Gene

KWMTBOMO12895  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012687

Annotation

transport_protein_Sec61_alpha_subunit_[Bombyx_mori]

Location

Bomo_Chr22(+):3678841-3684200      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.826

CDS

ATGGGAATAAAATTTTTGGAAGTAATTAAGCCGTTCTGCAGTATATTGCCAGAAATAGCGAAACCAGAACGTAAGATTCAATTCCGAGAGAAAGTATTATGGACAGCAATCACATTATTTATTTTCTTAGTATGCTGCCAGATTCCCTTATTTGGTATAATGTCATCAGACAGTGCCGATCCCTTCTATTGGATCCGTGTAATTCTTGCATCAAACAGAGGGACATTAATGGAGCTTGGTATCTCACCTATTGTAACATCAGGACTTATCATGCAGTTGCTTGCTGGTGCTAAAATCATTGAAGTTGGTGACACTCCGAAAGACAGGGCTTTGTTTAATGGTGCACAGAAATTATTTGGTATGGTGATTACTGTTGGTCAGGCTATTGTTTATGTAATGACTGGAATGTATGGTGAACCCAGTGAAATTGGTGCCGGAGTGTGCCTCCTCATTATCATACAACTGTTTGTGGCCGGTCTTATTGTGTTGTTGCTCGATGAATTGCTCCAGAAAGGATATGGATTGGGTTCTGGTATCTCTCTGTTTATTGCTACAAACATCTGTGAAACCATTGTATGGAAGGCATTTTCACCAGCCACTGTTAACACTGGTCGCGGCACAGAATTCGAGGGTGCTGTGATAGCATTGTTCCATCTGTTGGCAACACGTCCAGACAAAGTGCGAGCTCTCCGTGAAGCCTTCTATCGACAAAATCTACCCAACCTGATGAATCTACTAGCCACTGTTCTTGTCTTTGCTATAGTGATATACTTCCAGGGCTTCCGTGTAGATTTGCCCATCAAGTCTGCTCGTTATCGTGGACAGTATTCTTCATACCCAATCAAACTATTCTACACTTCTAATATACCCATCATTCTGCAGTCTGCTCTTGTCTCCAATCTTTATGTCATCTCACAGATGTTGGCAGTAAAATTCAGCGGCAACTTCCTAGTGAACGTTTTGGGTGTTTGGGCTGACGTGGGCGGCGGCGGCCCGGCGCGAGCTGCCCCGGTGGGCGGGCTGTGCTACTACCTGTCCCCGCCGGAGTCCCTCGCACACATCGCACACGACCCCGTGCACGCCCTGCTCTACGTGCTCTTCATGCTAGGCTCTTGCGCCTTCTTTTCAAAGACCTGGATCGATGTGTCTGGCTCCTCAGCCAAAGATGTGGCGAAACAACTGAAGGAACAGCAGATGGTGATGCGCGGTCACCGCGACAACTCCATGATCCACGAACTGAACCGCTACATCCCGACGGCGGCCGCGTTCGGAGGACTGTGCATCGGGGCTCTGTCAGTGCTGGCCGACTTCCTCGGGGCCATCGGCTCCGGCACTGGGATACTGCTCGCCGTCACCATCATTTACCAGTACTTCGAGATCTTTGTCAAGGAACAAGCGGAGATGGGCGGCATGAGCACACTGCTCTTCTAA

Protein

MGIKFLEVIKPFCSILPEIAKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWIRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMVITVGQAIVYVMTGMYGEPSEIGAGVCLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPATVNTGRGTEFEGAVIALFHLLATRPDKVRALREAFYRQNLPNLMNLLATVLVFAIVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLAVKFSGNFLVNVLGVWADVGGGGPARAAPVGGLCYYLSPPESLAHIAHDPVHALLYVLFMLGSCAFFSKTWIDVSGSSAKDVAKQLKEQQMVMRGHRDNSMIHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEMGGMSTLLF

Similarity

Belongs to the SecY/SEC61-alpha family.

Uniprot

Q19AA9   A0A2W1B0R4   A0A2A4JCT2   S4PMU9   A0A0N1IHS8   A0A2H1V1C7   + More
B7U2V4   Q8T4Q3   A0A1L8DUN6   A0A1B0CME3   A0A1B6FSR6   A0A1B6J4E2   Q5XUA5   Q1ZZP2   A0A067QRC4   A0A1Q3FFC9   A0A1B6CBH6   A0A1Q3FCK5   A0A1Q3FF93   A0A1Q3FEM3   A0A1Q3FBE2   A0A182Y9T2   A0A1S4H0B1   A0A2M3YZ00   A0A2M4A0E4   A0A182PFS4   A0A182M844   A0A182QGC1   A0A182USK1   W5JI79   A0A182U309   A0A182KUF3   A0A182XKX2   A0A182F0P2   A0A182R6I3   A0A182I572   A0A1Q3FXJ9   B0WNA0   A0A1W4WIQ9   A0A182J5B6   A0A023EV56   D6WE66   J3JTT5   A0A0A9ZAI2   Q17CM3   A0A1W7R9M7   B0W7A0   A0A2L2Y3A8   A0A182NF56   A0A3S3PP70   A0A182WH74   A0A026WQ47   Q8T4Q2   A0A1Y1KH87   A0A224XPE2   A0A023F5V7   A0A2D1QUH6   A0A069DZ35   U5EX20   K1QDB9   A0A182GQI7   T1EA34   Q95P60   Q7PVU5   A0A2I9LPQ2   T1HGZ3   Q16S36   A0A182H6T5   A0A0N7Z991   B4JQ75   A0A0P6B1Q8   A0A0K8TSU8   A0A0J7K8V1   A0A1I8PYB3   A0A336MU79   A0A158NK45   E2AGQ1   A0A023ESU7   A0A1W4VEW1   Q9BMG6   A0A1B0FAA1   B4P0D3   B3MP75   B4N7M7   B4I1W3   B3N5S1   A0A1L8EHE1   A0A1A9ZFD4   B4Q4N5   Q8STG9   T1PI22   B4M9K3   B4KKX5   A0A1B6MEM5   A0A084VMX8   A0A3B0KXD5   Q29PD8   B4GKK3   T1KJ96   A0A1A9W5I9  

Pubmed

19121390    28756777    23622113    26354079    24845553    25244985    + More
12364791    20920257    23761445    20966253    24945155    18362917    19820115    22516182    23537049    25401762    26823975    17510324    26561354    24508170    28004739    25474469    26334808    22992520    26483478    29248469    27129103    17994087    26369729    21347285    20798317    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16243437    16110336    17569856    17569867    26109357    26109356    25315136    24438588    15632085   

EMBL

BABH01030658    DQ533987    ABF85696.1    KZ150492    PZC70682.1    NWSH01002087    + More
PCG69232.1    GAIX01003365    JAA89195.1    KQ460041    KPJ18351.1    ODYU01000045    SOQ34152.1    FJ425873    ACJ66917.1    AY064124    AAL85625.1    GFDF01003937    JAV10147.1    AJWK01018613    AJWK01018614    GECZ01016541    JAS53228.1    GECU01028841    GECU01013686    JAS78865.1    JAS94020.1    AY737549    AAU84942.1    ABLF02035743    DQ416034    ABD76381.1    KK853050    KDR12041.1    GFDL01008833    JAV26212.1    GEDC01026633    JAS10665.1    GFDL01009765    JAV25280.1    GFDL01008827    JAV26218.1    GFDL01009046    JAV25999.1    GFDL01010140    JAV24905.1    AAAB01008984    GGFM01000743    MBW21494.1    GGFK01000898    MBW34219.1    AXCM01012857    AXCN02000829    ADMH02001466    ETN62479.1    APCN01003796    GFDL01002728    JAV32317.1    DS232009    EDS31548.1    GAPW01001234    JAC12364.1    KQ971324    EFA01230.1    APGK01059090    BT126644    KB741292    KB630724    KB631576    KB632349    AEE61607.1    ENN70407.1    ERL83812.1    ERL84392.1    ERL93225.1    GBHO01002170    GDHC01008995    JAG41434.1    JAQ09634.1    CH477307    EAT44074.1    GFAH01000554    JAV47835.1    DS231852    EDS37705.1    IAAA01000496    LAA02487.1    NCKU01000903    RWS13715.1    KK107133    EZA58120.1    AY064125    AAL85626.1    GEZM01084030    JAV60823.1    GFTR01006557    JAW09869.1    GBBI01002140    JAC16572.1    KY285075    ATP16178.1    GBGD01001330    JAC87559.1    GANO01001152    JAB58719.1    JH818630    EKC26790.1    JXUM01080757    KQ563205    KXJ74290.1    GAMD01001363    JAB00228.1    AF392805    AAK73749.1    EAA14690.5    GFWZ01000379    MBW20369.1    ACPB03016592    CH477685    EAT37275.1    JXUM01114826    JXUM01114827    KQ565820    KXJ70627.1    GDKW01001203    JAI55392.1    CH916372    EDV99055.1    GDIP01027756    JAM75959.1    GDAI01000395    JAI17208.1    LBMM01011640    KMQ86729.1    UFQT01002851    SSX34144.1    ADTU01018656    GL439383    EFN67387.1    GAPW01001228    GAPW01001227    JAC12370.1    AF326338    AAK14329.1    CCAG010016184    CM000157    EDW87891.1    CH902620    EDV32194.1    CH964214    EDW80366.1    CH480820    EDW54520.1    CH954177    EDV59080.1    GFDG01000672    JAV18127.1    CM000361    CM002910    EDX03962.1    KMY88525.1    AE014134    AY069569    AB062670    AAF52389.2    AAL39714.1    AHN54189.1    BAB78518.1    KA647538    AFP62167.1    CH940654    EDW57879.1    CH933807    EDW11705.1    GEBQ01005569    JAT34408.1    ATLV01014632    KE524975    KFB39322.1    OUUW01000064    SPP90061.1    CH379058    EAL34355.1    CH479184    EDW37169.1    CAEY01000120   

Proteomes

UP000005204    UP000218220    UP000053240    UP000092461    UP000007819    UP000027135    + More
UP000076408    UP000075885    UP000075883    UP000075886    UP000075903    UP000000673    UP000075902    UP000075882    UP000076407    UP000069272    UP000075900    UP000075840    UP000002320    UP000192223    UP000075880    UP000007266    UP000019118    UP000030742    UP000008820    UP000075884    UP000285301    UP000075920    UP000053097    UP000005408    UP000069940    UP000249989    UP000007062    UP000015103    UP000001070    UP000036403    UP000095300    UP000005205    UP000000311    UP000192221    UP000092444    UP000002282    UP000007801    UP000007798    UP000001292    UP000008711    UP000092445    UP000000304    UP000000803    UP000095301    UP000008792    UP000009192    UP000030765    UP000268350    UP000001819    UP000008744    UP000015104    UP000091820   

PRIDE

Q19AA9    B7U2V4    Q8T4Q3    Q5XUA5    B0WNA0    Q17CM3    + More
B0W7A0    Q8T4Q2    Q95P60    Q7PVU5    Q16S36    E2AGQ1    Q9BMG6   

Pfam

PF00344   SecY        + More
PF10559   Plug_translocon
PF05004   IFRD
PF04836   IFRD_C

Interpro

IPR019561   Translocon_Sec61/SecY_plug_dom        + More
IPR002208   SecY/SEC61-alpha       
IPR030659   SecY_CS       
IPR023201   SecY_dom_sf       
IPR007701   Interferon-rel_develop_reg_N       
IPR016024   ARM-type_fold       
IPR006921   Interferon-rel_develop_reg_C       

SUPFAM

SSF103491   SSF103491        + More
SSF48371   SSF48371       

Gene 3D

1.10.3370.10    

ProteinModelPortal

Q19AA9   A0A2W1B0R4   A0A2A4JCT2   S4PMU9   A0A0N1IHS8   A0A2H1V1C7   + More
B7U2V4   Q8T4Q3   A0A1L8DUN6   A0A1B0CME3   A0A1B6FSR6   A0A1B6J4E2   Q5XUA5   Q1ZZP2   A0A067QRC4   A0A1Q3FFC9   A0A1B6CBH6   A0A1Q3FCK5   A0A1Q3FF93   A0A1Q3FEM3   A0A1Q3FBE2   A0A182Y9T2   A0A1S4H0B1   A0A2M3YZ00   A0A2M4A0E4   A0A182PFS4   A0A182M844   A0A182QGC1   A0A182USK1   W5JI79   A0A182U309   A0A182KUF3   A0A182XKX2   A0A182F0P2   A0A182R6I3   A0A182I572   A0A1Q3FXJ9   B0WNA0   A0A1W4WIQ9   A0A182J5B6   A0A023EV56   D6WE66   J3JTT5   A0A0A9ZAI2   Q17CM3   A0A1W7R9M7   B0W7A0   A0A2L2Y3A8   A0A182NF56   A0A3S3PP70   A0A182WH74   A0A026WQ47   Q8T4Q2   A0A1Y1KH87   A0A224XPE2   A0A023F5V7   A0A2D1QUH6   A0A069DZ35   U5EX20   K1QDB9   A0A182GQI7   T1EA34   Q95P60   Q7PVU5   A0A2I9LPQ2   T1HGZ3   Q16S36   A0A182H6T5   A0A0N7Z991   B4JQ75   A0A0P6B1Q8   A0A0K8TSU8   A0A0J7K8V1   A0A1I8PYB3   A0A336MU79   A0A158NK45   E2AGQ1   A0A023ESU7   A0A1W4VEW1   Q9BMG6   A0A1B0FAA1   B4P0D3   B3MP75   B4N7M7   B4I1W3   B3N5S1   A0A1L8EHE1   A0A1A9ZFD4   B4Q4N5   Q8STG9   T1PI22   B4M9K3   B4KKX5   A0A1B6MEM5   A0A084VMX8   A0A3B0KXD5   Q29PD8   B4GKK3   T1KJ96   A0A1A9W5I9  

PDB

4CG7     E-value=0,     Score=2071

KEGG

733068    K10956 protein transport protein SEC61 subunit alpha | (RefSeq) Sec61alpha; transport protein Sec61

PATHWAY

03060    Protein export - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0015031   GO:0016021   GO:0005784   GO:0005789   GO:0008320   GO:0005048   GO:0006620   GO:0005783   GO:0006616   GO:0005791   GO:0008258   GO:0010942   GO:0046598   GO:0007391   GO:0042335   GO:0045169   GO:0034761   GO:0010507   GO:0098586   GO:0012505   GO:0016020   GO:0006979   GO:0010181   GO:0016040   GO:0045181   GO:0050660   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR10906  

Subcellular location

Membrane  

Length:

476

Number of predicted TMHs:

10

Exp number of AAs in TMHs:

232.84847

Exp number, first 60 AAs:

22.78397

Total prob of N-in:

0.99410

POSSIBLE N-term signal

sequence

inside

1  -  32

TMhelix

33  -  55

outside

56  -  74

TMhelix

75  -  97

inside

98  -  117

TMhelix

118  -  138

outside

139  -  142

TMhelix

143  -  165

inside

166  -  238

TMhelix

239  -  261

outside

262  -  280

TMhelix

281  -  303

inside

304  -  315

TMhelix

316  -  338

outside

339  -  357

TMhelix

358  -  380

inside

381  -  412

TMhelix

413  -  435

outside

436  -  439

TMhelix

440  -  462

inside

463  -  476

 

 

Pi

199.211664

Theta

184.626981

Tajima's D

-1.505897

CLR

1.123131

CSRT

0.0612469376531173

Interpretation

Uncertain