Gene

KWMTBOMO13053  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000408

Annotation

Ca2_/calmodulin-dependent_protein_kinase_II_[Bombyx_mori]

Location

Bomo_Chr22(-):7328804-7331509      View in EpiBrowser

Full name

Calcium/calmodulin-dependent protein kinase type II alpha chain      

Location in the cell

Cytoplasmic   Reliability : 2.103 Nuclear   Reliability : 1.978

CDS

ATGGCTAATCCAAATCGTGAAAGTGTTAGCACGCGGTTTTCGGACAACTATGAACTTAAGGAAGAATTAGGCAAGGGCGCCTTCTCGATTGTTAGGAGAGCTGTACAAAAGTCTACTGGATACGAGTTTGCGGCAAAAATCATAAATACCAAGAAACTCTCTGCAAGAGACTTCCAGAAATTGGAACGAGAAGCAAGAATCTGTCGTAAACTACAGCATCCCAATATTGTGCGACTACATGATTCCATTCAAGAAGAACATTGCCATTACCTTGTCTTTGATTTGGTTACCGGGGGTGAATTATTTGAAGACATAGTGGCGCGAGAATTTTATTCTGAAGCTGATGCGTCACACTGCATTCAGCAAATATTAGAATCTGTCCATCACTGTCACCATAATGGAGTTGTGCACAGAGATCTGAAACCAGAAAATCTTTTGCTCGCAAGCAAAGCTAAGGGAGCTGCTGTCAAGTTGGCCGATTTTGGGTTAGCTATCGAAGTTCAAGGAGATCAACAAGCATGGTTCGGATTCGCAGGTACACCCGGTTACTTATCGCCTGAAGTATTAAAAAAGGAACCTTATGGTAAACCAGTGGATATATGGGCTTGTGGGGTCATTCTATACATATTGTTAGTTGGCTACCCTCCATTTTGGGATGAAGATCAGTATCGTCTCTATGCGCAAATCAAAGCGGGAGCATATGATTATCCGTCTCCTGAGTGGGATACCGTTACTCCTGAAGCTAAGAGCCTTATTAATCAAATGCTTACTGTTAATCCTAGCAAAAGGATCACCGCTTCCGAAGCTCTGAAACATCCATGGATTTGCCACCGGGAACGCGTTGCTTCAGTTATGCATAGACAGGAAACTGTGGATTGTTTGAAAAAATTCAATGCACGTCGCAAGCTCAAGGGTGCAATTTTAACAACGATGCTTGCTACCAGAAATTTCTCTGGTAAATCAATGGTTAATAAAAAAGGCGATGGATCGCAAGTAAAAGAGTCTACTGATAGTAGTACAACGCTTGAAGATGATGATTTAGACAAAGACAAGAAAGGAGTGGACCGAGCATGCACGGTTATATCTAAAGAACATGACGAAGAAGCCCTGACAAAAGCGGACTCGTTTGGAAAAGCTCGGGGCGATAGTAATGCTTCTTTGCGCCGAGCGGAAGTGATTAAGGTTACTGAGGTGCTGATAGATGCAATCAATAATGGTGATTACGACACATATTCCAAGCTATGTGATCCCAATGTGACAGCTTTTGATCCTGATGCTCTAGGAAATCTGATTGAAGGTGTAGAATTCCATAAATTCTTTATTGACAATACACCGCCACATGTGAAAACTAATACCACTATTCTGAATCCAAGAGTACATCTTCTCGGTGATGATGTTGCAGTCATAGCATACGTCTGCGTAACACAAAGCGTAGATTCCGAAGGTCGACGGGCTACACACCAATCACAAGAGACTCGCATTTGGCACAAACGTCACAACAAGTGGACTGCCGTTCATTTCCATCGCTCCTAA

Protein

MANPNRESVSTRFSDNYELKEELGKGAFSIVRRAVQKSTGYEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEEHCHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVHHCHHNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLKKEPYGKPVDIWACGVILYILLVGYPPFWDEDQYRLYAQIKAGAYDYPSPEWDTVTPEAKSLINQMLTVNPSKRITASEALKHPWICHRERVASVMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGKSMVNKKGDGSQVKESTDSSTTLEDDDLDKDKKGVDRACTVISKEHDEEALTKADSFGKARGDSNASLRRAEVIKVTEVLIDAINNGDYDTYSKLCDPNVTAFDPDALGNLIEGVEFHKFFIDNTPPHVKTNTTILNPRVHLLGDDVAVIAYVCVTQSVDSEGRRATHQSQETRIWHKRHNKWTAVHFHRS

Description

A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Interacts with CASK.

Similarity

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Keywords

3D-structure   Alternative splicing   ATP-binding   Calmodulin-binding   Complete proteome   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Calcium/calmodulin-dependent protein kinase type II alpha chain
splice variant  In isoform 4.

Uniprot

D6RVR8   A0A2A4IUJ3   A0A2H1VUL8   A0A2W1C002   A0A068ETN5   A0A194R1R1   + More
A0A194PXS1   A0A212EQX4   A0A0L7KU84   L0MLR4   M9T9J6   A0A1W4VIE5   A0A1W4V592   A0A0Q5SUI1   H6SWV1   A0A0Q5SQ34   A0A0J9S2S8   A0A1W4VHL9   A0A0J9S152   A0A3B0K408   B4H9P5   D6WFJ6   B3MY38   A0A0P8XJA8   A0A0Q5SGF2   A0A3B0K6M9   K7IZZ8   E9GTA8   A0A1W4V4T2   A0A1J1J8D8   D1YSG7   B3P9P9   Q00168   A0A0P8XZJ0   A0A0J9S143   W8BK87   D1YSG8   B4NHL4   B4IKQ9   A0A0J9S2U8   A0A0A1X1U5   A0A0P9A9G3   B4L7C9   A0A158NYG2   A0A0Q9WUI9   B4JZN8   A0A0P6HFA1   B4MEZ2   A0A0M5J0P2   A0A0Q9XG85   A0A1B6M762   D0Z795   A0A1B6IH83   Q00168-2   A0A1W4VIF0   A0A034VW58   A0A1L8DKE5   A0A1W4V4U2   H6SWV0   A0A0Q5SUX1   A0A0J9UST1   A0A0P8ZJH8   A0A1W4VHM5   A0A0J9S1B9   A0A3B0K460   A0A0P9BTH1   A0A0P5IZC6   A0A0Q5SKE6   A0A1W4V597   A0A3B0K8F2   L0MLP2   A0A1L8DKH0   A0A0Q5SDU8   Q00168-3   A0A0J9S149   A4V134   A0A0A1WE61   A0A2I6SFN2   A0A0Q9XNP1   A0A034VR42   A0A1W4V4T9   A0A1W4VH12   A0A0Q9WKK4   A0A0J9USU2   A0A232FAJ7   A0A0P9BTI4   A0A0Q5SRX4   W8C8L1   A0A0J9UST8   A0A0Q5SDZ8   A0A0P6GF02   A0A0J9S1C8   T1INT6   A0A1J1J5E5   A0A0Q9XI62   A0A0Q9XFD3   A0A0P5SXQ1   A0A0P4WI42   A0A0A9X1X9   A0A131XKK0  

EC Number

2.7.11.17

Pubmed

19121390    28756777    26354079    22118469    26227816    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867    23740573    17994087    22936249    18362917    19820115    20075255    21292972    8380587    1910789    8397298    11980904    14687552    16880127    18327897    24495485    25830018    18057021    21347285    20479145    25348373    28648823    25401762    26823975    28049606   

EMBL

BABH01013256    AB563704    BAJ08364.1    NWSH01007804    PCG62803.1    ODYU01004251    + More
SOQ43924.1    KZ149892    PZC79035.1    KJ650044    AID54518.1    KQ460883    KPJ11459.1    KQ459586    KPI97823.1    AGBW02013205    OWR43869.1    JTDY01005762    KOB66660.1    AE014135    AGB96573.1    KC733178    AGI98593.1    CH954184    KQS21460.1    HQ176457    ADX05544.1    KQS21461.1    CM002916    KMZ07355.1    KMZ07359.1    OUUW01000017    SPP88944.1    CH479230    EDW36529.1    KQ971328    EEZ99807.2    CH902631    EDV34070.1    KPU74954.1    KQS21456.1    SPP88943.1    GL732563    EFX77393.1    CVRI01000070    CRL07177.1    ACZ95101.1    EDV45212.1    D13330    D13331    D13332    D13333    M74583    S65712    S65716    S65717    S65719    S65724    KPU74953.1    KMZ07357.1    GAMC01007408    JAB99147.1    ACZ95102.1    CH964272    EDW83583.1    CH480855    EDW52649.1    KMZ07353.1    KMZ07361.1    KMZ07363.1    KMZ07364.1    KMZ07370.1    GBXI01009887    GBXI01009476    GBXI01000596    JAD04405.1    JAD04816.1    JAD13696.1    KPU74955.1    KPU74956.1    KPU74957.1    CH933813    EDW10923.1    ADTU01003797    ADTU01003798    ADTU01003799    ADTU01003800    ADTU01003801    ADTU01003802    ADTU01003803    ADTU01003804    ADTU01003805    ADTU01003806    KRF99822.1    CH916380    EDV90904.1    GDIQ01029462    JAN65275.1    CH940665    EDW71093.1    CP012527    ALC48081.1    KRG07285.1    GEBQ01008219    JAT31758.1    CM000831    ACY70533.1    KRF85336.1    KRF85339.1    GECU01021431    JAS86275.1    GAKP01013220    GAKP01013219    GAKP01013210    JAC45733.1    GFDF01007141    JAV06943.1    HQ176456    ADX05543.1    KQS21462.1    KMZ07356.1    KPU74952.1    KMZ07358.1    SPP88945.1    KPU74951.1    GDIQ01205404    GDIQ01203754    GDIP01045962    JAK46321.1    JAM57753.1    KQS21457.1    SPP88942.1    AGB96574.1    GFDF01007142    JAV06942.1    KQS21459.1    KMZ07362.1    AAN06569.2    GBXI01017316    JAC96975.1    KY552652    AUO16381.1    KRG07290.1    GAKP01013218    GAKP01013211    JAC45741.1    KRF85341.1    KMZ07371.1    NNAY01000525    OXU27866.1    KPU74960.1    KQS21454.1    GAMC01007406    JAB99149.1    KMZ07366.1    KQS21458.1    GDIQ01035859    JAN58878.1    KMZ07368.1    JH431210    CRL07178.1    KRG07289.1    KRG07292.1    GDIQ01241340    GDIP01136672    JAK10385.1    JAL67042.1    GDRN01047452    JAI66722.1    GBHO01028877    GDHC01001256    JAG14727.1    JAQ17373.1    GEFH01001856    JAP66725.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000000803    UP000192221    UP000008711    UP000268350    UP000008744    UP000007266    UP000007801    UP000002358    UP000000305    UP000183832    UP000007798    UP000001292    UP000009192    UP000005205    UP000001070    UP000008792    UP000092553    UP000215335   

PRIDE

D6RVR8    L0MLR4    D1YSG7    Q00168    L0MLP2   

Pfam

PF08332   CaMKII_AD        + More
PF00069   Pkinase

Interpro

IPR000719   Prot_kinase_dom        + More
IPR032710   NTF2-like_dom_sf       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR013543   Ca/CaM-dep_prot_kinase-assoc       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF56112   SSF56112        + More
SSF54427   SSF54427       

ProteinModelPortal

D6RVR8   A0A2A4IUJ3   A0A2H1VUL8   A0A2W1C002   A0A068ETN5   A0A194R1R1   + More
A0A194PXS1   A0A212EQX4   A0A0L7KU84   L0MLR4   M9T9J6   A0A1W4VIE5   A0A1W4V592   A0A0Q5SUI1   H6SWV1   A0A0Q5SQ34   A0A0J9S2S8   A0A1W4VHL9   A0A0J9S152   A0A3B0K408   B4H9P5   D6WFJ6   B3MY38   A0A0P8XJA8   A0A0Q5SGF2   A0A3B0K6M9   K7IZZ8   E9GTA8   A0A1W4V4T2   A0A1J1J8D8   D1YSG7   B3P9P9   Q00168   A0A0P8XZJ0   A0A0J9S143   W8BK87   D1YSG8   B4NHL4   B4IKQ9   A0A0J9S2U8   A0A0A1X1U5   A0A0P9A9G3   B4L7C9   A0A158NYG2   A0A0Q9WUI9   B4JZN8   A0A0P6HFA1   B4MEZ2   A0A0M5J0P2   A0A0Q9XG85   A0A1B6M762   D0Z795   A0A1B6IH83   Q00168-2   A0A1W4VIF0   A0A034VW58   A0A1L8DKE5   A0A1W4V4U2   H6SWV0   A0A0Q5SUX1   A0A0J9UST1   A0A0P8ZJH8   A0A1W4VHM5   A0A0J9S1B9   A0A3B0K460   A0A0P9BTH1   A0A0P5IZC6   A0A0Q5SKE6   A0A1W4V597   A0A3B0K8F2   L0MLP2   A0A1L8DKH0   A0A0Q5SDU8   Q00168-3   A0A0J9S149   A4V134   A0A0A1WE61   A0A2I6SFN2   A0A0Q9XNP1   A0A034VR42   A0A1W4V4T9   A0A1W4VH12   A0A0Q9WKK4   A0A0J9USU2   A0A232FAJ7   A0A0P9BTI4   A0A0Q5SRX4   W8C8L1   A0A0J9UST8   A0A0Q5SDZ8   A0A0P6GF02   A0A0J9S1C8   T1INT6   A0A1J1J5E5   A0A0Q9XI62   A0A0Q9XFD3   A0A0P5SXQ1   A0A0P4WI42   A0A0A9X1X9   A0A131XKK0  

PDB

5U6Y     E-value=0,     Score=1826

KEGG

100462731    K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] | (RefSeq) CaMKII;

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04745    Phototransduction - fly - Bombyx mori (domestic silkworm)

GO

GO:0004683   GO:0005524   GO:0005516   GO:0043005   GO:0005737   GO:0045211   GO:0048786   GO:0050710   GO:0005954   GO:0010888   GO:0030424   GO:0007611   GO:0030425   GO:0060278   GO:0004674   GO:0008049   GO:0007616   GO:0008582   GO:0051489   GO:0009267   GO:0007268   GO:0006468   GO:0007619   GO:0007528   GO:1990443   GO:0004672   GO:0005515   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

Length:

510

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.77785

Exp number, first 60 AAs:

0

Total prob of N-in:

0.17946

outside

1  -  510

 

 

Pi

245.904893

Theta

218.404218

Tajima's D

0.420046

CLR

0.667881

CSRT

0.497275136243188

Interpretation

Uncertain