Gene

KWMTBOMO12761  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007159

Annotation

PREDICTED:_probable_isocitrate_dehydrogenase_[NAD]_subunit_alpha?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr21(-):13959295-13982013      View in EpiBrowser

Full name

Isocitrate dehydrogenase [NAD] subunit, mitochondrial       + More
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial      

Alternative Name

Isocitric dehydrogenase subunit alpha
NAD(+)-specific ICDH subunit alpha

Location in the cell

Mitochondrial   Reliability : 2.506

CDS

ATGGCTGCAAGAATAATCAGGAAAATTGTGCCAGCGACCAGAGCCGGCGCTGCTCAGTACAGCACTGGCGTGCGCAAGGTTACGCTCATCCCTGGACATGGTATTGGGCCCGAGATCACGGTCGCCGTTCAGAAAATCTTCGAAGCAGCTAAAGTACCTATCGAATGGGAGGAAGTGGATGTAACAGCTGTTAGGGGTCCAGATGGCAAATTCGGTATTCCTCAAAAAGCGATTGACTCTGTAAATGCCAATAAAATTGGCTTGAAGGGTCCCCTGATGACTCCAGTCGGTAAAGGCTACAGATCACTCAACTTGGCCCTCAGGAAGGAGTTTGACTTGTATGCTAATGTCAGACCTTGCAAGAGTTTAGAAGGGATCAAGACACTATACGACAACGTTGATGTGGTCACGATCAGAGAGAACACCGAGGGTGAGTATTCCGGTATCGAGCACGAGATCGTCGACGGGGTCGTGCAGTCCATCAAGCTGATCACGGAGGAGGCCAGTACGAGAGTGGCGGAGTTCGCCTTCCAGTTCGCCAGAGAAAACAAGAGGAAGAAGGTCACGGCCGTACACAAAGCTAATATTATGTAA

Protein

MAARIIRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM

Catalytic Activity

D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH

Subunit

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Similarity

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Keywords

Alternative splicing   Complete proteome   Magnesium   Manganese   Metal-binding   Mitochondrion   NAD   Oxidoreductase   Reference proteome   Transit peptide   Tricarboxylic acid cycle  

Feature

chain  Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
splice variant  In isoform A.

Uniprot

S4PM50   A0A3S2L4B0   A0A212F9U9   A0A2H1W2T3   I4DNF6   A0A2A4JKY2   + More
A0A194QGB9   A0A0N0PBV0   A0A2A4JMJ6   T1P9X3   Q9VWH4-2   A0A0Q5TGV1   A0A0T6BHJ7   A0A1I8P883   A0A0P8Y537   A0A0Q9XF11   A0A0Q9X3N4   A0A1W4VG47   J3JXM4   A0A0R3NYG4   A0A0A1WTA0   A0A0C9PPC6   A0A1L8EDB1   Q0QHK9   A0A336JXZ0   A0A3B0KVC3   K7JCI5   Q17P80   A0A1W7R8H8   A0A1A9YJC5   A0A195FQ87   A0A0L7RF09   T1GFT0   A0A1S4EVW3   B4JX16   D3TSB1   A0A1A9URI5   E2BLS1   A0A0K8VW82   A0A154PEB2   F4WXL5   A0A023EQF0   A0A088AAU7   V9ID72   A0A158NUX6   A0A1Y1K796   E9IDB6   A0A0K8WMC7   A0A1A9W960   A0A151WSW9   A0A1Q3FGV2   B0W6Q6   A0A026WW62   A0A0M9A3Y7   A0A411G7F0   A0A2P8Z4F6   A0A0K8TTP8   A0A182JHS8   A0A034VRS1   A0A1I8JVG7   A0A340TB72   A0A182LE36   A0A2C9GLB7   Q7PQX9   W8CDU6   A0A0J7L675   A0A182RT14   A0A3S7SX45   A0A2Z5REI8   A0A0M4ETP7   B4R7Q8   B4I761   Q9VWH4   A0A1L8E026   A0A195CQ27   B3NVP1   B4NDT7   B4L6W2   A0A151JQQ8   U5EUV7   A0A2M3Z5S3   A0A2M4AC44   A0A2M4BSD8   W5JJ40   A0A2J7Q4C6   A0A1W4VTF1   A0A067QPF5   B3MQR4   A0A0L0C9V8   E0VSE9   A0A310SK85   A0A1B6IXA7   A0A1B6DP32   B4MA38   A0A1L8EHZ0   Q29IW3   A0A1L8E0K4   A0A1B0A2U2   Q17P79   A0A1S4EVV7  

EC Number

1.1.1.41

Pubmed

23622113    22118469    22651552    26354079    25315136    10731132    + More
12537572    12537569    17994087    22516182    23537049    15632085    25830018    20075255    17510324    20353571    20798317    21719571    24945155    21347285    28004739    21282665    24508170    30249741    29403074    26369729    25348373    20966253    12364791    14747013    17210077    24495485    26760975    20920257    23761445    24845553    26108605    20566863   

EMBL

GAIX01003740    JAA88820.1    RSAL01000164    RVE45334.1    AGBW02009556    OWR50516.1    + More
ODYU01005928    SOQ47333.1    AK402883    BAM19446.1    NWSH01001097    PCG72621.1    KQ458981    KPJ04464.1    KQ460882    KPJ11466.1    PCG72622.1    KA645474    AFP60103.1    AE014298    AY089629    BT125839    AAN09496.1    CH954180    KQS30087.1    LJIG01000121    KRT86819.1    CH902621    KPU81686.1    CH933812    KRG07151.1    CH964239    KRF99549.1    APGK01052691    BT127994    KB741213    KB631874    AEE62956.1    ENN72661.1    ERL86877.1    CH379063    KRT06107.1    GBXI01012205    JAD02087.1    GBYB01003068    JAG72835.1    GFDG01002157    JAV16642.1    DQ374010    ABG77988.1    UFQS01000006    UFQT01000006    SSW97007.1    SSX17394.1    OUUW01000031    SPP89806.1    AAZX01004916    CH477193    EAT48554.1    GEHC01000215    JAV47430.1    KQ981335    KYN42586.1    KQ414606    KOC69572.1    CAQQ02047027    CAQQ02047028    CAQQ02047029    CAQQ02047030    CH916376    EDV95292.1    EZ424313    ADD20589.1    GL449036    EFN83405.1    GDHF01009173    JAI43141.1    KQ434886    KZC10183.1    GL888425    EGI61085.1    GAPW01002275    JAC11323.1    JR039209    AEY58582.1    ADTU01026813    GEZM01095029    JAV55545.1    GL762454    EFZ21406.1    GDHF01000001    JAI52313.1    KQ982769    KYQ50923.1    GFDL01008248    JAV26797.1    DS231849    EDS36887.1    KK107078    QOIP01000011    EZA60315.1    RLU16492.1    KQ435742    KOX76727.1    MH366020    QBB01829.1    PYGN01000200    PSN51382.1    GDAI01000080    JAI17523.1    GAKP01014729    JAC44223.1    APCN01000245    AAAB01008859    EAA08136.6    GAMC01001331    JAC05225.1    LBMM01000521    KMQ98141.1    MG836237    AYC62485.1    FX983737    BAX07236.1    CP012528    ALC49940.1    CM000366    EDX18391.1    CH480823    EDW56159.1    GFDF01001974    JAV12110.1    KQ977444    KYN02735.1    EDV46706.1    EDW81906.1    EDW06108.1    KQ978622    KYN29729.1    GANO01001283    JAB58588.1    GGFM01003120    MBW23871.1    GGFK01004971    MBW38292.1    GGFJ01006829    MBW55970.1    ADMH02001265    ETN63313.1    NEVH01018385    PNF23434.1    KK853168    KDR10371.1    EDV44690.2    JRES01000713    KNC29037.1    DS235750    EEB16305.1    KQ762031    OAD56356.1    GECU01016138    JAS91568.1    GEDC01026499    GEDC01009879    JAS10799.1    JAS27419.1    CH940655    EDW66097.2    GFDG01000580    JAV18219.1    EAL32540.3    GFDF01001982    JAV12102.1    EAT48553.1   

Proteomes

UP000283053    UP000007151    UP000218220    UP000053268    UP000053240    UP000095301    + More
UP000000803    UP000008711    UP000095300    UP000007801    UP000009192    UP000007798    UP000192221    UP000019118    UP000030742    UP000001819    UP000268350    UP000002358    UP000008820    UP000092443    UP000078541    UP000053825    UP000015102    UP000001070    UP000078200    UP000008237    UP000076502    UP000007755    UP000005203    UP000005205    UP000091820    UP000075809    UP000002320    UP000053097    UP000279307    UP000053105    UP000245037    UP000075880    UP000076407    UP000075903    UP000075882    UP000075840    UP000007062    UP000036403    UP000075900    UP000092553    UP000000304    UP000001292    UP000078542    UP000078492    UP000000673    UP000235965    UP000027135    UP000037069    UP000009046    UP000008792    UP000092445   

PRIDE

Q9VWH4   

Pfam

PF00180   Iso_dh

Interpro

IPR004434   Isocitrate_DH_NAD        + More
IPR019818   IsoCit/isopropylmalate_DH_CS       
IPR024084   IsoPropMal-DH-like_dom       

ProteinModelPortal

S4PM50   A0A3S2L4B0   A0A212F9U9   A0A2H1W2T3   I4DNF6   A0A2A4JKY2   + More
A0A194QGB9   A0A0N0PBV0   A0A2A4JMJ6   T1P9X3   Q9VWH4-2   A0A0Q5TGV1   A0A0T6BHJ7   A0A1I8P883   A0A0P8Y537   A0A0Q9XF11   A0A0Q9X3N4   A0A1W4VG47   J3JXM4   A0A0R3NYG4   A0A0A1WTA0   A0A0C9PPC6   A0A1L8EDB1   Q0QHK9   A0A336JXZ0   A0A3B0KVC3   K7JCI5   Q17P80   A0A1W7R8H8   A0A1A9YJC5   A0A195FQ87   A0A0L7RF09   T1GFT0   A0A1S4EVW3   B4JX16   D3TSB1   A0A1A9URI5   E2BLS1   A0A0K8VW82   A0A154PEB2   F4WXL5   A0A023EQF0   A0A088AAU7   V9ID72   A0A158NUX6   A0A1Y1K796   E9IDB6   A0A0K8WMC7   A0A1A9W960   A0A151WSW9   A0A1Q3FGV2   B0W6Q6   A0A026WW62   A0A0M9A3Y7   A0A411G7F0   A0A2P8Z4F6   A0A0K8TTP8   A0A182JHS8   A0A034VRS1   A0A1I8JVG7   A0A340TB72   A0A182LE36   A0A2C9GLB7   Q7PQX9   W8CDU6   A0A0J7L675   A0A182RT14   A0A3S7SX45   A0A2Z5REI8   A0A0M4ETP7   B4R7Q8   B4I761   Q9VWH4   A0A1L8E026   A0A195CQ27   B3NVP1   B4NDT7   B4L6W2   A0A151JQQ8   U5EUV7   A0A2M3Z5S3   A0A2M4AC44   A0A2M4BSD8   W5JJ40   A0A2J7Q4C6   A0A1W4VTF1   A0A067QPF5   B3MQR4   A0A0L0C9V8   E0VSE9   A0A310SK85   A0A1B6IXA7   A0A1B6DP32   B4MA38   A0A1L8EHZ0   Q29IW3   A0A1L8E0K4   A0A1B0A2U2   Q17P79   A0A1S4EVV7  

PDB

5YVT     E-value=1.1119e-68,     Score=656

KEGG

101739299    K00030 isocitrate dehydrogenase (NAD+) [EC:1.1.1.41] | (RefSeq) probable isocitrate dehydrogenase [N

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01210    2-Oxocarboxylic acid metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0000287   GO:0051287   GO:0005739   GO:0004449   GO:0006099   GO:0016616   GO:0016021   GO:0005488   GO:0005515   GO:0003677   GO:0004003   GO:0005634   GO:0006289   GO:0016286   GO:0055114  

Subcellular location

Mitochondrion  

Length:

197

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00951999999999999

Exp number, first 60 AAs:

0.00932

Total prob of N-in:

0.32667

outside

1  -  197

 

 

Pi

2.645011

Theta

19.197258

Tajima's D

0

CLR

1.365085

CSRT

0.379431028448578

Interpretation

Uncertain