Gene

KWMTBOMO13028

Pre Gene Modal

BGIBMGA000287

Annotation

putative_tRNA_N6-adenosine_threonylcarbamoyltransferase?_mitochondrial_[Operophtera_brumata]

Location

Bomo_Chr22(+):6657380-6658681      View in EpiBrowser

Full name

Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial      

Alternative Name

N6-L-threonylcarbamoyladenine synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein
tRNA threonylcarbamoyladenosine biosynthesis protein
t(6)A37 threonylcarbamoyladenosine biosynthesis protein HaOG216964
tRNA threonylcarbamoyladenosine biosynthesis protein HaOG216964
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC108734774
tRNA threonylcarbamoyladenosine biosynthesis protein LOC108734774
t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgepl1
tRNA threonylcarbamoyladenosine biosynthesis protein osgepl1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 6044601
tRNA threonylcarbamoyladenosine biosynthesis protein 6044601
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 5565046
tRNA threonylcarbamoyladenosine biosynthesis protein 5565046
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON014481
tRNA threonylcarbamoyladenosine biosynthesis protein CSON014481
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON010212
tRNA threonylcarbamoyladenosine biosynthesis protein CSON010212
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1_1
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1_1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1_0
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1_0
t(6)A37 threonylcarbamoyladenosine biosynthesis protein RvY_15393-1
tRNA threonylcarbamoyladenosine biosynthesis protein RvY_15393-1
O-sialoglycoprotein endopeptidase-like protein 1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1
tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 106084148
tRNA threonylcarbamoyladenosine biosynthesis protein 106084148
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC103518998
tRNA threonylcarbamoyladenosine biosynthesis protein LOC103518998
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 100168791
tRNA threonylcarbamoyladenosine biosynthesis protein 100168791
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 101899321
tRNA threonylcarbamoyladenosine biosynthesis protein 101899321
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 100118784
tRNA threonylcarbamoyladenosine biosynthesis protein 100118784
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 8239320
tRNA threonylcarbamoyladenosine biosynthesis protein 8239320
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106173665
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106173665

Location in the cell

Cytoplasmic   Reliability : 1.358

CDS

ATGTTCATGACACACAGAAACTCAAGATTATTGCGTATCCTTCGTCAAAATCGTTGGAAAACTACATCTTGTTCAAATGATTTTACAATTCTCGGAATTGAAACCTCTTGTGATGATACAGGTTGTGCTGTTATTGATGGAGCTGGCAATGTTCTTGGAGAGTCTCTTTATTCACAGAATGCAATACATGTAAGATATGGAGGAGTAAATCCTTTCATAGCTCATGAACTTCACCGAGAACACATAGAAACAGCTGTAACTGAAGCACTTTCCACAGCAAAGATTAAAATAAAAGATATTGATGCTGTTGCTGTTACTGTTAAACCTGGATTATTACTCAGTCTCCAAGTTGGAGTTCAGTATGCAAAATATATATGTATGGAGTATAATAAACCTATTATTCCGGTCCATCACATGGAAGCTCATGCTTTAGTAGCTAGGATTTATCACAACTTGCCATTTCCATTTATAGTTTTACTTATATCTGGAGGACATTGTCTTTTGTGTCTTGTTCAGGATGTAAATCAATTTTTACTTCTTGGAGAATCATTGGACAATGCCCCAGGAGAGATTCTAGACAAAGTTGCCAGAAGAATGAAACTAAAAAATATTAAAGAGTATTCTCAATTGGCTGGAGGCAAAGCAGTAGAGGAGGCTGCTAAGAAAGCTAACAATTCTCAACAATTCCAATTTCCTTTGCCTTTAAATAGAAATAGAGACTGTAATTTTAGTTTTAGTGGTCTTAAAGATTCACTTGTAAGAAAATTAATAAAAAAGGAAAAAGAACATGGTATTACTGGGGATTGTTTGATACCAGAATATAATGATTTATGTGCTTCATTTCAAATTGCCTTAGCTGAACACTTGGGGCATAGACTAGAGAGAGCAATTATCTTCTGTGAGGAAAAGAACTTAATCAATCCTAATAATAAAAATATAGTAGTTTCAGGTGGTGTTGCTTGTAATGATTTTATATTTAAATCAATGCAATTTGTTGCTGGTAAATCTGGTTATAGCTGTTATAGACCTCCACCTAAAGTTTGTACTGATAATGGGATAATGATAGCATGGAATGGTGTAGAAAAACTTAAGAAATCATATCAAATTCAATATGACTTACCACTTAGTGAAATAGATCCTATTGCACCTTTAGGAAAGAGTTTAATACATGAAGTAAAATGTGCTAATATACCAGTAAAAGTGACAAAATTAACAAACTTGTTATGA

Protein

MFMTHRNSRLLRILRQNRWKTTSCSNDFTILGIETSCDDTGCAVIDGAGNVLGESLYSQNAIHVRYGGVNPFIAHELHREHIETAVTEALSTAKIKIKDIDAVAVTVKPGLLLSLQVGVQYAKYICMEYNKPIIPVHHMEAHALVARIYHNLPFPFIVLLISGGHCLLCLVQDVNQFLLLGESLDNAPGEILDKVARRMKLKNIKEYSQLAGGKAVEEAAKKANNSQQFQFPLPLNRNRDCNFSFSGLKDSLVRKLIKKEKEHGITGDCLIPEYNDLCASFQIALAEHLGHRLERAIIFCEEKNLINPNNKNIVVSGGVACNDFIFKSMQFVAGKSGYSCYRPPPKVCTDNGIMIAWNGVEKLKKSYQIQYDLPLSEIDPIAPLGKSLIHEVKCANIPVKVTKLTNLL

Description

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

Catalytic Activity

adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA

Cofactor

a divalent metal cation

Subunit

Homodimer.

Similarity

Belongs to the KAE1 / TsaD family.

Keywords

Acetylation   Acyltransferase   Complete proteome   Metal-binding   Mitochondrion   Reference proteome   Transferase   Transit peptide   tRNA processing   Alternative splicing  

Feature

chain  Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
splice variant  In isoform 2.

Uniprot

A0A2A4IW70   A0A2W1C4D0   A0A0L7L9T2   A0A2H1X347   A0A194PWQ9   A0A194QW36   + More
A0A0L7L6I4   H9ISX1   S4PEC3   A0A1W4WPA9   A0A2J7RR99   A0A1Y1M9Q3   A0A182WK23   A0A2P8XPP6   A0A1B0D067   B0WXG7   A0A0C9RNQ0   D6WLE6   A0A182UVT3   A0A182LBN1   A0A182TQ06   A0A182XEV3   A0A182LU65   A0A1S4F805   A0A194PY26   A0A182HNX9   Q17CG3   Q7Q9I8   A0A182K7W4   A0A182IVK4   A0A212EXC0   A0A336MN16   A0A182QZQ6   A0A336M6N1   N6U739   A0A0A9Z2B8   A0A1B6DRA7   A0A0A9Z3T9   A0A146LH26   A0A0T6AYM3   A0A0P6CZV0   A0A154P9X6   A0A0N8A705   A0A182FCX8   A0A0N0BBB1   E2APZ2   A0A0N8AP11   A0A0P4XHK2   A0A293MWU7   A0A1D1VUR6   A0A2D4K1Q4   A0A0K8TTA4   A0A026WW60   A0A1Z5L8P8   A0A2A3E3K4   Q4V7F3   A0A1A9USV1   A0A1A9XCV2   A0A1B0BB71   U3IVP9   A0A1B0FI42   A0A1I8Q329   T1JHI2   A0A195DCF8   A0A1S3DIG3   Q6PEB4   R0KAD1   A0A1D2MBU8   A0A0L7RDD4   J9K955   A0A0N7ZD09   A0A1A9ZQH8   A0A1A9WDQ9   A0A1I8NB88   I3KJ85   A0A195C832   V9KZJ3   A0A2D4K1P7   K7J6Z0   A0A0V0GDI8   A0A3Q2PAL8   W5MQN2   A0A3Q3S1X1   A0A232FFV1   G1KPS6   G1T3F5   A0A0L0CNC3   A0A3Q0RGZ3   H2U594   V4C494   A0A147AXN1   A0A2R7W0S0   F4WM44   L5K2R2   F7A1U7   A0A195BC70   E0VDW1   A0A2R2MRT2   A0A023F2T3  

EC Number

2.3.1.234

Pubmed

28756777    26227816    26354079    19121390    23622113    28004739    + More
29403074    18362917    19820115    20966253    17510324    12364791    22118469    23537049    25401762    26823975    20798317    27649274    26369729    24508170    28528879    15489334    19694617    23749191    16141072    23576753    27289101    25315136    25186727    24402279    20075255    28648823    21993624    26108605    21551351    23254933    21719571    23258410    19892987    20566863    25474469   

EMBL

NWSH01005435    PCG64217.1    KZ149892    PZC79013.1    JTDY01002054    KOB72227.1    + More
ODYU01013074    SOQ59751.1    KQ459586    KPI97801.1    KQ461073    KPJ09748.1    JTDY01002647    KOB71010.1    BABH01013035    GAIX01003246    JAA89314.1    NEVH01000611    PNF43359.1    GEZM01036651    JAV82542.1    PYGN01001570    PSN33976.1    AJVK01009849    DS232164    EDS36497.1    GBYB01010050    JAG79817.1    KQ971343    EFA04757.2    AXCM01001015    KPI97928.1    APCN01002811    CH477308    EAT44058.1    AAAB01008900    EAA09387.4    AGBW02011787    OWR46139.1    UFQT01000821    SSX27378.1    AXCN02001020    UFQS01000410    UFQT01000410    SSX03672.1    SSX24037.1    APGK01046725    KB741067    ENN74407.1    GBHO01005598    GBHO01005597    GBHO01005596    GBHO01005595    GBHO01005594    GBHO01005593    JAG38006.1    JAG38007.1    JAG38008.1    JAG38009.1    JAG38010.1    JAG38011.1    GEDC01009109    JAS28189.1    GBHO01005592    GBHO01005591    GBHO01005590    GBRD01004962    JAG38012.1    JAG38013.1    JAG38014.1    JAG60859.1    GDHC01011218    GDHC01006384    JAQ07411.1    JAQ12245.1    LJIG01022502    KRT80233.1    GDIQ01085103    JAN09634.1    KQ434856    KZC08709.1    GDIP01176297    JAJ47105.1    KQ438551    KOX67162.1    GL441645    EFN64479.1    GDIQ01256971    JAJ94753.1    GDIP01241709    JAI81692.1    GFWV01019841    MAA44569.1    BDGG01000012    GAV05227.1    IACL01022076    LAB02645.1    GDAI01000458    JAI17145.1    KK107109    EZA59359.1    GFJQ02003649    JAW03321.1    KZ288427    PBC25872.1    BC097950    JXJN01011310    ADON01016377    CCAG010004713    JH432001    KQ980989    KYN10595.1    AK011265    AK045669    AK137332    BC058172    KB742542    EOB07271.1    LJIJ01002009    ODM90364.1    KQ414614    KOC68834.1    ABLF02027799    GDRN01055717    JAI65936.1    AERX01050422    KQ978220    KYM96298.1    JW871775    AFP04293.1    IACL01022077    LAB02647.1    GECL01000717    JAP05407.1    AHAT01016274    NNAY01000271    OXU29582.1    AAGW02003509    JRES01000256    KNC32919.1    KB201480    ESO96349.1    GCES01002983    JAR83340.1    KK854184    PTY12771.1    GL888217    EGI64688.1    KB031068    ELK04783.1    KQ976519    KYM82161.1    DS235088    EEB11567.1    GBBI01003281    JAC15431.1   

Proteomes

UP000218220    UP000037510    UP000053268    UP000053240    UP000005204    UP000192223    + More
UP000235965    UP000075920    UP000245037    UP000092462    UP000002320    UP000007266    UP000075903    UP000075882    UP000075902    UP000076407    UP000075883    UP000075840    UP000008820    UP000007062    UP000075881    UP000075880    UP000007151    UP000075886    UP000019118    UP000076502    UP000069272    UP000053105    UP000000311    UP000186922    UP000053097    UP000242457    UP000002494    UP000078200    UP000092443    UP000092460    UP000016666    UP000092444    UP000095300    UP000078492    UP000079169    UP000000589    UP000094527    UP000053825    UP000007819    UP000092445    UP000091820    UP000095301    UP000005207    UP000078542    UP000002358    UP000265000    UP000018468    UP000261640    UP000215335    UP000001646    UP000001811    UP000037069    UP000261340    UP000005226    UP000030746    UP000007755    UP000010552    UP000002281    UP000078540    UP000009046    UP000085678   

PRIDE

H9ISX1    Q4V7F3    Q6PEB4   

Pfam

PF00814   Peptidase_M22

Interpro

IPR000905   Gcp-like_dom        + More
IPR022450   TsaD       
IPR017861   KAE1/TsaD       
IPR017860   Peptidase_M22_CS       

ProteinModelPortal

A0A2A4IW70   A0A2W1C4D0   A0A0L7L9T2   A0A2H1X347   A0A194PWQ9   A0A194QW36   + More
A0A0L7L6I4   H9ISX1   S4PEC3   A0A1W4WPA9   A0A2J7RR99   A0A1Y1M9Q3   A0A182WK23   A0A2P8XPP6   A0A1B0D067   B0WXG7   A0A0C9RNQ0   D6WLE6   A0A182UVT3   A0A182LBN1   A0A182TQ06   A0A182XEV3   A0A182LU65   A0A1S4F805   A0A194PY26   A0A182HNX9   Q17CG3   Q7Q9I8   A0A182K7W4   A0A182IVK4   A0A212EXC0   A0A336MN16   A0A182QZQ6   A0A336M6N1   N6U739   A0A0A9Z2B8   A0A1B6DRA7   A0A0A9Z3T9   A0A146LH26   A0A0T6AYM3   A0A0P6CZV0   A0A154P9X6   A0A0N8A705   A0A182FCX8   A0A0N0BBB1   E2APZ2   A0A0N8AP11   A0A0P4XHK2   A0A293MWU7   A0A1D1VUR6   A0A2D4K1Q4   A0A0K8TTA4   A0A026WW60   A0A1Z5L8P8   A0A2A3E3K4   Q4V7F3   A0A1A9USV1   A0A1A9XCV2   A0A1B0BB71   U3IVP9   A0A1B0FI42   A0A1I8Q329   T1JHI2   A0A195DCF8   A0A1S3DIG3   Q6PEB4   R0KAD1   A0A1D2MBU8   A0A0L7RDD4   J9K955   A0A0N7ZD09   A0A1A9ZQH8   A0A1A9WDQ9   A0A1I8NB88   I3KJ85   A0A195C832   V9KZJ3   A0A2D4K1P7   K7J6Z0   A0A0V0GDI8   A0A3Q2PAL8   W5MQN2   A0A3Q3S1X1   A0A232FFV1   G1KPS6   G1T3F5   A0A0L0CNC3   A0A3Q0RGZ3   H2U594   V4C494   A0A147AXN1   A0A2R7W0S0   F4WM44   L5K2R2   F7A1U7   A0A195BC70   E0VDW1   A0A2R2MRT2   A0A023F2T3  

PDB

3ZEU     E-value=2.51861e-46,     Score=468

KEGG

101741595    K01409 N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] | (RefSeq) probable tRNA N6-adenosine t

GO

GO:0004222   GO:0005739   GO:0046872   GO:0061711   GO:0002949   GO:0000408   GO:0016740   GO:0016746   GO:0006412   GO:0043565   GO:0007155   GO:0005515   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR11735:SF6   PTHR11735  

Subcellular location

Mitochondrion  

Length:

408

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.60996999999999

Exp number, first 60 AAs:

0.00021

Total prob of N-in:

0.19952

outside

1  -  408

 

 

Pi

288.198019

Theta

223.965335

Tajima's D

0.905295

CLR

0

CSRT

0.630468476576171

Interpretation

Uncertain