Gene

KWMTBOMO13092  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000391

Annotation

PREDICTED:_glycine_dehydrogenase_(decarboxylating)?_mitochondrial_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr22(-):8224339-8242434      View in EpiBrowser

Full name

Glycine cleavage system P protein      

Location in the cell

Cytoplasmic   Reliability : 1.445 Mitochondrial   Reliability : 1.844

CDS

ATGCTAAGTGCCATTCGTCATGTTACAACACAAAGTACTCGTTCTGATACATTATTCCCAGATAGAGTGGACTTCCCGAGTAGACACATTGGCCCAAGGGATCAGGATATAGTTACTATGTTAGATTTATTAGGATACAAGAGTTTAGACCAGTTAACCAATGATGCAGTACCAAAGAAGATTCAATTCCAAGGTCTTATGAATATCAGTGAGCCCATAAGTGAATACGACCTAATAGAACGGGTTAGGTTGATAGCTGAAAAGAATGAAATATGGCGATCTTACATCGGAATGGGTTACCACAATTGTTGCGTACCGCATGCCATCATGAGGAACATGTTTGAAAATCCCGGATGGACTACACAATATACGCCGTATCAGCCAGAAGTCGCACAAGGTCGACTTGAAAGCTTGCTTAATTACCAAACGATGGTTAGTGACATGACTGGATTGGACGTTGCTAATGCTTCCTTACTGGATGAGGGTACGGCTGCTGCCGAAGCACTTTCACTGTGTCACAGGCATAACAAACGAACAAAGTTCGTCGTGTCCGAACGATTGCATCCCCAGACGCTAGCTGTAGTGCACACTAGAATGGATGCGCTGGGCTTAGATGTTCTGGTAGTTCCTGACGTGCGGCATGTGGATTTCGCCCAGAGGGATATTTCCGCAGTGCTCTTACAATGCCCTGATACTAGGGGCCTAGTTTACGACTACTCAGGCCTAGCAGCCGCCGCCCATGAGCACGGGACATTGGTGGTAGTGGCTACAGATCTCCTGGCGCTCGCATTAATTAGACCCCCTGCGGAATGCGGGGCGGCTTTAGCTGTGGGCACCTCACAAAGACTGGGAGTGCCTATGGGATACGGAGGACCTCACGCTGGTTTTTTCGCAGCAGAACATCAACTAGTTCGTCTCATGCCCGGCCGAATGGTCGGTGTCACTCGAGATACTACAGGAAGGGATGCTTATAGGCTAGCCCTACAAACTAGAGAGCAACACATCCGACGTGATAAAGCGACATCTAATATTTGTACCGCCCAGGCGCTCCTGGCGAACATGTCTGCCATGTATGCGGTTTACCACGGACCACAAGGTCTAAGAGAAATAGCAACTCGTGTGCACAATGCAACATTGGTGCTAGACCATGGTATTAAGATGCGCGGTCACAAACAATCAAACGATGTTTACTTTGACACACTCTATGTAGTGCCTAGTCCAGATCATGATGCGAGTGCCATTAAAGCTAGAGCGGAAGAGAAGAAGGTTAACCTCAGGTATTTCGATGAAGGCGCGGTGGGAGTCGCTTTGGATGAAACGACCACAATGAAGGACATTGAAGATTTACTTTGGATATTTGACTGCAAAAACGTACAAGAGGTGGCGCAAACCGAAGATATCTTGTCTAAGAGTGTATTGAAAGGTCCATTCAGAAGGACCTCACCGTATCTCACTCACCCTGTGTTCAACATGCACCACTCAGAAACGAAGCTCGTGAGGTACATGAAACGTCTCGAAAACAAGGATATATCTCTTGTACACTCCATGATACCGCTTGGTTCCTGTACAATGAAATTGAATTCCACAACCGAGATGATGCCTTGTTCGTATAAGCATTTCACGGACATACATCCTTTCGCTCCATTGGAGCAATGTCAAGGATATCATACACTGTTCGAGGAACTTGCTAATGATCTTTGTGCTATAACAGGATACGATCGGGTGTCTTTCCAACCCAATAGTGGGGCCCAAGGCGAATATGCGGGGTTGCGCACAATAAAGCGCTACCACGAGTACCGCGGGGACGCAGGACGGAACATTTGCTTGATCCCGGTGAGCGCGCACGGCACCAACCCGGCCTCCGCGCACATGGCCGGCATGCGCGTCTGCGCCATACGGGTCACGCCAACTGGTGACATCGATATGGCTCATCTTAAGGACATGGTGGAAGAACACAGTGAGAAAGTTTCGTGCCTAATGTTGACTTACCCAAGTACTTTCGGCGTCTTTGAAGAAAAAGCGGCGGATATATGTGCCCTGGTGCACGCACACGGAGGTCAAGTCTATTTGGACGGTGCCAACATGAATGCGCAGGTCGGTTTATGTCGTCCTGGAGATTACGGCAGTGACGTGTCTCATCTCAACCTCCATAAGACGTTCTGTATTCCACATGGTGGCGGCGGACCTGGCATGGGACCCATTGGAGTAAAAGCGCATCTCGCACCGTTTTTACCATCGCATCCTGTTGTCGATCCGTTGGCCGATTTAGGAGACGCGGCTCATAGCTTCGGTTCAGTCAGCGCCGCGCCATTTGGCTCGTCAGCTATTCTACCTATATCTTGGGCTTATATTAAGATGATGGGTCCGAAAGGACTGAGGCGGGCAACGCAAGTAGCCATTCTCAATGCAAATTACATGTCTCGAAGATTGGAAGATCATTATAAGACGCTATATAAAGGGGAAAGAGGCCTCGTTGCTCACGAATTCATTATCGACGTAAGAGATCTCAAGAAAACAGCCAATATTGAACCTGGAGATATTGCTAAACGACTTATGGACTTTGGATTTCATGCTCCAACAATGTCTTGGCCAGTTGCGGGGACGCTTATGATAGAACCGACAGAATCCGAAGATCTACAAGAATTGGACCGTTTCTGCGATGCTCTAATTACCATCAGAAAGGAAATTAAAGATATCGAAGATGGTCTTATTGACAAAAGATTAAATCCATTAAAGTTGGCTCCACATACGCAAGAAGAAGTTATCTCAGAAGAATGGAATCGTCCGTATACCAGGGAGCAAGCTGCTTTTCCAGCGCCATTCGTTAAAGGAGAGACCAAAATCTGGCCGACGGTTGGTCGTATTGATGATATGTATGGTGACAAACATCTTGTTTGCACGTGCCCCCCTGTGATCGATGACTTTTAA

Protein

MLSAIRHVTTQSTRSDTLFPDRVDFPSRHIGPRDQDIVTMLDLLGYKSLDQLTNDAVPKKIQFQGLMNISEPISEYDLIERVRLIAEKNEIWRSYIGMGYHNCCVPHAIMRNMFENPGWTTQYTPYQPEVAQGRLESLLNYQTMVSDMTGLDVANASLLDEGTAAAEALSLCHRHNKRTKFVVSERLHPQTLAVVHTRMDALGLDVLVVPDVRHVDFAQRDISAVLLQCPDTRGLVYDYSGLAAAAHEHGTLVVVATDLLALALIRPPAECGAALAVGTSQRLGVPMGYGGPHAGFFAAEHQLVRLMPGRMVGVTRDTTGRDAYRLALQTREQHIRRDKATSNICTAQALLANMSAMYAVYHGPQGLREIATRVHNATLVLDHGIKMRGHKQSNDVYFDTLYVVPSPDHDASAIKARAEEKKVNLRYFDEGAVGVALDETTTMKDIEDLLWIFDCKNVQEVAQTEDILSKSVLKGPFRRTSPYLTHPVFNMHHSETKLVRYMKRLENKDISLVHSMIPLGSCTMKLNSTTEMMPCSYKHFTDIHPFAPLEQCQGYHTLFEELANDLCAITGYDRVSFQPNSGAQGEYAGLRTIKRYHEYRGDAGRNICLIPVSAHGTNPASAHMAGMRVCAIRVTPTGDIDMAHLKDMVEEHSEKVSCLMLTYPSTFGVFEEKAADICALVHAHGGQVYLDGANMNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFLPSHPVVDPLADLGDAAHSFGSVSAAPFGSSAILPISWAYIKMMGPKGLRRATQVAILNANYMSRRLEDHYKTLYKGERGLVAHEFIIDVRDLKKTANIEPGDIAKRLMDFGFHAPTMSWPVAGTLMIEPTESEDLQELDRFCDALITIRKEIKDIEDGLIDKRLNPLKLAPHTQEEVISEEWNRPYTREQAAFPAPFVKGETKIWPTVGRIDDMYGDKHLVCTCPPVIDDF

Description

The glycine cleavage system catalyzes the degradation of glycine.

Catalytic Activity

glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2

Cofactor

pyridoxal 5'-phosphate

Subunit

The glycine cleavage system is composed of four proteins: P, T, L and H.

Similarity

Belongs to the GcvP family.

Uniprot

H9IT12   A0A3S2NGN9   A0A2W1BNA2   A0A2A4IX58   A0A212EZM4   A0A194R2E5   + More
A0A194Q384   A0A2A4IWY4   A0A2H1X3K9   A0A1I8MFF3   T1PEJ7   D6WE64   A0A1Y1KGY4   A0A067RMZ2   A0A1B0C9B3   A0A0T6AUW1   A0A0L0CEN6   A0A1Q3F0U8   Q16GC4   A0A1S4G1P4   B0W8H9   A0A0M5J049   A0A2J7PMS1   A0A1I8PDY3   A0A1W4XUL5   A0A182LUQ4   A0A182Q6G0   A0A182XKG0   A0A1A9ZRQ4   A0A1B0FFX4   A0A182HJI5   A0A084VTQ0   A0A336M525   B4NFG0   A0A182RJ72   A0A0K8VBT6   A0A182K3C7   A0A182JLN7   A0A1A9V932   A0A1W4U867   A0A3B0K068   A0A2M4BBW5   A0A034WL01   B3LW06   A0A2M4A4I3   A0A2M4BBY0   W8C960   A0A1B0DP67   Q9VH09   A0A182FAX3   A0A182PBG1   A0A182NL93   A0A2M3YZ66   W5JUT9   B4G6B4   A0A182VXP9   B4PKN1   B3P1P8   B5DWC3   A0A1A9WLS6   B4JIM1   A0A0A1XPE1   B5DWC6   B4LWC6   B4K539   A0A1J1IM25   E0VAY0   A0A151X270   N6SYU9   A0A1B6J3Y0   A0A195C421   A0A158NN64   A0A2J7PMR4   F4W8C6   A0A1B6HQR0   E1ZVT0   A0A026WCU6   A0A232ESS0   A0A182XXI7   A0A146KW83   A0A195FB38   A0A182S9M2   A0A182TD47   A0A224X6K0   E2B6Y8   A0A3R7MMD6   A0A023F4C4   A0A0N0U3G4   A0A154PHR3   A0A087UF92   A0A310SB32   Q1DGH8   A0A0C9RE33   A0A0P4VY99   A0A2A3E3E8   A0A3B0KPB4   V5GZN1   A0A131YUW6   W5MV75   E9IDT3  

EC Number

1.4.4.2

Pubmed

19121390    28756777    22118469    26354079    25315136    18362917    + More
19820115    28004739    24845553    26108605    17510324    24438588    17994087    25348373    24495485    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20920257    23761445    17550304    15632085    25830018    20566863    23537049    21347285    21719571    20798317    24508170    30249741    28648823    25244985    26823975    25474469    25765539    26830274    21282665   

EMBL

BABH01013155    BABH01013156    RSAL01000111    RVE47093.1    KZ150009    PZC75105.1    + More
NWSH01006060    PCG63703.1    AGBW02011240    OWR46948.1    KQ460883    KPJ11420.1    KQ459586    KPI97865.1    PCG63702.1    ODYU01013141    SOQ59832.1    KA646555    AFP61184.1    KQ971324    EFA01173.1    GEZM01086402    JAV59480.1    KK852572    KDR21089.1    AJWK01002141    LJIG01022791    KRT78699.1    JRES01000501    KNC30715.1    GFDL01013865    JAV21180.1    CH478294    EAT33293.1    DS231859    EDS39029.1    CP012526    ALC47048.1    NEVH01023960    PNF17634.1    AXCM01004705    AXCN02000111    AXCN02000112    CCAG010016676    APCN01002169    ATLV01016383    KE525080    KFB41344.1    UFQT01000542    SSX25110.1    CH964251    EDW83027.1    GDHF01016314    JAI36000.1    OUUW01000013    SPP87705.1    GGFJ01001394    MBW50535.1    GAKP01003623    JAC55329.1    CH902617    EDV41539.1    GGFK01002344    MBW35665.1    GGFJ01001392    MBW50533.1    GAMC01006921    JAB99634.1    AJVK01007926    AE014297    BT003457    AAF54512.1    AAO39460.1    GGFM01000811    MBW21562.1    ADMH02000300    ETN67048.1    CH479179    EDW23873.1    CM000160    EDW96790.1    CH954181    EDV49647.1    CM000070    EDY67752.2    CH916369    EDV93102.1    GBXI01001068    JAD13224.1    EDY67755.2    CH940650    EDW66563.1    CH933806    EDW14010.1    CVRI01000055    CRL01293.1    DS235019    EEB10536.1    KQ982579    KYQ54543.1    APGK01059092    APGK01059093    APGK01059094    APGK01059095    KB741292    ENN70408.1    GECU01013825    JAS93881.1    KQ978344    KYM94926.1    ADTU01021054    PNF17630.1    GL887908    EGI69417.1    GECU01030679    JAS77027.1    GL434631    EFN74714.1    KK107263    QOIP01000011    EZA53887.1    RLU16928.1    NNAY01002380    OXU21408.1    GDHC01018520    JAQ00109.1    KQ981693    KYN37596.1    GFTR01008360    JAW08066.1    GL446071    EFN88530.1    QCYY01003082    ROT65479.1    GBBI01002705    JAC16007.1    KQ435903    KOX69058.1    KQ434912    KZC11416.1    KK119563    KFM76031.1    KQ765330    OAD53966.1    CH901660    EAT32257.1    GBYB01006615    GBYB01006616    GBYB01006618    JAG76382.1    JAG76383.1    JAG76385.1    GDRN01104059    JAI57974.1    KZ288446    PBC25621.1    SPP87706.1    GANP01008338    JAB76130.1    GEDV01005790    JAP82767.1    AHAT01012995    GL762535    EFZ21248.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053240    UP000053268    + More
UP000095301    UP000007266    UP000027135    UP000092461    UP000037069    UP000008820    UP000002320    UP000092553    UP000235965    UP000095300    UP000192223    UP000075883    UP000075886    UP000076407    UP000092445    UP000092444    UP000075840    UP000030765    UP000007798    UP000075900    UP000075881    UP000075880    UP000078200    UP000192221    UP000268350    UP000007801    UP000092462    UP000000803    UP000069272    UP000075885    UP000075884    UP000000673    UP000008744    UP000075920    UP000002282    UP000008711    UP000001819    UP000091820    UP000001070    UP000008792    UP000009192    UP000183832    UP000009046    UP000075809    UP000019118    UP000078542    UP000005205    UP000007755    UP000000311    UP000053097    UP000279307    UP000215335    UP000076408    UP000078541    UP000075901    UP000075902    UP000008237    UP000283509    UP000053105    UP000076502    UP000054359    UP000242457    UP000018468   

PRIDE

H9IT12    Q9VH09   

Pfam

PF01212   Beta_elim_lyase        + More
PF02347   GDC-P

Interpro

IPR015424   PyrdxlP-dep_Trfase        + More
IPR020581   GDC_P       
IPR003437   GcvP       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR001597   ArAA_b-elim_lyase/Thr_aldolase       
IPR015422   PyrdxlP-dep_Trfase_dom1       

SUPFAM

SSF53383   SSF53383       

Gene 3D

3.40.640.10     3.90.1150.10    

CDD

cd00613  GDC-P

ProteinModelPortal

H9IT12   A0A3S2NGN9   A0A2W1BNA2   A0A2A4IX58   A0A212EZM4   A0A194R2E5   + More
A0A194Q384   A0A2A4IWY4   A0A2H1X3K9   A0A1I8MFF3   T1PEJ7   D6WE64   A0A1Y1KGY4   A0A067RMZ2   A0A1B0C9B3   A0A0T6AUW1   A0A0L0CEN6   A0A1Q3F0U8   Q16GC4   A0A1S4G1P4   B0W8H9   A0A0M5J049   A0A2J7PMS1   A0A1I8PDY3   A0A1W4XUL5   A0A182LUQ4   A0A182Q6G0   A0A182XKG0   A0A1A9ZRQ4   A0A1B0FFX4   A0A182HJI5   A0A084VTQ0   A0A336M525   B4NFG0   A0A182RJ72   A0A0K8VBT6   A0A182K3C7   A0A182JLN7   A0A1A9V932   A0A1W4U867   A0A3B0K068   A0A2M4BBW5   A0A034WL01   B3LW06   A0A2M4A4I3   A0A2M4BBY0   W8C960   A0A1B0DP67   Q9VH09   A0A182FAX3   A0A182PBG1   A0A182NL93   A0A2M3YZ66   W5JUT9   B4G6B4   A0A182VXP9   B4PKN1   B3P1P8   B5DWC3   A0A1A9WLS6   B4JIM1   A0A0A1XPE1   B5DWC6   B4LWC6   B4K539   A0A1J1IM25   E0VAY0   A0A151X270   N6SYU9   A0A1B6J3Y0   A0A195C421   A0A158NN64   A0A2J7PMR4   F4W8C6   A0A1B6HQR0   E1ZVT0   A0A026WCU6   A0A232ESS0   A0A182XXI7   A0A146KW83   A0A195FB38   A0A182S9M2   A0A182TD47   A0A224X6K0   E2B6Y8   A0A3R7MMD6   A0A023F4C4   A0A0N0U3G4   A0A154PHR3   A0A087UF92   A0A310SB32   Q1DGH8   A0A0C9RE33   A0A0P4VY99   A0A2A3E3E8   A0A3B0KPB4   V5GZN1   A0A131YUW6   W5MV75   E9IDT3  

PDB

4LHD     E-value=0,     Score=2605

KEGG

101736065    K00281 glycine dehydrogenase [EC:1.4.4.2] | (RefSeq) glycine dehydrogenase (decarboxylating), mitoch

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004375   GO:0005739   GO:0006546   GO:0016829   GO:0019464   GO:0005960   GO:0016594   GO:0030170   GO:0016021   GO:0006520   GO:0006544   GO:0003824   GO:0008237   GO:0008152   GO:0016491   GO:0015930   GO:0055114  

PANTHER

PTHR11773  

Subcellular location

Mitochondrion  

Length:

975

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.892929999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00505

outside

1  -  975

 

 

Pi

253.102703

Theta

177.35269

Tajima's D

1.55809

CLR

0.201964

CSRT

0.8013599320034

Interpretation

Uncertain