Gene

KWMTBOMO12929

Pre Gene Modal

BGIBMGA000468

Annotation

Uncharacterized_protein_OBRU01_08801_[Operophtera_brumata]

Location

Bomo_Chr22(-):4477609-4481039      View in EpiBrowser

Full name

Protein dispatched      

Location in the cell

PlasmaMembrane   Reliability : 4.852

CDS

ATGTTGGCCGCTTATTCCAGGTTTATTGTTCGTCATTCTTACCTCGTTCTTTTTACTGTAAGTATTTTGTCCATCGTACTTACTGTGATCCCGCTAATTCTACACGAGCTACCCTCATTTTCTGATCCCATAGTCGGATTTGAAACCCGGGGTACGACGTTAGCACATCGCTTCATTGCTTGGGAAAATCTGAATGACGAAACGAGGCCGTCCAAACGTCTTGCAGTGAACCCTAAAGAAATTGAAGATCAAATCAGAATGAACCGAACTTACTACAACAAGACTCACCAAGACAGATCTAGATCAGGACGCAGAAGGCCAAAAAAGAAGGATCGAAACAAGAAAAACAAAATGGTCCCGAATATCACAGGATTAGAAAAAACTTGGTCTGATTATAGTGAATTAAACATTTCTGATGGACATGTACATTGGGGTTTTGGAATAAATGTAACAAATGAAGATGAACATGCTGTACTACTCAAAGACCATTCCAGAAAACAGTGGTTGTCTTTGAAAAATATGCAGAGGATAGCTGACAAGCCCATCAATCTTAATTACGCTTCTGGAACGTGTGGTCCACCAATATCAGATTATGCTCACTTAGTTATTACCAACACAGATAATTCGAGTTTATTGTCATACAAGAATGTTGAGAGATTGTGTAAATTTCAGTCATATCTGGTTGAATTAGGTGGGTATGAATATTATGAATTATGTCAGAGGACAACACACTCTGAAGATATTTGCTGTCCTGTATGGAGTCTCCCAAATTATATTGCTTTAATATCTGGAAAGGATTCCTGTGTCAACTTAAACAAGGAAGATGTAAAAAAAGCTGTAACTATTTTGAAGAAATGTGCAGGATATTTTCATAATTTTACATTGATGGCTGCTTGTGATTTAGATCACTGTAATGTTCCGAAATACTGTACTCAGCACAACGCAGTCTATAATTTGTTATTTTATCTTATAGATTCAGAAGCATTTTCACCATTGAATAATGCACAAAAGTTTGTAAAGAATACAATGCTGTTTTTGCCACTTCCAAGAAGTGATACTGTATTGCCATATTATAAGAAACTGGAAAACTCAAATATGTCATATGACAATCTTGTTATACCAGCTATTGATTTTGGTTTGAAAAATGCTCTTTTTGATATTTGGATCATTGAGGATACTTGGTTGATAGCATTAGGTGGCATTTTTGTGTTTGCATGTGTGTGGATATATACAAGATCATTAATTCTCACGCTATTTCTGTTTGCCGCCATAACATTTTCTTTGGGTATAGCATACTTCTTCTATGTATATGTGTTTAATTTGCATTTTTTTCCCTTCATGAATTTGTTAGTAATAGTAATTGTATTAGGTATTGGTGCTGATGATGCATTTATTTATGTTAAGATATGGAAAATGATTGGAAAGCAACTTATCAAAGATAATGTGGTCTATCAAGAAAATGGTGTGCTAGATATCAATATTTCCAGTGCTGGTGAGACTATTTTAGTCCAAATTCTAGAAGAAACTATGAGACATTCTATAGTTACTATTTTTATCACAACCTTAACTACTGCAGTTGCATTTTATGCATCATATGTAAGTTATATTCCTGCCATAAACTGTTTCAGTGTATTTGCCGGAACAGCAGTTCTAGTCAACTTTGTTCTCATGATGACTTGGTTGCCTATATCAGTATTCATTGTAGATGTTAAATTGTATGCAAAGAAAAAAACTTTTTTAGATTTGGTCCACAAGAATGTGAATGAAATGTGGGAAAATATCAGAATTGTTTTAAACAGATTTACTATAATATGTGTTACAAAATTCCATATAGCATTTGTAGTGGTCATGGGCGCTTTAGGATTTATTAGTTTGGTGGTGGTGTTTTACTCTCCGGGCCTACACTTGCCAGATTCTAAACAATTTCAACTTTTCCAAACTTCTCATCCTTTTGAACAATATGAAATGCAGTATAGAGATAAATTTCTATTTGAAAGATTAAGCAAAGATCTGGGCACCGGCACTAAAATGCCTTTAAGGTGGGTATGGGGTGTAAAAGCTATTGACAATGGAAATCATATGGATCCTGCTTCAAAGGGACACCTTGTGTTTGATGAAAATTTTTCAATATCAGATCCCAAATCGCAATCTTGGTTGTTAGGGTTTTGTGCTCGAATTAAAGGTCAACCCTTTTATCAGCAGACCTTGGGTCCTTTACTCCCAAACTGCTTCATTGAAAGCTTTAAAATGTATATGAGTAGGCGATGTATTGATAATATTGATAAAATAAATAGATCACCTTGTTGTGAGACATCTAAATTTCCATACAAAAAAGAGGTCTTTGATTTCTGTATCATAAAGGCAATGGAATCATTGTATCAAACGCCTAGAGAACTCTTTATGCCTGGTGTAGCTGGCCCAAAATTTTTAAGAAGTGCCAAACCCCCAATTATTGCTGCTCTTGTTGTTGAATTTGAAAGTATTGTTCCATATTCACTGTCCTATTCTGAAATGAATAAGTTTTTCACTGAAGTCGAAAAATGGACACAAACAGAATTAGAAAACGCCCCAGCGGGAATGAAATGTGGCTGGTTTTTATCCGATTTTCAATTCTATGATCTACAAAGAACTCTAGCAAGTGGTACCATTGTAGCATTACTGTTATCTGCAGCTCTGGGCTTTATAGTTTTGATACCAGCTACATTAAATTTTGTAACGAGTGTATGCGCTTTGACTGCAATGATATTTTCATCAACTGTTACAATAGCTGTTCTAGTAATAAATAATTGGAAGTTAAATATTTTAGAAAGTGTAGCGATATCAACATCGGCTGGGCTAGCTGTGGATTTCAGTCTTCACTATGCCCTAAGCTACACAAACGCATCAGGAAACAAAAGTGCTCGTGTTAAATATGCTCTATCAGCATCATCGAGTCCAACTGCTGCGGCTGCACTAACTTCTGGATTCGCTGGTGTGTTTTTATTGAGATCTAATCTTCTACCGTATTCACAAATAGGTGCGTTTCTAGTTTTAATCATGACGGTTAGTTGGACCTATGCAACTTTCTTCCTTTGTTCGTTACTTCACATTGTCGGTAGGAGTTCGATAAAAGAATCTCCATCTCGGGAACGAAAACCAGTGTCTCGGGTTAATTCTGTTTCTTCAGGTGTACCTAATTTAGAAAGTCATGAGTTGGAGCACTTGGCTGATAGTAATCGTACAAATGTCACTCATTCTCAAAGTCCGTCTAGTGTTAGCGCGACAACGGTAGTTTTACACGATGACTACAAAACTCCTCATTGCAAAAATGGAAAAAATAGCATTAAAAATAATATTATAGTTGATGAAAATGACTGA

Protein

MLAAYSRFIVRHSYLVLFTVSILSIVLTVIPLILHELPSFSDPIVGFETRGTTLAHRFIAWENLNDETRPSKRLAVNPKEIEDQIRMNRTYYNKTHQDRSRSGRRRPKKKDRNKKNKMVPNITGLEKTWSDYSELNISDGHVHWGFGINVTNEDEHAVLLKDHSRKQWLSLKNMQRIADKPINLNYASGTCGPPISDYAHLVITNTDNSSLLSYKNVERLCKFQSYLVELGGYEYYELCQRTTHSEDICCPVWSLPNYIALISGKDSCVNLNKEDVKKAVTILKKCAGYFHNFTLMAACDLDHCNVPKYCTQHNAVYNLLFYLIDSEAFSPLNNAQKFVKNTMLFLPLPRSDTVLPYYKKLENSNMSYDNLVIPAIDFGLKNALFDIWIIEDTWLIALGGIFVFACVWIYTRSLILTLFLFAAITFSLGIAYFFYVYVFNLHFFPFMNLLVIVIVLGIGADDAFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFIVDVKLYAKKKTFLDLVHKNVNEMWENIRIVLNRFTIICVTKFHIAFVVVMGALGFISLVVVFYSPGLHLPDSKQFQLFQTSHPFEQYEMQYRDKFLFERLSKDLGTGTKMPLRWVWGVKAIDNGNHMDPASKGHLVFDENFSISDPKSQSWLLGFCARIKGQPFYQQTLGPLLPNCFIESFKMYMSRRCIDNIDKINRSPCCETSKFPYKKEVFDFCIIKAMESLYQTPRELFMPGVAGPKFLRSAKPPIIAALVVEFESIVPYSLSYSEMNKFFTEVEKWTQTELENAPAGMKCGWFLSDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVINNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKYALSASSSPTAAAALTSGFAGVFLLRSNLLPYSQIGAFLVLIMTVSWTYATFFLCSLLHIVGRSSIKESPSRERKPVSRVNSVSSGVPNLESHELEHLADSNRTNVTHSQSPSSVSATTVVLHDDYKTPHCKNGKNSIKNNIIVDEND

Description

Segment polarity protein which functions in hedgehog (Hh) signaling. Regulates the trafficking and the release of cholesterol-modified hedgehog protein from cells of the posterior compartment (P cells) and is hence required for the effective production of the Hh signal.

Similarity

Belongs to the dispatched family.

Keywords

Complete proteome   Developmental protein   Glycoprotein   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Protein dispatched

Uniprot

H9IT88   A0A3S2NNX2   A0A2A4J522   A0A0L7LGL6   A0A194Q9B1   A0A0N1ICI9   + More
A0A212EUJ8   A0A1Y1KAW2   A0A1Q3F822   Q16T20   A0A1S4FQ59   A0A1B6DLC4   B0WNC6   Q7QB81   E0VWS4   A0A067RAK6   A0A182G052   A0A182XUR8   A0A182NZ92   W5JMQ6   A0A336LQ07   A0A182JS53   A0A182IIG0   A0A336L3V2   A0A2M4AHA6   A0A182UYA9   A0A2M4AI62   A0A182MN79   A0A2M4BAR5   A0A182S4M9   A0A182PPZ7   A0A2M4BAQ5   A0A0K8TSG4   A0A1A9WPG7   A0A2P8ZMK8   A0A2M4AGN3   W8BU90   A0A182TNP5   A0A084VLB3   T1JPJ7   A0A182J2Y3   A0A182Q1X4   E2A1H2   A0A0A1WTC9   A0A1B0CVA3   A0A182YGK9   A0A151J7P7   B4PVJ5   B4I490   A0A0L0BXZ0   A0A1J1HMW4   A0A232FB32   K7IPY3   A0A0C9RKI5   B3NYI4   A0A195FU29   A0A023EYY9   Q9VNJ5   T1H8Y9   Q297W6   A0A1I8M5S7   A0A1I8NTV2   E9JAW1   A0A1A9VIY1   A0A1W4WYQ5   A0A154P851   A0A158N998   A0A1B0GEU1   A0A151I7J0   A0A195BTZ6   B4K8D4   A0A0M4EKQ3   A0A1A9ZL51   A0A1A9X666   A0A0A9XAS5   A0A0A9X7D2   B4LWP6   A0A2J7R5A6   A0A1W4WZR7   A0A2A3ESI9   A0A2S2PUY5   A0A3Q0IVG4   A0A0N8C5J3   A0A0N8C7I0   A0A0P5QPY7   A0A0P5QX41   A0A0P5QV00   A0A0P5R0J9   A0A164KRJ9   A0A0P5R8L4   A0A0P5NWA0   A0A0N8CEG6   A0A0P5XNW1   A0A0P5W3U1   A0A0P6HYD7   A0A0N8CE35   A0A0P5Z7K7   A0A0P5VQ34  

Pubmed

19121390    26227816    26354079    22118469    28004739    17510324    + More
12364791    14747013    17210077    20566863    24845553    20920257    23761445    26369729    29403074    24495485    24438588    20798317    25830018    25244985    17994087    17550304    26108605    28648823    20075255    25474469    10619433    10731132    12537572    12537569    12372301    12586063    17893096    15632085    25315136    21282665    21347285    25401762    26823975   

EMBL

BABH01013510    RSAL01000021    RVE52508.1    NWSH01003030    PCG67081.1    JTDY01001172    + More
KOB74663.1    KQ459324    KPJ01570.1    KQ460968    KPJ10227.1    AGBW02012392    OWR45131.1    GEZM01087614    JAV58579.1    GFDL01011330    JAV23715.1    CH477661    EAT37611.1    GEDC01014885    GEDC01010860    JAS22413.1    JAS26438.1    DS232010    EDS31580.1    AAAB01008880    EAA08570.5    DS235824    EEB17830.1    KK852818    KDR15655.1    ADMH02001121    ETN64049.1    UFQT01000109    SSX20156.1    APCN01002556    UFQS01001440    UFQT01001440    SSX10911.1    SSX30589.1    GGFK01006855    MBW40176.1    GGFK01007158    MBW40479.1    AXCM01000328    GGFJ01000961    MBW50102.1    GGFJ01000978    MBW50119.1    GDAI01000728    JAI16875.1    PYGN01000016    PSN57735.1    GGFK01006624    MBW39945.1    GAMC01006072    JAC00484.1    ATLV01014440    KE524972    KFB38757.1    JH432001    AXCN02001158    GL435766    EFN72645.1    GBXI01012532    JAD01760.1    AJWK01030343    AJWK01030344    AJWK01030345    AJWK01030346    AJWK01030347    KQ979640    KYN20036.1    CM000160    EDW97804.1    CH480821    EDW55033.1    JRES01001168    KNC24880.1    CVRI01000010    CRK88732.1    NNAY01000564    OXU27643.1    GBYB01007416    JAG77183.1    CH954181    EDV47965.1    KQ981268    KYN43931.1    GBBI01004295    JAC14417.1    AF200691    AE014297    AY075394    BT016019    BT050429    ACPB03008564    CM000070    EAL28089.1    GL770679    EFZ10014.1    KQ434827    KZC07514.1    ADTU01009049    ADTU01009050    ADTU01009051    CCAG010012587    KQ978451    KYM93927.1    KQ976405    KYM91877.1    CH933806    EDW16516.1    CP012526    ALC47821.1    GBHO01027686    GDHC01007243    JAG15918.1    JAQ11386.1    GBHO01027685    JAG15919.1    CH940650    EDW67711.1    NEVH01007392    PNF36015.1    KZ288189    PBC34667.1    GGMS01000048    MBY69251.1    GDIQ01112715    JAL39011.1    GDIQ01212632    GDIQ01107219    JAL44507.1    GDIQ01216228    GDIQ01114017    JAL37709.1    GDIQ01111119    JAL40607.1    GDIQ01109313    JAL42413.1    GDIQ01107218    JAL44508.1    LRGB01003257    KZS03479.1    GDIQ01111118    JAL40608.1    GDIQ01136814    JAL14912.1    GDIP01139719    JAL63995.1    GDIP01069378    JAM34337.1    GDIP01105371    JAL98343.1    GDIQ01020218    JAN74519.1    GDIP01140767    JAL62947.1    GDIP01060434    JAM43281.1    GDIP01097074    JAM06641.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000037510    UP000053268    UP000053240    + More
UP000007151    UP000008820    UP000002320    UP000007062    UP000009046    UP000027135    UP000069272    UP000076407    UP000075884    UP000000673    UP000075881    UP000075840    UP000075903    UP000075883    UP000075900    UP000075885    UP000091820    UP000245037    UP000075902    UP000030765    UP000075880    UP000075886    UP000000311    UP000092461    UP000076408    UP000078492    UP000002282    UP000001292    UP000037069    UP000183832    UP000215335    UP000002358    UP000008711    UP000078541    UP000000803    UP000015103    UP000001819    UP000095301    UP000095300    UP000078200    UP000192223    UP000076502    UP000005205    UP000092444    UP000078542    UP000078540    UP000009192    UP000092553    UP000092445    UP000092443    UP000008792    UP000235965    UP000242457    UP000079169    UP000076858   

PRIDE

H9IT88    Q9VNJ5   

Pfam

PF02460   Patched        + More
PF12349   Sterol-sensing
PF03176   MMPL
PF14779   BBS1
PF12796   Ank_2
PF13606   Ank_3
PF00023   Ank

Interpro

IPR000731   SSD        + More
IPR003392   Ptc/Disp       
IPR030223   Dispatched       
IPR004869   MMPL_dom       
IPR001036   Acrflvin-R       
IPR032728   BBS1_N       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR002110   Ankyrin_rpt       

SUPFAM

SSF50998   SSF50998        + More
SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9IT88   A0A3S2NNX2   A0A2A4J522   A0A0L7LGL6   A0A194Q9B1   A0A0N1ICI9   + More
A0A212EUJ8   A0A1Y1KAW2   A0A1Q3F822   Q16T20   A0A1S4FQ59   A0A1B6DLC4   B0WNC6   Q7QB81   E0VWS4   A0A067RAK6   A0A182G052   A0A182XUR8   A0A182NZ92   W5JMQ6   A0A336LQ07   A0A182JS53   A0A182IIG0   A0A336L3V2   A0A2M4AHA6   A0A182UYA9   A0A2M4AI62   A0A182MN79   A0A2M4BAR5   A0A182S4M9   A0A182PPZ7   A0A2M4BAQ5   A0A0K8TSG4   A0A1A9WPG7   A0A2P8ZMK8   A0A2M4AGN3   W8BU90   A0A182TNP5   A0A084VLB3   T1JPJ7   A0A182J2Y3   A0A182Q1X4   E2A1H2   A0A0A1WTC9   A0A1B0CVA3   A0A182YGK9   A0A151J7P7   B4PVJ5   B4I490   A0A0L0BXZ0   A0A1J1HMW4   A0A232FB32   K7IPY3   A0A0C9RKI5   B3NYI4   A0A195FU29   A0A023EYY9   Q9VNJ5   T1H8Y9   Q297W6   A0A1I8M5S7   A0A1I8NTV2   E9JAW1   A0A1A9VIY1   A0A1W4WYQ5   A0A154P851   A0A158N998   A0A1B0GEU1   A0A151I7J0   A0A195BTZ6   B4K8D4   A0A0M4EKQ3   A0A1A9ZL51   A0A1A9X666   A0A0A9XAS5   A0A0A9X7D2   B4LWP6   A0A2J7R5A6   A0A1W4WZR7   A0A2A3ESI9   A0A2S2PUY5   A0A3Q0IVG4   A0A0N8C5J3   A0A0N8C7I0   A0A0P5QPY7   A0A0P5QX41   A0A0P5QV00   A0A0P5R0J9   A0A164KRJ9   A0A0P5R8L4   A0A0P5NWA0   A0A0N8CEG6   A0A0P5XNW1   A0A0P5W3U1   A0A0P6HYD7   A0A0N8CE35   A0A0P5Z7K7   A0A0P5VQ34  

PDB

5U74     E-value=1.78489e-06,     Score=128

KEGG

101746020    no KO assigned | (RefSeq) protein dispatched

GO

GO:0016021   GO:0007224   GO:0022857   GO:0007280   GO:0045880   GO:0035222   GO:0007367   GO:0005886   GO:0016020   GO:0006887   GO:0008270   GO:0004046   GO:0005737   GO:0006520   GO:0006508   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR45951:SF3  

Subcellular location

Membrane  

Length:

1118

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

268.31014

Exp number, first 60 AAs:

22.63828

Total prob of N-in:

0.99976

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  35

outside

36  -  387

TMhelix

388  -  410

inside

411  -  416

TMhelix

417  -  439

outside

440  -  443

TMhelix

444  -  466

inside

467  -  513

TMhelix

514  -  536

outside

537  -  545

TMhelix

546  -  568

inside

569  -  608

TMhelix

609  -  631

outside

632  -  875

TMhelix

876  -  898

inside

899  -  904

TMhelix

905  -  927

outside

928  -  936

TMhelix

937  -  959

inside

960  -  971

TMhelix

972  -  994

outside

995  -  1008

TMhelix

1009  -  1031

inside

1032  -  1118

 

 

Pi

197.287613

Theta

169.717684

Tajima's D

0.328501

CLR

0.000922

CSRT

0.457727113644318

Interpretation

Uncertain