Gene
KWMTBOMO12881
Pre Gene Modal
BGIBMGA012697
Annotation
PREDICTED:_uncharacterized_protein_LOC106143518_[Amyelois_transitella]
Full name
Protein spaetzle 5
Alternative Name
Neurotrophic factor 2
Protein spatzle 5
Protein spatzle 5
Location in the cell
Nuclear Reliability : 2.586
Sequence
CDS
ATGAATATGAAAATAATCCGACAGCTAATAGACGCAGGCCAGTACGACATCCGGACGTTATTATCGGACGAGAGTCGCGACGATTTCGCGACGACAAAAAAGCCGGACTACCCCTACGAGTACGGACCTAACTCGTTGCCGCACGTCGACCACATCTCCCTAGTTAACGAATACCCAAAAAACTACAACACCAAGTTTCACACCCGATACAACCATGATATATTCTCCCAGAAGACACCACTACAGCCGCCGACTTCCAACGACCCGTCACCGTACAACTTAAACACGTTTCAATCGGCGAATTTCTCGAAGTTCGGGTTCCACGGACATTCTCCGAGCGCTCACTGGAGCCACGGTGGGAATATCTATGACGACTACAACAAGAAAATATTCAGACAGAACTCACCCGCGGACCTCGGCTACAATAATTTCTTTGAGGGTCAAAATTTTTATCCAAACTACGAAACGGATGAGTGGTTCAGGCAAGCCTCCGGCGCCGTGACGCGGTATAACCCAAACGAGTGGTGGAAATACGTCTCACCGTCGTCTCGCGCTGATGTGACTGTGGAACGCTCCGTGACGTTTCCGACCAGGACCACGACCCTCAAGAAGCGGAGGAAGAGGAACGCTGATCTCGTCAAAGCTGCTGCCAAGAAACCTCTAACCGGCACCGAAGCATTGAGAATTGCTCTAGGATTGGCTAGCGCAGAGACATCTGCCGAGCGACCCCGAAGACAGGCTGTAAATGCTCAAGAACTCTGCAGCGTGCGTACAGAGTACATCACACCTCGAGCAGCTCTCAACAACAAAGGGAACTGGAAATACGTAGTTAACATGCCTGATAATATGACACAGCTAGTACGGGCTGAGATTTGCACATCCACAACATGCAGTGGCCTGTGCACGATCCCTTCTGGATACACTTCCCGATGCGAACAAAAGTACATTCAAAAACGTCTGGTGGCTCTACAATCAAGCGGACAGAATTTATACACGGATATATTTTGGATTCCTAGCTGTTGTCAGTGTAGCATTATACCTAATAATTAA
Protein
MNMKIIRQLIDAGQYDIRTLLSDESRDDFATTKKPDYPYEYGPNSLPHVDHISLVNEYPKNYNTKFHTRYNHDIFSQKTPLQPPTSNDPSPYNLNTFQSANFSKFGFHGHSPSAHWSHGGNIYDDYNKKIFRQNSPADLGYNNFFEGQNFYPNYETDEWFRQASGAVTRYNPNEWWKYVSPSSRADVTVERSVTFPTRTTTLKKRRKRNADLVKAAAKKPLTGTEALRIALGLASAETSAERPRRQAVNAQELCSVRTEYITPRAALNNKGNWKYVVNMPDNMTQLVRAEICTSTTCSGLCTIPSGYTSRCEQKYIQKRLVALQSSGQNLYTDIFWIPSCCQCSIIPNN
Summary
Description
Neurotrophin which may function as a ligand for the Toll-related receptors Toll-6 and Toll-7 (PubMed:23892553). Binds to Toll-7 and Toll-6, and probably acts as their ligands in the promotion of motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:19018662, PubMed:23892553). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons (PubMed:19018662). May be involved in the normal development of specific neurons at the neuromuscular junction (PubMed:24124519).
Subunit
Homodimer; disulfide-linked.
Miscellaneous
'Spaetzle' means 'noodles' in German.
Keywords
Complete proteome
Disulfide bond
Glycoprotein
Reference proteome
Signal
Feature
chain Protein spaetzle 5
Uniprot
Pubmed
EMBL
Proteomes
Pfam
PF16077 Spaetzle
SUPFAM
SSF57501
SSF57501
Gene 3D
ProteinModelPortal
PDB
4BV4
E-value=5.97388e-07,
Score=127
Ontologies
GO
Topology
Length:
349
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01403
Exp number, first 60 AAs:
0
Total prob of N-in:
0.03025
outside
1 - 349
Population Genetic Test Statistics
Pi
225.185639
Theta
176.463779
Tajima's D
1.075587
CLR
0
CSRT
0.684415779211039
Interpretation
Uncertain
