Gene

KWMTBOMO12746  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007195

Annotation

PREDICTED:_cytochrome_P450_4C1-like_[Bombyx_mori]

Location

Bomo_Chr21(-):13659851-13680749      View in EpiBrowser

Full name

Cytochrome P450 4C1      

Alternative Name

CYPIVC1

Location in the cell

Cytoplasmic   Reliability : 1.649 Nuclear   Reliability : 1.17

CDS

ATGATTTGGGCTGTAGTTTTATTGATTATTTTTATATTCTTGATATGGAAGGCTTTAGAGGATGAGGAGAATCCTCTTGACTCTCTTCCCGGACCAGAAAGGAAGCCGATCATTGGAGCCACTATGCGATTCGTCAATTTAAATACAAGAGAAATGTTTATAAAACTGCGCGAGTACCATGCGATGTACGGTACCAGATACGTTGTGAAGATATTCAAGAGGAGAATCCTGCATCTGTCTAACGAAAGGGATGTTGAGGTCGTATTGTCTCATTCGAAGAACATTAAGAAAAGTAAGCCTTATACGTTTCTGAGTCCTTGGCTCGGGAGCGATCTCCTGTTGAGCACCGGTTTTAAATGGCACAGCAGACGTAAGATTCTGACACCAACGTTTCACTTTAACATCTTGAAGAGCTTCTTAGAAATCATCAAGGACAAGAGTTGTGACTTGGTGAAGAGATTGGAGGAGTACAGGGGCGAAGAAGTAGACTTGATGCCCGTTATCAGTGACTTTACATTGTTTACGATTTGCGAAACGGCAATGGGCACCCAATTGGATTCAGACAAGTCAGCAGAAACCAGCGAATACAAAATGGCCATACTACAAATAGGATCTTTGCTGCTCGACAGACTGACCAAAGTTTGGCTCCACAACGACTTTATATTCCGCCAGTTTACCGTTGGGCGAAAGTTTCAGAAGTGCCTCAAACAAGTCCACTCTTTCGCCCATAATGTTATAGTTGAGAGGAAACGACAACGAGCATCTGGTAGAGACCCTACTGTCGTCGCAGAAGATGTATTCGGTCGTAAAAAGAGATTGGCCATGTTGGATCTTTTATTGGAGGCGGAAGAGAAAAATGAAATTGATTTTGAAGGAATAATGGATGAAGTTAATACATTTATGTTTGAGGGACACGACACAACTGCAGTCGCTTTAACGTTCAGTTTGATGTTGGTCGCGGAGGATGATCAAGTTCAAGATCGCATTTACAAGGAACTGCAAGGGATTTTTGGAGATTCTGACCGTCGGCCAACAATCAGTGATGTTGCCGAGATGAAGTACTTGGAAGCTGTAGTGAAGGAGACTCTGAGGCTGTATCCAAGTGTCCCGTTCATCGCTCGAGAGATCACTGAGGACTTTATGTTAGATGACCTAAAGATAAAGAAAGGATCAGAAGTAGCAGTCCACATCTATGATTTGCATCGTCGTAAAGAGCTGTTTTCTGACCCCGAGAAGTTCCTGCCCGATAGATTCTTGAACGGAGAATTGAAGCATCCATACAGCTTCGTGCCCTTTAGCGCAGGACCAAGGAACTGTATTGGTCAACGCTTCGCGACGCTGGAAATGAAGTGCGTCCTCAGTGAGATCTGTCGTAGCTTCAGACTAGAACCCCGCACTAAGGGTTGGCGGCCTACCCTCGTAGCCGAAATGCTTTTACGACCAAACGAACCTATTCATGTAAAGTTTATTAAACGCAAACAAAGCTGA

Protein

MIWAVVLLIIFIFLIWKALEDEENPLDSLPGPERKPIIGATMRFVNLNTREMFIKLREYHAMYGTRYVVKIFKRRILHLSNERDVEVVLSHSKNIKKSKPYTFLSPWLGSDLLLSTGFKWHSRRKILTPTFHFNILKSFLEIIKDKSCDLVKRLEEYRGEEVDLMPVISDFTLFTICETAMGTQLDSDKSAETSEYKMAILQIGSLLLDRLTKVWLHNDFIFRQFTVGRKFQKCLKQVHSFAHNVIVERKRQRASGRDPTVVAEDVFGRKKRLAMLDLLLEAEEKNEIDFEGIMDEVNTFMFEGHDTTAVALTFSLMLVAEDDQVQDRIYKELQGIFGDSDRRPTISDVAEMKYLEAVVKETLRLYPSVPFIAREITEDFMLDDLKIKKGSEVAVHIYDLHRRKELFSDPEKFLPDRFLNGELKHPYSFVPFSAGPRNCIGQRFATLEMKCVLSEICRSFRLEPRTKGWRPTLVAEMLLRPNEPIHVKFIKRKQS

Catalytic Activity

an alkane + O2 + reduced [NADPH--hemoprotein reductase] = a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Keywords

Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase  

Feature

chain  Cytochrome P450 4C1

Uniprot

L0N6M8   L0N716   Q8ISJ8   B2BNZ3   A0A2W1BLR4   Q2I0J0   + More
A0A248QHK4   J7FIT5   A0A286QUL0   A0A1E1W5V0   A0A0U2DUD7   A0A194QLZ7   A0A068EU59   A0A068EVK2   A0A2A4ITL8   I4DP28   A0A0N1IEQ4   A0A1V0D9C7   L0N7C1   H9JWX8   H9JCC3   A0A1E1WH40   A0A0C5C1N3   C1LZ55   L0N4I2   A0A2H1WM10   A0A1E1WM70   D5L0M0   L0N5E9   A5HG32   A5A3F8   A0A248QFF8   A0A2H1V2B5   D5L0M2   D0FZ08   A9QW14   A0A2A4JUK6   Q8MTC9   A0A248QJ75   A0A2W1BJD8   L0N790   A0A212EXA9   Q2L7F2   A0A437B7J2   X5DT35   A0A437B7Q4   A0A068ETT9   X5DQR3   A0A3S2NFU8   Q25508   W5JEA0   A0A212F1V8   A0MNW3   A0A068F0W3   A0MNW4   A0A2W1BPC2   A0A172MA26   Q8MTD0   D5L0M1   A0A0K0LBB1   A0A2W1BJV4   A0A182S536   V5W638   A0A0P4W8L7   B3GVW3   Q6VT81   A0A288ZBI1   A0A0C5BXG0   A0A0P4W0N6   A0A0K0LBB5   A0A0P4W5K9   A0A423TV42   A0A2A4JU89   K4FC60   A0A084WPX4   A0A2A4JUC6   D4PEE6   U5EWH6   A0A182G0G5   A0A286MXM1   A0A068EWP1   A0A182R010   A0A411E526   A0A194QYS2   A0A182J4G2   A0A0N7ZBL1   A0A2M4BJK1   A0A248QEJ1   A0A2M4BJ51   A0A182P7I8   A0A182R7H9   P29981   A0A067RGT8   A0A182FK32   A0A0K0LBA8   A0A1E1WBF9  

EC Number

1.14.14.1

Pubmed

12000647    18651917    28756777    28881445    22984814    26354079    + More
22651552    19121390    19909380    15315820    22118469    24361403    7639512    20920257    23761445    14521903    24438588    19954531    25299618    2034694    24845553   

EMBL

AK343220    BAM73902.1    AK289284    BAM73811.1    AY063500    AAL48299.1    + More
EF591060    ABU88427.1    KZ150005    PZC75221.1    DQ355383    ABC84370.2    KX443462    ASO98037.1    JX310089    AFP20600.1    KX443461    ASO98036.1    GDQN01008735    GDQN01003028    GDQN01001407    JAT82319.1    JAT88026.1    JAT89647.1    KP058451    AKP80586.1    KQ458981    KPJ04476.1    KM016732    AID54884.1    PZC75222.1    KM016731    AID54883.1    NWSH01006615    PCG63327.1    AK403264    BAM19668.1    KQ460882    KPJ11479.1    KY212039    ARA91603.1    AK343191    BAM73880.1    BABH01041553    BABH01031558    BABH01031559    BABH01031560    GDQN01004730    GDQN01002632    GDQN01000042    JAT86324.1    JAT88422.1    JAT91012.1    KP001139    AJN91184.1    FN356972    CAX94850.1    AK289282    BAM73809.1    ODYU01009575    SOQ54099.1    GDQN01009628    GDQN01002954    JAT81426.1    JAT88100.1    GU731525    ADE05575.1    AK289281    BAM73808.1    EF528484    ABP99018.1    EF523434    ABP87671.1    KX443467    ASO98042.1    ODYU01000355    SOQ34985.1    SOQ34986.1    GU731527    ADE05577.1    AB498590    BAI45222.1    EU273876    ABX64439.1    NWSH01000604    PCG75378.1    AY113688    AAM54723.1    KX443466    ASO98041.1    KZ150007    PZC75159.1    AK289283    BAM73810.1    AGBW02011790    OWR46123.1    DQ352137    ABC72321.2    RSAL01000129    RVE46480.1    KF701164    AHW57334.1    RVE46478.1    KM016730    AID54882.1    KF701163    AHW57333.1    RVE46477.1    L38671    AAC21661.1    ADMH02001390    ETN62682.1    AGBW02010786    OWR47720.1    EF017796    ABK27871.1    KM016728    AID54880.1    EF017797    ABK27872.1    PZC75157.1    KX008607    ANC90156.1    AY113687    AAM54722.1    GU731526    ADE05576.1    KM217037    AIW80000.1    PZC75158.1    KF668286    AHC02483.1    GDRN01081741    JAI61951.1    FM163384    CAQ57674.1    AY328467    AAQ93010.1    KX812713    ASU43935.1    KP001143    AJN91188.1    GDRN01081744    JAI61950.1    KM217034    AIW79997.1    GDRN01081739    JAI61953.1    QCYY01001130    ROT80325.1    PCG75379.1    JN835470    AFH35031.1    ATLV01025136    KE525369    KFB52268.1    PCG75376.1    GU969106    ADD63783.1    GANO01002947    JAB56924.1    MF684339    ASX93973.1    KM016729    AID54881.1    AXCN02002442    MH236443    QBA57448.1    KQ461150    KPJ08736.1    GDRN01081740    JAI61952.1    GGFJ01003990    MBW53131.1    KX443468    ASO98043.1    GGFJ01003936    MBW53077.1    M63798    KK852692    KDR18347.1    KM217038    AIW80001.1    GDQN01006741    JAT84313.1   

Proteomes

UP000053268    UP000218220    UP000053240    UP000005204    UP000007151    UP000283053    + More
UP000000673    UP000075900    UP000283509    UP000030765    UP000069272    UP000075886    UP000075880    UP000075885    UP000027135   

PRIDE

L0N6M8    L0N716    L0N7C1    H9JWX8    H9JCC3    L0N4I2    + More
L0N5E9    A5HG32    A5A3F8    D0FZ08    L0N790    A0MNW3    P29981   

Pfam

PF00067   p450

Interpro

IPR002401   Cyt_P450_E_grp-I        + More
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       
IPR036396   Cyt_P450_sf       
IPR002403   Cyt_P450_E_grp-IV       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

L0N6M8   L0N716   Q8ISJ8   B2BNZ3   A0A2W1BLR4   Q2I0J0   + More
A0A248QHK4   J7FIT5   A0A286QUL0   A0A1E1W5V0   A0A0U2DUD7   A0A194QLZ7   A0A068EU59   A0A068EVK2   A0A2A4ITL8   I4DP28   A0A0N1IEQ4   A0A1V0D9C7   L0N7C1   H9JWX8   H9JCC3   A0A1E1WH40   A0A0C5C1N3   C1LZ55   L0N4I2   A0A2H1WM10   A0A1E1WM70   D5L0M0   L0N5E9   A5HG32   A5A3F8   A0A248QFF8   A0A2H1V2B5   D5L0M2   D0FZ08   A9QW14   A0A2A4JUK6   Q8MTC9   A0A248QJ75   A0A2W1BJD8   L0N790   A0A212EXA9   Q2L7F2   A0A437B7J2   X5DT35   A0A437B7Q4   A0A068ETT9   X5DQR3   A0A3S2NFU8   Q25508   W5JEA0   A0A212F1V8   A0MNW3   A0A068F0W3   A0MNW4   A0A2W1BPC2   A0A172MA26   Q8MTD0   D5L0M1   A0A0K0LBB1   A0A2W1BJV4   A0A182S536   V5W638   A0A0P4W8L7   B3GVW3   Q6VT81   A0A288ZBI1   A0A0C5BXG0   A0A0P4W0N6   A0A0K0LBB5   A0A0P4W5K9   A0A423TV42   A0A2A4JU89   K4FC60   A0A084WPX4   A0A2A4JUC6   D4PEE6   U5EWH6   A0A182G0G5   A0A286MXM1   A0A068EWP1   A0A182R010   A0A411E526   A0A194QYS2   A0A182J4G2   A0A0N7ZBL1   A0A2M4BJK1   A0A248QEJ1   A0A2M4BJ51   A0A182P7I8   A0A182R7H9   P29981   A0A067RGT8   A0A182FK32   A0A0K0LBA8   A0A1E1WBF9  

PDB

6C94     E-value=6.32599e-53,     Score=525

KEGG

101736640    K15001 cytochrome P450 family 4 [EC:1.14.-.-] | (RefSeq) cytochrome P450 4C1-like

GO

GO:0004497   GO:0020037   GO:0016705   GO:0005506   GO:0016021   GO:0046872   GO:0070330   GO:0005789   GO:0007264   GO:0005515   GO:0003677   GO:0004003   GO:0005634   GO:0006289   GO:0016286   GO:0055114  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

SignalP

Position:   1 - 20,         Likelihood:  0.573971

 

 

Length:

495

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

12.61442

Exp number, first 60 AAs:

12.58665

Total prob of N-in:

0.71352

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  19

outside

20  -  495

 

 

Pi

13.246809

Theta

13.180792

Tajima's D

-0.90119

CLR

13.446098

CSRT

0.153342332883356

Interpretation

Uncertain