Gene

KWMTBOMO12868  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012674

Annotation

mRNA_cap-binding_protein_eIF4E_[Bombyx_mori]

Location

Bomo_Chr22(+):2413602-2416910      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 4E      

Alternative Name

mRNA cap-binding protein

Location in the cell

Cytoplasmic   Reliability : 3.838

CDS

ATGGCTGGAAATACTACAGAAGAAGTAGAGGGGTCTACTACCACTGAAACGAAGACCAACAGTAACGCGGAGGTGCCCCCTGAATTTTTGATCAAGCACCCGTTACAAAACCAGTGGAGTCTCTGGTTTTACGACAATGACCGAAACAAAACATGGGAGGAGAATCTTATTGAGTTGACTACATTCGACACAGTTGAAGACTTTTGGAGATTGTACCATCATATTAAGCTACCGTCAGAACTTCGCCAAGGTCATGACTATGCAGTATTCAAGCAAGGCATTCGTCCTATGTGGGAAGACGATGCTAACAAGATGGGAGGAAGATGGCTTATCAGTCTTGAGAAAAAACAACGCTTTACTGATTTAGATAGGTTCTGGTTAGATGTGGTTCTTCTTTTAATTGGTGAAAATTTCGAGAATTCAGATGAGATTTGTGGTGCTGTTGTTAATGTCAGACCAAAAGTAGATAAAATTGCTATTTGGACAGCTGATGCAATGAAGCAGCATGCGACTATTGAAATTGGGAAAAAACTGAAAGAACAGCTAGGGATACACGGCAAGATTGGTTTCCAAGTACACAGAGACACAATGGTTAAGCATAGTTCTGCGACCAAGAATCTATACACTGTTTAG

Protein

MAGNTTEEVEGSTTTETKTNSNAEVPPEFLIKHPLQNQWSLWFYDNDRNKTWEENLIELTTFDTVEDFWRLYHHIKLPSELRQGHDYAVFKQGIRPMWEDDANKMGGRWLISLEKKQRFTDLDRFWLDVVLLLIGENFENSDEICGAVVNVRPKVDKIAIWTADAMKQHATIEIGKKLKEQLGIHGKIGFQVHRDTMVKHSSATKNLYTV

Description

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).

Subunit

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (By similarity). Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with CLOCK (By similarity). Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with LARP1. Interacts with METTL3 (By similarity). Interacts with RBM24; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex (By similarity).

Similarity

Belongs to the eukaryotic initiation factor 4E family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Initiation factor   Phosphoprotein   Protein biosynthesis   Reference proteome   RNA-binding   Translation regulation  

Feature

chain  Eukaryotic translation initiation factor 4E

Uniprot

Q1HPI1   H9JT12   A0A3S2L776   Q964Q9   A0A2A4J1X6   A0A194RBB2   + More
A0A194Q7W7   I4DIV4   A0A212EVY6   A0A0L7KXB8   F4X4J7   A0A195BDW1   A0A158NIK5   A0A151XFX1   A0A151JUN6   A0A151J2T1   A0A067QP74   E1ZYG8   E2BKQ9   A0A154NZK4   D6WJL4   A0A232F4T7   A0A2J7Q7I4   A0A0J7N7S4   A0A411G752   A0A2P8Y1J2   A0A2A3EFQ9   V9IJ38   A0A088AW55   A0A026W9Z0   A0A1Y1K7E4   A0A3L8DDP4   N6TAG4   A0A0M9A7G6   A0A151IJ30   T1IXQ5   J3JWY7   U5EUM7   A0A0M3TCE3   A0A1B6HUS2   A0A1B6DE09   A0A0A9X0Y9   A0A0K8TSA0   V4A1E3   A0A1B6ERR2   Q17JP2   Q17JP1   A0A0P4WMQ3   A0A0E9X8B5   A0A2R7VS18   A0A2Y9D418   B5DG04   A0A3B4DAX8   W5MSN2   B9EL09   A0A060VY39   A0A0P7WSQ5   D7REL4   A0A2U9CGI3   A9JT06   C1FY44   A0A1Z5KWR6   V9KN06   A0A2U9CCQ9   A0A0Q9WZF9   B8A6A1   A0A2R5LIK9   A0A444UN53   A0A3B3SAF5   B4MX95   A0A401PQS6   A0A3Q1FKS6   A0A1L8EIU2   A0A1L8EIG2   A0A1J1J7F9   A0A3B3WGS5   A0A087XAH6   A0A3B3VFU4   A0A3P9Q183   Q9N0T5   A0A2I4CRN8   A0A023EJP0   A0A3Q3KGT5   U6DU90   W8BCK9   A0A2P6KH27   A0A1A8GGZ9   A0A091ID53   A0A3P9Q1S7   A0A3P8YCK8   A0A0P8XVM0   A0A1L8EB67   C3Y029   A0A1A8FFF2   G3NYE6   A0A2R9CSB0   A0A3B3SAC9   A0A3B0JXP4   A0A3P8V793   I3M004  

Pubmed

19121390    11437917    26354079    22651552    22118469    26227816    + More
21719571    21347285    24845553    20798317    18362917    19820115    28648823    29403074    24508170    28004739    30249741    23537049    22516182    25401762    26823975    26369729    23254933    17510324    25613341    20566863    19878547    20433749    24755649    16191198    23594743    28528879    24402279    17994087    29240929    30297745    11913777    24945155    24495485    25069045    18563158    22722832    24487278   

EMBL

DQ443192    DQ443421    ABF51281.1    ABF51510.1    BABH01030746    RSAL01000108    + More
RVE47241.1    AF281654    ODYU01010467    AAK94897.1    SOQ55600.1    NWSH01003925    PCG65678.1    KQ460416    KPJ14907.1    KQ459324    KPJ01632.1    AK401222    BAM17844.1    AGBW02012108    OWR45631.1    JTDY01004841    KOB67686.1    GL888656    EGI58627.1    KQ976513    KYM82392.1    ADTU01016896    KQ982179    KYQ59284.1    KQ981733    KYN36548.1    KQ980336    KYN16486.1    KK853114    KDR11192.1    GL435215    EFN73765.1    GL448819    EFN83757.1    KQ434786    KZC05033.1    KQ971342    EFA04625.1    NNAY01000966    OXU25695.1    NEVH01017442    PNF24542.1    LBMM01008684    KMQ88700.1    MH365907    QBB01716.1    PYGN01001050    PSN38116.1    KZ288263    PBC30324.1    JR049929    AEY61128.1    KK107320    EZA52788.1    GEZM01093769    JAV56140.1    QOIP01000009    RLU18441.1    APGK01037209    KB740948    KB632348    ENN77264.1    ERL93182.1    KQ435727    KOX78026.1    KQ977412    KYN02907.1    JH431661    BT127755    AEE62717.1    GANO01003807    JAB56064.1    KR075864    ALE20583.1    GECU01029315    JAS78391.1    GEDC01020118    GEDC01013412    JAS17180.1    JAS23886.1    GBHO01029990    GBRD01011665    GDHC01011361    JAG13614.1    JAG54159.1    JAQ07268.1    GDAI01000580    JAI17023.1    KB202953    ESO87111.1    GECZ01029169    JAS40600.1    CH477231    EAT46933.1    EAT46932.1    GDRN01007367    JAI67949.1    GBXM01009743    JAH98834.1    KK854024    PTY09641.1    AAZO01007334    BT043563    ACH70678.1    AHAT01003979    BT056334    ACM08206.1    FR904332    CDQ59742.1    JARO02005466    KPP66741.1    HM051158    ADH59743.1    CP026257    AWP13982.1    BX927098    BC155151    AAI55152.1    DP001097    ACO88999.1    GFJQ02007562    JAV99407.1    JW867026    AFO99543.1    AWP13983.1    CH963876    KRF98552.1    GGLE01005236    MBY09362.1    SCEB01214206    RXM36605.1    EDW76928.1    BFAA01013763    GCB75471.1    GFDG01000286    JAV18513.1    GFDG01000287    JAV18512.1    CVRI01000075    CRL08365.1    AYCK01011211    AF257235    BC111272    GAPW01004346    GAPW01004345    JAC09252.1    HAAF01014713    CCP86535.1    GAMC01011802    JAB94753.1    MWRG01012060    PRD25635.1    HAEC01002226    SBQ70303.1    KL218441    KFP05295.1    CH902618    KPU78789.1    GFDG01002940    JAV15859.1    GG666477    EEN66395.1    HAEB01011603    SBQ58130.1    AJFE02104908    AJFE02104909    AJFE02104910    AJFE02104911    AJFE02104912    AJFE02104913    OUUW01000002    SPP77491.1    AGTP01041617   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000053268    UP000007151    + More
UP000037510    UP000007755    UP000078540    UP000005205    UP000075809    UP000078541    UP000078492    UP000027135    UP000000311    UP000008237    UP000076502    UP000007266    UP000215335    UP000235965    UP000036403    UP000245037    UP000242457    UP000005203    UP000053097    UP000279307    UP000019118    UP000030742    UP000053105    UP000078542    UP000030746    UP000008820    UP000087266    UP000261440    UP000018468    UP000193380    UP000034805    UP000192224    UP000246464    UP000000437    UP000007798    UP000261540    UP000288216    UP000257200    UP000183832    UP000261480    UP000028760    UP000261500    UP000242638    UP000009136    UP000192220    UP000261640    UP000054308    UP000265140    UP000007801    UP000001554    UP000007635    UP000240080    UP000268350    UP000265120    UP000005215   

PRIDE

Q1HPI1    H9JT12    D7REL4    Q9N0T5   

Pfam

PF01652   IF4E        + More
PF05699   Dimer_Tnp_hAT

Interpro

IPR001040   TIF_eIF_4E        + More
IPR019770   TIF_eIF_4E_CS       
IPR023398   TIF_eIF4e-like       
IPR012337   RNaseH-like_sf       
IPR008906   HATC_C_dom       

SUPFAM

SSF55418   SSF55418        + More
SSF53098   SSF53098       

Gene 3D

3.30.760.10    

ProteinModelPortal

Q1HPI1   H9JT12   A0A3S2L776   Q964Q9   A0A2A4J1X6   A0A194RBB2   + More
A0A194Q7W7   I4DIV4   A0A212EVY6   A0A0L7KXB8   F4X4J7   A0A195BDW1   A0A158NIK5   A0A151XFX1   A0A151JUN6   A0A151J2T1   A0A067QP74   E1ZYG8   E2BKQ9   A0A154NZK4   D6WJL4   A0A232F4T7   A0A2J7Q7I4   A0A0J7N7S4   A0A411G752   A0A2P8Y1J2   A0A2A3EFQ9   V9IJ38   A0A088AW55   A0A026W9Z0   A0A1Y1K7E4   A0A3L8DDP4   N6TAG4   A0A0M9A7G6   A0A151IJ30   T1IXQ5   J3JWY7   U5EUM7   A0A0M3TCE3   A0A1B6HUS2   A0A1B6DE09   A0A0A9X0Y9   A0A0K8TSA0   V4A1E3   A0A1B6ERR2   Q17JP2   Q17JP1   A0A0P4WMQ3   A0A0E9X8B5   A0A2R7VS18   A0A2Y9D418   B5DG04   A0A3B4DAX8   W5MSN2   B9EL09   A0A060VY39   A0A0P7WSQ5   D7REL4   A0A2U9CGI3   A9JT06   C1FY44   A0A1Z5KWR6   V9KN06   A0A2U9CCQ9   A0A0Q9WZF9   B8A6A1   A0A2R5LIK9   A0A444UN53   A0A3B3SAF5   B4MX95   A0A401PQS6   A0A3Q1FKS6   A0A1L8EIU2   A0A1L8EIG2   A0A1J1J7F9   A0A3B3WGS5   A0A087XAH6   A0A3B3VFU4   A0A3P9Q183   Q9N0T5   A0A2I4CRN8   A0A023EJP0   A0A3Q3KGT5   U6DU90   W8BCK9   A0A2P6KH27   A0A1A8GGZ9   A0A091ID53   A0A3P9Q1S7   A0A3P8YCK8   A0A0P8XVM0   A0A1L8EB67   C3Y029   A0A1A8FFF2   G3NYE6   A0A2R9CSB0   A0A3B3SAC9   A0A3B0JXP4   A0A3P8V793   I3M004  

PDB

4DUM     E-value=1.55114e-59,     Score=578

KEGG

732913    K03259 translation initiation factor 4E | (RefSeq) mRNA cap-binding protein eIF4E

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0003743   GO:0000340   GO:0016281   GO:0046983   GO:0048471   GO:0031370   GO:0019899   GO:0070491   GO:0006417   GO:0005845   GO:0000932   GO:0010494   GO:0005829   GO:0000082   GO:0001662   GO:0019827   GO:0033391   GO:0016442   GO:0045665   GO:0098978   GO:0045931   GO:0071549   GO:0098794   GO:0099578   GO:0017148   GO:0003723   GO:0006413   GO:0015074   GO:0030429   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

PANTHER

PTHR11960  

Subcellular location

Cytoplasm  
P-body  

Length:

210

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00023

Exp number, first 60 AAs:

0

Total prob of N-in:

0.10640

outside

1  -  210

 

 

Pi

227.791599

Theta

207.526761

Tajima's D

0.471467

CLR

0.391793

CSRT

0.500474976251187

Interpretation

Uncertain