Gene

KWMTBOMO12846

Pre Gene Modal

BGIBMGA012754

Annotation

PREDICTED:_palmitoyltransferase_ZDHHC18_[Amyelois_transitella]

Location

Bomo_Chr22(+):1551879-1556379      View in EpiBrowser

Full name

Palmitoyltransferase       + More
Palmitoyltransferase app      

Alternative Name

Protein approximated

Location in the cell

PlasmaMembrane   Reliability : 3.874

CDS

ATGGCGTCGCGGCGCGTGACGCGCAAGTGGGAAGTGTTCGCGGGGCGAAACCGGTTCTGGTGCGACGGGCGGCTCATGACTGCACCGCACCCCGGCGTCTTCCTGCTCACACTGGCGCTCATCTGCGGCACGTGCGCGCTGCACTTCGCGTTCGACTGTCCCTTCCTGGCCGTGCGCGTGTCGGCCGCCGTGCCCGCCGTGGGCGCCGCGCTGTTCGTGCTGACGCTGGCGGCGCTGCTGCGGACCGCGCTGTCCGACCCGGGCATCATCCCGCGCGCGGCCACGGCCGAGGCGGCGGCCCTGGAGGCTGCCGAAGCGGGTCGGCCTCCGCCGCGCGCGCGGGAGGTGCTCGTGCGAGGCCGCCCCGTCAAGCTCAAGTACTGCTTCACCTGTAAGATGTTCCGACCTCCGCGCGCGTCGCACTGCTCACTCTGCGACAACTGCGTGGACCGGTTCGACCATCACTGTCCGTGGGTGGGGAACTGCGTGGGCAAGCGCAACTACCGGTCGTTCTACACGTTCGTGGTGTCGCTGTCGTTCCTGGCGGTGTTCGTGTTCGCGTGCGCCGTGACGCACCTGGCGCTGGCGGCGCGGGGCGCGGGCGTGGCGGCGGCGCTGCACGCGTCCCCCGCCTCGGCGCTGGTGGCCGCCGTGTGCTTCCTGTCCGTGTGGTCCGTGCTGGGGCTCGCCGGCTTCCACACGTACCTCGCCTCCACCGACCAGACCACCAACGAGGACATTAAAGGTTCATTTTCGAGTCGGCGCGGCGTGTCCAACCCGAACCCGTACTCGCGAGGTAACGCCTGCGCCAACTGCTGGTACGTGCTGTGCGGTCCGCTGGCGCCCAGCCTCATCGACCGGCGCGGCGTGTTCACGATCGACGTGAAGGACGAGCTGCCGCCGAGCTTCGTCCGCGCGCTGGGAGCCGTGACCGTGGCCCCGGCGCCGGGCGGCGGCGCGGAGCCGGCCCGCCACGCCTACATGAACAGGTCGCTGGACGTGGAGCCGGCGGGGGCGGGCGCGGGGGCGGGGGCGGGCGCGGGGGCGGGGGGCGCGGTGGCGCTGAGCGCGTCCCGGCTGCGGCTGCTGCACGACACGACCATGATCGACGCGGCGCTGGACCTGGACGAGCCGGAGCCGCCGCCGCACCTGTCCGTGGCGCTGCCGCCCCTCCCCCCGCACCCGCTCACCGACTGCAACTGA

Protein

MASRRVTRKWEVFAGRNRFWCDGRLMTAPHPGVFLLTLALICGTCALHFAFDCPFLAVRVSAAVPAVGAALFVLTLAALLRTALSDPGIIPRAATAEAAALEAAEAGRPPPRAREVLVRGRPVKLKYCFTCKMFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRSFYTFVVSLSFLAVFVFACAVTHLALAARGAGVAAALHASPASALVAAVCFLSVWSVLGLAGFHTYLASTDQTTNEDIKGSFSSRRGVSNPNPYSRGNACANCWYVLCGPLAPSLIDRRGVFTIDVKDELPPSFVRALGAVTVAPAPGGGAEPARHAYMNRSLDVEPAGAGAGAGAGAGAGGAVALSASRLRLLHDTTMIDAALDLDEPEPPPHLSVALPPLPPHPLTDCN

Description

Palmitoylates Dlish which is required for the apical cell cortex localization, total cellular level and full activity of dachs.

Catalytic Activity

hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]

Subunit

Interacts with Dlish (via N-terminus including SH3 domain 1); this leads to palmitoylation of Dlish by app. Interacts with ft; this is likely to interfere with the interaction between app and Dlish, reducing the ability of app to palmitoylate Dlish and tether it to the apical cell cortex.

Similarity

Belongs to the DHHC palmitoyltransferase family.
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Belongs to the actin family.

Keywords

Acyltransferase   Alternative splicing   Cell membrane   Complete proteome   Endoplasmic reticulum   Lipoprotein   Membrane   Palmitate   Reference proteome   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Palmitoyltransferase app
splice variant  In isoform S.

Uniprot

A0A2H1V743   A0A3S2NK73   A0A212FI60   D6WMN7   A0A0T6B0T6   T1DPQ6   + More
A0A0N8P0N9   A0A182S9E3   A0A1I8MH71   A0A1I8MH67   A0A0R3P3F1   A0A0R1DXL5   A0A0Q5U6K8   A2VEY9-4   A2VEY9-3   A0A0J9UJS1   Q6NLJ6   A0A182GGI1   A0A0K8VB96   A0A1Q3G1M0   A0A1Y1L9P1   A0A1Q3G1S1   A0A2M3Z709   A0A1J1IZW7   A0A1Q3G1K9   A0A1Q3G1V4   A0A1Q3G1S9   A0A1Q3G1R9   A0A1Q3G1L2   A0A0J9RV84   A0A1Q3G1H7   A0A1Q3G1N8   A0A1Q3G1E5   A0A2M4AKJ3   T1E917   A0A2M3Z4A0   A0A1Y1L793   A0A0A1XP17   A0A0A1WSW5   A0A034WAW4   A0A0P8XSI6   A0A0L7QT25   W8ANY2   B4MLG2   A0A067QNT6   A0A0Q9WI55   A0A1W4UV67   A0A1I8QB68   A0A1I8MH70   A0A3B0J8S2   A0A1S4EYN0   A0A0R1E2F2   Q17LD8   A0A0Q5UAV8   B4J344   A0A2M4CTD3   A0A023EUZ5   A0A0A1XGZ5   A0A0J9RTU2   Q2M0R3   B3M7U3   A2VEY9   A0A2M4BEX1   A0A0A1WQD9   E0W385   A0A0K8V2I3   A0A0K8TYX9   A0A2M4BE79   B4LFF0   A0A1W4UTH4   B4QR78   A0A0J9RU84   Q9VTV6   B4KZZ3   A0A3B0J7V9   B3NH86   B4PGB3   V9I969   E2BKR2   A0A3L8DFQ4   A0A026W9J6   A0A084W9L5   D0QWS3   A0A453YJN4   F5HLQ3   A0A1B6CPV3   A0A0L0BUZ1   A0A151WSA0   F4X279   B4HFK6   A0A336KRX4   E2A947   A0A151INJ4   A0A182YFL5   V9IAI1   A0A182FCF7   A0A182J3X3   A0A2A3EF37   W5JTX3   A0A182QCH5  

EC Number

2.3.1.225

Pubmed

22118469    18362917    19820115    17994087    25315136    15632085    + More
17550304    10731132    12537572    18804377    18719403    27692068    27824307    22936249    26483478    28004739    25830018    25348373    24495485    24845553    17510324    18057021    24945155    23185243    20566863    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20798317    30249741    24508170    24438588    19859648    12364791    14747013    17210077    26108605    21719571    25244985    20920257    23761445   

EMBL

ODYU01000773    SOQ36074.1    RSAL01000015    RVE53071.1    AGBW02008428    OWR53424.1    + More
KQ971343    EFA04303.2    LJIG01016404    KRT80702.1    GAMD01001730    JAA99860.1    CH902618    KPU77652.1    CH379069    KRT07714.1    CM000159    KRK01733.1    CH954178    KQS43836.1    AE014296    BT030308    ABN49447.1    CM002912    KMY99200.1    BT012335    AAS77460.1    JXUM01011106    JXUM01011107    JXUM01011108    JXUM01011109    JXUM01011110    JXUM01011111    JXUM01011112    JXUM01011113    JXUM01011114    JXUM01011115    GDHF01026100    GDHF01017497    GDHF01016168    JAI26214.1    JAI34817.1    JAI36146.1    GFDL01001375    JAV33670.1    GEZM01062665    JAV69551.1    GFDL01001356    JAV33689.1    GGFM01003556    MBW24307.1    CVRI01000063    CRL04718.1    GFDL01001353    JAV33692.1    GFDL01001316    JAV33729.1    GFDL01001346    JAV33699.1    GFDL01001339    JAV33706.1    GFDL01001374    JAV33671.1    KMY99199.1    GFDL01001387    JAV33658.1    GFDL01001359    JAV33686.1    GFDL01001421    JAV33624.1    GGFK01007931    MBW41252.1    GAMD01001727    JAA99863.1    GGFM01002600    MBW23351.1    GEZM01062663    JAV69553.1    GBXI01001662    JAD12630.1    GBXI01012779    JAD01513.1    GAKP01008005    GAKP01008004    GAKP01008003    GAKP01008002    JAC50948.1    KPU77654.1    KQ414755    KOC61792.1    GAMC01016090    JAB90465.1    CH963847    EDW72818.2    KK853114    KDR11201.1    CH940647    KRF84264.1    OUUW01000002    SPP76282.1    KRK01732.1    CH477216    EAT47524.1    KQS43837.1    CH916366    EDV96115.1    GGFL01003910    MBW68088.1    GAPW01000328    JAC13270.1    GBXI01017124    GBXI01004065    JAC97167.1    JAD10227.1    KMY99201.1    EAL30867.3    EDV38816.2    GGFJ01002227    MBW51368.1    GBXI01013028    JAD01264.1    DS235882    EEB20091.1    GDHF01019258    GDHF01005678    JAI33056.1    JAI46636.1    GDHF01032828    GDHF01024048    JAI19486.1    JAI28266.1    GGFJ01002218    MBW51359.1    EDW69248.1    KRF84263.1    CM000363    EDX10208.1    KMY99197.1    AAF49939.3    CH933809    EDW18005.2    SPP76283.1    EDV51543.2    EDW94277.2    JR037217    AEY57643.1    GL448819    EFN83760.1    QOIP01000009    RLU19022.1    KK107320    EZA52782.1    ATLV01021831    KE525324    KFB46909.1    FJ821035    ACN94781.1    APCN01002922    APCN01002923    AAAB01008900    EGK97214.1    GEDC01021894    JAS15404.1    JRES01001294    KNC23857.1    KQ982779    KYQ50736.1    GL888565    EGI59495.1    CH480815    EDW41237.1    UFQS01000784    UFQT01000784    SSX06868.1    SSX27212.1    GL437711    EFN70032.1    KQ976932    KYN07042.1    JR037216    AEY57642.1    KZ288263    PBC30328.1    ADMH02000391    ETN66738.1    AXCN02000912   

Proteomes

UP000283053    UP000007151    UP000007266    UP000007801    UP000075901    UP000095301    + More
UP000001819    UP000002282    UP000008711    UP000000803    UP000069940    UP000183832    UP000053825    UP000007798    UP000027135    UP000008792    UP000192221    UP000095300    UP000268350    UP000008820    UP000001070    UP000009046    UP000000304    UP000009192    UP000008237    UP000279307    UP000053097    UP000030765    UP000075840    UP000007062    UP000037069    UP000075809    UP000007755    UP000001292    UP000000311    UP000078542    UP000076408    UP000069272    UP000075880    UP000242457    UP000000673    UP000075886   

PRIDE

A2VEY9    Q6NLJ6    Q9VTV6   

Pfam

PF01529   DHHC        + More
PF00022   Actin

Interpro

IPR001594   Palmitoyltrfase_DHHC        + More
IPR004000   Actin       
IPR020902   Actin/actin-like_CS       
IPR015623   Arp3       

ProteinModelPortal

A0A2H1V743   A0A3S2NK73   A0A212FI60   D6WMN7   A0A0T6B0T6   T1DPQ6   + More
A0A0N8P0N9   A0A182S9E3   A0A1I8MH71   A0A1I8MH67   A0A0R3P3F1   A0A0R1DXL5   A0A0Q5U6K8   A2VEY9-4   A2VEY9-3   A0A0J9UJS1   Q6NLJ6   A0A182GGI1   A0A0K8VB96   A0A1Q3G1M0   A0A1Y1L9P1   A0A1Q3G1S1   A0A2M3Z709   A0A1J1IZW7   A0A1Q3G1K9   A0A1Q3G1V4   A0A1Q3G1S9   A0A1Q3G1R9   A0A1Q3G1L2   A0A0J9RV84   A0A1Q3G1H7   A0A1Q3G1N8   A0A1Q3G1E5   A0A2M4AKJ3   T1E917   A0A2M3Z4A0   A0A1Y1L793   A0A0A1XP17   A0A0A1WSW5   A0A034WAW4   A0A0P8XSI6   A0A0L7QT25   W8ANY2   B4MLG2   A0A067QNT6   A0A0Q9WI55   A0A1W4UV67   A0A1I8QB68   A0A1I8MH70   A0A3B0J8S2   A0A1S4EYN0   A0A0R1E2F2   Q17LD8   A0A0Q5UAV8   B4J344   A0A2M4CTD3   A0A023EUZ5   A0A0A1XGZ5   A0A0J9RTU2   Q2M0R3   B3M7U3   A2VEY9   A0A2M4BEX1   A0A0A1WQD9   E0W385   A0A0K8V2I3   A0A0K8TYX9   A0A2M4BE79   B4LFF0   A0A1W4UTH4   B4QR78   A0A0J9RU84   Q9VTV6   B4KZZ3   A0A3B0J7V9   B3NH86   B4PGB3   V9I969   E2BKR2   A0A3L8DFQ4   A0A026W9J6   A0A084W9L5   D0QWS3   A0A453YJN4   F5HLQ3   A0A1B6CPV3   A0A0L0BUZ1   A0A151WSA0   F4X279   B4HFK6   A0A336KRX4   E2A947   A0A151INJ4   A0A182YFL5   V9IAI1   A0A182FCF7   A0A182J3X3   A0A2A3EF37   W5JTX3   A0A182QCH5  

PDB

6BML     E-value=1.41828e-12,     Score=176

KEGG

101745665    K16675 palmitoyltransferase ZDHHC9/14/18 [EC:2.3.1.225] | (RefSeq) palmitoyltransferase ZDHHC18-like

PATHWAY

04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0019706   GO:0016021   GO:0005794   GO:0018230   GO:0005783   GO:0006612   GO:0045179   GO:0005789   GO:0016324   GO:0048104   GO:0018345   GO:0001737   GO:0007389   GO:0016491   GO:0005885   GO:0034314   GO:0005524   GO:0008270   GO:0006457   GO:0006950   GO:0051082   GO:0015074   GO:0030429   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

PANTHER

PTHR11937:SF175   PTHR11937  

Subcellular location

Endoplasmic reticulum membrane  
Apical cell membrane  

Length:

400

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

96.64138

Exp number, first 60 AAs:

22.81608

Total prob of N-in:

0.99883

POSSIBLE N-term signal

sequence

inside

1  -  31

TMhelix

32  -  51

outside

52  -  60

TMhelix

61  -  80

inside

81  -  173

TMhelix

174  -  196

outside

197  -  210

TMhelix

211  -  233

inside

234  -  400

 

 

Pi

219.556349

Theta

185.014064

Tajima's D

0.688159

CLR

0.002844

CSRT

0.569821508924554

Interpretation

Uncertain