Gene

KWMTBOMO13070

Pre Gene Modal

BGIBMGA000399

Annotation

ribosomal_protein_L20_[Bombyx_mori]

Location

Bomo_Chr22(-):7921205-7923663      View in EpiBrowser

Full name

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial      

Alternative Name

Succinyl-CoA synthetase subunit alpha

Location in the cell

Mitochondrial   Reliability : 3.052

CDS

ATGGTATTTTTGTCTGTTATAAACTGGGCCCGCTGTCGTGGACCCGACGAATTTTGGAGAAAGCGACGGGTTTTTAGATTAGCCGCTCATTATATTGGCCGTCGACGAAATTGTTATTCGATTGCAGTTCGAAATGTTCACCGAGCTCTAGTTTATGCAACCAAAGCAAGAAAGCTTAAGAAAGAAGATATGAAAAGTCTTTGGGACGTTAGAATAACGGCTGCTTGTGAGCAACACAATATTACACTATTCTCTTTAAGAGAAGGCTTGGACAGAGCTAATATAATGTTGGATAGGAAATCTTTGTCAGACTTGGCTTCATGGGAACCAAAAACATTTGAAGCCCTCGCTGCTGTAGCTAAATACAAACTTGAAACAGACAGATTCATAGATGGACAAGATAAATGTCACCCCACAGGAATAAATCTAAACCTTAAGGATGTGATGTTAGAGGCATGGTTGAATGAAAAGAAAAAATAA

Protein

MVFLSVINWARCRGPDEFWRKRRVFRLAAHYIGRRRNCYSIAVRNVHRALVYATKARKLKKEDMKSLWDVRITAACEQHNITLFSLREGLDRANIMLDRKSLSDLASWEPKTFEALAAVAKYKLETDRFIDGQDKCHPTGINLNLKDVMLEAWLNEKKK

Description

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

Catalytic Activity

ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
CoA + GTP + succinate = GDP + phosphate + succinyl-CoA

Subunit

Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).

Similarity

Belongs to the bacterial ribosomal protein bL20 family.
Belongs to the succinate/malate CoA ligase alpha subunit family.

Uniprot

Q2F656   I4DKM9   A0A194R161   A0A2W1BP96   I4DMR6   Q95UN2   + More
S4PSF2   A0A212F5V6   A0A1B0CUR3   A0A1L8DR99   A0A1B0DAD7   A0A1Y1LP30   A0A1I8JV36   A0A240PM15   A0A2M4C3S3   A0A1Y9G8G2   A0A2M4C435   A0A1I8JVJ7   A0A1I8JTD1   A0A1C7CZS8   A7UVP7   A0A2M4C439   T1DH43   A0A1I8JW46   A0A2M4AR59   A0A2M4AR72   W5J4X0   A0A0P4VH45   A0A0V0G6H5   A0A240PLH4   Q16HN7   A0A2M3ZJR6   U5EGM8   A0A240PLQ6   A0A2M3ZCU7   A0A224XN64   A0A2M3ZK04   A0A1W4WHU5   A0A2C9GUJ9   A0A2M3ZJU0   A0A182YBD5   A0A1Y9HB34   A0A182SV10   N6UP67   A0A067R4B4   D6WJ74   A0A1Y9IV39   A0A084VXV8   A0A1Y9H380   A0A3F2YXL7   A0A023EGF5   J3JXD0   V5IAL4   A0A0A9XTS5   A0A2J7QKQ2   A0A1Q3FCQ1   A0A1L8EDN1   A0A1L8EAH9   R4WQB3   A0A0L7RD94   B0WSS3   A0A088ARQ4   A0A195F2Z5   A0A1I8PME7   A0A0K8TPB0   A0A2A3E2F6   A0A182GIX5   A0A182G411   A0A195DCE5   A0A158P311   A0A2R7X3F3   A0A0L0C3Y1   A0A195BCZ5   W8C256   A0A1A9WH21   A0A1A9Z1R0   A0A0K8VUZ0   A0A0M8ZM77   A0A0A1X1G4   A0A1A9Y9U9   A0A1B0BWM3   A0A1I8NHC3   E9IEY1   A0A1B0FA11   A0A3B0J411   A0A1A9WCT2   Q2M0C2   B4GRU2   A0A1W4VIX8   B4LBH4   B4QIY3   A0A154PA40   B4HGN3   Q9VU36   B4ML22   A0A1A9VMQ8   B4PHB1   A0A1B6C6W6   B3MAU3  

EC Number

6.2.1.4
6.2.1.5

Pubmed

19121390    22651552    26354079    28756777    23622113    22118469    + More
28004739    20966253    12364791    20920257    23761445    27129103    17510324    25244985    23537049    24845553    18362917    19820115    24438588    24945155    22516182    25401762    26823975    23691247    26369729    26483478    21347285    26108605    24495485    25830018    25315136    21282665    15632085    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304   

EMBL

BABH01013186    DQ311216    ABD36161.1    AK401847    KQ459586    BAM18469.1    + More
KPI97841.1    KQ460883    KPJ11442.1    KZ150009    PZC75127.1    AK402584    BAM19206.1    AY046535    AAL03954.1    GAIX01013893    JAA78667.1    AGBW02010128    OWR49116.1    AJWK01029612    GFDF01005092    JAV08992.1    AJVK01013276    GEZM01051805    JAV74691.1    GGFJ01010680    MBW59821.1    GGFJ01010770    MBW59911.1    APCN01000834    AAAB01008987    EDO63271.2    GGFJ01010627    MBW59768.1    GAMD01002506    JAA99084.1    GGFK01009881    MBW43202.1    GGFK01009953    MBW43274.1    ADMH02002105    ETN59001.1    GDKW01002870    JAI53725.1    GECL01002425    JAP03699.1    CH478156    EAT33765.1    GGFM01007991    MBW28742.1    GANO01003380    JAB56491.1    GGFM01005623    MBW26374.1    GFTR01002490    JAW13936.1    GGFM01008064    MBW28815.1    AXCM01001181    GGFM01008021    MBW28772.1    AXCN02001518    APGK01023663    KB740510    ENN80522.1    KK852902    KDR14058.1    KQ971343    EFA03160.1    ATLV01018208    KE525224    KFB42802.1    GAPW01005874    JAC07724.1    BT127899    KB632104    AEE62861.1    ERL88863.1    GALX01000980    JAB67486.1    GBHO01021376    GBRD01015877    GDHC01008808    JAG22228.1    JAG49949.1    JAQ09821.1    NEVH01013262    PNF29149.1    GFDL01009690    JAV25355.1    GFDG01001978    JAV16821.1    GFDG01003068    JAV15731.1    AK417886    BAN21101.1    KQ414614    KOC68828.1    DS232075    EDS34032.1    KQ981855    KYN34756.1    GDAI01001622    JAI15981.1    KZ288427    PBC25878.1    JXUM01067006    JXUM01067007    JXUM01067008    KQ562428    KXJ75934.1    JXUM01041704    JXUM01041705    KQ561294    KXJ79084.1    KQ980989    KYN10561.1    ADTU01001303    KK856302    PTY25435.1    JRES01000945    KNC26936.1    KQ976522    KYM82082.1    GAMC01000643    JAC05913.1    GDHF01009607    JAI42707.1    KQ438551    KOX67170.1    GBXI01009576    JAD04716.1    JXJN01021871    GL762728    EFZ20868.1    CCAG010018114    OUUW01000002    SPP76167.1    CH379069    EAL31012.1    CH479188    EDW40477.1    CH940647    EDW70784.1    CM000363    CM002912    EDX10314.1    KMY99348.1    KQ434856    KZC08703.1    CH480815    EDW41341.1    AE014296    BT089020    AAF49855.1    ACT98667.1    CH963847    EDW73080.1    CM000159    EDW94372.1    GEDC01028052    GEDC01007332    JAS09246.1    JAS29966.1    CH902618    EDV39177.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000092461    UP000092462    + More
UP000075902    UP000075885    UP000069272    UP000075903    UP000075840    UP000075882    UP000007062    UP000076407    UP000000673    UP000075880    UP000008820    UP000075881    UP000192223    UP000075883    UP000076408    UP000075886    UP000075901    UP000019118    UP000027135    UP000007266    UP000075920    UP000030765    UP000075884    UP000075900    UP000030742    UP000235965    UP000053825    UP000002320    UP000005203    UP000078541    UP000095300    UP000242457    UP000069940    UP000249989    UP000078492    UP000005205    UP000037069    UP000078540    UP000091820    UP000092445    UP000053105    UP000092443    UP000092460    UP000095301    UP000092444    UP000268350    UP000001819    UP000008744    UP000192221    UP000008792    UP000000304    UP000076502    UP000001292    UP000000803    UP000007798    UP000078200    UP000002282    UP000007801   

PRIDE

Q2F656    Q9VU36   

Pfam

PF00453   Ribosomal_L20        + More
PF16672   LAMTOR5
PF02629   CoA_binding
PF00549   Ligase_CoA
PF01039   Carboxyl_trans

Interpro

IPR005813   Ribosomal_L20        + More
IPR035566   Ribosomal_protein_L20_C       
IPR024135   LAMTOR5       
IPR036291   NAD(P)-bd_dom_sf       
IPR005811   CoA_ligase       
IPR003781   CoA-bd       
IPR033847   Citrt_syn/SCS-alpha_CS       
IPR005810   CoA_lig_alpha       
IPR016102   Succinyl-CoA_synth-like       
IPR017440   Cit_synth/succinyl-CoA_lig_AS       
IPR029045   ClpP/crotonase-like_dom_sf       
IPR034733   AcCoA_carboxyl       
IPR011762   COA_CT_N       
IPR011763   COA_CT_C       

SUPFAM

SSF74731   SSF74731        + More
SSF51735   SSF51735       
SSF52210   SSF52210       
SSF52096   SSF52096       

Gene 3D

1.10.1900.20     3.40.50.261    

CDD

cd07026  Ribosomal_L20

ProteinModelPortal

Q2F656   I4DKM9   A0A194R161   A0A2W1BP96   I4DMR6   Q95UN2   + More
S4PSF2   A0A212F5V6   A0A1B0CUR3   A0A1L8DR99   A0A1B0DAD7   A0A1Y1LP30   A0A1I8JV36   A0A240PM15   A0A2M4C3S3   A0A1Y9G8G2   A0A2M4C435   A0A1I8JVJ7   A0A1I8JTD1   A0A1C7CZS8   A7UVP7   A0A2M4C439   T1DH43   A0A1I8JW46   A0A2M4AR59   A0A2M4AR72   W5J4X0   A0A0P4VH45   A0A0V0G6H5   A0A240PLH4   Q16HN7   A0A2M3ZJR6   U5EGM8   A0A240PLQ6   A0A2M3ZCU7   A0A224XN64   A0A2M3ZK04   A0A1W4WHU5   A0A2C9GUJ9   A0A2M3ZJU0   A0A182YBD5   A0A1Y9HB34   A0A182SV10   N6UP67   A0A067R4B4   D6WJ74   A0A1Y9IV39   A0A084VXV8   A0A1Y9H380   A0A3F2YXL7   A0A023EGF5   J3JXD0   V5IAL4   A0A0A9XTS5   A0A2J7QKQ2   A0A1Q3FCQ1   A0A1L8EDN1   A0A1L8EAH9   R4WQB3   A0A0L7RD94   B0WSS3   A0A088ARQ4   A0A195F2Z5   A0A1I8PME7   A0A0K8TPB0   A0A2A3E2F6   A0A182GIX5   A0A182G411   A0A195DCE5   A0A158P311   A0A2R7X3F3   A0A0L0C3Y1   A0A195BCZ5   W8C256   A0A1A9WH21   A0A1A9Z1R0   A0A0K8VUZ0   A0A0M8ZM77   A0A0A1X1G4   A0A1A9Y9U9   A0A1B0BWM3   A0A1I8NHC3   E9IEY1   A0A1B0FA11   A0A3B0J411   A0A1A9WCT2   Q2M0C2   B4GRU2   A0A1W4VIX8   B4LBH4   B4QIY3   A0A154PA40   B4HGN3   Q9VU36   B4ML22   A0A1A9VMQ8   B4PHB1   A0A1B6C6W6   B3MAU3  

PDB

6GB2     E-value=6.5811e-24,     Score=268

KEGG

692841    K02887 large subunit ribosomal protein L20 | (RefSeq) RpL20; ribosomal protein L20

PATHWAY

03010    Ribosome - Bombyx mori (domestic silkworm)

GO

GO:0005840   GO:0006412   GO:0019843   GO:0003735   GO:0016021   GO:0019079   GO:0043154   GO:0071986   GO:0000027   GO:0005761   GO:0000166   GO:0004776   GO:0004775   GO:0005739   GO:0006099   GO:0048037   GO:0016874   GO:0005762   GO:0032543   GO:0005622   GO:0005515   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR10986  

Subcellular location

Mitochondrion  

Length:

159

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000790000000000001

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.07528

outside

1  -  159

 

 

Pi

222.257428

Theta

185.113309

Tajima's D

0.498932

CLR

0.072297

CSRT

0.516974151292435

Interpretation

Uncertain