Gene

KWMTBOMO13071  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000398

Annotation

PREDICTED:_succinyl-CoA:3-ketoacid_coenzyme_A_transferase_1?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr22(-):7927553-7936803      View in EpiBrowser

Full name

Succinyl-CoA:3-ketoacid-coenzyme A transferase       + More
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial      

Alternative Name

3-oxoacid CoA-transferase 1
Somatic-type succinyl-CoA:3-oxoacid CoA-transferase

Location in the cell

Cytoplasmic   Reliability : 2.153 Mitochondrial   Reliability : 1.688

CDS

ATGACTCTAAATATAAGAAAACTATTAGATGCCAATTATTCAAAGCTTGTGAATTCCATTGGAAAGATAAAAAGTTGTGCGACTTATGCCACAATTATTCGTAAAAGCAAAATATATGCCAGTGCTCAAGAAGTAGTTCAAGATGTATCAGATGGCTCAAAGTTATTAGTTGGTGGTTTTGGACTCTGTGGAATTCCTGAAAATCTAATTAAAGCTCTCAATATAAAAAAAGTATCAGCTCTGACAGTGGTATCTAACAATGCTGGTGTTGAAGATTTTGGCTTGGGTATTCTTCTTAAAAGTAAACAGATAAAAAGGATGATCTCCTCATATGTTGGAGAAAATGCGGAATTTGAAAGACAATTTTTAAGTGGAGAATTAGAGGTAGAATTGACACCGCAGGGTACACTGGCAGAAAGAATACGTGCAGGAGGTGCAGGTATTCCTGCCTTTTTTACACCTACTGGATTTGGTACTTTAATTCAGGAAGGCGGGTCACCAATTAAATATACCAAGGATGGAAAGATAGATATTCCTAGCTCTGCTCGTTTTGTACAGCAGTTTAATGGTAATAATTACGTAATGGAAGAAGCAATTACTGGCGATTTTGCTTTTGTTAAGGCTTGGAAAGCTGATAAACATGGTAATCTAATATTCAGGAAAAGTGCCAGGAACTTTAATCCAGCTATGTGCAGGGCTGCTCGCGTAACTATAGCCGAAGTGGAGGAAATTATTGATGAAATTGATCCAGATTTTGTTCATGTACCCTCAATATATGTGCACAGAATCATAAAGGAAGATAATTTTGAAAAGAGAATAGAAAGAAAAACTACAAGAAAACCAAATCAAACATCAAAATCGACTGATTCTCTGAGAGAAAAGATCATAAGAAGAGCTGCTTTAGAATTTAAAGATGGGATGCATGCAAATTTGGGTATAGGAATGCCTATGCTGGCAAGTAATTACATTCCAGAGAATGTTAAAGTTTTGCTTCAATCAGAAAATGGAATACTAGGTCTCGGTCCATTCCCCACAGAAGAAGAAGTGGATGCAGATCTGATCAATGCAGGCAAAGAAACAGTCACAATACTTCCAGGGGCCTCATTTTTCTCATCGGACGACAGCTTCGCTATGATCAGAGGAGGTCATATTGATCTCACTATACTAGGAGCGATGCAAGTTTCTCAATATGGTGATTTGGCCAATTGGATGATACCTGGTAAAATGGTAAAAGGAATGGGCGGTGCAATGGATTTAGTTTCTGCCCCAAGAACTAAAGTAGTGGTTACAATGGAACACACCGCCAAGAATGGATCGCACAAAATTCTCCCAGAGTGCACCTTACCGCTCACAGGAAAAAACTGTGTTGATATGATAATTACCGAAAAATGCGTCTTCGAAGTGGACAAAGAAAAAGGTCTTATATTAACTGAATTGGCAGAAGGCGTTAAAGTGGAAGATATTGTTGCGAGCACTGGTTGCGAGTTTAACGTAGCACAAAAAATAAAAACGATGGGTGACGTCACCAGACCCGAAACAATCACAGAATAA

Protein

MTLNIRKLLDANYSKLVNSIGKIKSCATYATIIRKSKIYASAQEVVQDVSDGSKLLVGGFGLCGIPENLIKALNIKKVSALTVVSNNAGVEDFGLGILLKSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGIPAFFTPTGFGTLIQEGGSPIKYTKDGKIDIPSSARFVQQFNGNNYVMEEAITGDFAFVKAWKADKHGNLIFRKSARNFNPAMCRAARVTIAEVEEIIDEIDPDFVHVPSIYVHRIIKEDNFEKRIERKTTRKPNQTSKSTDSLREKIIRRAALEFKDGMHANLGIGMPMLASNYIPENVKVLLQSENGILGLGPFPTEEEVDADLINAGKETVTILPGASFFSSDDSFAMIRGGHIDLTILGAMQVSQYGDLANWMIPGKMVKGMGGAMDLVSAPRTKVVVTMEHTAKNGSHKILPECTLPLTGKNCVDMIITEKCVFEVDKEKGLILTELAEGVKVEDIVASTGCEFNVAQKIKTMGDVTRPETITE

Description

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

Catalytic Activity

a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate

Subunit

Homodimer.

Similarity

Belongs to the 3-oxoacid CoA-transferase family.

Keywords

3D-structure   Alternative splicing   Complete proteome   Direct protein sequencing   Disease mutation   Mitochondrion   Phosphoprotein   Polymorphism   Reference proteome   Transferase   Transit peptide  

Feature

chain  Succinyl-CoA:3-ketoacid-coenzyme A transferase
splice variant  In isoform 2.
sequence variant  In dbSNP:rs75134564.

Uniprot

H9IT19   A0A2A4IVJ3   A0A2W1BNC2   A0A2H1V2Q3   A0A194PXU1   A0A194R2G5   + More
A0A212F5V5   A0A336MFG7   N6TV20   U4TUX9   A0A1B0GJ64   A0A1L8E0E9   A0A1L8E0L9   A0A3B4BP26   A0A3Q3G0V2   A0A250Y2C1   V5I9G0   A0A286X7M2   W5JLT9   G1SWU1   A0A3Q2CU35   A0A024R040   P55809   G3S0S5   A0A2R8ZA36   A0A2J8QA96   A0A2K5JD26   A0A182FHR6   A0A3B3TAC1   W5KET8   G3SL67   A0A2J8QA97   G2HJV4   Q5R5W4   A0A2J8WBL2   K7AMG2   Q6IAV5   A0A1W5AMW8   A0A2I2YC70   A9UVE4   A0A2M4A404   A0A2M4A489   A0A2M4BK57   A0A3B4E2G6   A0A1A8S3M3   A0A1A8UQ40   A0A2K6ABY2   A0A2R8Z6B4   A0A2K5JDH2   H2QQT8   A0A2M4A4A9   A0A2I4ARJ8   A0A2K6DXU9   A0A2K5WEE6   A0A096MW68   A0A2K5LVL3   F7GQS5   A0A1A8NIT5   Q6AZB2   A0A1Q3FYE4   A0A2M3Z4I0   H2UM92   A0A151MX15   A0A1A8DKE2   A0A2M3ZHG6   A0A0S7GQT5   M4AN89   A8KBV1   A0A2K6ABV8   A0A2K5JDM3   T1DG03   A0A1A8JNL7   A0A2I3MA25   A0A2K5LVP5   A0A2I3T5J5   A0A2K5JDH7   U3D6T2   A0A2C9KAL5   A0A1Q3FYH4   A0A3Q3DZC7   A0A1D5QBH8   A0A0K2V923   A0A146ZKZ9   A0A3B3Z5G1   A0A3Q3SUS5   A0A3P9PRC5   A0A3Q3EEJ0   A0A2K5WEA7   F1PJ13   A0A1U7T5Y7   A0A2K5JDM0   G7MV58   A0A0K2V8E5   E9FSH9   A0A2K6DXW1   A0A096NP49   A0A2U3WK17   A0A3Q3SUT1   G7P7F3   G1MBJ4  

EC Number

2.8.3.5

Pubmed

19121390    28756777    26354079    22118469    23537049    28087693    + More
21993624    20920257    23761445    11181995    8751852    10964512    15372022    14702039    15489334    19608861    20068231    21269460    25944712    9671268    21296660    22398555    22722832    29240929    25329095    21484476    18273011    16136131    17431167    25319552    23594743    21551351    22293439    23542700    25243066    15562597    16341006    22002653    21292972    20010809   

EMBL

BABH01013185    BABH01013186    NWSH01006491    PCG63398.1    KZ150009    PZC75125.1    + More
ODYU01000396    SOQ35111.1    KQ459586    KPI97843.1    KQ460883    KPJ11440.1    AGBW02010128    OWR49117.1    UFQT01000501    SSX24798.1    APGK01017123    KB739998    ENN81918.1    KB631679    ERL85334.1    AJWK01019415    GFDF01001871    JAV12213.1    GFDF01001870    JAV12214.1    GFFV01002202    JAV37743.1    GALX01003000    JAB65466.1    AAKN02031713    AAKN02031714    AAKN02031715    AAKN02031716    ADMH02001054    ETN64268.1    AAGW02030552    AAGW02030553    AAGW02030554    AAGW02030555    AAGW02030556    AAGW02030557    GQ900952    CH471119    ADO22469.1    EAW56015.1    U62961    AB029576    AK298352    AK312327    AK315902    AC008817    AC034222    AC114946    BC009001    CABD030105388    CABD030105389    CABD030105390    CABD030105391    CABD030105392    CABD030105393    CABD030105394    AJFE02034127    AJFE02034128    AJFE02034129    NBAG03000055    PNI93193.1    PNI93192.1    AK307018    BAK64012.1    ABGA01307032    ABGA01307033    ABGA01307034    ABGA01307035    ABGA01307036    ABGA01307037    ABGA01307038    ABGA01307039    CR860738    NDHI03003396    CAH92852.1    PNJ67122.1    PNJ67121.1    GABC01008359    GABF01003812    GABE01003125    JAA02979.1    JAA18333.1    JAA41614.1    CR457049    CAG33330.1    CH991547    EDQ90386.1    GGFK01002223    MBW35544.1    GGFK01002240    MBW35561.1    GGFJ01004294    MBW53435.1    HAEH01000548    HAEI01011133    SBS12552.1    HADY01000008    HAEJ01008741    SBS49198.1    AACZ04037931    AACZ04037932    GABD01007034    JAA26066.1    GGFK01002312    MBW35633.1    AQIA01058538    AQIA01058539    AHZZ02028961    JSUE03035824    JSUE03035825    JU322587    JU475768    AFE66343.1    AFH32572.1    HAEF01018593    HAEG01003262    SBR68886.1    AL954357    BX571721    BX649517    BC078408    BC163972    AAH78408.1    AAI63972.1    GFDL01002474    JAV32571.1    GGFM01002652    MBW23403.1    AKHW03004724    KYO29042.1    HADZ01015403    HAEA01006017    SBQ34497.1    GGFM01007117    MBW27868.1    GBYX01450494    JAO31000.1    BX530077    BC154254    BC155216    AAI54255.1    AAI55217.1    GAMD01002951    JAA98639.1    HAED01011345    HAEE01001680    SBR21700.1    GAMT01002740    GAMR01006857    GAMQ01000954    GAMP01008660    JAB09121.1    JAB27075.1    JAB40897.1    JAB44095.1    GFDL01002421    JAV32624.1    HACA01029055    CDW46416.1    GCES01019302    JAR67021.1    AAEX03003147    CM001258    EHH26468.1    HACA01029056    CDW46417.1    GL732524    EFX89209.1    CM001281    EHH54224.1    ACTA01092152    ACTA01100152   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000019118    + More
UP000030742    UP000092461    UP000261440    UP000264800    UP000005447    UP000000673    UP000001811    UP000265020    UP000005640    UP000001519    UP000240080    UP000233080    UP000069272    UP000261540    UP000018467    UP000007646    UP000001595    UP000192224    UP000001357    UP000233140    UP000002277    UP000192220    UP000233120    UP000233100    UP000028761    UP000233060    UP000006718    UP000000437    UP000005226    UP000050525    UP000002852    UP000008225    UP000076420    UP000264820    UP000261480    UP000261640    UP000242638    UP000261660    UP000002254    UP000189704    UP000000305    UP000245340    UP000009130    UP000008912   

PRIDE

H9IT19    P55809    Q6IAV5    F1PJ13   

Pfam

PF01144   CoA_trans        + More
PF03914   CBF
PF03127   GAT
PF00790   VHS
PF01282   Ribosomal_S24e

Interpro

IPR014388   3-oxoacid_CoA-transferase        + More
IPR004165   CoA_trans_fam_I       
IPR012792   3-oxoacid_CoA-transf_A       
IPR004163   CoA_transf_BS       
IPR012791   3-oxoacid_CoA-transf_B       
IPR037171   NagB/RpiA_transferase-like       
IPR004164   CoA_transf_AS       
IPR005612   CCAAT-binding_factor       
IPR016024   ARM-type_fold       
IPR002014   VHS_dom       
IPR004152   GAT_dom       
IPR008942   ENTH_VHS       
IPR038425   GAT_sf       
IPR012678   Ribosomal_L23/L15e_core_dom_sf       
IPR001976   Ribosomal_S24e       
IPR018098   Ribosomal_S24e_CS       

SUPFAM

SSF100950   SSF100950        + More
SSF48371   SSF48371       
SSF48464   SSF48464       
SSF54189   SSF54189       

Gene 3D

1.20.58.160     1.25.40.90    

ProteinModelPortal

H9IT19   A0A2A4IVJ3   A0A2W1BNC2   A0A2H1V2Q3   A0A194PXU1   A0A194R2G5   + More
A0A212F5V5   A0A336MFG7   N6TV20   U4TUX9   A0A1B0GJ64   A0A1L8E0E9   A0A1L8E0L9   A0A3B4BP26   A0A3Q3G0V2   A0A250Y2C1   V5I9G0   A0A286X7M2   W5JLT9   G1SWU1   A0A3Q2CU35   A0A024R040   P55809   G3S0S5   A0A2R8ZA36   A0A2J8QA96   A0A2K5JD26   A0A182FHR6   A0A3B3TAC1   W5KET8   G3SL67   A0A2J8QA97   G2HJV4   Q5R5W4   A0A2J8WBL2   K7AMG2   Q6IAV5   A0A1W5AMW8   A0A2I2YC70   A9UVE4   A0A2M4A404   A0A2M4A489   A0A2M4BK57   A0A3B4E2G6   A0A1A8S3M3   A0A1A8UQ40   A0A2K6ABY2   A0A2R8Z6B4   A0A2K5JDH2   H2QQT8   A0A2M4A4A9   A0A2I4ARJ8   A0A2K6DXU9   A0A2K5WEE6   A0A096MW68   A0A2K5LVL3   F7GQS5   A0A1A8NIT5   Q6AZB2   A0A1Q3FYE4   A0A2M3Z4I0   H2UM92   A0A151MX15   A0A1A8DKE2   A0A2M3ZHG6   A0A0S7GQT5   M4AN89   A8KBV1   A0A2K6ABV8   A0A2K5JDM3   T1DG03   A0A1A8JNL7   A0A2I3MA25   A0A2K5LVP5   A0A2I3T5J5   A0A2K5JDH7   U3D6T2   A0A2C9KAL5   A0A1Q3FYH4   A0A3Q3DZC7   A0A1D5QBH8   A0A0K2V923   A0A146ZKZ9   A0A3B3Z5G1   A0A3Q3SUS5   A0A3P9PRC5   A0A3Q3EEJ0   A0A2K5WEA7   F1PJ13   A0A1U7T5Y7   A0A2K5JDM0   G7MV58   A0A0K2V8E5   E9FSH9   A0A2K6DXW1   A0A096NP49   A0A2U3WK17   A0A3Q3SUT1   G7P7F3   G1MBJ4  

PDB

3DLX     E-value=0,     Score=1689

KEGG

101737459    K01027 3-oxoacid CoA-transferase [EC:2.8.3.5] | (RefSeq) succinyl-CoA:3-ketoacid coenzyme A transfer

PATHWAY

00072    Synthesis and degradation of ketone bodies - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00650    Butanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005739   GO:0008260   GO:0046952   GO:0008410   GO:0042182   GO:0005654   GO:0035774   GO:0007507   GO:0045471   GO:0007584   GO:0042594   GO:0060612   GO:0007420   GO:0009725   GO:0042803   GO:0014823   GO:0005759   GO:0046950   GO:0006886   GO:0005623   GO:0005840   GO:0003735   GO:0006412   GO:0008152   GO:0019843   GO:0005515   GO:0008237   GO:0016491   GO:0015930  

PANTHER

PTHR13707  

Subcellular location

Mitochondrion matrix  

Length:

516

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07006

Exp number, first 60 AAs:

0.00693

Total prob of N-in:

0.00475

outside

1  -  516

 

 

Pi

32.638249

Theta

183.509974

Tajima's D

-1.75795

CLR

270.598401

CSRT

0.0338483075846208

Interpretation

Possibly Positive selection