Gene

KWMTBOMO13062

Pre Gene Modal

BGIBMGA000295

Annotation

PREDICTED:_ras-related_GTP-binding_protein_Rab3_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr22(+):7603634-7608374      View in EpiBrowser

Full name

Ras-related protein Rab-3      

Location in the cell

Cytoplasmic   Reliability : 1.628

CDS

ATGACTGGCGAAGCAAAATGGCAGAAAGATGCTGCGGATCAGAACTTCGATTACATGTTCAAACTGTTGATCATAGGAAACAGCTCAGTAGGAAAAACTAGTTTCCTCTTCCGATATGCAGACGATTCCTTCACTTCAGCCTTTGTGTCTACCGTTGGTATCGACTTCAAAGTGAAAACGGTTTTCCGGCACGATAAGCGCGTCAAATTGCAAATATGGGATACTGCAGGTCAGGAACGCTACCGTACCATCACGACTGCCTATTATCGAGGTGCTATGGGCTTCATTCTGATGTATGATATTACTAACGAAGAAAGTTTCAACAGCGTACAGGACTGGGTTACCCAGATCAAGACATATTCGTGGGATAATGCTCAAGTTATTCTCGTCGGAAACAAATGTGACATGGAAGAAGAACGTGTAGTTAGCGCGGAGCGTGGACGACAGTTGGCTGATCAACTGGGTGTCGAGTTTTATGAAACAAGCGCAAAAGAAAATATAAACGTCAAGGCTGTATTCGAGCGACTAGTTGATATAATCTGCGACAAGATGTCCGAAAGTCTTGATTCGGAGCCAGCGATGTTGGCCGGAGGAGCCCGTGGTCAGCGTCTCACGGAGCAGCCTCAAGGAAGCAACAATCCTAACTGTAACTGCTAA

Protein

MTGEAKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEEERVVSAERGRQLADQLGVEFYETSAKENINVKAVFERLVDIICDKMSESLDSEPAMLAGGARGQRLTEQPQGSNNPNCNC

Description

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).

Subunit

Interacts with Rph.

Similarity

Belongs to the small GTPase superfamily. Rab family.

Keywords

3D-structure   Cell junction   Complete proteome   Cytoplasmic vesicle   Exocytosis   GTP-binding   Lipoprotein   Methylation   Nucleotide-binding   Prenylation   Protein transport   Reference proteome   Synapse   Transport  

Feature

chain  Ras-related protein Rab-3

Uniprot

Q19KB6   A0A3S2M535   A0A089FP72   A0A194R171   A0A1Q3FZV9   B0WTB7   + More
W8BDQ5   Q176R5   A0A023EJZ7   A0A0L0BPK0   A0A0A1X6N8   A0A0K8W7J2   A0A034VXF6   A0A0J9R9X3   B4P843   B4HMT4   B3NN60   A0A1W4VPM8   P25228   B4MNY2   A0A0A9XQQ7   A0A1B0CFP3   A0A1I8QE87   A0A1I8N6C6   A0A1B6LNV3   A0A3B0J454   Q28XJ2   B4GG85   B3MIJ6   A0A1B6EKV0   A0A1L8DV26   A0A2R7VU72   B4KN12   A0A0Q9XEQ3   A0A1J1J029   A0A1B6MV51   A0A1B0G6P1   A0A1A9ZX66   A0A1B6HRY1   A0A1B6DB46   A0A1A9YB24   A0A1A9VY18   A0A1B0BHL4   A0A336K368   D6X1H3   A0A1B6H1V7   E0VAW9   A0A1B6C9J6   A0A069DXG1   T1HH21   A0A0M3QUG5   W5JA76   A0A3F2YSG8   E2BGB1   A0A182YBZ1   Q7PPZ7   A0A3F2YSF8   A0A2P8YMP8   A0A0T6B704   B4K0H1   B4LKN6   A0A084VUF0   A0A182J5W5   L7M483   A0A224Z9H3   A0A131Z459   L7M7Q4   A0A131XB24   A0A023GGB9   A0A2J7PDR4   J9K5D5   A0A2S2P0S0   A0A2H8TJI8   A0A182T864   A0A182V5V8   A0A182FCT5   A0A0C9R8L2   A0A182X8H7   A0A0C9QFP4   A0A182RP42   A0A182WMH0   A0A182PFZ2   A0A182LS46   A0A182PZH2   A0A182N9N0   A0A1Y1L537   V5IDU4   B7PEJ6   E2AJT5   A0A088AML5   A0A2A3E5P0   V9IG11   A0A3L8D461   A0A026W5E7   A0A0J7L3B6   A0A0L8G4F2   A0A0L7RAG5   A0A195C262   A0A2R5LNM8   A0A293M1Q6  

Pubmed

19121390    28756777    26354079    24495485    17510324    24945155    + More
26483478    26108605    25830018    25348373    22936249    17994087    17550304    1648935    14722103    10731132    12537572    12537569    25401762    25315136    15632085    18362917    19820115    20566863    26334808    20920257    23761445    20798317    25244985    12364791    14747013    17210077    29403074    24438588    25576852    28797301    26830274    28049606    28004739    25765539    30249741    24508170   

EMBL

BABH01013209    DQ525204    ABF71469.1    RSAL01000037    RVE51147.1    KM035414    + More
KZ149892    AIP87049.1    PZC79043.1    KQ460883    KPJ11452.1    GFDL01001972    JAV33073.1    DS232084    EDS34351.1    GAMC01011442    GAMC01011441    JAB95113.1    CH477383    EAT42176.1    JXUM01095945    JXUM01095946    JXUM01095947    GAPW01004183    KQ564233    JAC09415.1    KXJ72553.1    JRES01001567    KNC21982.1    GBXI01007303    JAD06989.1    GDHF01005156    GDHF01005114    JAI47158.1    JAI47200.1    GAKP01010942    GAKP01010941    JAC48011.1    CM002911    KMY92841.1    CM000158    EDW90090.1    CH480816    EDW47296.1    CH954179    EDV56580.1    M64621    AB112932    AE013599    AY060449    CH963848    EDW73821.1    GBHO01021638    GBRD01009196    JAG21966.1    JAG56625.1    AJWK01010224    AJWK01010225    AJWK01010226    AJWK01010227    GEBQ01020569    GEBQ01014629    GEBQ01013762    GEBQ01011838    GEBQ01008793    JAT19408.1    JAT25348.1    JAT26215.1    JAT28139.1    JAT31184.1    OUUW01000001    SPP74142.1    CM000071    EAL26324.1    CH479183    EDW35505.1    CH902619    EDV38072.1    GECZ01031205    JAS38564.1    GFDF01003790    JAV10294.1    KK854072    PTY10698.1    CH933808    EDW08839.1    KRG04298.1    CVRI01000065    CRL05813.1    GEBQ01028079    GEBQ01021572    GEBQ01013296    GEBQ01005106    GEBQ01000180    JAT11898.1    JAT18405.1    JAT26681.1    JAT34871.1    JAT39797.1    CCAG010015977    CCAG010015978    GECU01030296    JAS77410.1    GEDC01014473    JAS22825.1    JXJN01014427    JXJN01014428    UFQS01000063    UFQT01000063    SSW98861.1    SSX19247.1    KQ971371    EFA09496.2    GECZ01001093    JAS68676.1    DS235019    EEB10525.1    GEDC01027131    JAS10167.1    GBGD01002845    JAC86044.1    ACPB03001028    CP012524    ALC40623.1    ADMH02002051    ETN59755.1    APCN01002761    GL448138    EFN85274.1    AAAB01008900    EAA09493.2    PYGN01000487    PSN45521.1    LJIG01009425    KRT83106.1    CH916446    EDV90871.1    CH940648    EDW61759.1    ATLV01016737    KE525103    KFB41594.1    AXCP01004228    GACK01005918    JAA59116.1    GFPF01012198    MAA23344.1    GEDV01002393    JAP86164.1    GACK01005905    JAA59129.1    GEFH01004834    JAP63747.1    GBBM01002446    JAC32972.1    NEVH01026385    PNF14468.1    ABLF02017393    GGMR01010189    MBY22808.1    GFXV01001643    MBW13448.1    GBYB01003131    JAG72898.1    GBYB01013303    JAG83070.1    AXCM01012845    AXCM01012846    AXCN02001010    GEZM01066380    GEZM01066379    JAV67918.1    GANP01011332    JAB73136.1    ABJB010261944    ABJB010797507    DS695319    EEC05018.1    GL440100    EFN66251.1    KZ288361    PBC27015.1    JR040728    AEY59264.1    QOIP01000013    RLU15292.1    KK107467    EZA50254.1    LBMM01001103    KMQ96919.1    KQ423910    KOF71922.1    KQ414618    KOC67892.1    KQ978344    KYM94959.1    GGLE01006985    MBY11111.1    GFWV01009239    MAA33968.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000002320    UP000008820    UP000069940    + More
UP000249989    UP000037069    UP000002282    UP000001292    UP000008711    UP000192221    UP000000803    UP000007798    UP000092461    UP000095300    UP000095301    UP000268350    UP000001819    UP000008744    UP000007801    UP000009192    UP000183832    UP000092444    UP000092445    UP000092443    UP000078200    UP000092460    UP000007266    UP000009046    UP000015103    UP000092553    UP000000673    UP000075840    UP000008237    UP000076408    UP000007062    UP000245037    UP000001070    UP000008792    UP000030765    UP000075880    UP000235965    UP000007819    UP000075901    UP000075903    UP000069272    UP000076407    UP000075900    UP000075920    UP000075885    UP000075883    UP000075886    UP000075884    UP000001555    UP000000311    UP000005203    UP000242457    UP000279307    UP000053097    UP000036403    UP000053454    UP000053825    UP000078542   

PRIDE

Q19KB6    P25228    L7M483    L7M7Q4    V5IDU4    B7PEJ6    + More

Pfam

PF00071   Ras        + More
PF08242   Methyltransf_12
PF13649   Methyltransf_25
PF08241   Methyltransf_11

Interpro

IPR027417   P-loop_NTPase        + More
IPR001806   Small_GTPase       
IPR037872   Rab3       
IPR005225   Small_GTP-bd_dom       
IPR029063   SAM-dependent_MTases       
IPR013217   Methyltransf_12       
IPR041698   Methyltransf_25       
IPR013216   Methyltransf_11       

SUPFAM

SSF52540   SSF52540        + More
SSF53335   SSF53335       

CDD

cd01865  Rab3

ProteinModelPortal

Q19KB6   A0A3S2M535   A0A089FP72   A0A194R171   A0A1Q3FZV9   B0WTB7   + More
W8BDQ5   Q176R5   A0A023EJZ7   A0A0L0BPK0   A0A0A1X6N8   A0A0K8W7J2   A0A034VXF6   A0A0J9R9X3   B4P843   B4HMT4   B3NN60   A0A1W4VPM8   P25228   B4MNY2   A0A0A9XQQ7   A0A1B0CFP3   A0A1I8QE87   A0A1I8N6C6   A0A1B6LNV3   A0A3B0J454   Q28XJ2   B4GG85   B3MIJ6   A0A1B6EKV0   A0A1L8DV26   A0A2R7VU72   B4KN12   A0A0Q9XEQ3   A0A1J1J029   A0A1B6MV51   A0A1B0G6P1   A0A1A9ZX66   A0A1B6HRY1   A0A1B6DB46   A0A1A9YB24   A0A1A9VY18   A0A1B0BHL4   A0A336K368   D6X1H3   A0A1B6H1V7   E0VAW9   A0A1B6C9J6   A0A069DXG1   T1HH21   A0A0M3QUG5   W5JA76   A0A3F2YSG8   E2BGB1   A0A182YBZ1   Q7PPZ7   A0A3F2YSF8   A0A2P8YMP8   A0A0T6B704   B4K0H1   B4LKN6   A0A084VUF0   A0A182J5W5   L7M483   A0A224Z9H3   A0A131Z459   L7M7Q4   A0A131XB24   A0A023GGB9   A0A2J7PDR4   J9K5D5   A0A2S2P0S0   A0A2H8TJI8   A0A182T864   A0A182V5V8   A0A182FCT5   A0A0C9R8L2   A0A182X8H7   A0A0C9QFP4   A0A182RP42   A0A182WMH0   A0A182PFZ2   A0A182LS46   A0A182PZH2   A0A182N9N0   A0A1Y1L537   V5IDU4   B7PEJ6   E2AJT5   A0A088AML5   A0A2A3E5P0   V9IG11   A0A3L8D461   A0A026W5E7   A0A0J7L3B6   A0A0L8G4F2   A0A0L7RAG5   A0A195C262   A0A2R5LNM8   A0A293M1Q6  

PDB

4RKF     E-value=3.67673e-96,     Score=894

KEGG

733064    K07883 Ras-related protein Rab-3C | (RefSeq) Rab3; ras-related GTP-binding protein Rab3

GO

GO:0003924   GO:0005525   GO:0048789   GO:0008021   GO:0048790   GO:0048786   GO:0016192   GO:0030054   GO:0045202   GO:0031982   GO:0032482   GO:0007269   GO:0031630   GO:0006887   GO:0048172   GO:0015031   GO:0005768   GO:0009306   GO:0006886   GO:0017157   GO:0006904   GO:0072659   GO:0005886   GO:0008168   GO:0004767   GO:0007264   GO:0006468   GO:0004683   GO:0005516   GO:0005515   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

  

Length:

218

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.61879

Exp number, first 60 AAs:

0.51826

Total prob of N-in:

0.23297

outside

1  -  218

 

 

Pi

300.365318

Theta

213.012135

Tajima's D

1.049488

CLR

0.851609

CSRT

0.671816409179541

Interpretation

Uncertain