Gene
KWMTBOMO12856
Pre Gene Modal
BGIBMGA012714
Annotation
Uncharacterized_protein_OBRU01_15168_[Operophtera_brumata]
Full name
Protein amnionless
Location in the cell
Extracellular Reliability : 1.895
Sequence
CDS
ATGTACACGAGCACTAGTTTGCTGTTGTTCTCGTCAATTGTCGCTATCGCATCAGCGGCTCTAGTGAAATGGGTGCCAAATGGGAGCTTCAACTTGCCTGCCAACTTCAAAGACAAGAAACTGCCGTGTTCAAAGCAAACTGTTGTGTTTCCTGATAGAATGACAGGGTCAGTGAAAATGCAGTCTGAGGAGAAAGTGAAAGAGCTTGTCTTGCCCGTGGATGGTGAGATTATTCTCGAAACCTTGATAGTTCTCGGTGAGGATCCAACAGAAACGAATTGCACAGAAGGTTACTCGTATTATATGGATCAGTCTATGTCTTCGTGGGCCCAAGCGGGCGTTTGGAGTTCTCTTCGATTCAATGAAGCCACGCCTGATTCTGAGAAGTTGCCCTGTGAAGGTGACGATGTCGAATTCCCGAATGCCAAATACACAGTGATACTGCCGGATTCAATGCAGTCTGTGCGCAGTTTAAAAGTTAGCGGCGAGACCTACACCACCGAGTCGTTTCTAAGCCGAGCTTCGGAATCTGAGGAGGAGCAAGCTTTTCAACTAAACAGCTTATTACAAACAGGAGTTAAAGTTTCTTCAAGGACTTGTCGTCACAAAAATGGTTGTCCGTGCCAGAAGTTTCCTTTGGAAATCGACTGCTCTTTGAAATATTGTCCGCAACCAAGCTGCTTGGCGCCAATCAAGCCGGACGGTTACTGCTGTAAGCAATGCGGAGGATACATTACATTTGAAATTGACGACGACTTCGATATGATAGCCTTCAATGAGCTAGTGGATAAAACTGTTCAGAGCTACGGGGGAAATGTTGTGTATCACATCGGTTTCGCGCCGGTCAAAGATTCTAGGACACTACAGCTTGTTGTTGTGGAAAAAGGAGCGTATACCGGAACTAGTGCTGAAATAGCTAATTATATTGATAAAACTATCGAGAAACATTGGTTTAAGAGTAGCAAGCTGGCGAAGATTAGCGGAAGTCCACTTGACAAAGCAAATTTGGGAGAGAAAATGTTTTTCTCAATGTTCTTTGCGGTCGCTTTAGTAATGGGAGCCATTTACTTATATTACTATAGATTACCTAAAATAGAATTTCCAGTAATAAACAGAGGCTCTAGACGGATGTTCAGCAGATTCCAAAGAAGAACAGACAGCGTGGTGTCGTTGACCCGAAGAGATTCGACCATTATAGGGGGCGGACGAACTGCGTTTAGGAACCCGATGTATGACTCAAGAAGGGGGCGTGTTGAGGTTGCAGAGTCAGTTGTTGAAGAATAA
Protein
MYTSTSLLLFSSIVAIASAALVKWVPNGSFNLPANFKDKKLPCSKQTVVFPDRMTGSVKMQSEEKVKELVLPVDGEIILETLIVLGEDPTETNCTEGYSYYMDQSMSSWAQAGVWSSLRFNEATPDSEKLPCEGDDVEFPNAKYTVILPDSMQSVRSLKVSGETYTTESFLSRASESEEEQAFQLNSLLQTGVKVSSRTCRHKNGCPCQKFPLEIDCSLKYCPQPSCLAPIKPDGYCCKQCGGYITFEIDDDFDMIAFNELVDKTVQSYGGNVVYHIGFAPVKDSRTLQLVVVEKGAYTGTSAEIANYIDKTIEKHWFKSSKLAKISGSPLDKANLGEKMFFSMFFAVALVMGAIYLYYYRLPKIEFPVINRGSRRMFSRFQRRTDSVVSLTRRDSTIIGGGRTAFRNPMYDSRRGRVEVAESVVEE
Summary
Description
Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity).
Necessary for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463). May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm.
Necessary for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463). May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm.
Subunit
Interacts with CUBN/cubilin.
Miscellaneous
The mutations described in PubMed:12590260 all affect the N-terminus of the protein; shorter isoforms produced from alternative transcription start sites might still fulfill a role in embryogenesis. This might explain the discrepancy with the embryonic lethality of null mutants in mice.
Keywords
3D-structure
Alternative promoter usage
Cell membrane
Coated pit
Complete proteome
Developmental protein
Direct protein sequencing
Disease mutation
Endosome
Glycoprotein
Membrane
Protein transport
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport
Feature
chain Protein amnionless
sequence variant In RH-MGA1; dbSNP:rs119478058.
sequence variant In RH-MGA1; dbSNP:rs119478058.
Uniprot
H9JT52
A0A0L7L551
A0A194Q7Z3
A0A2A4JM32
A0A2H1WYT1
A0A194RBC2
+ More
A0A1B6CBN0 A0A182JTP6 A0A1J1IBW9 A0A182WZT7 A0A1B6IRI4 A0A2C9GQY6 A0A182UN60 A7UVC0 A0A182WEX7 A0A1B6FU68 F7A691 A0A182MVE9 A0A369RXX7 A0A093PSX6 A0A087R599 A0A091NBA8 A0A091J3N5 A0A182MYT0 Q6GMB6 A0A093NMX8 A0A2P8YVP8 A0A2J7Q523 A0A218UEQ8 B3SA84 A0A0L0CDN4 A0A091IAI1 A0A182GFX6 A0A093ED96 A0A096NJV6 A0A093I595 Q17NN0 A0A182QM44 A0A091FYW5 A0A182JC96 A0A2I0TTY4 A0A091H0N3 A0A091V9A5 A0A2Y9NQW4 D3ZFK9 U3IVY9 A0A023EUT2 A0A3B3D8I5 A0A2Y9NK09 A0A091TK85 A0A452DX09 A0A2Y9T7K0 A0A0D9RCN3 A0A2U4CQC1 Q9BXJ7 A0A2K5HTI9 A0A091EGF4 A0A3L8SXJ6 A0A0A0AVW9 A0A1I8MIJ5 A0A2K5NC11 A0A3S1BTZ2 Q99JB7 J9JTK2 A0A2K6DCR4 A0A3M0JUV2 A0A2K6LN52 A0A091M782 A0A2I4CGU6 R0LFX1 A0A2R9AQL4 F7I7D2 F7I9N4 A0A2R8MMZ5 A0A091QTV6 A0A182FBC2 H2Q8Y4 A0A146PD76 B0X3N1 U3JJE6 A0A1B0FII0 A0A2J8QLR7 A0A091L2N4 A0A2J8SZK5 A0A2K5D7F9 A0A340X287 A0A2K5REQ8 A0A3P9HQ94 F1MQD9 A0A3Q3FPU2 H2LTV5 A0A3Q2P6U6 A0A1Q3FPW4 Q3T152 A0A3P9LGZ2
A0A1B6CBN0 A0A182JTP6 A0A1J1IBW9 A0A182WZT7 A0A1B6IRI4 A0A2C9GQY6 A0A182UN60 A7UVC0 A0A182WEX7 A0A1B6FU68 F7A691 A0A182MVE9 A0A369RXX7 A0A093PSX6 A0A087R599 A0A091NBA8 A0A091J3N5 A0A182MYT0 Q6GMB6 A0A093NMX8 A0A2P8YVP8 A0A2J7Q523 A0A218UEQ8 B3SA84 A0A0L0CDN4 A0A091IAI1 A0A182GFX6 A0A093ED96 A0A096NJV6 A0A093I595 Q17NN0 A0A182QM44 A0A091FYW5 A0A182JC96 A0A2I0TTY4 A0A091H0N3 A0A091V9A5 A0A2Y9NQW4 D3ZFK9 U3IVY9 A0A023EUT2 A0A3B3D8I5 A0A2Y9NK09 A0A091TK85 A0A452DX09 A0A2Y9T7K0 A0A0D9RCN3 A0A2U4CQC1 Q9BXJ7 A0A2K5HTI9 A0A091EGF4 A0A3L8SXJ6 A0A0A0AVW9 A0A1I8MIJ5 A0A2K5NC11 A0A3S1BTZ2 Q99JB7 J9JTK2 A0A2K6DCR4 A0A3M0JUV2 A0A2K6LN52 A0A091M782 A0A2I4CGU6 R0LFX1 A0A2R9AQL4 F7I7D2 F7I9N4 A0A2R8MMZ5 A0A091QTV6 A0A182FBC2 H2Q8Y4 A0A146PD76 B0X3N1 U3JJE6 A0A1B0FII0 A0A2J8QLR7 A0A091L2N4 A0A2J8SZK5 A0A2K5D7F9 A0A340X287 A0A2K5REQ8 A0A3P9HQ94 F1MQD9 A0A3Q3FPU2 H2LTV5 A0A3Q2P6U6 A0A1Q3FPW4 Q3T152 A0A3P9LGZ2
Pubmed
19121390
26227816
26354079
12364791
14747013
17210077
+ More
20431018 30042472 29403074 18719581 26108605 26483478 17510324 15057822 15632090 23749191 24945155 29451363 11279523 12508121 12975309 12590260 14576052 22631584 30282656 25315136 15489334 9851841 15342463 21183079 22722832 16136131 17554307 19393038
20431018 30042472 29403074 18719581 26108605 26483478 17510324 15057822 15632090 23749191 24945155 29451363 11279523 12508121 12975309 12590260 14576052 22631584 30282656 25315136 15489334 9851841 15342463 21183079 22722832 16136131 17554307 19393038
EMBL
BABH01030763
JTDY01002845
KOB70613.1
KQ459324
KPJ01643.1
NWSH01001131
+ More
PCG72462.1 ODYU01012113 SOQ58235.1 KQ460416 KPJ14917.1 GEDC01026435 JAS10863.1 CVRI01000047 CRK97728.1 GECU01018168 JAS89538.1 APCN01003309 AAAB01008986 EDO63297.1 GECZ01016002 JAS53767.1 AAMC01075696 AAMC01075697 AXCM01006675 NOWV01000139 RDD39309.1 KL669858 KFW77320.1 KL226108 KFM08653.1 KL380141 KFP86756.1 KK501363 KFP14320.1 BC074152 AAH74152.1 KL224603 KFW61522.1 PYGN01000334 PSN48330.1 NEVH01018372 PNF23689.1 MUZQ01000364 OWK52213.1 DS985260 EDV20393.1 JRES01000536 KNC30327.1 KL218472 KFP05629.1 JXUM01060631 KQ562111 KXJ76667.1 KL460545 KFV12466.1 AHZZ02032720 KK555391 KFV97869.1 CH477198 EAT48283.1 AXCN02001025 KL447555 KFO74853.1 KZ507224 PKU37259.1 KL516659 KFO88240.1 KL410729 KFQ98952.1 AABR07065586 AABR07065587 CH474034 EDL97480.1 ADON01080849 ADON01080850 ADON01080851 ADON01080852 ADON01080853 ADON01080854 ADON01080855 GAPW01001369 JAC12229.1 KK454952 KFQ75776.1 LWLT01000019 AQIB01045002 AF328788 AL117209 AY358468 KK718430 KFO56161.1 QUSF01000004 RLW10483.1 KL873269 KGL98111.1 RQTK01000015 RUS91274.1 AF320615 AF320616 AF320619 BC087954 ABLF02031630 QRBI01000152 RMB98706.1 KK521562 KFP66607.1 KB743197 EOB00435.1 AJFE02020022 AJFE02020023 KK681622 KFQ12829.1 AACZ04029300 GCES01144766 JAQ41556.1 DS232318 EDS39922.1 AGTO01000282 CCAG010003108 NBAG03000028 PNI97180.1 KL297664 KFP50694.1 NDHI03003534 PNJ26201.1 GFDL01005410 JAV29635.1 BC102126 AAI02127.1
PCG72462.1 ODYU01012113 SOQ58235.1 KQ460416 KPJ14917.1 GEDC01026435 JAS10863.1 CVRI01000047 CRK97728.1 GECU01018168 JAS89538.1 APCN01003309 AAAB01008986 EDO63297.1 GECZ01016002 JAS53767.1 AAMC01075696 AAMC01075697 AXCM01006675 NOWV01000139 RDD39309.1 KL669858 KFW77320.1 KL226108 KFM08653.1 KL380141 KFP86756.1 KK501363 KFP14320.1 BC074152 AAH74152.1 KL224603 KFW61522.1 PYGN01000334 PSN48330.1 NEVH01018372 PNF23689.1 MUZQ01000364 OWK52213.1 DS985260 EDV20393.1 JRES01000536 KNC30327.1 KL218472 KFP05629.1 JXUM01060631 KQ562111 KXJ76667.1 KL460545 KFV12466.1 AHZZ02032720 KK555391 KFV97869.1 CH477198 EAT48283.1 AXCN02001025 KL447555 KFO74853.1 KZ507224 PKU37259.1 KL516659 KFO88240.1 KL410729 KFQ98952.1 AABR07065586 AABR07065587 CH474034 EDL97480.1 ADON01080849 ADON01080850 ADON01080851 ADON01080852 ADON01080853 ADON01080854 ADON01080855 GAPW01001369 JAC12229.1 KK454952 KFQ75776.1 LWLT01000019 AQIB01045002 AF328788 AL117209 AY358468 KK718430 KFO56161.1 QUSF01000004 RLW10483.1 KL873269 KGL98111.1 RQTK01000015 RUS91274.1 AF320615 AF320616 AF320619 BC087954 ABLF02031630 QRBI01000152 RMB98706.1 KK521562 KFP66607.1 KB743197 EOB00435.1 AJFE02020022 AJFE02020023 KK681622 KFQ12829.1 AACZ04029300 GCES01144766 JAQ41556.1 DS232318 EDS39922.1 AGTO01000282 CCAG010003108 NBAG03000028 PNI97180.1 KL297664 KFP50694.1 NDHI03003534 PNJ26201.1 GFDL01005410 JAV29635.1 BC102126 AAI02127.1
Proteomes
UP000005204
UP000037510
UP000053268
UP000218220
UP000053240
UP000075881
+ More
UP000183832 UP000076407 UP000075840 UP000075903 UP000007062 UP000075920 UP000008143 UP000075883 UP000253843 UP000053258 UP000053286 UP000053119 UP000075884 UP000054081 UP000245037 UP000235965 UP000197619 UP000009022 UP000037069 UP000054308 UP000069940 UP000249989 UP000028761 UP000008820 UP000075886 UP000053760 UP000075880 UP000053283 UP000248483 UP000002494 UP000016666 UP000261560 UP000291000 UP000248484 UP000029965 UP000245320 UP000005640 UP000233080 UP000052976 UP000276834 UP000053858 UP000095301 UP000233060 UP000271974 UP000000589 UP000007819 UP000233120 UP000269221 UP000233180 UP000192220 UP000240080 UP000008225 UP000069272 UP000002277 UP000002320 UP000016665 UP000092444 UP000233020 UP000265300 UP000233040 UP000265200 UP000009136 UP000264800 UP000001038 UP000265000 UP000265180
UP000183832 UP000076407 UP000075840 UP000075903 UP000007062 UP000075920 UP000008143 UP000075883 UP000253843 UP000053258 UP000053286 UP000053119 UP000075884 UP000054081 UP000245037 UP000235965 UP000197619 UP000009022 UP000037069 UP000054308 UP000069940 UP000249989 UP000028761 UP000008820 UP000075886 UP000053760 UP000075880 UP000053283 UP000248483 UP000002494 UP000016666 UP000261560 UP000291000 UP000248484 UP000029965 UP000245320 UP000005640 UP000233080 UP000052976 UP000276834 UP000053858 UP000095301 UP000233060 UP000271974 UP000000589 UP000007819 UP000233120 UP000269221 UP000233180 UP000192220 UP000240080 UP000008225 UP000069272 UP000002277 UP000002320 UP000016665 UP000092444 UP000233020 UP000265300 UP000233040 UP000265200 UP000009136 UP000264800 UP000001038 UP000265000 UP000265180
ProteinModelPortal
H9JT52
A0A0L7L551
A0A194Q7Z3
A0A2A4JM32
A0A2H1WYT1
A0A194RBC2
+ More
A0A1B6CBN0 A0A182JTP6 A0A1J1IBW9 A0A182WZT7 A0A1B6IRI4 A0A2C9GQY6 A0A182UN60 A7UVC0 A0A182WEX7 A0A1B6FU68 F7A691 A0A182MVE9 A0A369RXX7 A0A093PSX6 A0A087R599 A0A091NBA8 A0A091J3N5 A0A182MYT0 Q6GMB6 A0A093NMX8 A0A2P8YVP8 A0A2J7Q523 A0A218UEQ8 B3SA84 A0A0L0CDN4 A0A091IAI1 A0A182GFX6 A0A093ED96 A0A096NJV6 A0A093I595 Q17NN0 A0A182QM44 A0A091FYW5 A0A182JC96 A0A2I0TTY4 A0A091H0N3 A0A091V9A5 A0A2Y9NQW4 D3ZFK9 U3IVY9 A0A023EUT2 A0A3B3D8I5 A0A2Y9NK09 A0A091TK85 A0A452DX09 A0A2Y9T7K0 A0A0D9RCN3 A0A2U4CQC1 Q9BXJ7 A0A2K5HTI9 A0A091EGF4 A0A3L8SXJ6 A0A0A0AVW9 A0A1I8MIJ5 A0A2K5NC11 A0A3S1BTZ2 Q99JB7 J9JTK2 A0A2K6DCR4 A0A3M0JUV2 A0A2K6LN52 A0A091M782 A0A2I4CGU6 R0LFX1 A0A2R9AQL4 F7I7D2 F7I9N4 A0A2R8MMZ5 A0A091QTV6 A0A182FBC2 H2Q8Y4 A0A146PD76 B0X3N1 U3JJE6 A0A1B0FII0 A0A2J8QLR7 A0A091L2N4 A0A2J8SZK5 A0A2K5D7F9 A0A340X287 A0A2K5REQ8 A0A3P9HQ94 F1MQD9 A0A3Q3FPU2 H2LTV5 A0A3Q2P6U6 A0A1Q3FPW4 Q3T152 A0A3P9LGZ2
A0A1B6CBN0 A0A182JTP6 A0A1J1IBW9 A0A182WZT7 A0A1B6IRI4 A0A2C9GQY6 A0A182UN60 A7UVC0 A0A182WEX7 A0A1B6FU68 F7A691 A0A182MVE9 A0A369RXX7 A0A093PSX6 A0A087R599 A0A091NBA8 A0A091J3N5 A0A182MYT0 Q6GMB6 A0A093NMX8 A0A2P8YVP8 A0A2J7Q523 A0A218UEQ8 B3SA84 A0A0L0CDN4 A0A091IAI1 A0A182GFX6 A0A093ED96 A0A096NJV6 A0A093I595 Q17NN0 A0A182QM44 A0A091FYW5 A0A182JC96 A0A2I0TTY4 A0A091H0N3 A0A091V9A5 A0A2Y9NQW4 D3ZFK9 U3IVY9 A0A023EUT2 A0A3B3D8I5 A0A2Y9NK09 A0A091TK85 A0A452DX09 A0A2Y9T7K0 A0A0D9RCN3 A0A2U4CQC1 Q9BXJ7 A0A2K5HTI9 A0A091EGF4 A0A3L8SXJ6 A0A0A0AVW9 A0A1I8MIJ5 A0A2K5NC11 A0A3S1BTZ2 Q99JB7 J9JTK2 A0A2K6DCR4 A0A3M0JUV2 A0A2K6LN52 A0A091M782 A0A2I4CGU6 R0LFX1 A0A2R9AQL4 F7I7D2 F7I9N4 A0A2R8MMZ5 A0A091QTV6 A0A182FBC2 H2Q8Y4 A0A146PD76 B0X3N1 U3JJE6 A0A1B0FII0 A0A2J8QLR7 A0A091L2N4 A0A2J8SZK5 A0A2K5D7F9 A0A340X287 A0A2K5REQ8 A0A3P9HQ94 F1MQD9 A0A3Q3FPU2 H2LTV5 A0A3Q2P6U6 A0A1Q3FPW4 Q3T152 A0A3P9LGZ2
PDB
6GJE
E-value=1.62208e-22,
Score=262
Ontologies
GO
Topology
Subcellular location
Apical cell membrane
Cell membrane
Endosome
Membrane
Coated pit
Cell membrane
Endosome
Membrane
Coated pit
SignalP
Position: 1 - 19,
Likelihood: 0.887010
Length:
427
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
36.85846
Exp number, first 60 AAs:
15.41181
Total prob of N-in:
0.73366
POSSIBLE N-term signal
sequence
inside
1 - 6
TMhelix
7 - 26
outside
27 - 339
TMhelix
340 - 362
inside
363 - 427
Population Genetic Test Statistics
Pi
129.025939
Theta
156.03929
Tajima's D
-0.274236
CLR
38.735752
CSRT
0.296235188240588
Interpretation
Uncertain
