Gene

KWMTBOMO13025

Annotation

PREDICTED:_osteopetrosis-associated_transmembrane_protein_1_[Bombyx_mori]

Location

Bomo_Chr22(-):6628246-6630229      View in EpiBrowser

Full name

Osteopetrosis-associated transmembrane protein 1      

Alternative Name

Chloride channel 7 beta subunit
Grey-lethal protein

Location in the cell

PlasmaMembrane   Reliability : 2.758

CDS

ATGACAACAGTGTATTTTTTCTTAGCTGTGATGTTTGCTCACGGTAATTTTGCAGATTATCGAGATGGAAAGGAATTGCCTGTAACAAGCTATAAATTAAAATACAATGGTGAGGGGTATTTGTTTGCGAATCCTAGTATTTGTACGAAATTACTTGATGAATTTGCGGATTCTGCATCTAATTTTACAAAATGCTCAATCAAACATGCGAGACCGATAAGACTATGTGAAAAATGTATTGATCATTATGTAAAATTTCGTGAGAGCTATAAAAATTTACTTCAAACCAATTTAAATGGAACTTCATGTGAAACCATCTTTATTTCTCATGATAGATTAGAGGTGGTTTTGAATTATCATGATAACATATTAGCTATTTGGAACAAAGGAAATTGTAATGATTGTTTTAACTGGACTAAAGATAAACCAGAAATTTCAAATAAAACTTACCATTTTTATCAAATTTTTAATGAAACAATGCAATGTATTGAAGACAATATAAATCCCAAAGAGAATAGTACAAAAGTGTGTGAGAACTGTATGCAGAGCTACATACAGCTGAATAACTATTATGAATCTCTTAGTTTTGACAGAATAGGGCTGGATATTATATGCATGGATGTTATTGATTCTATGAATGCAACTAGATCAATATGGAGCAAAAGCCTAAACTGTTGTAAATTGAGAAAGTCTCCAGAAATAATATTTTTGTGTTGTTCTGGAATTATTGCATGCTTACCAGTTTTGTATTATATTATGGTGAAATATTGTGGACCAATTAAGGACTTACCTAATATTTTAAAGCAATCAAGATTCAAACAAAGGATATTAAGAACAGTTAATGGTATCAATTAG

Protein

MTTVYFFLAVMFAHGNFADYRDGKELPVTSYKLKYNGEGYLFANPSICTKLLDEFADSASNFTKCSIKHARPIRLCEKCIDHYVKFRESYKNLLQTNLNGTSCETIFISHDRLEVVLNYHDNILAIWNKGNCNDCFNWTKDKPEISNKTYHFYQIFNETMQCIEDNINPKENSTKVCENCMQSYIQLNNYYESLSFDRIGLDIICMDVIDSMNATRSIWSKSLNCCKLRKSPEIIFLCCSGIIACLPVLYYIMVKYCGPIKDLPNILKQSRFKQRILRTVNGIN

Description

Required for osteoclast and melanocyte maturation and function.

Subunit

Chloride channel 7 are heteromers of alpha (CLCN7) and beta (OSTM1) subunits.

Similarity

Belongs to the OSTM1 family.

Keywords

Complete proteome   Glycoprotein   Lysosome   Membrane   Phosphoprotein   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Osteopetrosis-associated transmembrane protein 1

Uniprot

A0A194R1M0   A0A0L7LIK7   A0A2W1BVJ9   S4P862   A0A3S2NYQ5   V5GKU1   + More
A0A067RIN4   A0A1Y1NGE1   A0A2J7R9D7   A0A1Y1NJB3   A0A1S3CUS6   D6WMS9   J3JW21   A0A1B6LKF4   A0A1B6D2T6   A0A226DZ57   N6UIG6   C4A012   A0A2R7VTG6   A0A210QB24   A0A069DQ19   A0A1V4JLY8   A0A1D2M7Y7   V4A2A8   A0A3M0KPE0   K4FUM2   A0A218UZ73   A0A0Q3MT64   V9L6F5   V9L7E6   A0A0A9WZ00   A0A1L8D9F9   A0A1L8D9E9   A0A1L8D9V1   A0A1L8D9G3   C4WXH6   H0ZPI5   A0A2S2QS90   A0A1B0DM76   A0A1S3AIQ0   A0A1S3FMQ6   A0A0A9XCE5   J9JW58   R4GCB5   A0A1L8G2Y2   D8KWH2   D8KW62   C1FXW5   A0A1S3HCL3   H2ME03   A0A3P9HG19   A0A2K6S900   B3RF22   Q0VCT5   A0A3Q1NGQ7   L8IEK7   A0A1L8G919   R7T5C7   A0A0C9RH66   Q8BGT0   A0A3P9M7R7   A0A034VRH9   Q4QQU9   A0A1A6FXG1   Q5ZMW4   A0A3B3D927   G1TAU7   B7NZG5   A0A250YFY2   F6XMK4   B5FW42   A0A2Y9HAZ5   A0A2Y9FDB7   H0VGB2   A0A1U7QJ09   A0A3Q7U2U9   A0A3Q3MEG2   M3YEE2   A0A0F8AGX8   A0A2Y9KQA0   A0A2Y9FDD1   A0A384D8S9   F6UYP7   A0A3Q3FEU6   A0A340WFB0   A0A3P4MSJ6   A0A2Y9RXR7   A0A226NKK8   A0A226PUU2   A0A341C812   W5PMJ3   A0A2K5QK73   U6DMS9   A0A3Q7NM03   A0A2U3YJ63   D2H6J2   A0A3P8TB10  

Pubmed

26354079    26227816    28756777    23622113    24845553    28004739    + More
18362917    19820115    22516182    23537049    18563158    28812685    26334808    27289101    23254933    23056606    24402279    25401762    26823975    20360741    27762356    17554307    19393038    22751099    12627228    16141072    15489334    16525474    17242355    19144319    21183079    25348373    15057822    22673903    15592404    15642098    29451363    21993624    28087693    19892987    25835551    16341006    24621616    20809919    20010809   

EMBL

KQ461073    KPJ09751.1    JTDY01000931    KOB75393.1    KZ149892    PZC79009.1    + More
GAIX01009670    JAA82890.1    RSAL01000021    RVE52418.1    GALX01007463    JAB61003.1    KK852456    KDR23622.1    GEZM01003003    GEZM01003002    JAV96993.1    NEVH01006598    PNF37445.1    GEZM01003005    GEZM01003004    JAV96990.1    KQ971341    EFA04526.1    BT127439    AEE62401.1    GEBQ01015794    JAT24183.1    GEDC01017287    JAS20011.1    LNIX01000009    OXA49981.1    APGK01018863    KB740085    ENN81515.1    GG666776    EEN41872.1    KK854043    PTY10151.1    NEDP02004373    OWF45938.1    GBGD01002721    JAC86168.1    LSYS01006902    OPJ73216.1    LJIJ01002954    ODM89041.1    KB202917    ESO87406.1    QRBI01000106    RMC13144.1    JX053001    AFK11229.1    MUZQ01000087    OWK59023.1    LMAW01000747    KQK85567.1    JW874783    AFP07300.1    JW875234    AFP07751.1    GBHO01030984    GBHO01030983    GBRD01014174    GBRD01014173    GBRD01014172    GBRD01014171    GBRD01014170    GDHC01015807    GDHC01012071    GDHC01011921    JAG12620.1    JAG12621.1    JAG51652.1    JAQ02822.1    JAQ06558.1    JAQ06708.1    GFDF01010986    JAV03098.1    GFDF01010985    JAV03099.1    GFDF01010984    JAV03100.1    GFDF01010983    JAV03101.1    AK342643    BAH72596.1    ABQF01000444    ABQF01000445    GGMS01011385    MBY80588.1    AJVK01006883    GBHO01025202    JAG18402.1    ABLF02037283    CM004475    OCT78190.1    DP001174    ADK26710.1    DP001173    ADK26801.1    DP001088    ACO71278.1    DP000779    ACE77648.1    BC120014    AAI20015.1    JH881380    ELR54656.1    CM004474    OCT80398.1    AMQN01003456    KB311873    ELT88308.1    GBYB01006276    JAG76043.1    AF533890    AK004546    AK050513    BC057635    GAKP01014799    JAC44153.1    AABR07045438    AABR07045439    AABR07045440    AABR07045441    BC097978    AAH97978.1    LZPO01116608    OBS58284.1    AC171178    AJ719270    CAG30929.1    AAGW02029525    DP001039    ACJ76602.1    GFFW01002322    JAV42466.1    AAQR03003496    AAQR03003497    AAQR03003498    AAQR03003499    AAQR03003500    AAQR03003501    AAQR03003502    AAQR03003503    AAQR03003504    AAQR03003505    DP000891    ACH53020.1    AAKN02044839    AEYP01034111    AEYP01034112    KQ042093    KKF19066.1    AAEX03008592    CYRY02012786    VCW83749.1    MCFN01000027    OXB67972.1    AWGT02000016    OXB83187.1    AMGL01106525    AMGL01106526    HAAF01012106    CCP83929.1    GL192530    EFB26586.1   

Proteomes

UP000053240    UP000037510    UP000283053    UP000027135    UP000235965    UP000079169    + More
UP000007266    UP000198287    UP000019118    UP000001554    UP000242188    UP000190648    UP000094527    UP000030746    UP000269221    UP000197619    UP000051836    UP000007754    UP000092462    UP000079721    UP000081671    UP000007819    UP000001646    UP000186698    UP000085678    UP000001038    UP000265200    UP000233220    UP000009136    UP000014760    UP000000589    UP000265180    UP000002494    UP000092124    UP000000539    UP000261560    UP000001811    UP000002281    UP000005225    UP000248481    UP000005447    UP000189706    UP000286640    UP000261660    UP000000715    UP000248482    UP000248484    UP000261680    UP000002254    UP000265300    UP000198323    UP000198419    UP000252040    UP000002356    UP000233040    UP000286641    UP000245341    UP000265080   

PRIDE

Q8BGT0   

Pfam

PF09777   OSTMP1        + More
PF04757   Pex2_Pex12

Interpro

IPR019172   Osteopetrosis-assoc_TM_1        + More
IPR001841   Znf_RING       
IPR006845   Pex_N       
IPR013083   Znf_RING/FYVE/PHD       
IPR017907   Znf_RING_CS       

Gene 3D

3.30.40.10    

ProteinModelPortal

A0A194R1M0   A0A0L7LIK7   A0A2W1BVJ9   S4P862   A0A3S2NYQ5   V5GKU1   + More
A0A067RIN4   A0A1Y1NGE1   A0A2J7R9D7   A0A1Y1NJB3   A0A1S3CUS6   D6WMS9   J3JW21   A0A1B6LKF4   A0A1B6D2T6   A0A226DZ57   N6UIG6   C4A012   A0A2R7VTG6   A0A210QB24   A0A069DQ19   A0A1V4JLY8   A0A1D2M7Y7   V4A2A8   A0A3M0KPE0   K4FUM2   A0A218UZ73   A0A0Q3MT64   V9L6F5   V9L7E6   A0A0A9WZ00   A0A1L8D9F9   A0A1L8D9E9   A0A1L8D9V1   A0A1L8D9G3   C4WXH6   H0ZPI5   A0A2S2QS90   A0A1B0DM76   A0A1S3AIQ0   A0A1S3FMQ6   A0A0A9XCE5   J9JW58   R4GCB5   A0A1L8G2Y2   D8KWH2   D8KW62   C1FXW5   A0A1S3HCL3   H2ME03   A0A3P9HG19   A0A2K6S900   B3RF22   Q0VCT5   A0A3Q1NGQ7   L8IEK7   A0A1L8G919   R7T5C7   A0A0C9RH66   Q8BGT0   A0A3P9M7R7   A0A034VRH9   Q4QQU9   A0A1A6FXG1   Q5ZMW4   A0A3B3D927   G1TAU7   B7NZG5   A0A250YFY2   F6XMK4   B5FW42   A0A2Y9HAZ5   A0A2Y9FDB7   H0VGB2   A0A1U7QJ09   A0A3Q7U2U9   A0A3Q3MEG2   M3YEE2   A0A0F8AGX8   A0A2Y9KQA0   A0A2Y9FDD1   A0A384D8S9   F6UYP7   A0A3Q3FEU6   A0A340WFB0   A0A3P4MSJ6   A0A2Y9RXR7   A0A226NKK8   A0A226PUU2   A0A341C812   W5PMJ3   A0A2K5QK73   U6DMS9   A0A3Q7NM03   A0A2U3YJ63   D2H6J2   A0A3P8TB10  

KEGG

101743137    no KO assigned | (RefSeq) osteopetrosis-associated transmembrane protein 1

GO

GO:0016021   GO:0005829   GO:0030316   GO:0005765  

PANTHER

PTHR15644  

Subcellular location

Lysosome membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.957931

 

 

Length:

284

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.34029

Exp number, first 60 AAs:

0.20359

Total prob of N-in:

0.51813

outside

1  -  231

TMhelix

232  -  254

inside

255  -  284

 

 

Pi

186.185662

Theta

183.132345

Tajima's D

0.20495

CLR

0.56452

CSRT

0.427528623568822

Interpretation

Uncertain