Gene

KWMTBOMO12794  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007211

Annotation

PREDICTED:_uncharacterized_protein_LOC106129078_[Amyelois_transitella]

Location

Bomo_Chr21(+):14643365-14644414      View in EpiBrowser

Full name

Pyruvate dehydrogenase E1 component subunit beta       + More
Queuosine salvage protein      

Location in the cell

Mitochondrial   Reliability : 3.328

CDS

ATGTTGAATTCAATTCAGAATTCCGTAAAATATTTACGGTGGATAAACATTAAAACTACACTGAGGGGGGTAACACCGAAACGTGTACCAAATATTATTGCTAATCTTCCAAAAGAAAAAAATGAATTATCCGCTACGCACAAATTATTATTTTCACCGCGTACTGTTGGTCTTGAGATTACAGAAAAACCTCAAATCAGCCGAGTAAAACAAGACCCAATCCCTTATGTACCTATACTCAATCCTCGATCCATTTTGCCTCTTGTGGAAGATTGGGGTAAGGGCGAGATTGGTCTACCTTCACTTAAACAGGAGGAAATCCAAGCAGCCAGATTAATTGTGATTAGAAGGAAAAAGATGAAGAAACATCAAAGGAGGAAGCTTTGGAAGAGGATGAGGCATCGCTGGGCCAGGGTTAAGCAACGTCGACGTCAAATCAAAGAAAAAAAGTTTCAAAATGAACTTCTAGCTCTTGTGCAGAACGCAAATGAGTTCTCCGCAGAAAAATATGTTGCGGAGAAGATTCAAAAAGCGAACTACACCCCTATACCAACTCGCTGGAGACACAAGAGACTCCCGGAGTTCATTATACGTCAACTGCTTGGGATTGACAAGAAAATCAATTACAAACATACTGATACATACAAAGCTTAA

Protein

MLNSIQNSVKYLRWINIKTTLRGVTPKRVPNIIANLPKEKNELSATHKLLFSPRTVGLEITEKPQISRVKQDPIPYVPILNPRSILPLVEDWGKGEIGLPSLKQEEIQAARLIVIRRKKMKKHQRRKLWKRMRHRWARVKQRRRQIKEKKFQNELLALVQNANEFSAEKYVAEKIQKANYTPIPTRWRHKRLPEFIIRQLLGIDKKINYKHTDTYKA

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Involved in salvaging queuosine.

Catalytic Activity

[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2

Cofactor

thiamine diphosphate

Similarity

Belongs to the queuosine salvage protein family.

Uniprot

H9JCG6   A0A1E1VZP6   A0A3S2L6M1   S4NX15   A0A2A4JHD1   A0A2W1BGV2   + More
A0A194QHN1   A0A194RM54   A0A212EVT2   A0A0L7LT66   A0A1Q3FIS9   B0WJC6   A0A023EJY7   Q1HRL4   A0A182YJ86   A0A182K909   A0A182GZ96   A0A182ST98   A0A023EIG6   A0A182WLA3   A0A1I8Q9Y4   A0A182RZ05   W5J775   T1E7K7   A0A2M4ASY4   A0A182FHK4   A0A2M4BYC8   A0A2M4ASZ9   A0A336LR08   A0A182MWR5   A0A182R050   A0A182NJF2   A0A0P4VMP4   A0A226D0A8   E2C3F2   A0A195EZ90   A0A0L7RCZ5   A0A0N0U7F4  

EC Number

1.2.4.1

Pubmed

19121390    23622113    28756777    26354079    22118469    26227816    + More
24945155    17204158    25244985    26483478    20920257    23761445    27129103    20798317   

EMBL

BABH01031654    BABH01031655    GDQN01010923    JAT80131.1    RSAL01000117    RVE46815.1    + More
GAIX01012342    JAA80218.1    NWSH01001396    PCG71381.1    KZ150141    PZC72945.1    KQ458981    KPJ04445.1    KQ459995    KPJ18514.1    AGBW02012143    OWR45571.1    JTDY01000175    KOB78436.1    GFDL01007621    JAV27424.1    DS231958    EDS29061.1    GAPW01004176    JAC09422.1    DQ440080    ABF18113.1    JXUM01099084    JXUM01099085    JXUM01099086    KQ564468    KXJ72228.1    GAPW01004872    JAC08726.1    ADMH02002096    ETN59243.1    GAMD01002947    JAA98643.1    GGFK01010570    MBW43891.1    GGFJ01008919    MBW58060.1    GGFK01010569    MBW43890.1    UFQT01000045    SSX18817.1    AXCM01003810    AXCN02000446    GDKW01002872    JAI53723.1    LNIX01000042    OXA39002.1    GL452320    EFN77490.1    KQ981905    KYN33446.1    KQ414615    KOC68689.1    KQ435711    KOX79602.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    + More
UP000037510    UP000002320    UP000076408    UP000075881    UP000069940    UP000249989    UP000075901    UP000075920    UP000095300    UP000075900    UP000000673    UP000069272    UP000075883    UP000075886    UP000075884    UP000198287    UP000008237    UP000078541    UP000053825    UP000053105   

PRIDE

H9JCG6   

Pfam

PF08213   DUF1713        + More
PF00675   Peptidase_M16
PF02779   Transket_pyr
PF10343   Q_salvage

Interpro

IPR013177   DUF1713        + More
IPR011249   Metalloenz_LuxS/M16       
IPR011765   Pept_M16_N       
IPR027110   PDHB       
IPR029061   THDP-binding       
IPR005475   Transketolase-like_Pyr-bd       
IPR019438   Q_salvage       
IPR015421   PyrdxlP-dep_Trfase_major       

SUPFAM

SSF63411   SSF63411        + More
SSF52518   SSF52518       

Gene 3D

3.40.640.10    

ProteinModelPortal

H9JCG6   A0A1E1VZP6   A0A3S2L6M1   S4NX15   A0A2A4JHD1   A0A2W1BGV2   + More
A0A194QHN1   A0A194RM54   A0A212EVT2   A0A0L7LT66   A0A1Q3FIS9   B0WJC6   A0A023EJY7   Q1HRL4   A0A182YJ86   A0A182K909   A0A182GZ96   A0A182ST98   A0A023EIG6   A0A182WLA3   A0A1I8Q9Y4   A0A182RZ05   W5J775   T1E7K7   A0A2M4ASY4   A0A182FHK4   A0A2M4BYC8   A0A2M4ASZ9   A0A336LR08   A0A182MWR5   A0A182R050   A0A182NJF2   A0A0P4VMP4   A0A226D0A8   E2C3F2   A0A195EZ90   A0A0L7RCZ5   A0A0N0U7F4  

KEGG

101741203    K16830 aurora kinase A-interacting protein | (RefSeq) uncharacterized LOC101741203

GO

GO:0046872   GO:0003824   GO:0004739   GO:0006400   GO:0016021  

PANTHER

PTHR11624   PTHR21314  

Length:

217

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00015

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.14092

outside

1  -  217

 

 

Pi

22.778665

Theta

21.535946

Tajima's D

0.078917

CLR

0.490423

CSRT

0.395280235988201

Interpretation

Uncertain