Gene

KWMTBOMO12914

Pre Gene Modal

BGIBMGA000222

Annotation

PREDICTED:_cystinosin_homolog_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr22(+):4064752-4136552      View in EpiBrowser

Full name

Cystinosin homolog      

Location in the cell

PlasmaMembrane   Reliability : 4.767

CDS

ATGGCGGAATGCAGTGCAGTATTGAGGCCGCGAGCAGCCGCGTGCTCTATTTCTAGTCATAGAATACGCTTCTGTTTAGTTGTTATGTTAATTTTAGGTATACCGAGTGCACATTCCCAGTTAGACAAGATGTACGTCGAAGTAACTGATCTGAATCTTTTAGTCGAAGAAACTCGACTACTCAAACTGGTCCAAATAGGCCAATATAACACATCCCTAGAAGTGATATCAAATATTCAACATCCAGATATAGTTCAACTAGTGCCACCGTCAATAGAAATACCAGGTTCGAACGAACCTAATAAAACGGTGGTGATATCGTACGATATATGCGCGTACGGAAAGAGTCCGGGACATTCGGAAGTGACGTTCAATGTTACACCGCCAGGTTTTGTCAACTTAGACACAGTGTACCTACGTATAACCGTCATGCACTCCAACGAAATAAACATAATATCGTACATAATGGGTTGGATATACTTCGCGGCCTGGTCAGTTTCGTTCTACCCTCAAATATACATAAACTTCAAGAGGAAAAGCGTGGTCGGTCTCAACTTCGACTTCCTGGCGCTAAACATTATGGGCTTCACCATGTACTCGCTTTTCAACTGTGGACTGTATTTTTCTAAAGAGATTCAGAACGAGTACTTCAGTCGTCATCCCCGCGGATTGAATCCGGTGCAGCTTAACGACGTGTTCTTCTCCTTGCACGCAGCCTTCGCTACTCTCATCACCATCACCCAGTGCTTTTTATATGAGCGTGAAGAGCAACGGGTCTCGACGGTGGGGCGCGGGATACTCGGCGCGTTCTCAGCGGTCGTCATAGTAACGGGCAGCATCGCGGTCGTCGGCAAGATCGAGTGGCTGGACTGGCTCTACTACTGCAGCTACGTGAAGCTCGCCATCACGCTCATCAAATACGTGCCGCAGGCGTACATGAACTACAAACGCAAATCAACGGTCGGCTGGAGTATCGGCAACATTTTCCTCGACTTTGTGGGCGGTTTCCTTTCGATACTCCAGATGGTCCTCAACGCCTACAACTACAACGACTGGGTTTCGTTCTTCGGAGACGCGACCAAATTCGGCCTCGGCCTCTTTAGTCTCGTTTTCGATATATTCTTCATACTGCAGCACTATGTCTTCTATAGGCAATCTCGGTATATACTGATTCCCGGAACGACTGTATCAGAACATGAAGATGATTCGGAGAATGATCCCGAGACACGATCAGAAACACCTTATCAAGGAGACCCTGCTTAA

Protein

MAECSAVLRPRAAACSISSHRIRFCLVVMLILGIPSAHSQLDKMYVEVTDLNLLVEETRLLKLVQIGQYNTSLEVISNIQHPDIVQLVPPSIEIPGSNEPNKTVVISYDICAYGKSPGHSEVTFNVTPPGFVNLDTVYLRITVMHSNEINIISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSLFNCGLYFSKEIQNEYFSRHPRGLNPVQLNDVFFSLHAAFATLITITQCFLYEREEQRVSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYMNYKRKSTVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDIFFILQHYVFYRQSRYILIPGTTVSEHEDDSENDPETRSETPYQGDPA

Description

Thought to transport cystine out of lysosomes.

Similarity

Belongs to the cystinosin family.

Keywords

Complete proteome   Glycoprotein   Lysosome   Membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Cystinosin homolog

Uniprot

H9ISJ5   A0A2A4IVH4   A0A2A4IUV8   A0A2A4IV81   A0A2A4IVY3   A0A1E1W6N7   + More
M4PJ85   A0A2H1WKD8   A0A1E1W3M5   A0A212F623   A0A0N0PDU2   A0A194Q7T6   A0A1I8P1W0   A0A1J1HME6   A0A1I8MB83   A0A034WN59   A0A1L8EC03   A0A1L8EC79   A0A1L8ECD0   A0A1L8EBZ6   A0A1L8ECB8   A0A1L8ECJ6   A0A1I8P231   A0A1B6ISS5   A0A1B6ICR1   A0A1L8EBL5   A0A1L8EBA5   A0A1L8EAU4   A0A1L8EAP6   B4NHY0   A0A0K8W6E0   A0A1I8P1Z5   A0A1B6IYI5   A0A1J1HR70   A0A1B6JK51   E2AMM9   A0A310SSP4   A0A0M9A9F3   A0A1B6GX90   A0A1B6ETU5   A0A0K8WDW3   W8C7G5   B4MB48   A0A1B0CST0   A0A1W4UR63   A0A0Q9WCC3   A0A1B6KTV1   A0A195CSW6   A0A1A9ZL98   D6X2V5   A0A0C9RUP7   B3LZ90   A0A1Y1M4R8   A0A154PA44   A0A158NN70   A0A1J1HKW4   A0A1B6FEF1   A0A0A1WH94   A0A1B6FXE4   A0A1Y1M9N1   A0A1B6KVK1   A0A232FIG0   B4KBB8   A0A0C9QA94   A0A2J7R8J2   A0A0C9R4W8   A0A0L7QW11   B3P7H2   U5EI65   A0A1A9XI33   F4WNV6   A0A1Q3FMQ3   A0A1B0G851   A0A151I3L2   B4PN35   A0A195EEX3   A0A195FWH0   A0A0M4EPK6   A0A182GSY0   Q7YZ90   Q9VCR7   B4HFA3   Q177J0   A0A336LRJ9   A0A336K1D9   A0A336K603   A0A336LCR6   A0A336LM69   B4R1C6   A0A151XA25   A0A1L8DEF9   A0A1L8DE22   A0A0L0CIR5   J9K1S5   A0A1A9X197   J9K0V2   A0A1Q3FNR5   J3JZ80  

Pubmed

19121390    23465695    22118469    26354079    25315136    25348373    + More
17994087    20798317    24495485    18362917    19820115    18057021    28004739    21347285    25830018    28648823    21719571    17550304    26483478    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    17893096    17510324    26108605    22516182   

EMBL

BABH01013544    BABH01013545    BABH01013546    NWSH01006720    PCG63284.1    PCG63286.1    + More
PCG63288.1    PCG63283.1    GDQN01008398    GDQN01005888    JAT82656.1    JAT85166.1    KC514051    AGH06055.1    ODYU01009185    SOQ53436.1    GDQN01009469    GDQN01001932    JAT81585.1    JAT89122.1    AGBW02010108    OWR49159.1    KQ460041    KPJ18368.1    KQ459324    KPJ01583.1    CVRI01000009    CRK88706.1    GAKP01003190    JAC55762.1    GFDG01002522    JAV16277.1    GFDG01002525    JAV16274.1    GFDG01002524    JAV16275.1    GFDG01002521    JAV16278.1    GFDG01002523    JAV16276.1    GFDG01002526    JAV16273.1    GECU01017722    JAS89984.1    GECU01022972    GECU01018416    JAS84734.1    JAS89290.1    GFDG01002856    JAV15943.1    GFDG01002855    JAV15944.1    GFDG01002958    JAV15841.1    GFDG01002959    JAV15840.1    CH964272    EDW83630.2    GDHF01007855    GDHF01005672    JAI44459.1    JAI46642.1    GECU01015737    GECU01014143    JAS91969.1    JAS93563.1    CRK88705.1    GECU01008403    JAS99303.1    GL440840    EFN65297.1    KQ760444    OAD60288.1    KQ435720    KOX78643.1    GECZ01002720    JAS67049.1    GECZ01028471    JAS41298.1    GDHF01017826    GDHF01003042    JAI34488.1    JAI49272.1    GAMC01008021    JAB98534.1    CH940656    EDW58319.2    AJWK01026559    KRF78229.1    GEBQ01025101    JAT14876.1    KQ977372    KYN03219.1    KQ971372    EFA10650.1    GBYB01011346    JAG81113.1    CH902617    EDV43017.1    KPU80031.1    GEZM01042225    JAV80038.1    KQ434856    KZC08765.1    ADTU01021059    CRK88704.1    GECZ01021194    JAS48575.1    GBXI01016437    JAC97854.1    GECZ01014907    JAS54862.1    GEZM01042226    JAV80037.1    GEBQ01024514    GEBQ01014312    JAT15463.1    JAT25665.1    NNAY01000151    OXU30544.1    CH933806    EDW16846.2    KRG02346.1    KRG02347.1    KRG02348.1    GBYB01011348    JAG81115.1    NEVH01006721    PNF37154.1    GBYB01011344    JAG81111.1    KQ414721    KOC62780.1    CH954182    EDV54061.1    GANO01002753    JAB57118.1    GL888239    EGI64114.1    GFDL01006156    JAV28889.1    CCAG010000199    KQ976475    KYM83909.1    CM000160    EDW98090.2    KQ979039    KYN23409.1    KQ981208    KYN44793.1    CP012526    ALC46072.1    JXUM01085637    KQ563515    KXJ73712.1    AE014297    AAO41592.2    AY119096    CH480815    EDW43281.1    CH477375    EAT42338.1    UFQS01000059    UFQT01000059    SSW98773.1    SSX19159.1    SSW98774.1    SSX19160.1    SSW98775.1    SSX19161.1    UFQS01001649    UFQT01001649    SSX11724.1    SSX31289.1    SSW98776.1    SSX19162.1    CM000364    EDX14012.1    KQ982351    KYQ57225.1    GFDF01009370    JAV04714.1    GFDF01009371    JAV04713.1    JRES01000321    KNC32298.1    ABLF02031819    ABLF02031821    ABLF02007465    GFDL01005919    JAV29126.1    BT128561    AEE63518.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000095300    + More
UP000183832    UP000095301    UP000007798    UP000000311    UP000053105    UP000008792    UP000092461    UP000192221    UP000078542    UP000092445    UP000007266    UP000007801    UP000076502    UP000005205    UP000215335    UP000009192    UP000235965    UP000053825    UP000008711    UP000092443    UP000007755    UP000092444    UP000078540    UP000002282    UP000078492    UP000078541    UP000092553    UP000069940    UP000249989    UP000000803    UP000001292    UP000008820    UP000000304    UP000075809    UP000037069    UP000007819    UP000091820   

PRIDE

H9ISJ5    Q7YZ90    Q9VCR7   

Pfam

PF04193   PQ-loop        + More
PF09776   Mitoc_L55
PF00106   adh_short

Interpro

IPR005282   LC_transporter        + More
IPR006603   PQ-loop_rpt       
IPR018615   Ribosomal_L55_mit       
IPR010916   TonB_box_CS       
IPR002347   SDR_fam       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

H9ISJ5   A0A2A4IVH4   A0A2A4IUV8   A0A2A4IV81   A0A2A4IVY3   A0A1E1W6N7   + More
M4PJ85   A0A2H1WKD8   A0A1E1W3M5   A0A212F623   A0A0N0PDU2   A0A194Q7T6   A0A1I8P1W0   A0A1J1HME6   A0A1I8MB83   A0A034WN59   A0A1L8EC03   A0A1L8EC79   A0A1L8ECD0   A0A1L8EBZ6   A0A1L8ECB8   A0A1L8ECJ6   A0A1I8P231   A0A1B6ISS5   A0A1B6ICR1   A0A1L8EBL5   A0A1L8EBA5   A0A1L8EAU4   A0A1L8EAP6   B4NHY0   A0A0K8W6E0   A0A1I8P1Z5   A0A1B6IYI5   A0A1J1HR70   A0A1B6JK51   E2AMM9   A0A310SSP4   A0A0M9A9F3   A0A1B6GX90   A0A1B6ETU5   A0A0K8WDW3   W8C7G5   B4MB48   A0A1B0CST0   A0A1W4UR63   A0A0Q9WCC3   A0A1B6KTV1   A0A195CSW6   A0A1A9ZL98   D6X2V5   A0A0C9RUP7   B3LZ90   A0A1Y1M4R8   A0A154PA44   A0A158NN70   A0A1J1HKW4   A0A1B6FEF1   A0A0A1WH94   A0A1B6FXE4   A0A1Y1M9N1   A0A1B6KVK1   A0A232FIG0   B4KBB8   A0A0C9QA94   A0A2J7R8J2   A0A0C9R4W8   A0A0L7QW11   B3P7H2   U5EI65   A0A1A9XI33   F4WNV6   A0A1Q3FMQ3   A0A1B0G851   A0A151I3L2   B4PN35   A0A195EEX3   A0A195FWH0   A0A0M4EPK6   A0A182GSY0   Q7YZ90   Q9VCR7   B4HFA3   Q177J0   A0A336LRJ9   A0A336K1D9   A0A336K603   A0A336LCR6   A0A336LM69   B4R1C6   A0A151XA25   A0A1L8DEF9   A0A1L8DE22   A0A0L0CIR5   J9K1S5   A0A1A9X197   J9K0V2   A0A1Q3FNR5   J3JZ80  

KEGG

101747227    K12386 cystinosin | (RefSeq) cystinosin homolog

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0003735   GO:0005762   GO:0005765   GO:0005774   GO:0015811   GO:0015184   GO:0003333   GO:0015171  

PANTHER

PTHR13131  

Subcellular location

Lysosome membrane  

SignalP

Position:   1 - 39,         Likelihood:  0.880883

 

 

Length:

420

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

159.60169

Exp number, first 60 AAs:

13.31051

Total prob of N-in:

0.74357

POSSIBLE N-term signal

sequence

outside

1  -  148

TMhelix

149  -  168

inside

169  -  179

TMhelix

180  -  202

outside

203  -  232

TMhelix

233  -  252

inside

253  -  264

TMhelix

265  -  284

outside

285  -  288

TMhelix

289  -  308

inside

309  -  320

TMhelix

321  -  343

outside

344  -  362

TMhelix

363  -  382

inside

383  -  420

 

 

Pi

236.680076

Theta

180.048345

Tajima's D

1.158003

CLR

0.037106

CSRT

0.700114994250287

Interpretation

Uncertain