Gene

KWMTBOMO13085  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000307

Annotation

PREDICTED:_carboxypeptidase_E-like_[Bombyx_mori]

Location

Bomo_Chr22(+):8061445-8068296      View in EpiBrowser

Full name

Carboxypeptidase E      

Alternative Name

Carboxypeptidase H
Enkephalin convertase
Prohormone-processing carboxypeptidase

Location in the cell

Cytoplasmic   Reliability : 2.203

CDS

ATGCAAGACTTCAACTACTTGGCAACGAATGCTTTCGAAATTACACTGGAACTGGGCTGCGAAAAATATCCGTCAGCTGAACTTTTAGAAACCGAGTGGAACCGAAATCGCGAAGCGCTCGTGGAATATTTGTGGAAAGCCCACATCGGTGTCAAAGGTGTTGTCAGCGATAGTAAAGGTTTCATACCGAACGCTATTATTTCTGTTGTCAACTGCACCGGATCCGTAACGAAACCGATCCGACACGACGTCACGACAGGTCCATACGGTGATTACTATCGCTTGCTGACACCCGGACAGTACGAGATTACGGCTACACATACCGGTCACTTTCAAGCCTCACGAATGGTTTCCGTACCAAAGAACCAGAAGTCTGCTATCATCTTGGATTTCAGACTAGAAGAGTTTCAGGGTAAAACAAATTGGCTCCAAGATCTGTCTTCGTTCGGAGTTTACTCGCCTTCGTTGCGTAACAGTCAACCAAGGATATACAAGCGATCTCTTTATGAAAAAGTAGCTGAAACAATGCTAGAAAATAAGGAAATCGTTAAGCAATAA

Protein

MQDFNYLATNAFEITLELGCEKYPSAELLETEWNRNREALVEYLWKAHIGVKGVVSDSKGFIPNAIISVVNCTGSVTKPIRHDVTTGPYGDYYRLLTPGQYEITATHTGHFQASRMVSVPKNQKSAIILDFRLEEFQGKTNWLQDLSSFGVYSPSLRNSQPRIYKRSLYEKVAETMLENKEIVKQ

Description

Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.

Catalytic Activity

Release of C-terminal arginine or lysine residues from polypeptides.

Cofactor

Zn(2+)

Subunit

Interacts with secretogranin III/SCG3.

Similarity

Belongs to the peptidase M14 family.

Keywords

Carboxypeptidase   Cleavage on pair of basic residues   Complete proteome   Cytoplasmic vesicle   Glycoprotein   Hydrolase   Membrane   Metal-binding   Metalloprotease   Protease   Reference proteome   Secreted   Signal   Zinc   Zymogen  

Feature

propeptide  Activation peptide
chain  Carboxypeptidase E

Uniprot

H9IST0   A0A2W1BTP9   A0A2H1V3R4   S4PTF0   I4DQW2   A0A212F4B5   + More
A0A194PX08   A0A194R146   A0A0L7LI35   A0A0U4BW51   A0A1B6L3R9   A0A1B6IPR5   A0A2S2PVK1   E0W2S8   A0A139WAF4   J9JM00   N6T861   A0A2S2NLB9   U4UJ45   A0A0T6AVF3   V5I9C3   A0A2R7VX82   A0A087TJM9   A0A1Y3BKC5   A0A1B6FQI7   A0A1I9WL51   A0A1V1FKQ5   A0A2J7RN85   A0A1S0TH09   A0A1B6CEM3   A0A067QWF9   A0A0N4VH40   A0A147BJY4   A0A0R3QYI1   T1L1W8   A0A0P4ZGN0   A0A0P5BQN4   A0A0P5E6J9   A0A0P5YKZ9   A0A0P5TFT2   A0A0P5E828   A0A0N8A7Q2   A0A0P6HJT4   A0A0P5SXF1   A0A0P6BNB4   A0A1I7VHC7   J9EY12   A0A3R7STB3   A0A0A9XL37   A0A1B6DLD4   A0A0P5E1S9   A0A1S5QN46   A0A0H5S1A8   A0A3P7E2J6   A0A1I8EVF1   A0A0N5CY17   A0A0N4TY09   E9FTT2   A0A158R4K0   A0A1L8FJH6   A0A2F0B7R5   A0A2H6NEZ8   F6Z4Z3   A8E4W2   F7DEN5   A0A0B1TII8   A0A182EA36   A0A044T666   W5MZG2   A0A1I7XUR7   A0A1D2NM88   A0A093JBF7   Q5FVZ6   A0A158P615   A0A1I8ADR2   A0A1B6C9Z1   A0A3Q2YPC6   F1L1Q2   A0A2G9UE54   A0A3P6TWZ8   A0A1B6CXY6   A0A0R3S358   A0A2H2JMS4   A0A0N4U6U9   A0A060W8K8   A0A0D8XRI5   A5A6K7   A0A2K6GN36   A0A2K6GMZ4   T1IXL0   A0A238BPS3   A0A3Q4BCG0   T1IMV6   A0A1A7WCN8   A0A3Q3WGE6  

EC Number

3.4.17.10

Pubmed

19121390    28756777    23622113    22651552    22118469    26354079    + More
26227816    26694822    20566863    18362917    19820115    23537049    27538518    28410430    24845553    29652888    25217238    25401762    26823975    17885136    26850696    21292972    27762356    20431018    22919073    23874975    27289101    26392177    21685128    24755649    26856411    17574350   

EMBL

BABH01013177    KZ150009    PZC75113.1    ODYU01000339    SOQ34924.1    GAIX01012153    + More
JAA80407.1    AK404808    BAM20302.1    AGBW02010414    OWR48562.1    KQ459586    KPI97857.1    KQ460883    KPJ11427.1    JTDY01001037    KOB75065.1    KU218671    ALX00051.1    GEBQ01021696    JAT18281.1    GECU01018790    JAS88916.1    GGMS01000246    MBY69449.1    DS235879    EEB19934.1    KQ971409    KYB24878.1    ABLF02016878    ABLF02035270    ABLF02062804    APGK01040397    KB740979    ENN76419.1    GGMR01005360    MBY17979.1    KB632379    ERL94094.1    LJIG01022706    KRT79135.1    GALX01003185    JAB65281.1    KK854143    PTY12072.1    KK115515    KFM65318.1    MUJZ01018092    OTF80464.1    GECZ01017329    JAS52440.1    KU932235    APA33871.1    FX985399    BAX07412.1    NEVH01002545    PNF42294.1    JH712371    EFO13755.2    GEDC01025439    GEDC01007084    JAS11859.1    JAS30214.1    KK853170    KDR10344.1    UXUI01010082    VDD94735.1    GEGO01004307    JAR91097.1    UZAG01017839    VDO36908.1    CAEY01000922    GDIP01213083    JAJ10319.1    GDIP01185988    LRGB01003123    JAJ37414.1    KZS04404.1    GDIP01150888    JAJ72514.1    GDIP01056442    JAM47273.1    GDIP01127438    JAL76276.1    GDIP01145437    JAJ77965.1    GDIP01174321    JAJ49081.1    GDIQ01026810    JAN67927.1    GDIP01138832    JAL64882.1    GDIP01012235    JAM91480.1    ADBV01000496    EJW87098.1    QCYY01001938    ROT74091.1    GBHO01022965    GBRD01000314    GDHC01003988    GDHC01003389    JAG20639.1    JAG65507.1    JAQ14641.1    JAQ15240.1    GEDC01010823    JAS26475.1    GDIP01148235    JAJ75167.1    KR068529    AMO02546.1    LN856424    CRZ22415.1    UYWW01001340    VDM10344.1    UYYF01004332    VDN02537.1    UZAD01013452    VDN94997.1    GL732524    EFX89423.1    CM004478    OCT71750.1    NTJE010095063    MBV99042.1    IACI01099262    LAA31104.1    AAMC01037071    AAMC01037072    AAMC01037073    AAMC01037074    AAMC01037075    AAMC01037076    AAMC01037077    AAMC01037078    AAMC01037079    AAMC01037080    BC153352    AAI53353.1    KN550039    KHJ95200.1    UYRW01001203    VDK75166.1    CMVM020000124    AHAT01017459    LJIJ01000006    ODN06398.1    KL217287    KFV76224.1    BC089691    CR855829    AAH89691.1    CAJ82957.1    GEDC01030672    GEDC01027203    GEDC01013472    GEDC01003824    GEDC01003543    JAS06626.1    JAS10095.1    JAS23826.1    JAS33474.1    JAS33755.1    JI169697    ADY44056.1    KZ347075    PIO68491.1    UYRX01001045    VDK87869.1    GEDC01019037    JAS18261.1    UYYG01001158    VDN57063.1    FR904362    CDQ60885.1    KN716356    KJH46367.1    AB222135    AFFK01020101    KZ270033    OZC07377.1    JH431096    HADW01002085    SBP03485.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000037510    UP000009046    + More
UP000007266    UP000007819    UP000019118    UP000030742    UP000054359    UP000235965    UP000027135    UP000038041    UP000274131    UP000050602    UP000015104    UP000076858    UP000095285    UP000004810    UP000283509    UP000006672    UP000270924    UP000093561    UP000046394    UP000276776    UP000038020    UP000278627    UP000000305    UP000046393    UP000186698    UP000008143    UP000077448    UP000271087    UP000024404    UP000018468    UP000095283    UP000094527    UP000053875    UP000035642    UP000095287    UP000264820    UP000277928    UP000050640    UP000005237    UP000038040    UP000274756    UP000193380    UP000053766    UP000002277    UP000233160    UP000261620   

PRIDE

H9IST0    A5A6K7   

Pfam

PF00246   Peptidase_M14        + More
PF10613   Lig_chan-Glu_bd
PF01392   Fz

Interpro

IPR015567   Pept_M14B_carboxypept_D2        + More
IPR008969   CarboxyPept-like_regulatory       
IPR000834   Peptidase_M14       
IPR019594   Glu/Gly-bd       
IPR036790   Frizzled_dom_sf       
IPR034239   M14_CPZ_CPD       
IPR020067   Frizzled_dom       

SUPFAM

SSF49464   SSF49464        + More
SSF63501   SSF63501       

Gene 3D

1.10.2000.10    

CDD

cd03867  M14_CPZ

ProteinModelPortal

H9IST0   A0A2W1BTP9   A0A2H1V3R4   S4PTF0   I4DQW2   A0A212F4B5   + More
A0A194PX08   A0A194R146   A0A0L7LI35   A0A0U4BW51   A0A1B6L3R9   A0A1B6IPR5   A0A2S2PVK1   E0W2S8   A0A139WAF4   J9JM00   N6T861   A0A2S2NLB9   U4UJ45   A0A0T6AVF3   V5I9C3   A0A2R7VX82   A0A087TJM9   A0A1Y3BKC5   A0A1B6FQI7   A0A1I9WL51   A0A1V1FKQ5   A0A2J7RN85   A0A1S0TH09   A0A1B6CEM3   A0A067QWF9   A0A0N4VH40   A0A147BJY4   A0A0R3QYI1   T1L1W8   A0A0P4ZGN0   A0A0P5BQN4   A0A0P5E6J9   A0A0P5YKZ9   A0A0P5TFT2   A0A0P5E828   A0A0N8A7Q2   A0A0P6HJT4   A0A0P5SXF1   A0A0P6BNB4   A0A1I7VHC7   J9EY12   A0A3R7STB3   A0A0A9XL37   A0A1B6DLD4   A0A0P5E1S9   A0A1S5QN46   A0A0H5S1A8   A0A3P7E2J6   A0A1I8EVF1   A0A0N5CY17   A0A0N4TY09   E9FTT2   A0A158R4K0   A0A1L8FJH6   A0A2F0B7R5   A0A2H6NEZ8   F6Z4Z3   A8E4W2   F7DEN5   A0A0B1TII8   A0A182EA36   A0A044T666   W5MZG2   A0A1I7XUR7   A0A1D2NM88   A0A093JBF7   Q5FVZ6   A0A158P615   A0A1I8ADR2   A0A1B6C9Z1   A0A3Q2YPC6   F1L1Q2   A0A2G9UE54   A0A3P6TWZ8   A0A1B6CXY6   A0A0R3S358   A0A2H2JMS4   A0A0N4U6U9   A0A060W8K8   A0A0D8XRI5   A5A6K7   A0A2K6GN36   A0A2K6GMZ4   T1IXL0   A0A238BPS3   A0A3Q4BCG0   T1IMV6   A0A1A7WCN8   A0A3Q3WGE6  

PDB

3MN8     E-value=8.32971e-26,     Score=286

KEGG

101740426    K01294 carboxypeptidase E [EC:3.4.17.10] | (RefSeq) carboxypeptidase E-like

GO

GO:0004181   GO:0008270   GO:0004970   GO:0016021   GO:0016485   GO:0006518   GO:0005615   GO:0030424   GO:0006937   GO:0030536   GO:2000294   GO:0045887   GO:0060456   GO:0043025   GO:0061837   GO:0098793   GO:1903745   GO:0014055   GO:0014057   GO:0071244   GO:0090326   GO:0031410   GO:0030141   GO:0030070   GO:0097060   GO:0005794   GO:0030658   GO:0072657   GO:0016055   GO:0003214   GO:0033366   GO:0042043   GO:0050839   GO:0030667   GO:0030072  

PANTHER

PTHR11532:SF73  

Subcellular location

Cytoplasmic vesicle   Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.   With evidence from 4 publications.
Secretory vesicle   Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.   With evidence from 4 publications.
Secretory vesicle membrane   Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.   With evidence from 4 publications.
Secreted   Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.   With evidence from 4 publications.

Length:

185

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01184

Exp number, first 60 AAs:

0.00167

Total prob of N-in:

0.16057

outside

1  -  185

 

 

Pi

212.750765

Theta

176.996929

Tajima's D

0.581703

CLR

0.504871

CSRT

0.543972801359932

Interpretation

Uncertain