Gene
KWMTBOMO12922
Annotation
PREDICTED:_calcium_uniporter_protein?_mitochondrial_[Papilio_polytes]
Full name
Calcium uniporter protein, mitochondrial
Location in the cell
Mitochondrial Reliability : 1.941 Nuclear Reliability : 1.514
Sequence
CDS
ATGAAGTTACGAGTGCGAGAGGTGACGGTGACATACCGCCGGGGGTTACCCGTGATCACGGTACCGCTGCCCTCAAGACGCGAGCGATGCCGCTTTACACTACGTCCAGTCTCTCAGACCGTCGGCGACCTCCTCGAGCAGGTGAAAGCAGAAGACCGTGGGGTGGAGCGTGCTGCTGCACTGGCCGCAGACGAGCGGGTCCGGATCTCTTCGAGTGACACCATCGAGTCATTACTGGAAACCGATTTCCGACTCATCATTAACGACACGGAGTACTACGTTAAGAGCCCGTCACAAGAGCGTCTAAGCATGGAAGAGGTTACTCAGTTGAGTGACGTCAGGAATTTGGTGAATCAACTGTACGAGGCTCTGAACGTGAGGGAGCACCAGATAAGGAAGGAGAGGGAACTGAGGGCGCAGCTGGAGAAAATTAACACCGAGTTACAACCTCTCGAAGACAAACGTAGGAGCCTCGAAGTTGAGACTTCGCGTCGTACTTCCGCTCTAACGTGGTTCGGTCTTGGCCTGATGGGAGTTCAGTTCGGCGTTCTGGCCCGTTTGACATGGTGGGAGTACTCCTGGGACATCATGGAGCCCGTCACTTACTTCGTAACATACGGAACGGCTATGGCGGCGTATGCTTACTTCGTTCTAACTAAACAGGAGTACATTTTGCCCGATGTCAAAGATCGACAGCATCTGTTGATGCTACACAAGAAGGCAAAGAAGATCGGGCTCGATATTAACCAATACAATAATCTTAAAGATCAGATAGCAAAATTAGAAAAAGACCTCGCTCGTCTCCGCGACCCGCTCCAAATCCACCTACCCTCGATGTACGTCGAGAAGACAACCGACGACAGAAGGTCACCGCTCACCAAAATCAAGGACATGCTCGAAGAGACCAGCAAGAAAATGAAAATCACGTAA
Protein
MKLRVREVTVTYRRGLPVITVPLPSRRERCRFTLRPVSQTVGDLLEQVKAEDRGVERAAALAADERVRISSSDTIESLLETDFRLIINDTEYYVKSPSQERLSMEEVTQLSDVRNLVNQLYEALNVREHQIRKERELRAQLEKINTELQPLEDKRRSLEVETSRRTSALTWFGLGLMGVQFGVLARLTWWEYSWDIMEPVTYFVTYGTAMAAYAYFVLTKQEYILPDVKDRQHLLMLHKKAKKIGLDINQYNNLKDQIAKLEKDLARLRDPLQIHLPSMYVEKTTDDRRSPLTKIKDMLEETSKKMKIT
Summary
Description
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by micu1 and micu2. At low Ca(2+) levels mcu activity is down-regulated by micu1 and micu2; at higher Ca(2+) levels micu1 increases mcu activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.
Subunit
Component of the uniplex complex (By similarity). Homooligomer; forms a pentamer (By similarity).
Similarity
Belongs to the MCU (TC 1.A.77) family.
Keywords
Calcium
Calcium channel
Calcium transport
Coiled coil
Complete proteome
Ion channel
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix
Transport
Feature
chain Calcium uniporter protein, mitochondrial
Uniprot
A0A194QDP5
A0A2J7PPL6
A0A2P8YUM7
A0A067QNA3
A0A1B6MIF9
T1IW70
+ More
A0A084WKA8 A0A182QG26 A0A2M4BQC8 A0A182YLE2 A0A182LLB4 A0A182FC59 A0A2M4BQL9 A0A2M4BQC1 A0A2M4ARS2 A0A2M4ART4 A0A2M3ZAM9 A0A2M3ZAP9 A0A2M3ZIP6 A0A2M3ZAS1 Q7Q5P0 A0A2M4BNF5 A0A182VGA1 A0A2M4CJ22 A0A2M4CJ40 A0A1J1I6H3 A0A182JBW0 A0A2S2PEC4 A0A1L8E073 Q16IS4 J9K3F8 A0A1L8DZT8 A0A2H8TP84 A0A0P5CEW2 A0A0P5U3C6 A0A0P6JIP9 A0A0P5EAN9 A0A0P6IL74 A0A0P5CHB5 A0A0P6BAX3 A0A0P5UAT5 A0A1B6M8Y7 A0A0P5HWD2 A0A1S3D4I7 A0A1B6C807 E9GCX4 A0A2P6L790 A0A2L2YNX1 A0A1Y1KF21 A0A3L8S7D3 H3ATQ5 A0A1Y1KK12 A0A093GVH1 A0A218UCX5 U3KE57 A0A1B6G862 H0Z1W4 A0A091N4R7 A0A3B4D9S8 A0A091V326 A0A093Q3M6 A0A3Q2TYK9 U3INF1 A0A087QU32 A0A2P4SRZ8 G1N1N2 A0A091KRA7 A0A2R5LCB4 E1BWX3 A0A093BD16 A0A226P5B1 A0A091I8Z5 A0A1D5P9H3 A0A1B6FHA8 A0A226N8M5 W5UR31 A0A1V4KK76 A0A3Q3L3D6 A0A091NQA6 R7U192 K1QGP7 W5MPZ3 A0A094MCX0 A0A1U7S0D2 A0A2D0QMI8 A0A151P022 A0A3Q3IRV5 A0A0A9XL87 A0A3Q3IG40 A0A3Q3IG33 K0A5D6 Q08BI9 A0A093FHS9 A0A0A0AK11 A0A3S1AUN8 A0A0A9XHU6 A0A146LJT1 A0A2D4NHT0
A0A084WKA8 A0A182QG26 A0A2M4BQC8 A0A182YLE2 A0A182LLB4 A0A182FC59 A0A2M4BQL9 A0A2M4BQC1 A0A2M4ARS2 A0A2M4ART4 A0A2M3ZAM9 A0A2M3ZAP9 A0A2M3ZIP6 A0A2M3ZAS1 Q7Q5P0 A0A2M4BNF5 A0A182VGA1 A0A2M4CJ22 A0A2M4CJ40 A0A1J1I6H3 A0A182JBW0 A0A2S2PEC4 A0A1L8E073 Q16IS4 J9K3F8 A0A1L8DZT8 A0A2H8TP84 A0A0P5CEW2 A0A0P5U3C6 A0A0P6JIP9 A0A0P5EAN9 A0A0P6IL74 A0A0P5CHB5 A0A0P6BAX3 A0A0P5UAT5 A0A1B6M8Y7 A0A0P5HWD2 A0A1S3D4I7 A0A1B6C807 E9GCX4 A0A2P6L790 A0A2L2YNX1 A0A1Y1KF21 A0A3L8S7D3 H3ATQ5 A0A1Y1KK12 A0A093GVH1 A0A218UCX5 U3KE57 A0A1B6G862 H0Z1W4 A0A091N4R7 A0A3B4D9S8 A0A091V326 A0A093Q3M6 A0A3Q2TYK9 U3INF1 A0A087QU32 A0A2P4SRZ8 G1N1N2 A0A091KRA7 A0A2R5LCB4 E1BWX3 A0A093BD16 A0A226P5B1 A0A091I8Z5 A0A1D5P9H3 A0A1B6FHA8 A0A226N8M5 W5UR31 A0A1V4KK76 A0A3Q3L3D6 A0A091NQA6 R7U192 K1QGP7 W5MPZ3 A0A094MCX0 A0A1U7S0D2 A0A2D0QMI8 A0A151P022 A0A3Q3IRV5 A0A0A9XL87 A0A3Q3IG40 A0A3Q3IG33 K0A5D6 Q08BI9 A0A093FHS9 A0A0A0AK11 A0A3S1AUN8 A0A0A9XHU6 A0A146LJT1 A0A2D4NHT0
Pubmed
EMBL
KQ459324
KPJ01576.1
NEVH01022660
PNF18249.1
PYGN01000352
PSN47937.1
+ More
KK853210 KDR09811.1 GEBQ01004328 JAT35649.1 JH431609 ATLV01024104 KE525349 KFB50652.1 AXCN02000409 GGFJ01006081 MBW55222.1 GGFJ01006080 MBW55221.1 GGFJ01006063 MBW55204.1 GGFK01010148 MBW43469.1 GGFK01010149 MBW43470.1 GGFM01004845 MBW25596.1 GGFM01004866 MBW25617.1 GGFM01007696 MBW28447.1 GGFM01004840 MBW25591.1 AAAB01008960 EAA10820.3 GGFJ01005475 MBW54616.1 GGFL01001168 MBW65346.1 GGFL01001169 MBW65347.1 CVRI01000043 CRK95893.1 GGMR01014647 MBY27266.1 GFDF01002142 JAV11942.1 CH478055 EAT34170.1 ABLF02024654 GFDF01002143 JAV11941.1 GFXV01003647 MBW15452.1 GDIP01176403 JAJ46999.1 GDIP01122652 JAL81062.1 GDIQ01006737 JAN88000.1 GDIP01144248 JAJ79154.1 GDIQ01004731 JAN90006.1 GDIP01186245 JAJ37157.1 GDIP01019142 JAM84573.1 GDIP01115660 JAL88054.1 GEBQ01007599 JAT32378.1 GDIQ01227910 JAK23815.1 GEDC01027734 GEDC01023395 GEDC01009597 GEDC01006733 GEDC01004715 GEDC01003432 JAS09564.1 JAS13903.1 JAS27701.1 JAS30565.1 JAS32583.1 JAS33866.1 GL732539 EFX82630.1 MWRG01001277 PRD34429.1 IAAA01043361 LAA09806.1 GEZM01086654 JAV59128.1 QUSF01000053 RLV97655.1 AFYH01171896 AFYH01171897 AFYH01171898 GEZM01086655 JAV59127.1 KK377165 KFV46538.1 MUZQ01000423 OWK51559.1 AGTO01001003 GECZ01011134 JAS58635.1 ABQF01054631 KK841511 KFP83904.1 KL410604 KFQ97736.1 KL671824 KFW83588.1 AADN05000336 ADON01129199 ADON01129200 KL225904 KFM04736.1 PPHD01026371 POI26891.1 KK751291 KFP41850.1 GGLE01003027 MBY07153.1 KN126311 KFU88683.1 AWGT02000171 OXB74677.1 KL218277 KFP03908.1 GECZ01020255 JAS49514.1 MCFN01000142 OXB63842.1 JT416422 AHH42048.1 LSYS01003057 OPJ84791.1 KL389426 KFP91119.1 AMQN01009904 KB306540 ELT99754.1 JH816371 EKC20781.1 AHAT01004009 AHAT01004010 AHAT01004011 KL335692 KFZ49704.1 AKHW03001467 KYO42408.1 GBHO01024046 GBRD01014841 JAG19558.1 JAG50985.1 JX424822 AFS66692.1 BC124705 KK631873 KFV56165.1 KL871860 KGL93823.1 RQTK01002033 RUS68760.1 GBHO01024045 JAG19559.1 GDHC01010371 JAQ08258.1 IACM01180475 LAB45205.1
KK853210 KDR09811.1 GEBQ01004328 JAT35649.1 JH431609 ATLV01024104 KE525349 KFB50652.1 AXCN02000409 GGFJ01006081 MBW55222.1 GGFJ01006080 MBW55221.1 GGFJ01006063 MBW55204.1 GGFK01010148 MBW43469.1 GGFK01010149 MBW43470.1 GGFM01004845 MBW25596.1 GGFM01004866 MBW25617.1 GGFM01007696 MBW28447.1 GGFM01004840 MBW25591.1 AAAB01008960 EAA10820.3 GGFJ01005475 MBW54616.1 GGFL01001168 MBW65346.1 GGFL01001169 MBW65347.1 CVRI01000043 CRK95893.1 GGMR01014647 MBY27266.1 GFDF01002142 JAV11942.1 CH478055 EAT34170.1 ABLF02024654 GFDF01002143 JAV11941.1 GFXV01003647 MBW15452.1 GDIP01176403 JAJ46999.1 GDIP01122652 JAL81062.1 GDIQ01006737 JAN88000.1 GDIP01144248 JAJ79154.1 GDIQ01004731 JAN90006.1 GDIP01186245 JAJ37157.1 GDIP01019142 JAM84573.1 GDIP01115660 JAL88054.1 GEBQ01007599 JAT32378.1 GDIQ01227910 JAK23815.1 GEDC01027734 GEDC01023395 GEDC01009597 GEDC01006733 GEDC01004715 GEDC01003432 JAS09564.1 JAS13903.1 JAS27701.1 JAS30565.1 JAS32583.1 JAS33866.1 GL732539 EFX82630.1 MWRG01001277 PRD34429.1 IAAA01043361 LAA09806.1 GEZM01086654 JAV59128.1 QUSF01000053 RLV97655.1 AFYH01171896 AFYH01171897 AFYH01171898 GEZM01086655 JAV59127.1 KK377165 KFV46538.1 MUZQ01000423 OWK51559.1 AGTO01001003 GECZ01011134 JAS58635.1 ABQF01054631 KK841511 KFP83904.1 KL410604 KFQ97736.1 KL671824 KFW83588.1 AADN05000336 ADON01129199 ADON01129200 KL225904 KFM04736.1 PPHD01026371 POI26891.1 KK751291 KFP41850.1 GGLE01003027 MBY07153.1 KN126311 KFU88683.1 AWGT02000171 OXB74677.1 KL218277 KFP03908.1 GECZ01020255 JAS49514.1 MCFN01000142 OXB63842.1 JT416422 AHH42048.1 LSYS01003057 OPJ84791.1 KL389426 KFP91119.1 AMQN01009904 KB306540 ELT99754.1 JH816371 EKC20781.1 AHAT01004009 AHAT01004010 AHAT01004011 KL335692 KFZ49704.1 AKHW03001467 KYO42408.1 GBHO01024046 GBRD01014841 JAG19558.1 JAG50985.1 JX424822 AFS66692.1 BC124705 KK631873 KFV56165.1 KL871860 KGL93823.1 RQTK01002033 RUS68760.1 GBHO01024045 JAG19559.1 GDHC01010371 JAQ08258.1 IACM01180475 LAB45205.1
Proteomes
UP000053268
UP000235965
UP000245037
UP000027135
UP000030765
UP000075886
+ More
UP000076408 UP000075882 UP000069272 UP000007062 UP000075903 UP000183832 UP000075880 UP000008820 UP000007819 UP000079169 UP000000305 UP000276834 UP000008672 UP000197619 UP000016665 UP000007754 UP000261440 UP000053283 UP000053258 UP000000539 UP000016666 UP000053286 UP000001645 UP000198419 UP000054308 UP000198323 UP000190648 UP000261660 UP000014760 UP000005408 UP000018468 UP000189705 UP000221080 UP000050525 UP000261600 UP000000437 UP000053858 UP000271974
UP000076408 UP000075882 UP000069272 UP000007062 UP000075903 UP000183832 UP000075880 UP000008820 UP000007819 UP000079169 UP000000305 UP000276834 UP000008672 UP000197619 UP000016665 UP000007754 UP000261440 UP000053283 UP000053258 UP000000539 UP000016666 UP000053286 UP000001645 UP000198419 UP000054308 UP000198323 UP000190648 UP000261660 UP000014760 UP000005408 UP000018468 UP000189705 UP000221080 UP000050525 UP000261600 UP000000437 UP000053858 UP000271974
PRIDE
Pfam
PF04678 MCU
ProteinModelPortal
A0A194QDP5
A0A2J7PPL6
A0A2P8YUM7
A0A067QNA3
A0A1B6MIF9
T1IW70
+ More
A0A084WKA8 A0A182QG26 A0A2M4BQC8 A0A182YLE2 A0A182LLB4 A0A182FC59 A0A2M4BQL9 A0A2M4BQC1 A0A2M4ARS2 A0A2M4ART4 A0A2M3ZAM9 A0A2M3ZAP9 A0A2M3ZIP6 A0A2M3ZAS1 Q7Q5P0 A0A2M4BNF5 A0A182VGA1 A0A2M4CJ22 A0A2M4CJ40 A0A1J1I6H3 A0A182JBW0 A0A2S2PEC4 A0A1L8E073 Q16IS4 J9K3F8 A0A1L8DZT8 A0A2H8TP84 A0A0P5CEW2 A0A0P5U3C6 A0A0P6JIP9 A0A0P5EAN9 A0A0P6IL74 A0A0P5CHB5 A0A0P6BAX3 A0A0P5UAT5 A0A1B6M8Y7 A0A0P5HWD2 A0A1S3D4I7 A0A1B6C807 E9GCX4 A0A2P6L790 A0A2L2YNX1 A0A1Y1KF21 A0A3L8S7D3 H3ATQ5 A0A1Y1KK12 A0A093GVH1 A0A218UCX5 U3KE57 A0A1B6G862 H0Z1W4 A0A091N4R7 A0A3B4D9S8 A0A091V326 A0A093Q3M6 A0A3Q2TYK9 U3INF1 A0A087QU32 A0A2P4SRZ8 G1N1N2 A0A091KRA7 A0A2R5LCB4 E1BWX3 A0A093BD16 A0A226P5B1 A0A091I8Z5 A0A1D5P9H3 A0A1B6FHA8 A0A226N8M5 W5UR31 A0A1V4KK76 A0A3Q3L3D6 A0A091NQA6 R7U192 K1QGP7 W5MPZ3 A0A094MCX0 A0A1U7S0D2 A0A2D0QMI8 A0A151P022 A0A3Q3IRV5 A0A0A9XL87 A0A3Q3IG40 A0A3Q3IG33 K0A5D6 Q08BI9 A0A093FHS9 A0A0A0AK11 A0A3S1AUN8 A0A0A9XHU6 A0A146LJT1 A0A2D4NHT0
A0A084WKA8 A0A182QG26 A0A2M4BQC8 A0A182YLE2 A0A182LLB4 A0A182FC59 A0A2M4BQL9 A0A2M4BQC1 A0A2M4ARS2 A0A2M4ART4 A0A2M3ZAM9 A0A2M3ZAP9 A0A2M3ZIP6 A0A2M3ZAS1 Q7Q5P0 A0A2M4BNF5 A0A182VGA1 A0A2M4CJ22 A0A2M4CJ40 A0A1J1I6H3 A0A182JBW0 A0A2S2PEC4 A0A1L8E073 Q16IS4 J9K3F8 A0A1L8DZT8 A0A2H8TP84 A0A0P5CEW2 A0A0P5U3C6 A0A0P6JIP9 A0A0P5EAN9 A0A0P6IL74 A0A0P5CHB5 A0A0P6BAX3 A0A0P5UAT5 A0A1B6M8Y7 A0A0P5HWD2 A0A1S3D4I7 A0A1B6C807 E9GCX4 A0A2P6L790 A0A2L2YNX1 A0A1Y1KF21 A0A3L8S7D3 H3ATQ5 A0A1Y1KK12 A0A093GVH1 A0A218UCX5 U3KE57 A0A1B6G862 H0Z1W4 A0A091N4R7 A0A3B4D9S8 A0A091V326 A0A093Q3M6 A0A3Q2TYK9 U3INF1 A0A087QU32 A0A2P4SRZ8 G1N1N2 A0A091KRA7 A0A2R5LCB4 E1BWX3 A0A093BD16 A0A226P5B1 A0A091I8Z5 A0A1D5P9H3 A0A1B6FHA8 A0A226N8M5 W5UR31 A0A1V4KK76 A0A3Q3L3D6 A0A091NQA6 R7U192 K1QGP7 W5MPZ3 A0A094MCX0 A0A1U7S0D2 A0A2D0QMI8 A0A151P022 A0A3Q3IRV5 A0A0A9XL87 A0A3Q3IG40 A0A3Q3IG33 K0A5D6 Q08BI9 A0A093FHS9 A0A0A0AK11 A0A3S1AUN8 A0A0A9XHU6 A0A146LJT1 A0A2D4NHT0
PDB
6O5B
E-value=1.28695e-81,
Score=771
Ontologies
GO
PANTHER
Topology
Subcellular location
Mitochondrion inner membrane
Length:
309
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
41.80774
Exp number, first 60 AAs:
0.00179
Total prob of N-in:
0.99588
inside
1 - 167
TMhelix
168 - 190
outside
191 - 199
TMhelix
200 - 219
inside
220 - 309
Population Genetic Test Statistics
Pi
224.861753
Theta
167.184128
Tajima's D
1.002505
CLR
0.053272
CSRT
0.666116694165292
Interpretation
Uncertain
