A182LR04   A0A182XGF1   Q7PYT0   A0A182QAE8   E9IHC3   A0A182HZX5   A0A026WRS5   A0A3L8DNY1   A0A182XW07   A0A182VRG3   A0A182IS55   A0A067R9T8   A0A182JVU5   B3MKJ4   A0A0N0BDG7   A0A0J7KQ17   E2ACZ3   B4KL66   A0A195FTM4   F4WA86   A0A0K8SIM3   E0V9E3   A0A2J7RGZ3   A0A1Q3G2V2   A0A1A9W851   A0A151IIZ1   N6TFV9   A0A1Q3G2P6   A0A151WGG9  

EC Number

6.3.5.3

Pubmed

19121390    28756777    26354079    22118469    25348373    25830018    + More
23537049    17994087    20075255    28648823    18057021    20920257    23761445    24495485    17510324    29403074    26108605    15632085    8270203    10731132    12537572    18362917    19820115    17550304    25315136    28004739    22936249    20966253    12364791    14747013    17210077    21282665    24508170    30249741    25244985    24845553    20798317    21719571    20566863   

EMBL

BABH01013153    BABH01013154    ODYU01003346    SOQ41989.1    NWSH01004978    PCG64537.1    + More
KZ150009    PZC75103.1    KQ459586    KPI97867.1    KQ460883    KPJ11417.1    AGBW02011240    OWR46951.1    UFQT01000742    SSX26872.1    UFQT01000651    SSX26123.1    CVRI01000001    CRK86525.1    GDHF01017584    GDHF01010392    GDHF01003373    JAI34730.1    JAI41922.1    JAI48941.1    GDHF01018707    JAI33607.1    GAKP01010819    JAC48133.1    GFDF01002811    JAV11273.1    GDHF01033368    GDHF01020785    GDHF01000125    JAI18946.1    JAI31529.1    JAI52189.1    GALX01004330    JAB64136.1    CCAG010014695    JXJN01025727    GBXI01008161    JAD06131.1    GEDC01006286    JAS31012.1    CP012523    ALC38170.1    KB632012    ERL87998.1    GANO01000762    JAB59109.1    AJWK01028155    CH963857    EDW76327.1    LJIG01009308    KRT83339.1    NNAY01001258    OXU24590.1    GEBQ01003678    JAT36299.1    CH480820    EDW54457.1    CH940649    EDW63604.1    KRF81184.1    KRF81185.1    OUUW01000010    SPP86101.1    ADMH02001227    ETN63588.1    AJVK01022373    AJVK01022374    GGFK01000529    MBW33850.1    GGFK01000483    MBW33804.1    KQ414786    KOC60876.1    CH916368    EDW02888.1    GAMC01009326    JAB97229.1    KQ765605    OAD53852.1    CH477339    EAT43159.1    PYGN01002080    PSN31568.1    JRES01001393    KNC23191.1    KZ288322    PBC28158.1    CH379058    EAL34261.2    U00683    AE014134    BT011143    GGFK01000700    MBW34021.1    KRT03322.1    CH479180    EDW28224.1    CH954177    EDV58565.1    KQ971338    EFA02192.2    KA647478    AFP62107.1    CM000157    EDW88848.2    GEZM01017306    GEZM01017305    JAV90783.1    CM000361    CM002910    EDX03901.1    KMY88446.1    AXCM01001046    AAAB01008987    EAA01024.2    AXCN02000239    GL763196    EFZ20043.1    APCN01002018    KK107128    EZA58391.1    QOIP01000006    RLU21996.1    KK852794    KDR16414.1    CH902620    EDV31547.1    KQ435878    KOX70064.1    LBMM01004407    KMQ92447.1    GL438630    EFN68691.1    CH933807    EDW11727.1    KRG02871.1    KQ981272    KYN43813.1    GL888045    EGI68877.1    GBRD01012666    JAG53158.1    DS234992    EEB09999.1    NEVH01003749    PNF40114.1    GFDL01000976    JAV34069.1    KQ977412    KYN02867.1    APGK01039519    APGK01039520    KB740971    ENN76633.1    GFDL01000973    JAV34072.1    KQ983176    KYQ46907.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000183832    + More
UP000192223    UP000095300    UP000092444    UP000092443    UP000092460    UP000092553    UP000092445    UP000030742    UP000078200    UP000092461    UP000007798    UP000002358    UP000215335    UP000001292    UP000008792    UP000268350    UP000000673    UP000092462    UP000069272    UP000053825    UP000001070    UP000075884    UP000008820    UP000245037    UP000037069    UP000242457    UP000001819    UP000000803    UP000005203    UP000075885    UP000008744    UP000008711    UP000007266    UP000002282    UP000095301    UP000075903    UP000075900    UP000192221    UP000000304    UP000075902    UP000075883    UP000075882    UP000076407    UP000007062    UP000075886    UP000075840    UP000053097    UP000279307    UP000076408    UP000075920    UP000075880    UP000027135    UP000075881    UP000007801    UP000053105    UP000036403    UP000000311    UP000009192    UP000078541    UP000007755    UP000009046    UP000235965    UP000091820    UP000078542    UP000019118    UP000075809   

PRIDE

H9IT11    P35421   

Pfam

PF18076   FGAR-AT_N        + More
PF00586   AIRS
PF18072   FGAR-AT_linker
PF02769   AIRS_C
PF16041   DUF4793
PF16040   DUF4792
PF16884   ADH_N_2
PF00107   ADH_zinc_N

Interpro

IPR041609   PurL_linker        + More
IPR010918   PurM-like_C_dom       
IPR029062   Class_I_gatase-like       
IPR036676   PurM-like_C_sf       
IPR017926   GATASE       
IPR036604   PurS-like_sf       
IPR016188   PurM-like_N       
IPR040707   FGAR-AT_N       
IPR010073   PurL_large       
IPR036921   PurM-like_N_sf       
IPR032008   DUF4792       
IPR032010   DUF4793       
IPR020843   PKS_ER       
IPR014190   PTGR1       
IPR011032   GroES-like_sf       
IPR013149   ADH_C       
IPR041694   ADH_N_2       
IPR036291   NAD(P)-bd_dom_sf       
IPR001156   Transferrin-like_dom       

SUPFAM

SSF52317   SSF52317        + More
SSF56042   SSF56042       
SSF55326   SSF55326       
SSF82697   SSF82697       
SSF51735   SSF51735       
SSF50129   SSF50129       

Gene 3D

3.30.1330.10     3.40.50.880     3.90.650.10    

CDD

cd08294  leukotriene_B4_DH_like

ProteinModelPortal

H9IT11   A0A2H1VMD1   A0A2A4IX63   A0A2W1BTP0   A0A194PX17   A0A194R136   + More
A0A212EZS4   A0A336M968   A0A336MBE0   A0A1J1HEV2   A0A0K8VSR0   A0A0K8V3V5   A0A034W2Y8   A0A1L8DXU7   A0A0K8TXD6   V5I8P4   A0A1W4X6B4   A0A1I8NMG1   A0A1B0FM81   A0A1A9YDW6   A0A1B0C4Y6   A0A0A1X5F9   A0A1B6DZ99   A0A0M4ENV9   A0A1B0A5L8   U4U6Q1   W4VRR3   A0A1A9UNK4   A0A1B0CYC3   B4MUY2   K7J2R4   A0A0T6B804   A0A232F240   A0A1B6MKA9   B4I1Q0   B4LRK9   A0A3B0KLY5   W5JJV4   A0A1B0D1U8   A0A182FRW1   A0A2M3ZZG9   A0A2M3ZZ22   A0A0L7QQW1   B4JB83   W8C4W9   A0A182NFP0   A0A310SK93   Q17A67   A0A2P8XHT0   A0A0L0BT40   A0A2A3E8W2   Q29PN1   P35421   A0A2M3ZZU5   A0A0R3NQR5   A0A088A349   A0A182PE24   B4G6J9   B3N9S0   D2A2F6   T1PHX9   B4NZR4   A0A1I8N5A6   A0A182UMY3   A0A182RX40   A0A1Y1MYP2   A0A1W4VW44   B4Q468   A0A182TPE8   A0A182MGH3   A0A182LR04   A0A182XGF1   Q7PYT0   A0A182QAE8   E9IHC3   A0A182HZX5   A0A026WRS5   A0A3L8DNY1   A0A182XW07   A0A182VRG3   A0A182IS55   A0A067R9T8   A0A182JVU5   B3MKJ4   A0A0N0BDG7   A0A0J7KQ17   E2ACZ3   B4KL66   A0A195FTM4   F4WA86   A0A0K8SIM3   E0V9E3   A0A2J7RGZ3   A0A1Q3G2V2   A0A1A9W851   A0A151IIZ1   N6TFV9   A0A1Q3G2P6   A0A151WGG9  

PDB

4MGH     E-value=2.66125e-56,     Score=555

KEGG

101735940    K01952 phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] | (RefSeq) phosphoribosylformylglycin

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006189   GO:0006541   GO:0004642   GO:0016021   GO:0047522   GO:0005737   GO:0032440   GO:0005524   GO:0046872   GO:0006164   GO:0016740  

Length:

530

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03239

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00097

outside

1  -  530

 

 

Pi

432.471813

Theta

219.498373

Tajima's D

3.305929

CLR

0.141545

CSRT

0.992300384980751

Interpretation

Uncertain