Gene

KWMTBOMO12779

Annotation

hypothetical_protein_KGM_02824_[Danaus_plexippus]

Location

Bomo_Chr21(+):14383065-14403749      View in EpiBrowser

Full name

Microtubule-associated protein futsch       + More
Alpha-amylase      

Alternative Name

MAP1B homolog

Location in the cell

Cytoplasmic   Reliability : 2.522

CDS

ATGCTGCGGGGGCTGCTATCATGGGACGCTGGAGAGCACCAGGTCGATTTGGAGAAGGAACTTGCTACCCTTACGGCACAGGCACCGGAAGGGGAGGAAGCTCGCTATGGAGAGAGGCTGATCCAGTTCGCCTCGGAGAACCTGGTGACGGAGATCCTGATCCACCCGCAGATGAACACGCTGATGCAGTGCATGCGGAACCTGCTCAGCTCGTTCACGAGGCACAGGCACCTCGTGCACGCTGGATACACCTTCGCCGGAAACGGCTCCTGGATCATGCAAGACGGGACCTTCTCCCTGGCAGACTTCACAGACGCATACCAAGAGAACGAGGTCCAACGCGTTATTCGCGCATACGAGAACTCCATCTCGATCGATGTCCACTGCTCTACCAGCGGCGGGGGCGAGTGGGGCAGGCTCCCCGAGATGCCCTTCGTCAAATACTGCAAAATCAGGGTCAACCCTACTGATAAACTGGACCCTAGCTCTCAGGCCATCAAGGATTTTATCTTTAAACGTGACCTATTGGGCCCGAGGCATCCCCCATTACTTCCGTACCCTTTTATGTCTGTCTGA

Protein

MLRGLLSWDAGEHQVDLEKELATLTAQAPEGEEARYGERLIQFASENLVTEILIHPQMNTLMQCMRNLLSSFTRHRHLVHAGYTFAGNGSWIMQDGTFSLADFTDAYQENEVQRVIRAYENSISIDVHCSTSGGGEWGRLPEMPFVKYCKIRVNPTDKLDPSSQAIKDFIFKRDLLGPRHPPLLPYPFMSV

Description

During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by Fmr1.

Subunit

Heterodimer of a heavy and a light chain. Interacts with Fmr1.

Miscellaneous

'Futsch' means 'gone' in German.

Similarity

Belongs to the glycosyl hydrolase 13 family.

Keywords

Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Microtubule   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Microtubule-associated protein futsch

Uniprot

A0A212EMI4   A0A3S2TIC9   A0A2W1BJ16   A0A194QHP0   A0A194RR39   A0A0L7LU20   + More
A0A2H1V5A6   A4IJ78   A0A1Y1KDM4   D6W9J1   A0A1I8N0Y2   W8BXP6   A0A1A9WCP8   A0A0A9WLA3   B3P9H8   A0A1B6IFC7   A0A1B0G446   A0A0R3NYE5   A0A0R3NYW6   Q29J01   B4PXP4   A0A1W4VS68   A0A1A9XAH7   M9NGG5   Q9W596   A0A0M3QYS9   A0A1A9ZRR8   A0A3B0KDE7   A0A1B0ATD1   A0A1A9UPH8   B4L480   A0A2P8YIH9   B4N1K5   A0A1I8PFQ4   B4MD01   A0A1B6DHQ9   A0A0L7RHR1   A0A088ACQ6   A0A1J1IZA5   A0A151I8Z5   A0A023EWM3   A0A195EDS2   A0A3L8DQ17   A0A195F2T2   A0A151WKN8   A0A158NDG7   A0A232EYR2   T1HAN9   A0A0J7L3P1   A0A0N0BDI5   K7IMG8   A0A154PLK1   A0A2Y9D0U7   A0A1Y9J0K7   A0A1S4GBB2   A0A182YHT9   A0A1B6M4Q5   Q0H6L5   Q0H6L4   Q0H6L3   Q0H6L6   A0A3R7SM39   B4I9E0   A0A336LLG9   B4GTL7   A0A0L0CN79   A0A0K2U468   B4JNT3   A0A2R7VZ47   U4TXE0   N6T9R7   E9J760   A0A0P5FZQ6   A0A182JSF9   A0A0P5JSG3   A0A2P2HW79   A0A0P5ENG7   A0A0P5FXU3   A0A0P6DMC4   A0A0P6G415   A0A0N7ZZC8   A0A0N8ATV5   A0A0P6E8R3   A0A0P6FFV1   A0A0N8DZ12   A0A0P5FWN8   A0A0P5JV90   A0A0P5WVF2   A0A0P4Y595   A0A0P5L9E6   A0A0P5W5G9   A0A0P5USX1   A0A0N8D0C2   A0A0P5JW72   A0A0P6GAG5   A0A0P6GCT4   A0A0P6EHX6   A0A0P5H8R7  

EC Number

3.2.1.1

Pubmed

22118469    28756777    26354079    26227816    28004739    18362917    + More
19820115    25315136    24495485    25401762    17994087    15632085    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    10839355    10731137    18419581    10839356    11733059    16949836    17372656    21159966    29403074    25474469    30249741    21347285    28648823    20075255    12364791    25244985    16547109    26108605    23537049    21282665   

EMBL

AGBW02013836    OWR42686.1    RSAL01000117    RVE46820.1    KZ150275    PZC71653.1    + More
KQ458981    KPJ04455.1    KQ459995    KPJ18506.1    JTDY01000099    KOB78874.1    ODYU01000533    SOQ35454.1    BT030436    ABO52856.1    GEZM01091393    JAV56857.1    KQ971312    EEZ98500.1    GAMC01012561    JAB93994.1    GBHO01038004    JAG05600.1    CH954183    EDV45474.2    GECU01022071    JAS85635.1    CCAG010008295    CH379063    KRT06091.1    KRT06092.1    EAL32502.2    CM000162    EDX00897.2    AE014298    AFH07176.1    AL031128    EU523737    CAA20006.1    CP012528    ALC48213.1    OUUW01000011    SPP86280.1    JXJN01003232    JXJN01003233    JXJN01003234    JXJN01003235    JXJN01003236    CH933810    EDW07358.2    PYGN01000570    PSN44063.1    CH963925    EDW78244.2    CH940660    EDW58073.1    GEDC01012133    JAS25165.1    KQ414590    KOC70405.1    CVRI01000064    CRL05611.1    KQ978323    KYM95138.1    GBBI01004977    JAC13735.1    KQ979039    KYN23256.1    QOIP01000005    RLU22525.1    KQ981855    KYN34885.1    KQ983002    KYQ48406.1    ADTU01001025    ADTU01001026    ADTU01001027    ADTU01001028    ADTU01001029    ADTU01001030    NNAY01001605    OXU23449.1    ACPB03014737    LBMM01000892    KMQ97266.1    KQ435876    KOX70141.1    KQ434960    KZC12637.1    APCN01000822    APCN01000823    AAAB01008987    GEBQ01009071    JAT30906.1    DQ185012    ABB00666.1    DQ185013    ABB00667.1    DQ185014    ABB00668.1    DQ185011    ABB00665.1    QCYY01002917    ROT66601.1    CH480825    EDW43821.1    UFQT01000054    SSX19074.1    CH479190    EDW25887.1    JRES01000262    KNC32874.1    HACA01015637    CDW32998.1    CH916371    EDV92376.1    KK854183    PTY12742.1    KB631698    ERL85462.1    APGK01038521    APGK01038522    KB740960    ENN76999.1    GL768421    EFZ11354.1    GDIQ01269612    JAJ82112.1    GDIQ01200436    JAK51289.1    IACF01000234    LAB66031.1    GDIQ01269613    JAJ82111.1    GDIQ01248869    JAK02856.1    GDIQ01075475    JAN19262.1    GDIQ01041193    JAN53544.1    GDIP01197713    JAJ25689.1    GDIQ01243419    JAK08306.1    GDIQ01077973    JAN16764.1    GDIQ01060483    JAN34254.1    GDIQ01077972    JAN16765.1    GDIQ01250369    JAK01356.1    GDIQ01219125    JAK32600.1    GDIP01081272    JAM22443.1    GDIP01234606    JAI88795.1    GDIQ01173138    JAK78587.1    GDIP01090970    JAM12745.1    GDIP01130465    GDIP01112120    JAL91594.1    GDIP01081271    JAM22444.1    GDIQ01194333    JAK57392.1    GDIQ01047542    JAN47195.1    GDIQ01035143    JAN59594.1    GDIQ01062433    JAN32304.1    GDIQ01236522    JAK15203.1   

Proteomes

UP000007151    UP000283053    UP000053268    UP000053240    UP000037510    UP000007266    + More
UP000095301    UP000091820    UP000008711    UP000092444    UP000001819    UP000002282    UP000192221    UP000092443    UP000000803    UP000092553    UP000092445    UP000268350    UP000092460    UP000078200    UP000009192    UP000245037    UP000007798    UP000095300    UP000008792    UP000053825    UP000005203    UP000183832    UP000078542    UP000078492    UP000279307    UP000078541    UP000075809    UP000005205    UP000215335    UP000015103    UP000036403    UP000053105    UP000002358    UP000076502    UP000075840    UP000076407    UP000076408    UP000283509    UP000001292    UP000008744    UP000037069    UP000001070    UP000030742    UP000019118    UP000075881   

PRIDE

A4IJ78    M9NGG5    Q9W596   

Pfam

PF06740   DUF1213        + More
PF00128   Alpha-amylase
PF02806   Alpha-amylase_C

Interpro

IPR026074   MAP1        + More
IPR009603   MAP_Futsch       
IPR006048   A-amylase/branching_C       
IPR031319   A-amylase_C       
IPR006047   Glyco_hydro_13_cat_dom       
IPR017853   Glycoside_hydrolase_SF       
IPR006046   Alpha_amylase       
IPR013780   Glyco_hydro_b       

SUPFAM

SSF51445   SSF51445       

Gene 3D

2.60.40.1180    

ProteinModelPortal

A0A212EMI4   A0A3S2TIC9   A0A2W1BJ16   A0A194QHP0   A0A194RR39   A0A0L7LU20   + More
A0A2H1V5A6   A4IJ78   A0A1Y1KDM4   D6W9J1   A0A1I8N0Y2   W8BXP6   A0A1A9WCP8   A0A0A9WLA3   B3P9H8   A0A1B6IFC7   A0A1B0G446   A0A0R3NYE5   A0A0R3NYW6   Q29J01   B4PXP4   A0A1W4VS68   A0A1A9XAH7   M9NGG5   Q9W596   A0A0M3QYS9   A0A1A9ZRR8   A0A3B0KDE7   A0A1B0ATD1   A0A1A9UPH8   B4L480   A0A2P8YIH9   B4N1K5   A0A1I8PFQ4   B4MD01   A0A1B6DHQ9   A0A0L7RHR1   A0A088ACQ6   A0A1J1IZA5   A0A151I8Z5   A0A023EWM3   A0A195EDS2   A0A3L8DQ17   A0A195F2T2   A0A151WKN8   A0A158NDG7   A0A232EYR2   T1HAN9   A0A0J7L3P1   A0A0N0BDI5   K7IMG8   A0A154PLK1   A0A2Y9D0U7   A0A1Y9J0K7   A0A1S4GBB2   A0A182YHT9   A0A1B6M4Q5   Q0H6L5   Q0H6L4   Q0H6L3   Q0H6L6   A0A3R7SM39   B4I9E0   A0A336LLG9   B4GTL7   A0A0L0CN79   A0A0K2U468   B4JNT3   A0A2R7VZ47   U4TXE0   N6T9R7   E9J760   A0A0P5FZQ6   A0A182JSF9   A0A0P5JSG3   A0A2P2HW79   A0A0P5ENG7   A0A0P5FXU3   A0A0P6DMC4   A0A0P6G415   A0A0N7ZZC8   A0A0N8ATV5   A0A0P6E8R3   A0A0P6FFV1   A0A0N8DZ12   A0A0P5FWN8   A0A0P5JV90   A0A0P5WVF2   A0A0P4Y595   A0A0P5L9E6   A0A0P5W5G9   A0A0P5USX1   A0A0N8D0C2   A0A0P5JW72   A0A0P6GAG5   A0A0P6GCT4   A0A0P6EHX6   A0A0P5H8R7  

KEGG

105842668    no KO assigned | (RefSeq) microtubule-associated protein futsch-like

GO

GO:0005874   GO:0000226   GO:0008017   GO:0030425   GO:0042995   GO:0003779   GO:0005829   GO:0015631   GO:0007409   GO:0005875   GO:0045202   GO:0031114   GO:0043025   GO:0016358   GO:0008582   GO:0008088   GO:0030424   GO:0019900   GO:0008355   GO:0043524   GO:0048813   GO:0060052   GO:0048749   GO:1901215   GO:0007528   GO:0007017   GO:0015630   GO:0007399   GO:0103025   GO:0005975   GO:0043169   GO:0004556  

PANTHER

PTHR13843  

Subcellular location

Cytoplasm  
Cytoskeleton  

Length:

191

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0143

Exp number, first 60 AAs:

0.00038

Total prob of N-in:

0.02780

outside

1  -  191

 

 

Pi

22.861197

Theta

20.723021

Tajima's D

-1.223354

CLR

0.780051

CSRT

0.101694915254237

Interpretation

Uncertain