Gene

KWMTBOMO12776

Pre Gene Modal

BGIBMGA007152

Annotation

PREDICTED:_DDB1-_and_CUL4-associated_factor_12_[Bombyx_mori]

Location

Bomo_Chr21(-):14220215-14227163      View in EpiBrowser

Full name

Deoxyhypusine hydroxylase      

Alternative Name

Deoxyhypusine dioxygenase
Deoxyhypusine monooxygenase

Location in the cell

Nuclear   Reliability : 2.454

CDS

ATGGCGCAGACTCTTCGTAGAGCAGTAGAGGGCAGGTACCCCTCTTGCTATTTACCCAATCGATTGAAAGAAAGGAAAGCCAAAGCTAAAGCTTTGAGATTAGAGCAACGTAAACCAGACAAACCGGAAGATTTTGTTTGCTATTCAGACAGTGACAGTGAAGAGGAAACACCGACGCAACAACATCAAATTTTATCAACGTCATATAATTTTGTCGACTATGTACGTTCAAGAGAAATACTTGCTCCTGAGCCTCGATCAGTCGACCCATCGTATGCAACCCGACACATGCTCACACATGATATGTTTCATGAGACACCAGTCAACCTCGGTAACATGAACAAGGTCTTCTGCTCACAATGGCTATCAGACAGACAAGTTGTATTTGGCACCAAATGTAACAAGTTAATGGTGTATGATGTCCGCACTCGGTCCTTGGACGCCATCCCCACACTGCGCCCGCGCGCCGCCTGGCCGCCGCCGGACCACCAGACCGGCATACACGCGCTCCAGATCAATCCTTCCAGAACACTGCTAGCGACCGGTGCGAGGAATTCTTGTGAATTAGCCATATACAGCCTACCTACACTAGACCCGGTCTGCGTTGGAGAAGCTCATAAAGATTGGATCCTGGACATGTGCTGGTTGGACGACGAGTTCGTGGTGACGGGGTCGCGCGATAATAAGCTTGCACTGTGGCGCGCCCCGGCCGCCCCCCCGCCCCGCGCGCACCTGCACCACTACGTGCACCCCCACGCCGTGCGGGAGTGTCGGTCGGGTCTAAAAGTCCGAGCGCTGACGTTCAACGAGCGCTGGCGGGAGATAGCGGCACTTACCCTCAACGGCTACATACACGTGTTCAACGCGGAGACCTTCCGCCAGACGCTGTCCAGGAAGCTGCCCTCGTGCCAGGACTTGGTGTGTCTAGCCACCCAGCAAGAGAGCGGCATGTACGCGATCGGCTGCAAGTCGTACACGCTGCTGCTGGACTGCCGCACGCTGCAGTCCGTCAAGAAGGTCACCTCCCGGTACTCCGGCTGCGGGGTCCGCTCCGCCAGCTTCCGGGGGAACATGCTCACCATCGGGACCGGACTGGGTCTCCTGATGTTCTACGACCTGCGCGCGGGTAAGTACCTGGAGAGCAGCATCCACTCGTCCAAGACGGTGACGCTGAAGGCGTCCCGCGGCTACCTGTTCCCCGAGGAGGAGGCGGAGGGCGGCGTCAAGCACGTGCCCGCCATCTACACGCACTGCTACGACTCCTCGGGCACCAGGGTGTTCACCGCGGGCGGGCCCCTACCGGCTCCCCTAGTCGGGAACTACGCAGCCATATGGCAGTAG

Protein

MAQTLRRAVEGRYPSCYLPNRLKERKAKAKALRLEQRKPDKPEDFVCYSDSDSEEETPTQQHQILSTSYNFVDYVRSREILAPEPRSVDPSYATRHMLTHDMFHETPVNLGNMNKVFCSQWLSDRQVVFGTKCNKLMVYDVRTRSLDAIPTLRPRAAWPPPDHQTGIHALQINPSRTLLATGARNSCELAIYSLPTLDPVCVGEAHKDWILDMCWLDDEFVVTGSRDNKLALWRAPAAPPPRAHLHHYVHPHAVRECRSGLKVRALTFNERWREIAALTLNGYIHVFNAETFRQTLSRKLPSCQDLVCLATQQESGMYAIGCKSYTLLLDCRTLQSVKKVTSRYSGCGVRSASFRGNMLTIGTGLGLLMFYDLRAGKYLESSIHSSKTVTLKASRGYLFPEEEAEGGVKHVPAIYTHCYDSSGTRVFTAGGPLPAPLVGNYAAIWQ

Description

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Catalytic Activity

[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O

Cofactor

Fe(2+)

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Uniprot

H9JCA7   A0A2H1WL49   A0A194QG40   B0X2Z8   A0A1L8DNM1   A0A182PM82   + More
A0A182RH58   A0A182JYZ8   A0A182ND54   A0A1Q3F3B3   A0A182JLA1   A0A182T2Z8   A0A084VWL7   Q17DJ1   A0A182UBS0   A0A182X3A9   A0A182MJR0   A0A1W4WT74   A0A182VQ15   A0A182HZF0   Q7QKC2   A0A182LQG2   A0A182VKJ3   A0A2P8YZY5   A0A182QF97   A0A1B0C9L4   A0A1J1IL38   A0A1Y1LFN9   A0A2J7QK27   D6WCT6   A0A336MNM5   A0A067RUN9   A0A2M4APH4   W5J4K4   A0A182F6R1   A0A2M4BM77   A0A2M3Z9C2   A0A195EN51   F4WRW0   A0A195BUX7   A0A158NEK5   A0A151XIU2   A0A195FLA6   A0A195BXW5   E2AFP2   A0A026WYK8   E9ID87   E2B5Y4   T1HMI4   A0A0V0GB69   A0A182Y4R5   A0A1B6L9I8   A0A0A9W184   A0A1I8PTU3   A0A0L7RFL8   A0A2A3EPQ9   A0A088AKW5   A0A1B6JL94   A0A154P0N9   A0A1A9YG53   A0A1B6FEX8   K7JAI9   A0A1A9VBC6   A0A1B0AK90   A0A1B6DPS3   A0A3B0JQM3   A0A1W4UBC4   B4NH58   B4PN20   B4K5L6   B4HHI2   Q9VGE3   B3M032   A0A1I8MU32   Q295S9   B4GFQ6   B4LWG4   B4JT78   B3P1H5   N6TRP9   A0A0M9A5C4   A0A0K8VQ02   A0A034VCG9   A0A1A9WJC9   W8BEG9   A0A1B0F9U7   N6T871   A0A310SH56   A0A2W1BN22   A0A212F9W7   E0VJR3   A0A2S2NJR9   X1WTX5   A0A023EQ92   A0A0M3QYI5   B4QTH9   A0A232FBQ3  

EC Number

1.14.99.29

Pubmed

19121390    26354079    24438588    17510324    12364791    14747013    + More
17210077    20966253    29403074    28004739    18362917    19820115    24845553    20920257    23761445    21719571    21347285    20798317    24508170    30249741    21282665    25244985    25401762    26823975    20075255    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136    15632085    23537049    25348373    24495485    28756777    22118469    20566863    24945155    28648823   

EMBL

BABH01031615    ODYU01009375    SOQ53758.1    KQ458981    KPJ04457.1    DS232304    + More
EDS39500.1    GFDF01006144    JAV07940.1    GFDL01013028    JAV22017.1    ATLV01017659    KE525181    KFB42361.1    CH477293    EAT44511.1    AXCM01000816    APCN01001973    AAAB01008799    EAA03757.4    PYGN01000262    PSN49804.1    AXCN02001214    AJWK01002461    CVRI01000049    CRK99177.1    GEZM01057108    JAV72443.1    NEVH01013278    PNF28940.1    KQ971311    EEZ99060.1    UFQS01001276    UFQT01001276    SSX10085.1    SSX29807.1    KK852405    KDR24525.1    GGFK01009370    MBW42691.1    ADMH02002112    ETN58851.1    GGFJ01004912    MBW54053.1    GGFM01004334    MBW25085.1    KQ978625    KYN29596.1    GL888292    EGI63117.1    KQ976401    KYM92387.1    ADTU01013478    KQ982080    KYQ60326.1    KQ981490    KYN41193.1    KQ978501    KYM93437.1    GL439118    EFN67793.1    KK107064    QOIP01000008    EZA60856.1    RLU19467.1    RLU19624.1    GL762454    EFZ21425.1    GL445887    EFN88953.1    ACPB03015269    GECL01000764    JAP05360.1    GEBQ01030526    GEBQ01019605    JAT09451.1    JAT20372.1    GBHO01043381    GBHO01014904    GDHC01017196    JAG00223.1    JAG28700.1    JAQ01433.1    KQ414599    KOC69772.1    KZ288195    PBC33773.1    GECU01007702    JAT00005.1    KQ434791    KZC05392.1    GECZ01021003    GECZ01011459    GECZ01009193    JAS48766.1    JAS58310.1    JAS60576.1    AAZX01001753    GEDC01009628    JAS27670.1    OUUW01000008    SPP84477.1    CH964272    EDW84555.1    CM000160    EDW97032.1    CH933806    EDW14053.1    CH480815    EDW42521.1    AE014297    AY069488    AAF54740.2    AAL39633.1    AGB95877.1    CH902617    EDV41989.2    CM000070    EAL28629.1    CH479182    EDW34441.1    CH940650    EDW66601.1    CH916373    EDV94968.1    CH954181    EDV49434.1    APGK01006423    APGK01006424    KB736759    KB632379    ENN83144.1    ERL94087.1    KQ435750    KOX76263.1    GDHF01011391    JAI40923.1    GAKP01019731    GAKP01019729    GAKP01019727    JAC39223.1    GAMC01009498    GAMC01009496    JAB97057.1    CCAG010002599    APGK01040417    KB740979    ENN76429.1    KQ764626    OAD54463.1    KZ150013    PZC75024.1    AGBW02009556    OWR50524.1    DS235226    EEB13619.1    GGMR01004814    MBY17433.1    ABLF02036816    ABLF02042531    GAPW01001856    JAC11742.1    CP012526    ALC47679.1    CM000364    EDX13284.1    NNAY01000518    OXU27898.1   

Proteomes

UP000005204    UP000053268    UP000002320    UP000075885    UP000075900    UP000075881    + More
UP000075884    UP000075880    UP000075901    UP000030765    UP000008820    UP000075902    UP000076407    UP000075883    UP000192223    UP000075920    UP000075840    UP000007062    UP000075882    UP000075903    UP000245037    UP000075886    UP000092461    UP000183832    UP000235965    UP000007266    UP000027135    UP000000673    UP000069272    UP000078492    UP000007755    UP000078540    UP000005205    UP000075809    UP000078541    UP000078542    UP000000311    UP000053097    UP000279307    UP000008237    UP000015103    UP000076408    UP000095300    UP000053825    UP000242457    UP000005203    UP000076502    UP000092443    UP000002358    UP000078200    UP000092445    UP000268350    UP000192221    UP000007798    UP000002282    UP000009192    UP000001292    UP000000803    UP000007801    UP000095301    UP000001819    UP000008744    UP000008792    UP000001070    UP000008711    UP000019118    UP000030742    UP000053105    UP000091820    UP000092444    UP000007151    UP000009046    UP000007819    UP000092553    UP000000304    UP000215335   

PRIDE

H9JCA7    Q9VGE3   

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR019775   WD40_repeat_CS       
IPR011989   ARM-like       
IPR027517   Deoxyhypusine_hydroxylase       
IPR004155   PBS_lyase_HEAT       
IPR021133   HEAT_type_2       
IPR016024   ARM-type_fold       

SUPFAM

SSF50978   SSF50978        + More
SSF48371   SSF48371       

Gene 3D

2.130.10.10     1.25.10.10    

ProteinModelPortal

H9JCA7   A0A2H1WL49   A0A194QG40   B0X2Z8   A0A1L8DNM1   A0A182PM82   + More
A0A182RH58   A0A182JYZ8   A0A182ND54   A0A1Q3F3B3   A0A182JLA1   A0A182T2Z8   A0A084VWL7   Q17DJ1   A0A182UBS0   A0A182X3A9   A0A182MJR0   A0A1W4WT74   A0A182VQ15   A0A182HZF0   Q7QKC2   A0A182LQG2   A0A182VKJ3   A0A2P8YZY5   A0A182QF97   A0A1B0C9L4   A0A1J1IL38   A0A1Y1LFN9   A0A2J7QK27   D6WCT6   A0A336MNM5   A0A067RUN9   A0A2M4APH4   W5J4K4   A0A182F6R1   A0A2M4BM77   A0A2M3Z9C2   A0A195EN51   F4WRW0   A0A195BUX7   A0A158NEK5   A0A151XIU2   A0A195FLA6   A0A195BXW5   E2AFP2   A0A026WYK8   E9ID87   E2B5Y4   T1HMI4   A0A0V0GB69   A0A182Y4R5   A0A1B6L9I8   A0A0A9W184   A0A1I8PTU3   A0A0L7RFL8   A0A2A3EPQ9   A0A088AKW5   A0A1B6JL94   A0A154P0N9   A0A1A9YG53   A0A1B6FEX8   K7JAI9   A0A1A9VBC6   A0A1B0AK90   A0A1B6DPS3   A0A3B0JQM3   A0A1W4UBC4   B4NH58   B4PN20   B4K5L6   B4HHI2   Q9VGE3   B3M032   A0A1I8MU32   Q295S9   B4GFQ6   B4LWG4   B4JT78   B3P1H5   N6TRP9   A0A0M9A5C4   A0A0K8VQ02   A0A034VCG9   A0A1A9WJC9   W8BEG9   A0A1B0F9U7   N6T871   A0A310SH56   A0A2W1BN22   A0A212F9W7   E0VJR3   A0A2S2NJR9   X1WTX5   A0A023EQ92   A0A0M3QYI5   B4QTH9   A0A232FBQ3  

PDB

5YZV     E-value=0.0180329,     Score=90

KEGG

101740776    K11803 WD repeat-containing protein 40A | (RefSeq) DDB1- and CUL4-associated factor 12

GO

GO:0080008   GO:0046872   GO:0019135   GO:0008612   GO:0043067   GO:0035071   GO:0005515   GO:0007023   GO:0048487   GO:0005085   GO:0007264   GO:0048015   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

Length:

446

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.21246

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04359

outside

1  -  446

 

 

Pi

17.6926

Theta

21.700414

Tajima's D

-0.71335

CLR

0.837149

CSRT

0.191090445477726

Interpretation

Uncertain