Gene

KWMTBOMO13079

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_integrator_complex_subunit_12_[Bombyx_mori]

Location

Bomo_Chr22(+):8018134-8020111      View in EpiBrowser

Full name

Integrator complex subunit 12      

Location in the cell

Nuclear   Reliability : 4.145

CDS

ATGTCATCAATTGATTTCGATCCAGCTATAAAATTATGTTTAAAATACTTACATTCAAGTTCTGTAGATTCTACGGAACAATTGCGATTGACTCTCGATGATCACATCAGACAATCATATGGTAGTGCAAAAACTCTTGGTAATATGTTACCGAAGAAATATCTTAACGAAGAGAAGATGGAGTCACCTAGATCCAAACACAAAATAGATAAGAATGCAGTAACTAAGACGGTTCCTGTACCACAACAAAGTCCACAACAAATTCAAATACCTGAGAGAGAAAACGATGATGGTTCAGTTATGGATGGAGAATTGGCTTTTGACTTGTTAGAGGAAGACTTGACTTGTGCTGTCTGTAGACAAATAGCTGTGCAAGCCGGAAATCGCTTAGTGGAGTGTGATGGGTGCCGGGCACTGTACCATCAGGATTGTCATAAGCCTGTGATCAGTGACAATGATATCGCTGCAGGTTGGCAATGTGCAACCTGTCTTGCAGCACATGGATTTACAACTAATTATTCAAGTAAAACTTCATCGAGCTCCAAGTCACCATCAAGAGTGTCTGGTTCCACAACCCCTGTAAAAATTTCATCTAGCAGTTCATCTTCATCATCACCATCGAAAGTTGTTACTCCAAATATGAATATCATTTCTGCAGACAAAAGGTTGCAGATAATGAAGAAGAAAGCTGCAAAACAACATGAAAAGAAGAAAAGCTCTAAGTCGTAA

Protein

MSSIDFDPAIKLCLKYLHSSSVDSTEQLRLTLDDHIRQSYGSAKTLGNMLPKKYLNEEKMESPRSKHKIDKNAVTKTVPVPQQSPQQIQIPERENDDGSVMDGELAFDLLEEDLTCAVCRQIAVQAGNRLVECDGCRALYHQDCHKPVISDNDIAAGWQCATCLAAHGFTTNYSSKTSSSSKSPSRVSGSTTPVKISSSSSSSSSPSKVVTPNMNIISADKRLQIMKKKAAKQHEKKKSSKS

Description

Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424, PubMed:23288851). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS1 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).

Subunit

Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS1 and IntS9 (PubMed:23288851). Interaction with IntS1 is likely to be important for promoting 3'-end processing of snRNAs (PubMed:23288851).

Similarity

Belongs to the Integrator subunit 12 family.

Keywords

Complete proteome   Metal-binding   Nucleus   Reference proteome   Zinc   Zinc-finger  

Feature

chain  Integrator complex subunit 12

Uniprot

A0A1E1WKX3   S4PHC4   A0A3S2TAL7   A0A2H1V257   A0A2W1BP86   A0A2A4J0L5   + More
A0A194PXV1   A0A194R2F5   H9ISS7   A0A3L8DX39   A0A026WDK3   A0A310SSQ7   A0A182R8H4   A0A084WQ69   A0A182MWM9   A0A182W341   E2ADR6   A0A0J7KNG3   A0A0M8ZRP6   A0A182PG82   A0A0L7R303   A0A182HVJ6   Q7QA92   A0A182UWA0   A0A1Q3F1Y1   A0A182XF28   A0A182LNJ5   A0A182TWX5   A0A088A4N1   A0A1B0D4L3   A0A2A3E9B1   A0A195B0W7   A0A151IEY6   F4WPF2   A0A158NR00   A0A195E6I2   B0WMX5   A0A195EUD0   A0A151WMC7   Q170V4   A0A182YJQ0   E9ISL8   A0A182K051   A0A182QGN7   A0A023EP97   A0A182G6H7   E2BN22   A0A182NCQ6   A0A232EJR5   A0A182IPC5   A0A0P6IU04   A0A1S4FHT6   A0A2M4APF1   A0A1B0CAG0   W5JET0   A0A182FPJ7   A0A1L8DCI5   Q9VBB3   A0A0M4EIX1   A0A0L0CQ62   B3P8A1   B4QWS4   B4PSC5   B4IBZ7   A0A1W4VKF2   W8C9L1   B3M3B9   E0VMJ4   A0A0K8ULE7   A0A034WKR7   T1JLY1   B4JY74   G1QCI4   G9K5W7   G5AT22   A0A3Q1HSR5   S9YB32   G1PIZ5   A0A3Q7P609   A0A340WYU8   A0A1L8HV76   A0A2Y9N0D8   A0A341C618   K9J136   A0A2U4AQT2   A0A1U7SW01   A0A2U4AR75  

Pubmed

23622113    28756777    26354079    19121390    30249741    24508170    + More
24438588    20798317    12364791    14747013    17210077    20966253    21719571    21347285    17510324    25244985    21282665    24945155    26483478    28648823    26999592    20920257    23761445    10731132    12537572    12537569    21078872    23097424    23288851    26108605    17994087    17550304    24495485    20566863    25348373    21993624    23236062    21993625    23149746    27762356   

EMBL

GDQN01003400    JAT87654.1    GAIX01003327    JAA89233.1    RSAL01002880    RVE40395.1    + More
ODYU01000339    SOQ34920.1    KZ150009    PZC75117.1    NWSH01004475    PCG65064.1    KQ459586    KPI97853.1    KQ460883    KPJ11430.1    BABH01013178    QOIP01000003    RLU25011.1    KK107273    EZA53761.1    KQ760801    OAD58966.1    ATLV01025277    KE525379    KFB52363.1    AXCM01000759    GL438820    EFN68428.1    LBMM01005008    KMQ91918.1    KQ435885    KOX69587.1    KQ414663    KOC65260.1    APCN01005788    AAAB01008898    EAA09080.4    GFDL01013480    JAV21565.1    AJVK01024655    KZ288315    PBC28315.1    KQ976691    KYM77937.1    KQ977835    KYM99375.1    GL888243    EGI64047.1    ADTU01023715    KQ979608    KYN20454.1    DS232003    EDS31367.1    KQ981965    KYN31860.1    KQ982944    KYQ48993.1    CH477466    EAT40483.1    GL765434    EFZ16312.1    AXCN02000334    GAPW01002301    JAC11297.1    JXUM01045220    KQ561430    KXJ78610.1    GL449382    EFN82926.1    NNAY01003972    OXU18551.1    GDUN01000704    JAN95215.1    GGFK01009343    MBW42664.1    AJWK01003749    ADMH02001712    ETN61329.1    GFDF01009922    JAV04162.1    AE014297    AY070574    AAL48045.1    CP012526    ALC46721.1    JRES01000062    KNC34505.1    CH954182    EDV53505.1    CM000364    EDX14591.1    CM000160    EDW98587.1    CH480828    EDW45155.1    GAMC01002064    JAC04492.1    CH902617    EDV43580.1    DS235313    EEB14600.1    GDHF01024996    JAI27318.1    GAKP01004576    GAKP01004574    JAC54378.1    JH431482    CH916377    EDV90636.1    AAPE02006782    JP011694    AES00292.1    JH166824    GEBF01007386    EHB00183.1    JAN96246.1    KB017014    EPY81200.1    AAPE02032741    CM004466    OCT99918.1    GABZ01005966    JAA47559.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000053240    UP000005204    UP000279307    + More
UP000053097    UP000075900    UP000030765    UP000075883    UP000075920    UP000000311    UP000036403    UP000053105    UP000075885    UP000053825    UP000075840    UP000007062    UP000075903    UP000076407    UP000075882    UP000075902    UP000005203    UP000092462    UP000242457    UP000078540    UP000078542    UP000007755    UP000005205    UP000078492    UP000002320    UP000078541    UP000075809    UP000008820    UP000076408    UP000075881    UP000075886    UP000069940    UP000249989    UP000008237    UP000075884    UP000215335    UP000075880    UP000092461    UP000000673    UP000069272    UP000000803    UP000092553    UP000037069    UP000008711    UP000000304    UP000002282    UP000001292    UP000192221    UP000007801    UP000009046    UP000001070    UP000001074    UP000006813    UP000257200    UP000286641    UP000265300    UP000186698    UP000248483    UP000252040    UP000245320    UP000189704   

PRIDE

H9ISS7    Q9VBB3   

Pfam

PF00628   PHD        + More
PF01565   FAD_binding_4
PF02913   FAD-oxidase_C
PF00878   CIMR

Interpro

IPR019787   Znf_PHD-finger        + More
IPR019786   Zinc_finger_PHD-type_CS       
IPR011011   Znf_FYVE_PHD       
IPR039053   Int12       
IPR013083   Znf_RING/FYVE/PHD       
IPR001965   Znf_PHD       
IPR039054   Int12_PHD       
IPR006094   Oxid_FAD_bind_N       
IPR036318   FAD-bd_PCMH-like_sf       
IPR016166   FAD-bd_PCMH       
IPR025650   Alkyl-DHAP_Synthase       
IPR016171   Vanillyl_alc_oxidase_C-sub2       
IPR016164   FAD-linked_Oxase-like_C       
IPR004113   FAD-linked_oxidase_C       
IPR016169   FAD-bd_PCMH_sub2       
IPR016167   FAD-bd_PCMH_sub1       
IPR009011   Man6P_isomerase_rcpt-bd_dom_sf       
IPR000479   CIMR       

SUPFAM

SSF57903   SSF57903        + More
SSF55103   SSF55103       
SSF56176   SSF56176       

Gene 3D

3.30.40.10     1.10.45.10     3.30.43.10     3.30.465.10     2.70.130.10    

CDD

cd15501  PHD_Int12

ProteinModelPortal

A0A1E1WKX3   S4PHC4   A0A3S2TAL7   A0A2H1V257   A0A2W1BP86   A0A2A4J0L5   + More
A0A194PXV1   A0A194R2F5   H9ISS7   A0A3L8DX39   A0A026WDK3   A0A310SSQ7   A0A182R8H4   A0A084WQ69   A0A182MWM9   A0A182W341   E2ADR6   A0A0J7KNG3   A0A0M8ZRP6   A0A182PG82   A0A0L7R303   A0A182HVJ6   Q7QA92   A0A182UWA0   A0A1Q3F1Y1   A0A182XF28   A0A182LNJ5   A0A182TWX5   A0A088A4N1   A0A1B0D4L3   A0A2A3E9B1   A0A195B0W7   A0A151IEY6   F4WPF2   A0A158NR00   A0A195E6I2   B0WMX5   A0A195EUD0   A0A151WMC7   Q170V4   A0A182YJQ0   E9ISL8   A0A182K051   A0A182QGN7   A0A023EP97   A0A182G6H7   E2BN22   A0A182NCQ6   A0A232EJR5   A0A182IPC5   A0A0P6IU04   A0A1S4FHT6   A0A2M4APF1   A0A1B0CAG0   W5JET0   A0A182FPJ7   A0A1L8DCI5   Q9VBB3   A0A0M4EIX1   A0A0L0CQ62   B3P8A1   B4QWS4   B4PSC5   B4IBZ7   A0A1W4VKF2   W8C9L1   B3M3B9   E0VMJ4   A0A0K8ULE7   A0A034WKR7   T1JLY1   B4JY74   G1QCI4   G9K5W7   G5AT22   A0A3Q1HSR5   S9YB32   G1PIZ5   A0A3Q7P609   A0A340WYU8   A0A1L8HV76   A0A2Y9N0D8   A0A341C618   K9J136   A0A2U4AQT2   A0A1U7SW01   A0A2U4AR75  

PDB

1WEV     E-value=4.27836e-11,     Score=161

KEGG

101736687    K13149 integrator complex subunit 12 | (RefSeq) integrator complex subunit 12

GO

GO:0016180   GO:0046872   GO:0034472   GO:0032039   GO:0008168   GO:0008610   GO:0016491   GO:0071949   GO:0008609   GO:0005634   GO:0051219   GO:0007041   GO:0038023   GO:0005515   GO:0008270   GO:0007165   GO:0016020   GO:0019843   GO:0008237   GO:0008152   GO:0015930  

PANTHER

PTHR13415   PTHR46568  

Subcellular location

Nucleus  

Length:

242

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00197

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02138

outside

1  -  242

 

 

Pi

314.632242

Theta

209.801515

Tajima's D

1.834132

CLR

0

CSRT

0.855757212139393

Interpretation

Uncertain