Gene

KWMTBOMO13049

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr22(-):7254591-7259149      View in EpiBrowser

Full name

Probable RNA-directed DNA polymerase from transposon X-element       + More
Probable RNA-directed DNA polymerase from transposon BS      
RNA-directed DNA polymerase from mobile element jockey      

Alternative Name

Reverse transcriptase

Location in the cell

Mitochondrial   Reliability : 1.363 Nuclear   Reliability : 2.035

CDS

ATGGACGCTGTATTTGCGGAATTTCTCCGGCTTCGCTACCCAAAGCTCACTTCCGAGTTTCAGGCCTTCAAGGCCGATCACACTGCGAGCCCTCTCGTGGACTCCACCGAGCTCGCTGCTCCTGCGTCGCCTGTACCTGCGTGCAAAGCTTCTGCATCGAGCACCGCAGCCTCCGTCGTGCCTGCCGTTCCCGCGTCGCCTATACTGGCGAGTAAAACTGCTGCGTCGTCCGCCGTGGTCACCGTTCCAGCAGCGCGATCATCCGCGGCCTCCGTCGCGCCGTCCAAAACACCTACTCGTAGGTCACCTGCGCCCGCCTCCTCGTCCTCCGACTCTGACTCGGAGATGGAGGTCGACCTCGCTCCCGCCTCATCGACGGATGGATTCACCCTGGTGCAAAAGGGTAAGAAGCGTGCCGCGGAGTCTCGAGCTCCCGCGGCCGCTAAAATTAGCAAAGCCGCGAACGCGTCGCGCCCCCGCCCTCAGACTCCCGTTGCGCCTCCAGCCCGTGCCACTCCGTCGCCGCGTCCGGTGGCACAAAATAAAGCCCAGACCCCTCCCCCGGTAATCCTTCAAGAGAAGGCAGCTTGGGAACGAGTTTCCCTGGCCCTTAAGGCCAAAAATATCAATTTTACGAATGCCCGTAACCTCGCGAACGGCATTCAAATTAAGGTTCGAACATCCGACGACCATAGGGCCCTCTCTTCTTACCTCCGTAAGGAGCGTATAAGTTTCCACACATATACGCTCCAGGAGGAGCGCGAACTCCGTGCCGTTATACGTGGCATCCCTAAAGAGTTGGATGCCGAGCTCGTCAAGGCCGACCTTCTCGAACAAGGCCTACCGGTTAACTCCGTACACCGCATGCACACAGGCCGCGGAAGGGAGCCATATAATATGGTTCTCGTCGCCCTCCAGCCTACCCCGAGGCGTGATCAGGTTTCTGACTTTTTGCGTGACCATCAAATTGATATCTTTTTAGTGCAGGAGACCCTACTTAAGCCTGCGCGCCGTGACCCTAAAATCGCGAACTATAACATGGTCAGGAACGACAGGCTCTCTGCTCGTGGTGGTGGTACCGTCATTTACTATAGAAGAGCCCTGCATTGCGTCCCACTCGATCCTCCCGCGCTCGCTAATATCGAAGCATCAGTGTGCCGAATCTCACTGACGGGACACGCGCCGATCGTTATCGCGTCCGTTTATCTTCCACCGGATAAGATCGTTCTAAGCAGTGATATCGAGGCGCTGCTCGGCATGGGGAGCTCTGTCATTCTGGCGGGCGACCTAAATTGTAAACACATTAGGTGGAACTCACACACCACAACCCCGAATGGCAGGCGGCTTGACGCGTTAGTCGATAATCTCGCCTTCGATATCGTCGCTCCGCTAATCCCGACTCACTACCCGCTAAATATCGCGCATCGCCCGGATATACTCGACATAGCGTTATTAAAAAACGTAACTCTGCGCTTACACTCGATCGAAGTAGTTTCAGAGTTAGATTCAGACCACCGTCCCGTCGTTATGAAGCTCGGTCGCGCTCCCGATTCCGTTCCCGTCACGAGGACTGTGGTGGATTGGCACACGCTGGGCATCAGCCTGGCTGAATCTGATCCACCATCGCTACCGTTTAGCCCGGACTCTACCCCGTCTCCTCAGGATACCGCTGAAGCCATAGACATCTTAACGTCACACATCACCTCGACATTAGATAGGTCATCGAAACAAGTTGTAGCGGAGGACTTCCTTCACCGCTTCAAATTGTCCGACGATATTAGGGAACTCCTTAGAGCTAAGAACGCCTCGATACGCGCCTACGACAGGTATCCTACCGCGGAAAATCGTATTCGAATGCGTGCCCTACAACGCGACGTAAAGTCTCGCATCGCCGAAGTCCGAGATGCCAGATGGTCTGATTTCTTAGAAGGACTCGCGCCCTCCCAAAGGTCTTACTACCGCTTAGCTCGTACTCTCAAATCGGATACGGTAGTAACTATGCCCCCCCTCGTAGGCCCCTCAGGCCGACTCACGGCGTTCGATGATGACGAAAAAGCAGAGCTGCTGGCCGATACATTGCAAACCCAGTGCACGCCCAGCACTCAATCCGTGGACCCTGTGCATGTAGAATTAGTAGACAGTGAGGTAGAACGCAGAGCCTCCTTGCCACCCTCTGATGTGTTACCACCCGTCACCCCGATGGAAGTTAAAGACTTGATCAAAGACCTACGTCCTCGCAAGGCTCCCGGTTCCGACGGTATATCCAACCGCGTTATTAAACTTCTACCCGTCCAACTCATCGTGATGTTGGTATCTATTTTCAATGCCGCTATGGCGAACTGTATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGCATACATAAACCCGGTAAACCAAAAAATCATCCGACGAGCTACCGCCCGATTAGCCTCCTCATGTCTCTAGGCAAACTGTATGAGCGTCTGCTCTACAAACGCCTCAGAGACTTCGTCTCATCCAAGGGCATTCTCATCGATGAACAATTCGGATTCCGTACAAATCACTCATGCGTTCAACAGGTGCACCGCCTCACGGAGCACATTCTTGTGGGGCTTAATCGACCAAAACCGTTATACACGGGAGCTCTCTTCTTCGACGTCGCAAAAGCGTTCGACAAAGTCTGGCACAACGGTTTGATTTTCAAACTATTCAACATGGGTGTGCCGGATAGTCTCGTGCTCATCATACGGGACTTCTTGTCGAACCGCTCTTTTCGATATCGAGTCGAGGGAACCCGCTCCTCCCCACGACCTCTCACAGCTGGAGTCCCGCAAGGCTCTGTCCTCTCACCCCTCCTATTTAGCTTATTCGTTAACGATATTCCCCGGTCGCCGCCGACCCATTTAGCTTTATTCGCCGACGACACGACTGTTTACTATTCCAGTAGAAACAAGTCCCTAATCGCGAAGAAGCTTCAGAGCGCAGCCCTAGCCCTAGGACAGTGGTTCCGAAAATGGCGCATAGACATCAACCCAGCGAAAAGTACTGCGGTGCTCTTTCAGAGGGGAAGCCCCACACGGATTTCCTCCCGTATTAGGAGGAGGAATCTCACACCCCCGATTACTCTCTTTAGTCAATCCATACCCTGGGCCAGGAAGGTCAAGTACCTGGGCGTTACCCTGGATGCATCGATGACATTCCGCCCGCATATAAAATCAGTCCGTGACCGTGCCGCGTTTATTCTCGGTAGACTCTACCCCATGATTTGTAAGCGGAGTAAAATGTCCCTTCGGAACAAGGTGACACTTTACAAAACTTGCATAAGGCCCGTCATGACTTACGCGAGTGTGGTGTTCGCTCACGCGGCCCGCACGCACATAGACATCCTTCAATCTCTACAATCCCGCTTTTGCAGGTTAGCCGTCGGGGCTCCGTGGTTCGTGAGGAACGTTGACCTACACGACGACCTGGGCCTCGAATCAATTCGGAAATACATGAAGTCAGCGTCGGAACGATACTTCGATAAGGCTATGCGTCATGATAATCGCCTTATCGTAGCCGCCGCTGACTACTCCCCGAATCCTGATCATGCAGGAGCCAGTCACCGTCGACGCCCTAGACACGTCCTTACGGATCCATCAGATCCAATAACCTTCGCACTAGACGCCTTCAGCTCTAGGAGCAGGCTTAGGGACCTCGGTAACCGTACTCGTCGAACTCGACAAAGAGTTCGCCGTGCAACCTAA

Protein

MDAVFAEFLRLRYPKLTSEFQAFKADHTASPLVDSTELAAPASPVPACKASASSTAASVVPAVPASPILASKTAASSAVVTVPAARSSAASVAPSKTPTRRSPAPASSSSDSDSEMEVDLAPASSTDGFTLVQKGKKRAAESRAPAAAKISKAANASRPRPQTPVAPPARATPSPRPVAQNKAQTPPPVILQEKAAWERVSLALKAKNINFTNARNLANGIQIKVRTSDDHRALSSYLRKERISFHTYTLQEERELRAVIRGIPKELDAELVKADLLEQGLPVNSVHRMHTGRGREPYNMVLVALQPTPRRDQVSDFLRDHQIDIFLVQETLLKPARRDPKIANYNMVRNDRLSARGGGTVIYYRRALHCVPLDPPALANIEASVCRISLTGHAPIVIASVYLPPDKIVLSSDIEALLGMGSSVILAGDLNCKHIRWNSHTTTPNGRRLDALVDNLAFDIVAPLIPTHYPLNIAHRPDILDIALLKNVTLRLHSIEVVSELDSDHRPVVMKLGRAPDSVPVTRTVVDWHTLGISLAESDPPSLPFSPDSTPSPQDTAEAIDILTSHITSTLDRSSKQVVAEDFLHRFKLSDDIRELLRAKNASIRAYDRYPTAENRIRMRALQRDVKSRIAEVRDARWSDFLEGLAPSQRSYYRLARTLKSDTVVTMPPLVGPSGRLTAFDDDEKAELLADTLQTQCTPSTQSVDPVHVELVDSEVERRASLPPSDVLPPVTPMEVKDLIKDLRPRKAPGSDGISNRVIKLLPVQLIVMLVSIFNAAMANCIFPAVWKEADVIGIHKPGKPKNHPTSYRPISLLMSLGKLYERLLYKRLRDFVSSKGILIDEQFGFRTNHSCVQQVHRLTEHILVGLNRPKPLYTGALFFDVAKAFDKVWHNGLIFKLFNMGVPDSLVLIIRDFLSNRSFRYRVEGTRSSPRPLTAGVPQGSVLSPLLFSLFVNDIPRSPPTHLALFADDTTVYYSSRNKSLIAKKLQSAALALGQWFRKWRIDINPAKSTAVLFQRGSPTRISSRIRRRNLTPPITLFSQSIPWARKVKYLGVTLDASMTFRPHIKSVRDRAAFILGRLYPMICKRSKMSLRNKVTLYKTCIRPVMTYASVVFAHAARTHIDILQSLQSRFCRLAVGAPWFVRNVDLHDDLGLESIRKYMKSASERYFDKAMRHDNRLIVAAADYSPNPDHAGASHRRRPRHVLTDPSDPITFALDAFSSRSRLRDLGNRTRRTRQRVRRAT

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

At least 30 copies of X-element are present in the genome and some elements are polymorphic between different strains.
Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  Probable RNA-directed DNA polymerase from transposon X-element

Uniprot

Q93137   Q9XXW0   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139WA11   V5GNJ2   V5GNF3   X1WLB2   A0A023EYS8   X1WNI2   A0A2S2QEE0   A0A023EZE6   A0A2J7QR37   A0A2J7PU96   A0A2J7QY69   A0A2J7PBY3   A0A2J7R7D0   X1WZH0   A0A2S2Q383   A0A224X6Q4   A0A2J7Q6J2   A0A224X6T4   A0A2M4BD67   A0A087UCW3   A0A2M4BDV6   A0A087UGF5   A0A224X6S1   A0A2S2N814   A0A224XI99   A0A2M4CV52   A0A224X6U5   A0A2J7QB68   A0A2S2NGV8   A0A2M4CV42   J9LFC9   A0A2J7PVX3   A0A2S2R9D4   A0A069DZL8   A0A224XJI0   A0A2M4BD66   A0A2M4BDA5   A0A2M4BD62   Q9NBX4   A0A2S2N6Q7   A0A2S2PJG2   A0A1Y1KFR3   A0A0A9YJ00   A0A224X6W2   A0A2H8TF37   A0A2M4BD83   A0A0A9YU04   Q95SX7   A0A224XIB0   A0A2S2NPG3   A0A2A4K918   A0A2S2P698   A0A142LX49   A0A142LX26   Q24335   A0A352X8G4   A0A2H8TKI9   A0A224X6R6   A0A069DX78   A0A2J7Q0S7   Q8I7P8   P21328   A0A023F0I3   A0A1B6EGD8  

EC Number

2.7.7.49

Pubmed

10333566    26354079    10380107    28004739    18362917    19820115    + More
25474469    26334808    11405632    25401762    7753626    12537569    25527032    2441397    30148503    2463954    3040362    1714378   

EMBL

U07847    AAA17752.1    AB018558    BAA76304.1    AB055391    BAB21761.1    + More
KQ459265    KPJ02064.1    AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ971729    KYB24751.1    GALX01005299    JAB63167.1    GALX01005359    JAB63107.1    ABLF02042518    ABLF02057746    GBBI01004395    JAC14317.1    ABLF02008153    ABLF02008462    ABLF02008464    GGMS01006359    MBY75562.1    GBBI01004571    JAC14141.1    NEVH01011985    PNF31054.1    NEVH01021205    PNF19912.1    NEVH01009134    PNF33528.1    NEVH01027074    PNF13841.1    NEVH01006736    PNF36716.1    ABLF02034467    GGMS01002992    MBY72195.1    GFTR01008279    JAW08147.1    NEVH01017470    PNF24199.1    GFTR01008261    JAW08165.1    GGFJ01001858    MBW50999.1    KK119261    KFM75202.1    GGFJ01001857    MBW50998.1    KK119692    KFM76444.1    GFTR01008271    JAW08155.1    GGMR01000676    MBY13295.1    GFTR01008256    JAW08170.1    GGFL01004957    MBW69135.1    GFTR01008251    JAW08175.1    NEVH01016302    PNF25823.1    GGMR01003407    MBY16026.1    GGFL01005012    MBW69190.1    ABLF02023911    NEVH01020940    PNF20481.1    GGMS01017365    MBY86568.1    GBGD01000415    JAC88474.1    GFTR01008257    JAW08169.1    GGFJ01001844    MBW50985.1    GGFJ01001842    MBW50983.1    GGFJ01001843    MBW50984.1    AF237761    AAF81411.1    GGMR01000226    MBY12845.1    GGMR01016905    MBY29524.1    GEZM01084969    JAV60363.1    GBHO01010547    GBHO01010546    JAG33057.1    JAG33058.1    GFTR01008260    JAW08166.1    GFXV01000908    MBW12713.1    GGFJ01001822    MBW50963.1    GBHO01021814    GBHO01010549    JAG21790.1    JAG33055.1    AY060438    AAL25477.1    GFTR01008246    JAW08180.1    GGMR01006408    MBY19027.1    NWSH01000032    PCG80496.1    GGMR01012305    MBY24924.1    KU543685    AMS38375.1    KU543673    AMS38352.1    M17214    AAA28508.1    DNOY01000259    HBE18313.1    GFXV01002840    MBW14645.1    GFTR01008269    JAW08157.1    GBGD01000389    JAC88500.1    NEVH01019963    PNF22185.1    AY180919    AAN87272.1    M22874    M38643    GBBI01003747    JAC14965.1    GEDC01000337    JAS36961.1   

Proteomes

UP000053268    UP000007266    UP000007819    UP000235965    UP000054359    UP000218220    + More

PRIDE

Q93137    Q9XXW0    Q9BPQ0    Q9NBX4    Q95SX7    Q24335    + More
Q8I7P8    P21328   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF07530   PRE_C2HC
PF03372   Exo_endo_phos
PF07727   RVT_2

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR000477   RT_dom       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       

SUPFAM

SSF56219   SSF56219       

Gene 3D

3.60.10.10    

ProteinModelPortal

Q93137   Q9XXW0   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139WA11   V5GNJ2   V5GNF3   X1WLB2   A0A023EYS8   X1WNI2   A0A2S2QEE0   A0A023EZE6   A0A2J7QR37   A0A2J7PU96   A0A2J7QY69   A0A2J7PBY3   A0A2J7R7D0   X1WZH0   A0A2S2Q383   A0A224X6Q4   A0A2J7Q6J2   A0A224X6T4   A0A2M4BD67   A0A087UCW3   A0A2M4BDV6   A0A087UGF5   A0A224X6S1   A0A2S2N814   A0A224XI99   A0A2M4CV52   A0A224X6U5   A0A2J7QB68   A0A2S2NGV8   A0A2M4CV42   J9LFC9   A0A2J7PVX3   A0A2S2R9D4   A0A069DZL8   A0A224XJI0   A0A2M4BD66   A0A2M4BDA5   A0A2M4BD62   Q9NBX4   A0A2S2N6Q7   A0A2S2PJG2   A0A1Y1KFR3   A0A0A9YJ00   A0A224X6W2   A0A2H8TF37   A0A2M4BD83   A0A0A9YU04   Q95SX7   A0A224XIB0   A0A2S2NPG3   A0A2A4K918   A0A2S2P698   A0A142LX49   A0A142LX26   Q24335   A0A352X8G4   A0A2H8TKI9   A0A224X6R6   A0A069DX78   A0A2J7Q0S7   Q8I7P8   P21328   A0A023F0I3   A0A1B6EGD8  

KEGG

105841788    no KO assigned | (RefSeq) predicted GPI-anchored protein 58

GO

GO:0003964   GO:0004519   GO:0006313  

Length:

1243

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.60173000000001

Exp number, first 60 AAs:

0.00013

Total prob of N-in:

0.00010

outside

1  -  1243

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0.330191

CSRT

0

Interpretation

Uncertain