Gene

KWMTBOMO12792

Pre Gene Modal

BGIBMGA007146

Annotation

kynureninase_[Bombyx_mori]

Location

Bomo_Chr21(-):14621607-14623004      View in EpiBrowser

Full name

Kynureninase      

Alternative Name

L-kynurenine hydrolase

Location in the cell

Cytoplasmic   Reliability : 2.893

CDS

ATGTACGAGTATCAAGACGGACCAGAATTTCCAAAATTTCTGGACAATAACGACCAATTGGGACATTTCAGGCAACGGTTTTACATAAAACAGGGTACGATCTACATGTGCGGCAACTCTCTCGGACTTGCCTGTAAAGATGCTGAAGAAACTCTTTATGAAGTTCTAAATAAATGGAAAGACGAAGGCATCAAGATGTGGAACGTCGATCAGGGAAAATACTTCTTGTACTCCGAATTCTTGGCTGACATCATGGCACCCTTAGTCGGAGCAGATCCTGACGAAATCAGTATAACAGGTTGCACCACCATTAATATACACCAGACGATCAGCACTTTCTACAAGCCGACCGCAGAAAAATACAAGATTTTGGTTGACGATATTAATTTCCCGACGGATCGATACGCTGTTGATGGTCAAATAAGACTAAAGGGACTCAACCCAAGAGACGCGGTTAAACTGGTCAAAAGTCGTGATGGAAAATTCATGTCCGAGGATGACATTATTGAAGCAATGACTGAAGATGTGGCCATCATTTTACTGCCTGCAGTTTATTACAGAAGCGCTCAGATATTAGACATGACTAAAATCACTAAAGCTGCCAAAGAACGAAACATCTTTATTGGGTGGGACTTTTGTCACGCAATCGGAGCTATTGAGATAGATTTAAAGGCTTTAGACGCAGATTTCGCTATTTGGTGCACTTATAAGTACTTGAATGGTGGTCCCGGCTCGTCGGCAGCTCTGTACATTAATAGGAAACATTTCAAATTACTCCCAGGGCTAACTGGATGGTACGGGAACAAACCACACACGCAGTTTCAACTCAATCAGGAATTTGATCACCAGCAAAATGCTAGCGGATGGCAGATCGGGACTCCCACAATATTTTCAATGGCAACTTTAGAAGGATCCTTAAGAATATTTAAAGAAGCAGGTATAGGCAATATTAGAAAGAAATCGCTTCACATAACTGGTTATTTGATGTATTTGATCGAGAATAGATTATCTGAATACGGTTTTTCCGTCGGTAATGTGAAAGAAGACGCCAAAAGGGGTGGGCACGTTTGCTTAGAGCACGATGACGCGTACAGAATAAGCATTGCCCTAAAACAAAGAGGCGTGGTACAGGATTTTAGGGAACCGAACGTAATACGTTTGACGCCGGCGGCTCTGTACACCACTTATCAAGACGTTTATGATTTGGTCAACATTCTATTGGATATCGTTAAAACAGAGAGCCATAAGAAGATCAGCGAGAAAAGAAACTTTGTAGTCTAA

Protein

MYEYQDGPEFPKFLDNNDQLGHFRQRFYIKQGTIYMCGNSLGLACKDAEETLYEVLNKWKDEGIKMWNVDQGKYFLYSEFLADIMAPLVGADPDEISITGCTTINIHQTISTFYKPTAEKYKILVDDINFPTDRYAVDGQIRLKGLNPRDAVKLVKSRDGKFMSEDDIIEAMTEDVAIILLPAVYYRSAQILDMTKITKAAKERNIFIGWDFCHAIGAIEIDLKALDADFAIWCTYKYLNGGPGSSAALYINRKHFKLLPGLTGWYGNKPHTQFQLNQEFDHQQNASGWQIGTPTIFSMATLEGSLRIFKEAGIGNIRKKSLHITGYLMYLIENRLSEYGFSVGNVKEDAKRGGHVCLEHDDAYRISIALKQRGVVQDFREPNVIRLTPAALYTTYQDVYDLVNILLDIVKTESHKKISEKRNFVV

Description

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.

Catalytic Activity

3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine
H2O + L-kynurenine = anthranilate + H(+) + L-alanine

Cofactor

pyridoxal 5'-phosphate

Subunit

Homodimer.

Similarity

Belongs to the kynureninase family.

Keywords

Complete proteome   Hydrolase   Pyridine nucleotide biosynthesis   Pyridoxal phosphate   Reference proteome  

Feature

chain  Kynureninase

Uniprot

B7XB96   B7XB98   H9JCA1   B7XB97   A0A2H1V4U2   A0A2A4JIY7   + More
A0A0L7LSI9   A0A2W1BIA0   A0A3S0SVJ7   A0A418K5H7   A0A033UEU0   A0A178PGN5   A0A1T1DBU0   A0A2T4RVK4   A0A2A5PS09   A0A418IW87   A0A2T4PT37   A0A3A0HY57   A0A239Y9X0   A0A431ZG21   A0A3S4W7N0   D7UWX4   A0A378MI65   A0A386H4K2   A0A2P1MJM0   A0A3E0IT25   A0A2W4BR79   A0A1L8ZT05   A0A0U2VXT2   A0A200JEA2   A0A242AVQ8   A0A1E5H8H7   A0A1E5H194   A0A242H0S1   A0A0S3K8V2   A0A242BAP1   A0A242LQM4   A0A099WEX4   A0A242CJK0   R3WRF4   A0A242LS99   R2TEH9   A0A1E5G812   A0A430B1F6   A0A194RL00   A0A194QLX1   A0A347ST33   A0A417Z420   K6DPA8   A0A1L8TNN5   A0A0F4KSI3   W1SK05   A0A410PVU2   A0A345FW72   R2VJH0   A0A1H9UAF2   A0A3D5UAS9   A0A200HNF0   A0A242HAW8   A0A358NJT8   A0A1V4M4W3   S0LCY0   A0A231P1N9   A0A1V4LYL8   A0A3D5UFK5   A0A101W7W6   A0A077ZA92   A8MKD2   A0A161S1G1   A0A1I3CUW2   A0A0B5RXW5   A0A0U3GY28   H1H6F8   A0A352IIT1   A0A223B1F8   A0A1H6ST67   A0A3D8LWQ2   A0A363E434   A0A0E1Z6P1   A0A226QR05   A0A150LQZ3   A0A1V9ASG0   A0A1S2R494   A0A3D2NZ14   A0A3Q9QX59   A0A1I3LFP4   A0A2N5H369   M8DLA5   A0A1G9XCX8   A0A1G5RTD5   A0A077JAJ8   A0A073K7J3   B3ZK69   A0A1S0QN57   Q81PP8   A0REX2   A0A0V8J965   A0A246PSA2   A0A2H3NEQ8   A0A2B0LGN2  

EC Number

3.7.1.3

Pubmed

19121390    26227816    28756777    28066335    27375578    30080680    + More
26354079    30249635    23087684    24708037    30148503    26758181    26984839    25700417    25931591    12721629    18952800    17337577    24343101   

EMBL

AB441721    BAH03383.1    AB441723    BAH03385.1    BABH01031652    AB441722    + More
BAH03384.1    ODYU01000454    SOQ35284.1    NWSH01001396    PCG71383.1    JTDY01000175    KOB78438.1    KZ150141    PZC72947.1    RXWV01000024    RTX73670.1    QXVD01000003    RIO74925.1    JIZS01000061    EZX16319.1    LSKY01000011    OAO31436.1    MRDD01000123    OOV38292.1    PZHD01000005    QYIW01000007    PTK16613.1    RIN82491.1    NXJQ01000014    PCQ19598.1    PZFK01000013    PTI29512.1    QXSE01000064    RIL47552.1    LT906462    SNV55176.1    RXWZ01000146    RTX85855.1    LR134483    VEI31793.1    ACCR02000003    EFI84182.1    UGPG01000001    STY45213.1    CP032416    AYD40463.1    CP027770    AVP35578.1    QKXQ01000013    REI01483.1    PIEU01000035    PZL76192.1    MPHG01000011    OJH20815.1    CP013655    ALS38100.1    NIBQ01000001    OUZ35514.1    NGKX01000001    OTN85024.1    MIKC01000041    OEG21268.1    MIKB01000003    OEG18592.1    NGLZ01000001    OTO69238.1    CP013614    ALS00691.1    NGKY01000001    OTN90378.1    NGNB01000001    OTP52834.1    JNFA01000003    KGL44299.1    NGLE01000001    OTO10424.1    AJAU01000020    EOL44405.1    NGNA01000001    OTP53403.1    AJAR01000012    EOH98524.1    MIJY01000046    OEG08853.1    NGKB01000007    RSU14129.1    KQ459995    KPJ18513.1    KQ458981    KPJ04446.1    CP031513    QOCR01000008    AXX65192.1    RHW49207.1    QOCS01000019    RHW45445.1    AJLS01000183    EKN62626.1    JXKQ01000004    OJG45788.1    JXBZ01000010    KJY48181.1    ALAN01000072    ETI68314.1    CP035281    QAT42996.1    CP030933    AXG40004.1    AJDQ01000004    EOI57826.1    FOHA01000025    SES06445.1    DPPW01000004    HCX60826.1    NIBK01000002    OUZ14262.1    NGLY01000002    OTO72806.1    DOON01000238    HBV68499.1    LQBE01000007    OPL09552.1    AHYV01000005    EOT51185.1    MJUZ01000030    OXS28632.1    LQBE01000052    OPL07581.1    DPPW01000287    HCX62308.1    LOES01000257    KUO67528.1    HG806148    CDW57307.1    CP000853    ABW20264.1    LQNU01000066    KZE78054.1    FOQA01000003    SFH78049.1    CP010817    AJH14878.1    CP013690    ALU27191.1    AGEE01000017    EHO12643.1    DNNJ01000237    HBC31364.1    CP016202    ASS41056.1    FNYS01000003    SEI70951.1    QREZ01000180    RDV21624.1    QCWL01000001    PUF89158.1    AGEC02000012    EHO08468.1    NDYL01000001    OXB94966.1    LQYS01000041    KYD14469.1    NADP01000077    OQP00001.1    MLYR01000056    OIK13152.1    DPSW01000401    HCJ58535.1    CP022572    AZU64264.1    FORR01000002    SFI83350.1    PGVB01000007    PLR98425.1    APBN01000001    EMT54433.1    FNHW01000001    SDM94652.1    FMWL01000002    SCZ77333.1    CP008855    AIM16988.1    JOTN01000016    KEK18238.1    CP009641    AJI13781.1    AP014833    LZQX01000020    BAR76538.1    OJD93154.1    AE016879    AE017334    AE017225    CP000485    LNQN01000002    KSU83450.1    NJGF01000008    OWT50915.1    NUDC01000010    PEL93479.1    NUWN01000097    PFK31162.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000274792    UP000285221    UP000024810    + More
UP000078243    UP000190921    UP000241766    UP000284270    UP000241209    UP000266607    UP000242084    UP000273693    UP000278754    UP000010119    UP000254879    UP000266301    UP000243559    UP000256562    UP000249828    UP000182481    UP000067523    UP000196151    UP000194948    UP000094469    UP000094764    UP000195080    UP000065511    UP000195233    UP000194625    UP000029844    UP000195139    UP000013840    UP000194563    UP000013858    UP000095094    UP000288028    UP000053240    UP000053268    UP000261753    UP000284109    UP000284822    UP000006316    UP000182077    UP000033695    UP000018877    UP000287601    UP000253883    UP000013750    UP000198948    UP000195774    UP000194680    UP000014104    UP000215488    UP000057710    UP000030665    UP000000269    UP000076630    UP000199287    UP000031842    UP000069030    UP000004834    UP000260453    UP000183077    UP000256371    UP000250782    UP000005402    UP000198394    UP000075455    UP000192799    UP000180019    UP000282892    UP000199545    UP000235118    UP000012081    UP000199544    UP000199208    UP000031100    UP000027822    UP000031861    UP000181973    UP000217643    UP000000427    UP000000594    UP000000761    UP000054099    UP000197457    UP000220965    UP000242656   

PRIDE

B7XB96    B7XB98    H9JCA1    B7XB97   

Pfam

PF00266   Aminotran_5        + More
PF05222   AlaDh_PNT_N
PF01262   AlaDh_PNT_C

Interpro

IPR015421   PyrdxlP-dep_Trfase_major        + More
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR015424   PyrdxlP-dep_Trfase       
IPR000192   Aminotrans_V_dom       
IPR010111   Kynureninase       
IPR008143   Ala_DH/PNT_CS2       
IPR007698   AlaDH/PNT_NAD(H)-bd       
IPR008141   Ala_DH       
IPR036291   NAD(P)-bd_dom_sf       
IPR007886   AlaDH/PNT_N       

SUPFAM

SSF53383   SSF53383        + More
SSF51735   SSF51735       

Gene 3D

3.40.640.10     3.90.1150.10    

CDD

cd05305  L-AlaDH

ProteinModelPortal

B7XB96   B7XB98   H9JCA1   B7XB97   A0A2H1V4U2   A0A2A4JIY7   + More
A0A0L7LSI9   A0A2W1BIA0   A0A3S0SVJ7   A0A418K5H7   A0A033UEU0   A0A178PGN5   A0A1T1DBU0   A0A2T4RVK4   A0A2A5PS09   A0A418IW87   A0A2T4PT37   A0A3A0HY57   A0A239Y9X0   A0A431ZG21   A0A3S4W7N0   D7UWX4   A0A378MI65   A0A386H4K2   A0A2P1MJM0   A0A3E0IT25   A0A2W4BR79   A0A1L8ZT05   A0A0U2VXT2   A0A200JEA2   A0A242AVQ8   A0A1E5H8H7   A0A1E5H194   A0A242H0S1   A0A0S3K8V2   A0A242BAP1   A0A242LQM4   A0A099WEX4   A0A242CJK0   R3WRF4   A0A242LS99   R2TEH9   A0A1E5G812   A0A430B1F6   A0A194RL00   A0A194QLX1   A0A347ST33   A0A417Z420   K6DPA8   A0A1L8TNN5   A0A0F4KSI3   W1SK05   A0A410PVU2   A0A345FW72   R2VJH0   A0A1H9UAF2   A0A3D5UAS9   A0A200HNF0   A0A242HAW8   A0A358NJT8   A0A1V4M4W3   S0LCY0   A0A231P1N9   A0A1V4LYL8   A0A3D5UFK5   A0A101W7W6   A0A077ZA92   A8MKD2   A0A161S1G1   A0A1I3CUW2   A0A0B5RXW5   A0A0U3GY28   H1H6F8   A0A352IIT1   A0A223B1F8   A0A1H6ST67   A0A3D8LWQ2   A0A363E434   A0A0E1Z6P1   A0A226QR05   A0A150LQZ3   A0A1V9ASG0   A0A1S2R494   A0A3D2NZ14   A0A3Q9QX59   A0A1I3LFP4   A0A2N5H369   M8DLA5   A0A1G9XCX8   A0A1G5RTD5   A0A077JAJ8   A0A073K7J3   B3ZK69   A0A1S0QN57   Q81PP8   A0REX2   A0A0V8J965   A0A246PSA2   A0A2H3NEQ8   A0A2B0LGN2  

PDB

2HZP     E-value=7.59494e-68,     Score=653

KEGG

100233161    no KO assigned | (RefSeq) Kynu, BmKynu; kynureninase

GO

GO:0034354   GO:0005737   GO:0030429   GO:0043420   GO:0097053   GO:0006569   GO:0030170   GO:0019805   GO:0009435   GO:0042853   GO:0000286   GO:0003824   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

PANTHER

PTHR14084   PTHR42795  

Subcellular location

Cytoplasm  

Length:

426

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03599

Exp number, first 60 AAs:

0.00093

Total prob of N-in:

0.00346

outside

1  -  426

 

 

Pi

16.6873

Theta

12.367949

Tajima's D

1.031496

CLR

0

CSRT

0.678266086695665

Interpretation

Uncertain