Gene

KWMTBOMO12947  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000236

Annotation

isovaleryl_coenzyme_A_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr22(+):4928110-4938561      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 1.522 Mitochondrial   Reliability : 2.024

CDS

ATGGTTGTTAGGTTGTGTGTGAGACGCTTGCTAAGGAAAACCGCGAATAAAACCGGTCATCGATGCATCTCGCATTATCCCATTGACGATCATGTGTTTGGACTCTCCGAAGAACAACAACAGCTCAGAAAAATGGTATTCGACTTTGCTCAGAAGGAATTGGCGCCAAAAGCAGCTGAAATCGACAAAGAAAACAATTTTAAAGAACTAAGGCCATTTTGGAAGAAACTTGGAGATCTCGGATTGCTAGGTATTACCGCAAGTTCCGACTATGGAGGTACAGGGGGAAAATATTCGGACCATTGTGTCATTATGGAGGAATTATCAAGGGCCAGCGGTGGTATCGCCTTGTCATATGGAGCTCATTCGAATTTGTGCGTGAACCAGATCAACAGAAACGGTACAGAGGAGCAGAAAAGTAAATATTTACCAAAGTTATGTTCAGGAGAGCATATCGGAGCACTGGCAATGTCCGAACCAGGGTCAGGCAGTGACGTGGTGTCTATGAAGTTACGAGCAGAGAAGAAAGGCGATTATTATGTGTTGAACGGAAATAAGTTTTGGATTACTAATGGACCAGACGCAGATGTTTTAGTGGTATACGCCAAGACAAATTGGTCGACGAGTAAACAACAACATGGGATTTCAGCTTTTTTAATTGAAAAAGATTATCCTGGGTTTTCAACAGCTCAAAAATTAGATAAACTAGGTATGAGGGGTTCAAACACAGGGGAATTGGTGTTTGAGGATTGTAAGGTACCGGCAGCAAATTTATTAGGACAGGAAAACAAAGGGGTGTACGTACTAATGTCCGGCTTAGACCTGGAGAGACTGGTTCTTGCTGCAGGTCCCGTCGGATTAATGCAGGCCGCGATAGACACAGCCTTCTTGTACGCACACACCAGGAAACAATTTGGGAAGAACATTGGAGAGTTTCAATTGATACAGGGTAAAATGGCAGATATGTATACAACGTTAAGTGCATGTCGTAGCTACTTATACAATGTGGCTAAAGCGTGTGATAACGGCCATGTTAACAGTAAGGATTGCGCGGGCGTGATACTCTACTGTGCGGAAAAAGCAACACAGGTCGCTTTAGATGCAATCCAAATATTAGGCGGAAATGGGTACATCAATGACTATCCTACTGGTAGGATTTTGAGAGATGCAAAGCTGTATGAAATAGGTGCAGGAACTTCAGAAGTGAGGAGAATGTTAATTGGAAGAGCTTTAAATAATGAATACAAGTGA

Protein

MVVRLCVRRLLRKTANKTGHRCISHYPIDDHVFGLSEEQQQLRKMVFDFAQKELAPKAAEIDKENNFKELRPFWKKLGDLGLLGITASSDYGGTGGKYSDHCVIMEELSRASGGIALSYGAHSNLCVNQINRNGTEEQKSKYLPKLCSGEHIGALAMSEPGSGSDVVSMKLRAEKKGDYYVLNGNKFWITNGPDADVLVVYAKTNWSTSKQQHGISAFLIEKDYPGFSTAQKLDKLGMRGSNTGELVFEDCKVPAANLLGQENKGVYVLMSGLDLERLVLAAGPVGLMQAAIDTAFLYAHTRKQFGKNIGEFQLIQGKMADMYTTLSACRSYLYNVAKACDNGHVNSKDCAGVILYCAEKATQVALDAIQILGGNGYINDYPTGRILRDAKLYEIGAGTSEVRRMLIGRALNNEYK

Cofactor

FAD

Similarity

Belongs to the acyl-CoA dehydrogenase family.

Uniprot

B5UB85   D2SNL6   A0A2H1WEI4   A0A0N1ICI2   A0A212EZL0   A0A194QDM0   + More
A0A2A4J6L8   E0W349   A0A0P4W309   E9GS77   A0A154P1H5   A0A0N7ZIY7   K7IUR0   A0A1S4F3T4   B0X633   U5EUB2   Q17GD3   A0A182YJH3   A0A182FFH5   A0A1Q3F1W5   A0A084WMZ7   A0A0P6EKI7   A0A182WI57   A0A182T4W4   A0A1B6KKR0   A0A336K0R5   A0A182INW0   A0A1B6FE49   A0A182H9F3   A0A232F5Q6   A0A182MS73   A0A2M4BNU3   A0A2M4A812   A0A2M4BNY6   W5JBT8   A0A182N7I3   T1E9J3   A0A0P6B5X2   A0A182UKR0   A0A182X250   A0A182L429   Q7QIC5   A0A182R9B6   A0A182PEX0   B3M691   A0A182V0F8   A0A2M3ZHG1   A0A1W4UEZ7   B3NBR7   A0A182I6B1   A0A2M3ZH71   Q29CZ7   B4H9H6   B4KZ54   B4K041   B4LEK2   A0A3M7RYJ7   B4HJZ3   A0A0A1XKN1   B4PG06   A0A3B0J6Q1   B4QM45   Q9VSL9   A0A0K8WEC0   A0A1I8NSK4   A0A034VY15   A0A034VTX1   A0A310SC54   D3TLC7   A0A023ESZ9   A0A1A9UJD5   A0A0L0BYS5   A0A1A9Z2Q7   A0A0M4EK03   B4MXU5   B7P6T5   A0A1B0BA97   A0A1A9YN39   A0A1L8DYZ7   A0A0K8RJD6   T1PCM6   A0A1I8MJ66   A0A1B0CM01   W8BYD7   D6WJK5   D3PGR5   C1C1U2   A0A2P2HZ63   A0A026WU13   A0A3L8DG85   A0A1W7RAA9   A0A1I8AG09   A0A1L8DYV7   A0A226EXE4   R7UHR6   A0A088AHV5   A0A087SWH9   A0A2A3EAW3   A0A067R9Z1   A0A2S2R6I3  

Pubmed

19121390    21040472    20074338    26354079    22118469    20566863    + More
21292972    20075255    17510324    25244985    24438588    26483478    28648823    20920257    23761445    20966253    12364791    14747013    17210077    17994087    15632085    30375419    25830018    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25348373    20353571    24945155    26108605    25315136    24495485    18362917    19820115    24508170    30249741    26392177    23254933    24845553   

EMBL

BABH01013466    BABH01013467    AB458683    AB462483    BAG72196.1    BAG74561.1    + More
EZ407145    ACX53707.1    ODYU01008136    SOQ51488.1    KQ460968    KPJ10212.1    AGBW02011262    OWR46923.1    KQ459324    KPJ01556.1    NWSH01003026    PCG67090.1    DS235882    EEB20055.1    GDRN01076512    JAI62883.1    GL732561    EFX77663.1    KQ434786    KZC05088.1    GDIP01240841    GDIQ01006328    LRGB01000781    JAI82560.1    JAN88409.1    KZS15972.1    AAZX01002655    DS232400    EDS41164.1    GANO01002402    JAB57469.1    CH477263    EAT45617.1    GFDL01013557    JAV21488.1    ATLV01024541    ATLV01024542    KE525352    KFB51591.1    GDIQ01061266    JAN33471.1    GEBQ01028223    GEBQ01021061    JAT11754.1    JAT18916.1    UFQS01000015    UFQT01000015    SSW97372.1    SSX17758.1    GECZ01021280    JAS48489.1    JXUM01030163    JXUM01030164    KQ560874    KXJ80523.1    NNAY01000902    OXU26005.1    AXCM01000817    GGFJ01005541    MBW54682.1    GGFK01003560    MBW36881.1    GGFJ01005542    MBW54683.1    ADMH02001849    ETN60883.1    GAMD01001297    JAB00294.1    GDIP01019394    JAM84321.1    AAAB01008807    EAA04728.3    CH902618    EDV39711.1    GGFM01007139    MBW27890.1    CH954178    EDV50663.1    APCN01003602    GGFM01007121    MBW27872.1    CH379070    EAL30617.1    CH479229    EDW36452.1    CH933809    EDW17851.1    CH916386    EDV94289.1    CH940647    EDW69087.1    REGN01002396    RNA28397.1    CH480815    EDW40729.1    GBXI01002785    JAD11507.1    CM000159    EDW93150.1    OUUW01000002    SPP77405.1    CM000363    CM002912    EDX09728.1    KMY98412.1    AE014296    AY089640    AAF50398.1    AAL90378.1    GDHF01002808    JAI49506.1    GAKP01012212    JAC46740.1    GAKP01012211    JAC46741.1    KQ794714    OAD47022.1    CCAG010009360    EZ422229    ADD18505.1    GAPW01001667    JAC11931.1    JRES01001151    KNC25141.1    CP012525    ALC43460.1    CH963876    EDW76864.1    ABJB010000880    ABJB010035133    ABJB010059759    ABJB010215077    DS647752    EEC02307.1    JXJN01010876    GFDF01002437    JAV11647.1    GADI01002800    JAA71008.1    KA646439    AFP61068.1    AJWK01017981    AJWK01017982    GAMC01008244    JAB98311.1    KQ971342    EFA04754.2    BT120821    ADD24461.1    BT080821    ACO15245.1    IACF01001202    LAB66916.1    KK107109    EZA59106.1    QOIP01000008    RLU19455.1    GFAH01000307    JAV48082.1    GFDF01002475    JAV11609.1    LNIX01000001    OXA61848.1    AMQN01008687    KB303737    ELU02822.1    KK112265    KFM57218.1    KZ288310    PBC28614.1    KK852601    KDR20512.1    GGMS01016418    MBY85621.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000218220    UP000009046    + More
UP000000305    UP000076502    UP000076858    UP000002358    UP000002320    UP000008820    UP000076408    UP000069272    UP000030765    UP000075920    UP000075901    UP000075880    UP000069940    UP000249989    UP000215335    UP000075883    UP000000673    UP000075884    UP000075902    UP000076407    UP000075882    UP000007062    UP000075900    UP000075885    UP000007801    UP000075903    UP000192221    UP000008711    UP000075840    UP000001819    UP000008744    UP000009192    UP000001070    UP000008792    UP000276133    UP000001292    UP000002282    UP000268350    UP000000304    UP000000803    UP000095300    UP000092444    UP000078200    UP000037069    UP000092445    UP000092553    UP000007798    UP000001555    UP000092460    UP000092443    UP000095301    UP000092461    UP000007266    UP000053097    UP000279307    UP000095287    UP000198287    UP000014760    UP000005203    UP000054359    UP000242457    UP000027135   

PRIDE

B5UB85    Q9VSL9   

Pfam

PF02771   Acyl-CoA_dh_N        + More
PF00441   Acyl-CoA_dh_1
PF02770   Acyl-CoA_dh_M
PF00227   Proteasome

Interpro

IPR009100   AcylCoA_DH/oxidase_NM_dom        + More
IPR006091   Acyl-CoA_Oxase/DH_cen-dom       
IPR009075   AcylCo_DH/oxidase_C       
IPR006089   Acyl-CoA_DH_CS       
IPR013786   AcylCoA_DH/ox_N       
IPR036250   AcylCo_DH-like_C       
IPR037069   AcylCoA_DH/ox_N_sf       
IPR034183   IVD       
IPR001353   Proteasome_sua/b       
IPR023333   Proteasome_suB-type       
IPR029055   Ntn_hydrolases_N       
IPR016050   Proteasome_bsu_CS       
IPR000243   Pept_T1A_subB       

SUPFAM

SSF56645   SSF56645        + More
SSF47203   SSF47203       
SSF56235   SSF56235       

Gene 3D

1.10.540.10     3.60.20.10    

CDD

cd01156  IVD

ProteinModelPortal

B5UB85   D2SNL6   A0A2H1WEI4   A0A0N1ICI2   A0A212EZL0   A0A194QDM0   + More
A0A2A4J6L8   E0W349   A0A0P4W309   E9GS77   A0A154P1H5   A0A0N7ZIY7   K7IUR0   A0A1S4F3T4   B0X633   U5EUB2   Q17GD3   A0A182YJH3   A0A182FFH5   A0A1Q3F1W5   A0A084WMZ7   A0A0P6EKI7   A0A182WI57   A0A182T4W4   A0A1B6KKR0   A0A336K0R5   A0A182INW0   A0A1B6FE49   A0A182H9F3   A0A232F5Q6   A0A182MS73   A0A2M4BNU3   A0A2M4A812   A0A2M4BNY6   W5JBT8   A0A182N7I3   T1E9J3   A0A0P6B5X2   A0A182UKR0   A0A182X250   A0A182L429   Q7QIC5   A0A182R9B6   A0A182PEX0   B3M691   A0A182V0F8   A0A2M3ZHG1   A0A1W4UEZ7   B3NBR7   A0A182I6B1   A0A2M3ZH71   Q29CZ7   B4H9H6   B4KZ54   B4K041   B4LEK2   A0A3M7RYJ7   B4HJZ3   A0A0A1XKN1   B4PG06   A0A3B0J6Q1   B4QM45   Q9VSL9   A0A0K8WEC0   A0A1I8NSK4   A0A034VY15   A0A034VTX1   A0A310SC54   D3TLC7   A0A023ESZ9   A0A1A9UJD5   A0A0L0BYS5   A0A1A9Z2Q7   A0A0M4EK03   B4MXU5   B7P6T5   A0A1B0BA97   A0A1A9YN39   A0A1L8DYZ7   A0A0K8RJD6   T1PCM6   A0A1I8MJ66   A0A1B0CM01   W8BYD7   D6WJK5   D3PGR5   C1C1U2   A0A2P2HZ63   A0A026WU13   A0A3L8DG85   A0A1W7RAA9   A0A1I8AG09   A0A1L8DYV7   A0A226EXE4   R7UHR6   A0A088AHV5   A0A087SWH9   A0A2A3EAW3   A0A067R9Z1   A0A2S2R6I3  

PDB

1IVH     E-value=5.24624e-168,     Score=1517

KEGG

100190958    K00253 isovaleryl-CoA dehydrogenase [EC:1.3.8.4] | (RefSeq) Ivd; isovaleryl coenzyme A dehydrogenase

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0050660   GO:0003995   GO:0008470   GO:0005739   GO:0016491   GO:0006552   GO:0005759   GO:0005634   GO:0005839   GO:0051603   GO:0004298   GO:0016021   GO:0008152   GO:0016627   GO:0007155   GO:0005515   GO:0008237   GO:0015930   GO:0055114  

Subcellular location

Nucleus  

Length:

416

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.43588

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01754

outside

1  -  416

 

 

Pi

245.37758

Theta

197.104815

Tajima's D

0.844714

CLR

0.194583

CSRT

0.615569221538923

Interpretation

Uncertain