Gene

KWMTBOMO12902  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000475

Annotation

calreticulin_[Bombyx_mori]

Location

Bomo_Chr22(-):3849823-3854601      View in EpiBrowser

Full name

Calreticulin      

Location in the cell

ER   Reliability : 3.984

CDS

ATGAAAGCTGTTGTACTGGTCGTTGTCAGCTTGCTGGCATTATCTTCGATAAATTGTGATGTATTCTTTGAGGAGAAGTTTCCTGATGATTCGTGGGAAAGCAATTGGGTGTACAGTGAGCACCCAGGAAAAGAATTTGGAAAGTTTAAATTGACTGCTGGAAAGTTCTTCAGCGACCCAGAGGATGACAAAGGTTTGAAAACCTCTGAAGATGCGAGGTTCTATGCTCTCTCCCGTAAGTTCAAACCGTTCAGTAATGAGGGTAAACCCTTGGTCGTCCAGTTCACTGTCAAACATGAACAAGACATTGACTGTGGAGGCGGATACCTCAAGGTCTTTGACTGCAAACTGGAGCAGAAGGACATGCACGGAGAGACTCCATATGAGATTATGTTCGGCCCTGACATCTGTGGTCCAGGAACCAAGAAGGTACACGTAATCTTCAGTTACAAGGGTAAGAACCACCTCATCAAAAAAGATATCCGCTGCAAAGATGATGTCTACACACATTTGTACACTCTGATTGTGAAACCCGACAACACCTATGAAGTCCTCATTGACAATGAGAAAGTTGAATCTGGCGACCTAGAGGCCGATTGGGACTTCCTTCCGCCCAAGAAAATCAAGGACCCTGAAGCCAAGAAACCAGAAGACTGGGATGACAAGCCCACTATTCCAGACCCCGAAGACAAGAAGCCTGAGGATTGGGACAAACCTGAACACATTCCAGACCCAGATGCCACCAAACCTGAAGACTGGGATGATGAGATGGACGGAGAATGGGAGCCACCTATGATTGACAACCCAGACTACAAGGGCGTTTGGGCACCAAAACAGATTGATAACCCAGCTTACAAAGGCCCATGGGTCCATCCCGAAATCGACAACCCAGAGTACACTCCTGATTCAAACCTGTACAAGCGCGACGAAATCTGCGCTGTCGGTCTCGATTTGTGGCAAGTCAAGTCCGGTACCATCTTTGACGACTTCCTTATTACTGACGACCCGGCCGCCGCCAAAGAGAGGGGAGAGGTCATCAAGAAAAGGCAGGAGGGAGAAAAGAAAATGAAGAGCGAACAAGACGAGGCCGAGAGGGAGAAGGAGAAGGCGGAAAAGCCTGACGATGAGGAAGATGATGAGGACCTCGACGATGAGACTGGAGACGCAGCGCCTGTGGAGGAACACGATGAGCTGTAG

Protein

MKAVVLVVVSLLALSSINCDVFFEEKFPDDSWESNWVYSEHPGKEFGKFKLTAGKFFSDPEDDKGLKTSEDARFYALSRKFKPFSNEGKPLVVQFTVKHEQDIDCGGGYLKVFDCKLEQKDMHGETPYEIMFGPDICGPGTKKVHVIFSYKGKNHLIKKDIRCKDDVYTHLYTLIVKPDNTYEVLIDNEKVESGDLEADWDFLPPKKIKDPEAKKPEDWDDKPTIPDPEDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWEPPMIDNPDYKGVWAPKQIDNPAYKGPWVHPEIDNPEYTPDSNLYKRDEICAVGLDLWQVKSGTIFDDFLITDDPAAAKERGEVIKKRQEGEKKMKSEQDEAEREKEKAEKPDDEEDDEDLDDETGDAAPVEEHDEL

Description

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).

Subunit

Monomer.

Similarity

Belongs to the calreticulin family.

Keywords

Calcium   Chaperone   Complete proteome   Direct protein sequencing   Disulfide bond   Endoplasmic reticulum   Lectin   Metal-binding   Reference proteome   Repeat   Signal   Zinc  

Feature

chain  Calreticulin

Uniprot

H9IT95   C0JMI5   Q7Z1E6   A0A3S2LQF1   A0A2H1WNA6   A0A2A4J7I0   + More
I4DIN8   A0A0N0PDW9   A0A3G1T1R1   I4DMH6   A0A286SBT4   Q8WPG8   E2GAH8   A0A212F6J6   A0A1E1W6M9   A0A0L7L560   S4NNE7   G8XR25   A0A2P8ZDY7   A0A1B6MUX5   U5EW38   A0A2J7PN12   A0A067RDJ6   A0A0U3SX76   G9C5E9   A0A1B0CBU1   A0A1J1J5D6   A0A154PAH0   A0A087ZP00   V9IHC2   A0A0M9A0L8   A0A1J0M5J4   A0A158NKM2   A0A1I8MLA7   A0A0P6IZ50   R4WHW2   A0A2A3EN82   R4G8F8   A0A1L8DU30   V5G380   A0A336KF65   A0A1B1H1L7   A0A1D1ZFS8   D6X0K3   A0A0L7QSZ9   A0A151IEL6   B6E229   A0A151WRI1   A0A0K8TS40   Q8IS63   A0A0C9RCN9   A0A1B0CZK2   A0A1Q3FG05   A0A1Q3FG87   J9JQR2   A0A2H8TI14   A0A194Q9D3   B0WJE0   I3WY52   E2C9L2   A0A310SL21   A0A0L0CMX7   A0A195BNH1   F4WWF5   B4JHQ4   A0A224XDL0   A0A1Y1M8N9   A0A182RZI4   A0A2S2NYT1   A0A182UCM8   A0A0C5DKG5   A0A0M4EEZ3   A0A1L8EIQ7   A0A0A0VDH2   A0A182LRI9   A0A182VEK0   Q8WR36   A0A182NZZ1   Q17MI1   A0A0C5DIF3   A0A182XG76   Q7PQK3   A0A182IDC0   B4K4E6   B4MGG3   A0A026WU53   E1U7W1   A0A182G1Z1   A0A1S4EXL5   A0A084VKA2   H2EQR8   H2EQS4   G9BIX2   A0A1A9W3J9   A0A0A1WEC8   A0A2K8FTM3   E1ZZT0   A0A3B0JS76   A0A023ET66   A0A1W6EW73  

Pubmed

19121390    16172913    11280994    22651552    26354079    11888648    + More
22118469    26227816    23622113    29403074    24845553    26694822    21835214    21347285    25315136    23691247    18362917    19820115    20857219    26369729    12692281    20798317    26108605    21719571    17994087    28004739    25797793    25863177    12124367    17510324    12364791    14747013    17210077    24508170    20648599    26483478    24438588    25150160    25244985    25830018    24945155   

EMBL

BABH01013561    FJ360528    ACN29696.1    AY297158    AB090887    AAP50845.1    + More
BAC57964.1    RSAL01000354    RVE42248.1    ODYU01009852    SOQ54549.1    NWSH01002717    PCG67628.1    AK401156    BAM17778.1    KQ460041    KPJ18355.1    MG770328    AXY94930.1    AK402494    BAM19116.1    KX963769    ASZ00086.1    AB063250    BAB79277.1    HM240516    ADN06079.1    AGBW02010006    OWR49353.1    GDQN01008431    JAT82623.1    JTDY01002928    KOB70471.1    GAIX01013961    JAA78599.1    EU826537    ACJ07154.1    PYGN01000085    PSN54723.1    GEBQ01000260    JAT39717.1    GANO01000728    JAB59143.1    NEVH01023960    PNF17706.1    KK852572    KDR21098.1    KU218664    ALX00044.1    HQ851390    AEV89768.1    AJWK01005828    CVRI01000073    CRL07616.1    KQ434857    KZC08841.1    JR047822    AEY60518.1    KQ435798    KOX73389.1    KU663637    APD15631.1    ADTU01018888    GDIQ01002234    JAN92503.1    AK416945    BAN20160.1    KZ288204    PBC33263.1    ACPB03001035    GAHY01001047    JAA76463.1    GFDF01004135    JAV09949.1    GALX01004006    JAB64460.1    UFQS01000350    UFQT01000350    SSX03101.1    SSX23467.1    KX384605    ANQ80539.1    GDJX01002130    JAT65806.1    KQ971371    EFA10099.1    KQ414756    KOC61679.1    KQ977862    KYM99270.1    FJ196458    ACI23246.1    KQ982805    KYQ50512.1    GDAI01000434    JAI17169.1    AY150370    AAN73309.1    GBYB01006065    JAG75832.1    AJVK01009612    GFDL01008559    JAV26486.1    GFDL01008494    JAV26551.1    ABLF02038187    GFXV01001949    MBW13754.1    KQ459324    KPJ01595.1    DS231959    EDS29114.1    JQ783054    AFL48552.1    GL453868    EFN75351.1    KQ764887    OAD54229.1    JRES01000179    KNC33567.1    KQ976439    KYM86763.1    GL888406    EGI61497.1    CH916369    EDV93893.1    GFTR01005909    JAW10517.1    GEZM01037806    JAV81921.1    GGMR01009718    MBY22337.1    KP221723    AJO70188.1    CP012524    ALC40685.1    GFDG01000265    JAV18534.1    KM538170    AIW68605.1    AXCM01016328    AF457551    AAL68781.1    CH477205    EAT47943.1    KP299971    AJO70005.1    AAAB01008880    EAA08693.2    APCN01005098    CH933806    EDW13898.2    CH940675    EDW58213.2    KK107105    EZA59567.1    FJ882064    ACZ68113.1    JXUM01039197    KQ561194    KXJ79399.1    ATLV01014171    KE524947    KFB38396.1    JQ013463    JQ013464    JQ013465    JQ013466    JQ013467    JQ013468    JQ013471    JQ013472    JQ013473    JQ013474    JQ013475    JQ013476    AEY77803.1    AEY77804.1    AEY77805.1    AEY77806.1    AEY77807.1    AEY77808.1    AEY77811.1    AEY77812.1    AEY77813.1    AEY77814.1    AEY77815.1    AEY77816.1    JQ013469    JQ013470    JQ013477    AEY77809.1    AEY77810.1    AEY77817.1    HQ596362    AEC50079.1    GBXI01017226    JAC97065.1    KY618827    AQW43013.1    GL435522    EFN73303.1    OUUW01000007    SPP83262.1    GAPW01002029    JAC11569.1    KY563578    ARK19987.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000007151    UP000037510    + More
UP000245037    UP000235965    UP000027135    UP000092461    UP000183832    UP000076502    UP000005203    UP000053105    UP000005205    UP000095301    UP000242457    UP000015103    UP000007266    UP000053825    UP000078542    UP000075809    UP000092462    UP000007819    UP000053268    UP000002320    UP000008237    UP000037069    UP000078540    UP000007755    UP000001070    UP000075900    UP000075902    UP000092553    UP000075883    UP000075903    UP000075885    UP000008820    UP000076407    UP000007062    UP000075840    UP000009192    UP000008792    UP000053097    UP000069940    UP000249989    UP000030765    UP000076408    UP000091820    UP000000311    UP000268350   

PRIDE

H9IT95    C0JMI5    Q7Z1E6   

Pfam

PF00262   Calreticulin

Interpro

IPR001580   Calret/calnex        + More
IPR018124   Calret/calnex_CS       
IPR009033   Calreticulin/calnexin_P_dom_sf       
IPR009169   Calreticulin       
IPR013320   ConA-like_dom_sf       

SUPFAM

SSF63887   SSF63887        + More
SSF49899   SSF49899       

Gene 3D

2.10.250.10    

ProteinModelPortal

H9IT95   C0JMI5   Q7Z1E6   A0A3S2LQF1   A0A2H1WNA6   A0A2A4J7I0   + More
I4DIN8   A0A0N0PDW9   A0A3G1T1R1   I4DMH6   A0A286SBT4   Q8WPG8   E2GAH8   A0A212F6J6   A0A1E1W6M9   A0A0L7L560   S4NNE7   G8XR25   A0A2P8ZDY7   A0A1B6MUX5   U5EW38   A0A2J7PN12   A0A067RDJ6   A0A0U3SX76   G9C5E9   A0A1B0CBU1   A0A1J1J5D6   A0A154PAH0   A0A087ZP00   V9IHC2   A0A0M9A0L8   A0A1J0M5J4   A0A158NKM2   A0A1I8MLA7   A0A0P6IZ50   R4WHW2   A0A2A3EN82   R4G8F8   A0A1L8DU30   V5G380   A0A336KF65   A0A1B1H1L7   A0A1D1ZFS8   D6X0K3   A0A0L7QSZ9   A0A151IEL6   B6E229   A0A151WRI1   A0A0K8TS40   Q8IS63   A0A0C9RCN9   A0A1B0CZK2   A0A1Q3FG05   A0A1Q3FG87   J9JQR2   A0A2H8TI14   A0A194Q9D3   B0WJE0   I3WY52   E2C9L2   A0A310SL21   A0A0L0CMX7   A0A195BNH1   F4WWF5   B4JHQ4   A0A224XDL0   A0A1Y1M8N9   A0A182RZI4   A0A2S2NYT1   A0A182UCM8   A0A0C5DKG5   A0A0M4EEZ3   A0A1L8EIQ7   A0A0A0VDH2   A0A182LRI9   A0A182VEK0   Q8WR36   A0A182NZZ1   Q17MI1   A0A0C5DIF3   A0A182XG76   Q7PQK3   A0A182IDC0   B4K4E6   B4MGG3   A0A026WU53   E1U7W1   A0A182G1Z1   A0A1S4EXL5   A0A084VKA2   H2EQR8   H2EQS4   G9BIX2   A0A1A9W3J9   A0A0A1WEC8   A0A2K8FTM3   E1ZZT0   A0A3B0JS76   A0A023ET66   A0A1W6EW73  

PDB

6ENY     E-value=8.66959e-104,     Score=963

KEGG

692629    K08057 calreticulin | (RefSeq) Crt; calreticulin

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0005509   GO:0051082   GO:0006457   GO:0005783   GO:0030246   GO:0005788   GO:0046872   GO:0005515   GO:0045181   GO:0050660   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR11073  

Subcellular location

Endoplasmic reticulum  
Endoplasmic reticulum lumen  

SignalP

Position:   1 - 19,         Likelihood:  0.998973

 

 

Length:

398

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.06515

Exp number, first 60 AAs:

1.06515

Total prob of N-in:

0.05929

outside

1  -  398

 

 

Pi

208.510498

Theta

191.037319

Tajima's D

0.583979

CLR

0.201832

CSRT

0.535473226338683

Interpretation

Uncertain