Gene

KWMTBOMO13093

Pre Gene Modal

BGIBMGA000311

Annotation

fadd_[Bombyx_mori]

Location

Bomo_Chr22(+):8247565-8249447      View in EpiBrowser

Full name

Fas-associated death domain protein      

Alternative Name

Death domain-containing adapter protein BG4
FAS-associating death domain-containing protein

Location in the cell

Cytoplasmic   Reliability : 1.434

CDS

ATGACTAAGTCAGAATATTCACTACTAAAAGATGAGATAATTTTACGTGCAAGTGGAACTCCAAGACACGGTGAGATTTTGAGGTCTGTAAAAGAAATATATAAACAAAGTATTAACTCTAAAAGAAGATATGAACAAATTGAAACGATTGCGCAGCTGTTGAAAGTGTTGGAAATACGAGATGTATTGTCTGAAAATAGCATTGAGCCACTGAAAGAAGTCGCACGAAGACTACAAGATAATAATGAATTACTGCGTAAAATTACAGATTATGAGTTAATTTCTGTATCAAAGAAGGACCTAAATAACACAGTATCATCATTTACTGCAACGCATGATGAAAAAATTGAAAGTGTTATAAAGTTGAATCCATTTGGTGGCAATTTAAGTCCAAGAAAAAAAGAAAGACTATTTGAAACTATAATAGAAGAAACAGGTACAAACTGGCGGGCTTTAGCTAGAAAATTAAAAATTCGAGAATGTGTAATTATCAAGATTGATGCTGAAGAAACTACACTAGCAGATAAAGTAAAAAAAATACTGGAGATATATGAGCAACGAGCAGATCCACAAAGGTGGTTTTTTGTTCTTTGTGATGCTTTGGAAGAATCATACAGGCGCGATATAGCAGATTCATTAAGAAATATTATAGTAATGAATATTTAA

Protein

MTKSEYSLLKDEIILRASGTPRHGEILRSVKEIYKQSINSKRRYEQIETIAQLLKVLEIRDVLSENSIEPLKEVARRLQDNNELLRKITDYELISVSKKDLNNTVSSFTATHDEKIESVIKLNPFGGNLSPRKKERLFETIIEETGTNWRALARKLKIRECVIIKIDAEETTLADKVKKILEIYEQRADPQRWFFVLCDALEESYRRDIADSLRNIIVMNI

Description

Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.
Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (By similarity).

Subunit

Interacts (via N-terminus) with Dredd; likely to bind Dredd simultaneously with Diap2 to form a trimeric complex (PubMed:10934188, PubMed:22549468). Interacts with imd (PubMed:12433364).
N-terminus interacts with Dredd. Interacts with imd (By similarity).

Keywords

Apoptosis   Complete proteome   Cytoplasm   Reference proteome  

Feature

chain  Fas-associated death domain protein

Uniprot

E9JEH5   A0A2W1BN96   A0A194PWY2   A0A1E1W1V6   A0A2H1VMF1   A0A212EZM2   + More
A0A194R1M1   A0A0L7KMS2   V5I957   A0A0A1WHQ2   A0A1A9W4C5   W8BX82   A0A1I8NPT0   A0A151IJ70   A0A034WFD2   A0A0K8VTX1   A0A1W4W5W4   A0A0L0CPL0   A0A1B0AVT4   D6WJL3   F4X4J8   A0A151XG39   A0A151JUS0   A0A158NIK4   A0A1A9UGD4   A0A1A9YI96   A0A151J2S1   B4IX97   E9IPB2   E1ZYG9   B3LVL4   A0A1I8NBE9   T1IRM9   A0A0L7QTI3   A0A1A9ZU79   T1J1E4   A0A1B0G3A2   A0A154NZM1   A0A0M4EYB8   A0A1Y1N579   B3P7N8   A0A3B0JZX5   E2BKQ8   N6THJ9   B4QZD4   B4L107   B9EQZ9   H0RN71   Q9V3B4   A0A2P8Y1H6   B4HM84   A0A067QNS8   A0A0M9A655   B4G312   B4LGS4   A0A2A3EEW3   A0A087UJ91   A0A232F4J6   A0A2P8Y1H9   B4PLJ9   A0A0B5KML6   B4MX96   Q297U0  

Pubmed

19121390    21040523    28756777    26354079    22118469    26227816    + More
25830018    24495485    25348373    26108605    18362917    19820115    21719571    21347285    17994087    21282665    20798317    18057021    25315136    28004739    23537049    10934188    10731132    12537572    17465907    12433364    22549468    29403074    24845553    28648823    17550304    25205508    15632085   

EMBL

BABH01013154    GQ426292    ADM32518.1    KZ150009    PZC75104.1    KQ459586    + More
KPI97866.1    GDQN01010132    JAT80922.1    ODYU01003346    SOQ41988.1    AGBW02011240    OWR46949.1    KQ460883    KPJ11419.1    JTDY01008809    KOB64386.1    GALX01003515    JAB64951.1    GBXI01016096    JAC98195.1    GAMC01000645    JAC05911.1    KQ977412    KYN02908.1    GAKP01006459    JAC52493.1    GDHF01009990    JAI42324.1    JRES01000080    KNC34313.1    JXJN01004386    KQ971342    EFA04650.1    GL888656    EGI58628.1    KQ982179    KYQ59285.1    KQ981733    KYN36547.1    ADTU01016895    ADTU01016896    KQ980336    KYN16485.1    CH916366    EDV97429.1    GL764479    EFZ17590.1    GL435215    EFN73766.1    CH902617    EDV42584.1    KPU79801.1    AFFK01018673    KQ414755    KOC61786.1    JH431783    CCAG010013739    KQ434786    KZC05032.1    CP012525    ALC43475.1    GEZM01017388    GEZM01017387    JAV90737.1    CH954182    EDV54199.1    OUUW01000005    SPP81060.1    GL448819    EFN83756.1    APGK01037209    KB740948    ENN77263.1    CM000364    EDX13870.1    CH933809    EDW18164.1    BT058074    ACM78516.1    BT132793    AEU04542.1    AF295103    AF222005    AE014297    AM412815    AM412816    AM412817    AM412818    AAF44325.1    AAF55950.1    AAG22535.1    PYGN01001050    PSN38112.1    CH480815    EDW43132.1    KK853114    KDR11191.1    KQ435727    KOX78027.1    CH479179    EDW24207.1    CH940647    EDW70539.1    KZ288263    PBC30323.1    KK120062    KFM77430.1    NNAY01000966    OXU25691.1    PSN38111.1    CM000160    EDW97948.1    KJ639817    AJG36592.1    CH963876    EDW76929.1    CM000070   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000037510    UP000091820    + More
UP000095300    UP000078542    UP000192223    UP000037069    UP000092460    UP000007266    UP000007755    UP000075809    UP000078541    UP000005205    UP000078200    UP000092443    UP000078492    UP000001070    UP000000311    UP000007801    UP000095301    UP000053825    UP000092445    UP000092444    UP000076502    UP000092553    UP000008711    UP000268350    UP000008237    UP000019118    UP000000304    UP000009192    UP000000803    UP000245037    UP000001292    UP000027135    UP000053105    UP000008744    UP000008792    UP000242457    UP000054359    UP000215335    UP000002282    UP000007798    UP000001819   

PRIDE

E9JEH5    Q9V3B4   

Pfam

PF00531   Death        + More
PF01335   DED
PF15261   JHY

Interpro

IPR000488   Death_domain        + More
IPR011029   DEATH-like_dom_sf       
IPR001875   DED_dom       
IPR027968   JHY       
IPR002398   Pept_C14       

SUPFAM

SSF47986   SSF47986       

ProteinModelPortal

E9JEH5   A0A2W1BN96   A0A194PWY2   A0A1E1W1V6   A0A2H1VMF1   A0A212EZM2   + More
A0A194R1M1   A0A0L7KMS2   V5I957   A0A0A1WHQ2   A0A1A9W4C5   W8BX82   A0A1I8NPT0   A0A151IJ70   A0A034WFD2   A0A0K8VTX1   A0A1W4W5W4   A0A0L0CPL0   A0A1B0AVT4   D6WJL3   F4X4J8   A0A151XG39   A0A151JUS0   A0A158NIK4   A0A1A9UGD4   A0A1A9YI96   A0A151J2S1   B4IX97   E9IPB2   E1ZYG9   B3LVL4   A0A1I8NBE9   T1IRM9   A0A0L7QTI3   A0A1A9ZU79   T1J1E4   A0A1B0G3A2   A0A154NZM1   A0A0M4EYB8   A0A1Y1N579   B3P7N8   A0A3B0JZX5   E2BKQ8   N6THJ9   B4QZD4   B4L107   B9EQZ9   H0RN71   Q9V3B4   A0A2P8Y1H6   B4HM84   A0A067QNS8   A0A0M9A655   B4G312   B4LGS4   A0A2A3EEW3   A0A087UJ91   A0A232F4J6   A0A2P8Y1H9   B4PLJ9   A0A0B5KML6   B4MX96   Q297U0  

KEGG

100529236    K02373 FAS-associated death domain protein | (RefSeq) fadd

PATHWAY

04215    Apoptosis - multiple species - Bombyx mori (domestic silkworm)
04624    Toll and Imd signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0007165   GO:0042981   GO:0006919   GO:0050829   GO:0006955   GO:0007291   GO:0005737   GO:0050700   GO:0061057   GO:0002230   GO:0006915   GO:0006963   GO:0045089   GO:0005829   GO:0005515   GO:0004375   GO:0006546   GO:0006544   GO:0003824   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR10454  

Subcellular location

Cytoplasm  

Length:

221

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.08976

outside

1  -  221

 

 

Pi

122.550072

Theta

164.254725

Tajima's D

-0.861387

CLR

455.087699

CSRT

0.166591670416479

Interpretation

Uncertain