Gene

KWMTBOMO12883

Pre Gene Modal

BGIBMGA012694

Annotation

PREDICTED:_phosphatidate_cytidylyltransferase?_photoreceptor-specific_[Amyelois_transitella]

Location

Bomo_Chr22(-):3227755-3251446      View in EpiBrowser

Full name

Phosphatidate cytidylyltransferase       + More
Phosphatidate cytidylyltransferase, photoreceptor-specific      

Alternative Name

CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Location in the cell

PlasmaMembrane   Reliability : 4.971

CDS

ATGAGTGAAATAAGGCAACGGCGGGGAGATGGCGATGGAAACCAGAAAATAGAAGCTGCTGTCGAGTCGGATCATGTCGACTCTGAAGAGGAGAAAGTCCTAGAAGAGAAGTATGTGGACGAGCTAGCGAAGTCCTTACCGCAAGGCACTGACAAAACTCCAGAAATCCTTGACTCTGCGCTTTCTGGACTATCTACGAGATGGAGGAACTGGGTGATTCGTGGAATATTTACATGGTTGATGATCGGAGGTTTCTGTTTGCTGATCTACGGTGGACCTCTCGCTCTCATGATTACGGTCCTCTGCGTTCAAGTGAAGTGTTTTGAAGAGATCATCAACATTGGATATGCAGTCTACCGTGTCCATGGTCTCCCATGGTTCCGTTCCTTGTCTTGGTACTTCCTATTGACTTCCAATTATTTCTTCTATGGGGAAAACTTGATTGACTACTTTGGTGTTGTCATCAACAGAACGGACTACCTCAAGTTTCTGGTGACGTACCACCGTTTCATATCGTTCAGCTTGTACTGCGTCGGCTTCGTTTGGTTCGTGCTGTCTCTGGTCAAACGCTACTACATGCGGCAGTTCAGCCTGTTCGCTTGGACCCACGTCGCTCTGCTGATCGTCGTTACGCAGTCGTATCTCATCATCCAGAACATATTTGAGGGTCTGATCTGGTTCATAGTGCCGGTGTCGATGATCATCTGCAATGACGTCATGGCCTACGTATTCGGCTTCTTCTTCGGCAAGACTCCGCTCATCAAACTGAGCCCCAAGAAGACCTGGGAGGGTTTCATTGGCGGCGGTATATCTACAGTCATATTCGGTCTCGGGCTTTCCTATATAATGTCACAATATCCTTACCTTGTTTGTCCCATCGAATACTCCGAGAGTGTGGGCCGCATGATGGACTGCGAGCCCTCGCTGCTGTTCAGACTCCAGGAGTACACGCCGCCTCAATTCCTGCAACCCGTTATGAAAGTGATCGGCATGGACAAGTTCAACATGTACCCCTTCATGATTCACTCGCTGTTCCTGAGCACCTTCAGTTCAGTGATTGGACCGTTCGGTGGTTTCTTCGCTTCCGGATTCAAGAGGGCCTTCAAGATCAAGGACTTCGGAGATGTGATCCCTGGGCACGGCGGCATCATGGACCGCTTCGACTGCCAGTTCCTGATGGCCACCTTCGTCAACGTCTACATCACCAGCTTCATCCGCACCGCTACTCCTCAGAAGCTGCTGCAGCAGGTGTACAACTTGAAGCCGGAACAGCAGCTTCAAATGTTCTACGCCCTTAAGGAGTCCCTGGAACATAGGAATATTCTGAACGCCATACCCTAG

Protein

MSEIRQRRGDGDGNQKIEAAVESDHVDSEEEKVLEEKYVDELAKSLPQGTDKTPEILDSALSGLSTRWRNWVIRGIFTWLMIGGFCLLIYGGPLALMITVLCVQVKCFEEIINIGYAVYRVHGLPWFRSLSWYFLLTSNYFFYGENLIDYFGVVINRTDYLKFLVTYHRFISFSLYCVGFVWFVLSLVKRYYMRQFSLFAWTHVALLIVVTQSYLIIQNIFEGLIWFIVPVSMIICNDVMAYVFGFFFGKTPLIKLSPKKTWEGFIGGGISTVIFGLGLSYIMSQYPYLVCPIEYSESVGRMMDCEPSLLFRLQEYTPPQFLQPVMKVIGMDKFNMYPFMIHSLFLSTFSSVIGPFGGFFASGFKRAFKIKDFGDVIPGHGGIMDRFDCQFLMATFVNVYITSFIRTATPQKLLQQVYNLKPEQQLQMFYALKESLEHRNILNAIP

Description

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:7816135, PubMed:24603715). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135). In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715). Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715). This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715).

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate

Similarity

Belongs to the CDS family.

Keywords

Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   Nucleotidyltransferase   Phospholipid biosynthesis   Phospholipid metabolism   Phosphoprotein   Reference proteome   Sensory transduction   Transferase   Transmembrane   Transmembrane helix   Vision  

Feature

chain  Phosphatidate cytidylyltransferase, photoreceptor-specific

Uniprot

A0A3S2NGU7   A0A2A4K0Y5   A0A194Q891   A0A212FDQ1   A0A0N1PHA0   A0A067QR92   + More
A0A2J7Q7J6   A0A2P8Y1F1   A0A195CGB7   A0A1Q3FKG6   A0A1Q3FKC3   F4X838   A0A195F9H8   A0A158NCB0   A0A151J6A2   A0A1J1J7I7   E2AG77   A0A034W123   A0A0K8U383   A0A1B6IMZ7   V9IGJ0   A0A0C9RIF2   W8B3M9   A0A026WKY4   A0A0L7QP64   A0A1B0CWJ0   A0A1B0GFE8   A0A154PIL1   A0A1A9X0G9   A0A2A3EEX9   K7J483   Q17JP6   A0A1B6LEU8   A0A182WJU2   A0A182PDP4   A0A182RCL3   A0A182Y2N6   A0A232F4I7   A0A182J196   Q1HRB7   A0A182UU30   B0WRX4   A0A182I2M8   A0A182WX36   Q7QJ08   A0A0M8ZNQ7   A0A1D2NM81   A0A1B6G1U6   A0A182FGL9   B4HIZ8   A0A2M4A5V6   B4QLI4   A0A2M4CUT9   B4LFG6   X2JC55   B4PCT2   P56079   H9ZJM9   B3NF51   F3YDP2   A0A2M4BMA5   A0A1B0DAQ0   D6WJ88   A0A2M3ZGH4   A0A1W4VP43   T1P9V2   A0A1B6CB71   A0A023ESH4   V5GV21   A0A182NJX1   Q29FD7   B4H1H0   B4KWY0   B4MXE3   A0A0M5JB16   A0A3B0KFP3   B3M419   A0A0N7ZHF4   E9GA99   A0A1Y1KXL5   U5EIN5   A0A0P5GSH7   A0A1L8DYP2   A0A0A9W898   A0A0J7L254   A0A182R0V8   A0A1W4WHG4   A0A2H8TWY3   A0A151WFL8   B4IWR7   A0A0F7VK29   R4FPG7   A0A224XD54   A0A069DYY0   J9JUZ1   A0A023F925   A0A0V0GC37   N6U2G1   A0A2S2QSM6   B6IDT4  

EC Number

2.7.7.41

Pubmed

26354079    22118469    24845553    29403074    21719571    21347285    + More
20798317    25348373    24495485    24508170    30249741    20075255    17510324    25244985    28648823    17204158    12364791    14747013    17210077    27289101    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    7816135    18327897    24603715    18362917    19820115    25315136    24945155    15632085    18057021    21292972    28004739    25401762    26823975    26334808    25474469    23537049   

EMBL

RSAL01000108    RVE47228.1    NWSH01000262    PCG77907.1    KQ459324    KPJ01609.1    + More
AGBW02009028    OWR51828.1    KQ460232    KPJ16413.1    KK853114    KDR11188.1    NEVH01017442    PNF24556.1    PYGN01001050    PSN38085.1    KQ977873    KYM99128.1    GFDL01006966    JAV28079.1    GFDL01006995    JAV28050.1    GL888912    EGI57387.1    KQ981727    KYN37098.1    ADTU01011780    ADTU01011781    KQ979863    KYN18754.1    CVRI01000075    CRL08363.1    GL439266    EFN67568.1    GAKP01010568    JAC48384.1    GDHF01031311    GDHF01014513    JAI21003.1    JAI37801.1    GECU01019423    JAS88283.1    JR046328    AEY60175.1    GBYB01013002    JAG82769.1    GAMC01010823    GAMC01010822    GAMC01010820    JAB95735.1    KK107167    QOIP01000010    EZA56331.1    RLU17805.1    KQ414843    KOC60291.1    AJWK01032487    CCAG010017310    KQ434908    KZC11314.1    KZ288263    PBC30315.1    AAZX01003264    CH477231    EAT46929.1    GEBQ01017749    JAT22228.1    NNAY01001043    OXU25373.1    DQ440177    ABF18210.1    DS232062    EDS33584.1    APCN01000170    AAAB01008807    EAA04188.4    KQ435955    KOX68030.1    LJIJ01000006    ODN06380.1    GECZ01013363    JAS56406.1    CH480815    EDW40652.1    GGFK01002781    MBW36102.1    CM000363    CM002912    EDX09644.1    KMY98285.1    GGFL01004753    MBW68931.1    CH940647    EDW69264.1    AE014296    AHN58001.1    CM000159    EDW93836.1    BT133385    AFH36370.1    CH954178    EDV50393.1    BT126403    AED98583.1    GGFJ01005069    MBW54210.1    AJVK01013365    AJVK01013366    AJVK01013367    KQ971343    EFA04441.1    GGFM01006840    MBW27591.1    KA644728    AFP59357.1    GEDC01026763    GEDC01024211    GEDC01015771    GEDC01011520    GEDC01006408    GEDC01004981    JAS10535.1    JAS13087.1    JAS21527.1    JAS25778.1    JAS30890.1    JAS32317.1    GAPW01001378    JAC12220.1    GALX01000482    JAB67984.1    CH379067    EAL31318.1    CH479202    EDW30147.1    CH933809    EDW18601.1    CH963876    EDW76712.1    CP012525    ALC43431.1    OUUW01000012    SPP87180.1    CH902618    EDV40381.1    GDIP01245105    JAI78296.1    GL732536    EFX83743.1    GEZM01071041    JAV66104.1    GANO01002560    JAB57311.1    GDIQ01259618    JAJ92106.1    GFDF01002672    JAV11412.1    GBHO01040881    GBHO01040880    GBRD01005127    GDHC01011658    GDHC01004225    GDHC01003234    JAG02723.1    JAG02724.1    JAG60694.1    JAQ06971.1    JAQ14404.1    JAQ15395.1    LBMM01001179    KMQ96771.1    AXCN02000532    GFXV01006969    MBW18774.1    KQ983211    KYQ46642.1    CH916366    EDV96293.1    LN830646    CFW94155.1    ACPB03017242    GAHY01000188    JAA77322.1    GFTR01006040    JAW10386.1    GBGD01001605    JAC87284.1    ABLF02036211    GBBI01000741    JAC17971.1    GECL01000444    JAP05680.1    APGK01044857    KB741028    KB632297    ENN74811.1    ERL91694.1    GGMS01011470    MBY80673.1    BT050524    ACJ13231.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000007151    UP000053240    UP000027135    + More
UP000235965    UP000245037    UP000078542    UP000007755    UP000078541    UP000005205    UP000078492    UP000183832    UP000000311    UP000053097    UP000279307    UP000053825    UP000092461    UP000092444    UP000076502    UP000091820    UP000242457    UP000002358    UP000008820    UP000075920    UP000075885    UP000075900    UP000076408    UP000215335    UP000075880    UP000075903    UP000002320    UP000075840    UP000076407    UP000007062    UP000053105    UP000094527    UP000069272    UP000001292    UP000000304    UP000008792    UP000000803    UP000002282    UP000008711    UP000092462    UP000007266    UP000192221    UP000095301    UP000075884    UP000001819    UP000008744    UP000009192    UP000007798    UP000092553    UP000268350    UP000007801    UP000000305    UP000036403    UP000075886    UP000192223    UP000075809    UP000001070    UP000015103    UP000007819    UP000019118    UP000030742   

PRIDE

X2JC55    P56079    H9ZJM9    F3YDP2   

Pfam

PF05712   MRG        + More
PF12906   RINGv

Interpro

IPR000374   PC_trans        + More
IPR016720   PC_Trfase_euk       
IPR000953   Chromo/chromo_shadow_dom       
IPR038217   MRG_C_sf       
IPR026541   MRG_dom       
IPR016197   Chromo-like_dom_sf       
IPR011016   Znf_RING-CH       
IPR013083   Znf_RING/FYVE/PHD       

SUPFAM

SSF54160   SSF54160       

Gene 3D

1.10.274.30     3.30.40.10    

CDD

cd00024  CHROMO

ProteinModelPortal

A0A3S2NGU7   A0A2A4K0Y5   A0A194Q891   A0A212FDQ1   A0A0N1PHA0   A0A067QR92   + More
A0A2J7Q7J6   A0A2P8Y1F1   A0A195CGB7   A0A1Q3FKG6   A0A1Q3FKC3   F4X838   A0A195F9H8   A0A158NCB0   A0A151J6A2   A0A1J1J7I7   E2AG77   A0A034W123   A0A0K8U383   A0A1B6IMZ7   V9IGJ0   A0A0C9RIF2   W8B3M9   A0A026WKY4   A0A0L7QP64   A0A1B0CWJ0   A0A1B0GFE8   A0A154PIL1   A0A1A9X0G9   A0A2A3EEX9   K7J483   Q17JP6   A0A1B6LEU8   A0A182WJU2   A0A182PDP4   A0A182RCL3   A0A182Y2N6   A0A232F4I7   A0A182J196   Q1HRB7   A0A182UU30   B0WRX4   A0A182I2M8   A0A182WX36   Q7QJ08   A0A0M8ZNQ7   A0A1D2NM81   A0A1B6G1U6   A0A182FGL9   B4HIZ8   A0A2M4A5V6   B4QLI4   A0A2M4CUT9   B4LFG6   X2JC55   B4PCT2   P56079   H9ZJM9   B3NF51   F3YDP2   A0A2M4BMA5   A0A1B0DAQ0   D6WJ88   A0A2M3ZGH4   A0A1W4VP43   T1P9V2   A0A1B6CB71   A0A023ESH4   V5GV21   A0A182NJX1   Q29FD7   B4H1H0   B4KWY0   B4MXE3   A0A0M5JB16   A0A3B0KFP3   B3M419   A0A0N7ZHF4   E9GA99   A0A1Y1KXL5   U5EIN5   A0A0P5GSH7   A0A1L8DYP2   A0A0A9W898   A0A0J7L254   A0A182R0V8   A0A1W4WHG4   A0A2H8TWY3   A0A151WFL8   B4IWR7   A0A0F7VK29   R4FPG7   A0A224XD54   A0A069DYY0   J9JUZ1   A0A023F925   A0A0V0GC37   N6U2G1   A0A2S2QSM6   B6IDT4  

PDB

4Q2G     E-value=2.9973e-05,     Score=114

KEGG

101741056    K00981 phosphatidate cytidylyltransferase [EC:2.7.7.41] | (RefSeq) phosphatidate cytidylyltransferas

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)

GO

GO:0016024   GO:0016021   GO:0004605   GO:0008270   GO:0005789   GO:0010868   GO:0016056   GO:0010513   GO:0007291   GO:0043052   GO:0010883   GO:0007602   GO:0007601   GO:0007430   GO:0008610   GO:0016020   GO:0016772   GO:0010181   GO:0016040   GO:0045181   GO:0050660   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR13773  

Subcellular location

Membrane  

Length:

446

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

157.07321

Exp number, first 60 AAs:

0

Total prob of N-in:

0.90636

inside

1  -  75

TMhelix

76  -  98

outside

99  -  164

TMhelix

165  -  187

inside

188  -  198

TMhelix

199  -  221

outside

222  -  225

TMhelix

226  -  248

inside

249  -  260

TMhelix

261  -  283

outside

284  -  338

TMhelix

339  -  361

inside

362  -  446

 

 

Pi

194.788407

Theta

170.389893

Tajima's D

0.822148

CLR

0.338377

CSRT

0.609869506524674

Interpretation

Uncertain