SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO12746  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA007195
Annotation
PREDICTED:_cytochrome_P450_4C1-like_[Bombyx_mori]
Full name
Cytochrome P450 4C1      
Alternative Name
CYPIVC1
Location in the cell
Cytoplasmic   Reliability : 1.649 Nuclear   Reliability : 1.17
 

Sequence

CDS
ATGATTTGGGCTGTAGTTTTATTGATTATTTTTATATTCTTGATATGGAAGGCTTTAGAGGATGAGGAGAATCCTCTTGACTCTCTTCCCGGACCAGAAAGGAAGCCGATCATTGGAGCCACTATGCGATTCGTCAATTTAAATACAAGAGAAATGTTTATAAAACTGCGCGAGTACCATGCGATGTACGGTACCAGATACGTTGTGAAGATATTCAAGAGGAGAATCCTGCATCTGTCTAACGAAAGGGATGTTGAGGTCGTATTGTCTCATTCGAAGAACATTAAGAAAAGTAAGCCTTATACGTTTCTGAGTCCTTGGCTCGGGAGCGATCTCCTGTTGAGCACCGGTTTTAAATGGCACAGCAGACGTAAGATTCTGACACCAACGTTTCACTTTAACATCTTGAAGAGCTTCTTAGAAATCATCAAGGACAAGAGTTGTGACTTGGTGAAGAGATTGGAGGAGTACAGGGGCGAAGAAGTAGACTTGATGCCCGTTATCAGTGACTTTACATTGTTTACGATTTGCGAAACGGCAATGGGCACCCAATTGGATTCAGACAAGTCAGCAGAAACCAGCGAATACAAAATGGCCATACTACAAATAGGATCTTTGCTGCTCGACAGACTGACCAAAGTTTGGCTCCACAACGACTTTATATTCCGCCAGTTTACCGTTGGGCGAAAGTTTCAGAAGTGCCTCAAACAAGTCCACTCTTTCGCCCATAATGTTATAGTTGAGAGGAAACGACAACGAGCATCTGGTAGAGACCCTACTGTCGTCGCAGAAGATGTATTCGGTCGTAAAAAGAGATTGGCCATGTTGGATCTTTTATTGGAGGCGGAAGAGAAAAATGAAATTGATTTTGAAGGAATAATGGATGAAGTTAATACATTTATGTTTGAGGGACACGACACAACTGCAGTCGCTTTAACGTTCAGTTTGATGTTGGTCGCGGAGGATGATCAAGTTCAAGATCGCATTTACAAGGAACTGCAAGGGATTTTTGGAGATTCTGACCGTCGGCCAACAATCAGTGATGTTGCCGAGATGAAGTACTTGGAAGCTGTAGTGAAGGAGACTCTGAGGCTGTATCCAAGTGTCCCGTTCATCGCTCGAGAGATCACTGAGGACTTTATGTTAGATGACCTAAAGATAAAGAAAGGATCAGAAGTAGCAGTCCACATCTATGATTTGCATCGTCGTAAAGAGCTGTTTTCTGACCCCGAGAAGTTCCTGCCCGATAGATTCTTGAACGGAGAATTGAAGCATCCATACAGCTTCGTGCCCTTTAGCGCAGGACCAAGGAACTGTATTGGTCAACGCTTCGCGACGCTGGAAATGAAGTGCGTCCTCAGTGAGATCTGTCGTAGCTTCAGACTAGAACCCCGCACTAAGGGTTGGCGGCCTACCCTCGTAGCCGAAATGCTTTTACGACCAAACGAACCTATTCATGTAAAGTTTATTAAACGCAAACAAAGCTGA
Protein
MIWAVVLLIIFIFLIWKALEDEENPLDSLPGPERKPIIGATMRFVNLNTREMFIKLREYHAMYGTRYVVKIFKRRILHLSNERDVEVVLSHSKNIKKSKPYTFLSPWLGSDLLLSTGFKWHSRRKILTPTFHFNILKSFLEIIKDKSCDLVKRLEEYRGEEVDLMPVISDFTLFTICETAMGTQLDSDKSAETSEYKMAILQIGSLLLDRLTKVWLHNDFIFRQFTVGRKFQKCLKQVHSFAHNVIVERKRQRASGRDPTVVAEDVFGRKKRLAMLDLLLEAEEKNEIDFEGIMDEVNTFMFEGHDTTAVALTFSLMLVAEDDQVQDRIYKELQGIFGDSDRRPTISDVAEMKYLEAVVKETLRLYPSVPFIAREITEDFMLDDLKIKKGSEVAVHIYDLHRRKELFSDPEKFLPDRFLNGELKHPYSFVPFSAGPRNCIGQRFATLEMKCVLSEICRSFRLEPRTKGWRPTLVAEMLLRPNEPIHVKFIKRKQS

Summary

Catalytic Activity
an alkane + O2 + reduced [NADPH--hemoprotein reductase] = a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Cofactor
heme
Similarity
Belongs to the cytochrome P450 family.
Keywords
Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase  
Feature
chain  Cytochrome P450 4C1
EC Number
1.14.14.1
EMBL
AK343220    BAM73902.1    AK289284    BAM73811.1    AY063500    AAL48299.1    + More
EF591060    ABU88427.1    KZ150005    PZC75221.1    DQ355383    ABC84370.2    KX443462    ASO98037.1    JX310089    AFP20600.1    KX443461    ASO98036.1    GDQN01008735    GDQN01003028    GDQN01001407    JAT82319.1    JAT88026.1    JAT89647.1    KP058451    AKP80586.1    KQ458981    KPJ04476.1    KM016732    AID54884.1    PZC75222.1    KM016731    AID54883.1    NWSH01006615    PCG63327.1    AK403264    BAM19668.1    KQ460882    KPJ11479.1    KY212039    ARA91603.1    AK343191    BAM73880.1    BABH01041553    BABH01031558    BABH01031559    BABH01031560    GDQN01004730    GDQN01002632    GDQN01000042    JAT86324.1    JAT88422.1    JAT91012.1    KP001139    AJN91184.1    FN356972    CAX94850.1    AK289282    BAM73809.1    ODYU01009575    SOQ54099.1    GDQN01009628    GDQN01002954    JAT81426.1    JAT88100.1    GU731525    ADE05575.1    AK289281    BAM73808.1    EF528484    ABP99018.1    EF523434    ABP87671.1    KX443467    ASO98042.1    ODYU01000355    SOQ34985.1    SOQ34986.1    GU731527    ADE05577.1    AB498590    BAI45222.1    EU273876    ABX64439.1    NWSH01000604    PCG75378.1    AY113688    AAM54723.1    KX443466    ASO98041.1    KZ150007    PZC75159.1    AK289283    BAM73810.1    AGBW02011790    OWR46123.1    DQ352137    ABC72321.2    RSAL01000129    RVE46480.1    KF701164    AHW57334.1    RVE46478.1    KM016730    AID54882.1    KF701163    AHW57333.1    RVE46477.1    L38671    AAC21661.1    ADMH02001390    ETN62682.1    AGBW02010786    OWR47720.1    EF017796    ABK27871.1    KM016728    AID54880.1    EF017797    ABK27872.1    PZC75157.1    KX008607    ANC90156.1    AY113687    AAM54722.1    GU731526    ADE05576.1    KM217037    AIW80000.1    PZC75158.1    KF668286    AHC02483.1    GDRN01081741    JAI61951.1    FM163384    CAQ57674.1    AY328467    AAQ93010.1    KX812713    ASU43935.1    KP001143    AJN91188.1    GDRN01081744    JAI61950.1    KM217034    AIW79997.1    GDRN01081739    JAI61953.1    QCYY01001130    ROT80325.1    PCG75379.1    JN835470    AFH35031.1    ATLV01025136    KE525369    KFB52268.1    PCG75376.1    GU969106    ADD63783.1    GANO01002947    JAB56924.1    MF684339    ASX93973.1    KM016729    AID54881.1    AXCN02002442    MH236443    QBA57448.1    KQ461150    KPJ08736.1    GDRN01081740    JAI61952.1    GGFJ01003990    MBW53131.1    KX443468    ASO98043.1    GGFJ01003936    MBW53077.1    M63798    KK852692    KDR18347.1    KM217038    AIW80001.1    GDQN01006741    JAT84313.1   
Pfam
PF00067   p450
Interpro
IPR002401   Cyt_P450_E_grp-I        + More
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       
IPR036396   Cyt_P450_sf       
IPR002403   Cyt_P450_E_grp-IV       
SUPFAM
SSF48264   SSF48264       
Gene 3D
PDB
6C94     E-value=6.32599e-53,     Score=525

Ontologies

Topology

Subcellular location
Endoplasmic reticulum membrane  
Microsome membrane  
SignalP
Position:   1 - 20,         Likelihood:  0.573971
 
 
Length:
495
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
12.61442
Exp number, first 60 AAs:
12.58665
Total prob of N-in:
0.71352
POSSIBLE N-term signal
sequence
inside
1  -  1
TMhelix
2  -  19
outside
20  -  495
 
 

Population Genetic Test Statistics

Pi
13.246809
Theta
13.180792
Tajima's D
-0.90119
CLR
13.446098
CSRT
0.153342332883356
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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