Gene

KWMTBOMO12865

Pre Gene Modal

BGIBMGA012709

Annotation

akirin_protein_[Bombyx_mori]

Location

Bomo_Chr22(-):2380661-2386601      View in EpiBrowser

Full name

Akirin      

Alternative Name

Protein bhringi

Location in the cell

Nuclear   Reliability : 4.234

CDS

ATGGCGTGTGCTACATTAAAAAGAAATCTGGATTGGGAGTCTAAGGCGCAATTACCTACAAAGAGAAGAAGATGTTCACCATTTGCAGCAAGTCCAAGCACAAGTCCTGGGTTAAAAACATCAGAATCGAAACCATCTTCATTTGGAGAATCCGTTAGTGCACCTGTGAAAATTACCCCAGAACGCATGGCACAAGAGATTTATGATGAGATTAAACGACTGCATAGACGTGGACAGCTGCGCCTGGCCAACGGCTCTGCTGCATCATGCTCATCATCAAGTGGATCCGAAGGAGACTGTTCACCGCCTCATCAATCAGCTCATGGCCCACAACGTGCCCGCACTCGTGCACTATTCACTTTTAAACAGGTTCGTATGATCTGTGAGCGAATGCTCCATGATCAGGAGGTGGCTCTACGTGCTGAGTATGAGTCTGTACTCAGCACCAAGCTTGCTGAACAGTATGAAGCCTTTGTGAGGTTCAACCTGGATCAGGTGCAGCGCCGACCCCCGCCCAGCACGTGCATGTCGCTCGGTATGGACGCCGAACACATGCACCAGGACCTCGTACCCAGCTATCTGTCCTAA

Protein

MACATLKRNLDWESKAQLPTKRRRCSPFAASPSTSPGLKTSESKPSSFGESVSAPVKITPERMAQEIYDEIKRLHRRGQLRLANGSAASCSSSSGSEGDCSPPHQSAHGPQRARTRALFTFKQVRMICERMLHDQEVALRAEYESVLSTKLAEQYEAFVRFNLDQVQRRPPPSTCMSLGMDAEHMHQDLVPSYLS

Description

Required for embryonic development and for normal innate immune response. Effector of immune deficiency pathway (Imd) acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel). Not part of the Toll pathway (PubMed:18066067). NF-kappa-B factor Relish (Rel) cofactor that orchestrates NF-kappa-B factor Relish (Rel) transcriptional selectivity by recruiting the Osa-containing-SWI/SNF-like Brahma complex (BAP) through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes (PubMed:25180232).

Subunit

Interacts with dmap1 (PubMed:24947515). Interacts with bap60 and rel; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232). Interacts with bap55; interaction is immune stimulation-dependent (PubMed:25180232).

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

Similarity

Belongs to the akirin family.

Keywords

Complete proteome   Developmental protein   Immunity   Innate immunity   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  Akirin

Uniprot

H6WS69   H9JT47   S4NXV2   A0A2A4IWW2   A0A212EVV2   A0A194RCA2   + More
A0A194Q9G3   A0A0K8TNC4   U5EWM8   B0X0M8   A0A1J1IB17   T1DF49   T1E2E5   A0A1L8DCY5   T1E2G9   A0A182PIV6   A0A182WI31   A0A023EJ88   A0A1L3N235   A0A182Y884   A0A1L3N228   A0A182R6Q1   A0A182VLD0   A0A182L3Z9   A0A182X279   Q7QIE8   A0A182I6D9   A0A182H6N2   C3RX28   A0A182QLK0   A0A1L3N225   A0A182N7F5   A0A2M4CTL6   A0A2M4AHW6   A0A182FFJ8   A0A1I8MWN9   A0A2M3Z691   T1PBY3   A0A1Q3F078   A0A182J5N6   A0A1I8NMV6   A0A0L0CF21   B4KYP4   A0A1B0DFL2   B4HV59   B4QKD7   M9MRW4   Q9VS59   B4PK68   B3NFE2   Q2M142   B4ML70   B4LDW6   A0A0M4E8R9   Q16MV0   S4UAH5   A0A1L3N221   A0A0A1WHV1   A0A1A9WCW0   B3M5R2   A0A3B0J618   A0A1W4UNU3   A0A1A9VMU2   A0A1A9Z8W3   D3TSF1   A0A0M9A5Y4   W8BNC5   A0A034WPL1   A0A0C9QIA2   A0A0K8VQS4   A0A2A3EBB0   V9IJI1   A0A088AHT4   E5L9J4   A0A1A9Y9Y9   A0A1B0BQ76   A0A154PTI5   K7IUT5   A0A1B6L1T5   A0A1B6GEC8   A0A1B6I263   A0A0L7RIM6   A0A1B6JQA6   A0A067R299   A0A0C9QZ52   D6WLM5   A0A2P8XZD6   A0A0T6B914   A0A1B6DP15   B4J2H1   N6UJ91   A0A232FBL3   A0A1Y1JWR6   A0A1E1X1X1   A0A0L8IF12  

Pubmed

19121390    23622113    22118469    26354079    26369729    24330624    + More
24945155    25244985    20966253    12364791    14747013    17210077    26483478    19229557    25315136    26108605    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    18327897    18066067    25180232    24947515    17550304    15632085    17510324    25830018    18057021    20353571    24495485    25348373    20978910    20075255    24845553    18362917    19820115    29403074    23537049    28648823    28004739    28503490   

EMBL

JQ289152    AEZ56541.1    BABH01030749    BABH01030750    GAIX01012007    JAA80553.1    + More
NWSH01005788    PCG63956.1    AGBW02012108    OWR45628.1    KQ460416    KPJ14910.1    KQ459324    KPJ01635.1    GDAI01001711    JAI15892.1    GANO01000491    JAB59380.1    KU973619    DS232242    APH10051.1    EDS38270.1    CVRI01000042    CRK95633.1    GALA01000787    JAA94065.1    GALA01000794    JAA94058.1    GFDF01009761    JAV04323.1    GALA01000724    JAA94128.1    GAPW01004581    JAC09017.1    KU973610    APH10042.1    KU973605    KU973606    APH10038.1    KU973616    APH10048.1    KU973615    APH10047.1    KU973611    APH10043.1    KU973614    APH10046.1    KU973607    KU973612    KU973620    AAAB01008807    APH10040.1    EAA04195.4    APCN01003620    KU973613    APH10045.1    JXUM01027402    JXUM01027403    JXUM01027404    KQ560789    KXJ80878.1    EU637024    KU973617    ACF49499.1    APH10049.1    AXCN02000573    KU973608    APH10041.1    GGFL01004499    MBW68677.1    GGFK01007064    MBW40385.1    GGFM01003263    MBW24014.1    KA646194    AFP60823.1    GFDL01014085    JAV20960.1    JRES01000492    KNC30812.1    CH933809    EDW17758.1    AJVK01058809    CH480817    EDW50830.1    CM000363    CM002912    EDX09560.1    KMY98080.1    AE014296    ADV37495.1    ADV37496.1    ADV37497.1    AGB94206.1    AY095189    AAF50569.1    AAM12282.1    CM000159    EDW93748.1    CH954178    EDV50484.1    CH379069    EAL30734.1    CH963847    EDW73128.2    CH940647    EDW68989.1    CP012525    ALC43328.1    KU973618    CH477848    APH10050.1    EAT35663.1    JX193853    AGI44629.1    KU973621    APH10053.1    GBXI01016197    GBXI01009315    GBXI01004652    JAC98094.1    JAD04977.1    JAD09640.1    CH902618    EDV40696.1    KPU78698.1    KPU78699.1    OUUW01000002    SPP77175.1    CCAG010020666    EZ424353    ADD20629.1    KQ435727    KOX77905.1    GAMC01011684    JAB94871.1    GAKP01002705    JAC56247.1    GBYB01003254    JAG73021.1    GDHF01020519    GDHF01011374    JAI31795.1    JAI40940.1    KZ288310    PBC28582.1    JR050267    AEY61215.1    HQ383975    ADQ64468.1    JXJN01018483    KQ435119    KZC14744.1    AAZX01002635    GEBQ01022294    JAT17683.1    GECZ01011997    GECZ01008985    JAS57772.1    JAS60784.1    GECU01026693    GECU01025064    GECU01001999    GECU01000803    JAS81013.1    JAS82642.1    JAT05708.1    JAT06904.1    KQ414583    KOC70715.1    GECU01024818    GECU01006282    JAS82888.1    JAT01425.1    KK853069    KDR11818.1    GBYB01009079    JAG78846.1    KQ971343    EFA04133.1    PYGN01001127    PSN37365.1    LJIG01009065    KRT83825.1    GEDC01009888    JAS27410.1    CH916366    EDV97056.1    APGK01032729    KB740848    KB631868    ENN78702.1    ERL86828.1    NNAY01000550    OXU27727.1    GEZM01101887    GEZM01101886    JAV52230.1    GFAC01005925    JAT93263.1    KQ415861    KOG00018.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000002320    + More
UP000183832    UP000075885    UP000075920    UP000076408    UP000075900    UP000075903    UP000075882    UP000076407    UP000007062    UP000075840    UP000069940    UP000249989    UP000075886    UP000075884    UP000069272    UP000095301    UP000075880    UP000095300    UP000037069    UP000009192    UP000092462    UP000001292    UP000000304    UP000000803    UP000002282    UP000008711    UP000001819    UP000007798    UP000008792    UP000092553    UP000008820    UP000091820    UP000007801    UP000268350    UP000192221    UP000078200    UP000092445    UP000092444    UP000053105    UP000242457    UP000005203    UP000092443    UP000092460    UP000076502    UP000002358    UP000053825    UP000027135    UP000007266    UP000245037    UP000001070    UP000019118    UP000030742    UP000215335    UP000053454   

PRIDE

H6WS69    H9JT47    Q9VS59   

Interpro

IPR024132   Akirin       

ProteinModelPortal

H6WS69   H9JT47   S4NXV2   A0A2A4IWW2   A0A212EVV2   A0A194RCA2   + More
A0A194Q9G3   A0A0K8TNC4   U5EWM8   B0X0M8   A0A1J1IB17   T1DF49   T1E2E5   A0A1L8DCY5   T1E2G9   A0A182PIV6   A0A182WI31   A0A023EJ88   A0A1L3N235   A0A182Y884   A0A1L3N228   A0A182R6Q1   A0A182VLD0   A0A182L3Z9   A0A182X279   Q7QIE8   A0A182I6D9   A0A182H6N2   C3RX28   A0A182QLK0   A0A1L3N225   A0A182N7F5   A0A2M4CTL6   A0A2M4AHW6   A0A182FFJ8   A0A1I8MWN9   A0A2M3Z691   T1PBY3   A0A1Q3F078   A0A182J5N6   A0A1I8NMV6   A0A0L0CF21   B4KYP4   A0A1B0DFL2   B4HV59   B4QKD7   M9MRW4   Q9VS59   B4PK68   B3NFE2   Q2M142   B4ML70   B4LDW6   A0A0M4E8R9   Q16MV0   S4UAH5   A0A1L3N221   A0A0A1WHV1   A0A1A9WCW0   B3M5R2   A0A3B0J618   A0A1W4UNU3   A0A1A9VMU2   A0A1A9Z8W3   D3TSF1   A0A0M9A5Y4   W8BNC5   A0A034WPL1   A0A0C9QIA2   A0A0K8VQS4   A0A2A3EBB0   V9IJI1   A0A088AHT4   E5L9J4   A0A1A9Y9Y9   A0A1B0BQ76   A0A154PTI5   K7IUT5   A0A1B6L1T5   A0A1B6GEC8   A0A1B6I263   A0A0L7RIM6   A0A1B6JQA6   A0A067R299   A0A0C9QZ52   D6WLM5   A0A2P8XZD6   A0A0T6B914   A0A1B6DP15   B4J2H1   N6UJ91   A0A232FBL3   A0A1Y1JWR6   A0A1E1X1X1   A0A0L8IF12  

KEGG

100862827    no KO assigned | (RefSeq) akirin protein

GO

GO:0001228   GO:0050829   GO:0005719   GO:0003712   GO:0007526   GO:0045089   GO:0005700   GO:0045087   GO:0045088   GO:0005634   GO:0045944  

PANTHER

PTHR13293  

Subcellular location

Nucleus  

Length:

195

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.18840

outside

1  -  195

 

 

Pi

157.466322

Theta

169.024178

Tajima's D

-0.459202

CLR

0.421345

CSRT

0.250337483125844

Interpretation

Uncertain