Gene

KWMTBOMO12744  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007169

Annotation

ras-like_protein_1_[Bombyx_mori]

Location

Bomo_Chr21(-):13621442-13627619      View in EpiBrowser

Full name

Ras-like protein 1      

Alternative Name

Dmras85D

Location in the cell

Cytoplasmic   Reliability : 3.417

CDS

ATGACCGAGTACAAATTGGTGGTTGTGGGTGCGGGAGGCGTTGGTAAATCCGCATTGACTATACAGCTGATACAGAATCACTTCGTGGACGAATACGATCCCACGATAGAGGATTCGTACCGTAAACAAGTCGTGATCGACGGTGAGACGTGTTTACTCGACATCCTGGACACGGCTGGCCAGGAAGAGTATTCGGCGATGAGAGACCAATACATGCGGACCGGGGAAGGATTCTTGCTGGTATTCGCCGTCAACAGTGCTAAAAGTTTCGAAGACATTGGCTCGTATCGCGAGCAGATCAAGCGAGTGAAGGACGCGGAAGAGGTGCCCATGGTACTTGTGGGCAACAAGTGCGACCTACAGTCGTGGGCCGTAGACATGGCGCGAGCACGAGAGGTGGCGCAAAGCTATAATGTTCCGTTCGTCGAAACATCGGCCAAAACACGCATGGGAGTTGACGACGCTTTCTACACGCTCGTGAGGGAGATACGCAAAGATAAAGTCAGCCGAGACAAGAAATTCAAAGGGAAGAAACCACGTCACGTTCACAAAATAATTAAAGATTGCACCCTTTTTTAA

Protein

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGSYREQIKRVKDAEEVPMVLVGNKCDLQSWAVDMARAREVAQSYNVPFVETSAKTRMGVDDAFYTLVREIRKDKVSRDKKFKGKKPRHVHKIIKDCTLF

Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells (PubMed:11290305). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).

Similarity

Belongs to the small GTPase superfamily. Ras family.

Keywords

Cell membrane   Complete proteome   GTP-binding   Lipoprotein   Membrane   Methylation   Nucleotide-binding   Prenylation   Reference proteome  

Feature

chain  Ras-like protein 1
propeptide  Removed in mature form

Uniprot

Q5KT36   A0A212FCP0   A0A0N1I665   E1AXG7   A0A0K8TML9   A0A2W1BNR1   + More
A0A2A4JWG2   A0A2H1V4W3   A0A437AWZ2   A0A1L8EGY4   T1PFW1   A0A034VYK3   A0A182NMS1   A0A182QRH8   A0A1I8PYA8   A0A1L8DV36   A0A182Y4M9   A0A182LW57   A0A182NZF6   A0A182TCM6   A0A182VM02   A0A182TSC9   A0A182VRX6   A0A084W105   A0A182X368   A0A182IR05   A0A182LQJ2   Q7QK91   A0A182HZJ5   A0A286RSD1   A0A1W4X007   A0A0K8WGR4   W8BVW0   A0A1A9XU59   A0A1B0AVL1   A0A1B0A3K2   D3TQ15   A0A0L0BR78   A0A336LS28   A0A336K696   A0A336LPE2   T1DIT9   Q16N58   A0A023EJ57   A0A1Y1LDW3   U5EY41   A0A336K410   A0A182RH15   A0A0T6AT07   A0A1Q3F0D0   B0WFI4   A0A2A3ER73   A0A088AUS1   K7IUG8   A0A2P8YZW3   A0A0A1XAM4   A0A0C9QIW7   A0A0M8ZRZ6   W5JB40   A0A182FAZ6   A0A0M4N074   A0A2M4AK70   T1DRK1   A0A2R7W4P7   E2A1F7   A0A154PIR6   A0A2M3ZHN1   A0A151IGY0   F4X8P7   A0A195BAI3   A0A195FCW5   A0A158NBH4   E2C6M4   A0A195DRH7   E9JAU0   A0A3L8DTG8   A0A067QHD4   D6W9R1   A0A0L7QL89   A0A1J1IZH1   A0A224XXJ8   A0A0P4VLU4   A0A023F5P8   T1HWY3   A0A069DNZ5   A0A1S3CVU8   A0A291NZI5   A0A291NZD2   A0A291NZB1   A0A291NZ71   A0A291NZJ7   A0A0Q9WNG4   B4LY29   B4PUP5   P83831   B4HKC7   P08646   P83832   B3NZR4   B3M185  

Pubmed

19121390    19946625    22118469    26354079    21167168    26369729    + More
28756777    25315136    25348373    25244985    24438588    20966253    12364791    14747013    17210077    24495485    20353571    26108605    24330624    17510324    24945155    28004739    20075255    29403074    25830018    20920257    23761445    20798317    21719571    21347285    21282665    30249741    24845553    18362917    19820115    27129103    25474469    26334808    17994087    18057021    10552039    14762063    3110012    6430564    10731132    12537572    12537569    7873789    11290305    18503409    19965758   

EMBL

BABH01031555    BABH01031556    BABH01031557    AB176555    BAD83777.1    AGBW02009157    + More
OWR51502.1    KQ460882    KPJ11484.1    HQ026487    ADM25851.1    GDAI01002185    JAI15418.1    KZ150005    PZC75245.1    NWSH01000508    PCG75974.1    ODYU01000681    SOQ35867.1    RSAL01000317    RVE42590.1    GFDG01000894    JAV17905.1    KA647646    AFP62275.1    GAKP01012335    GAKP01012334    JAC46618.1    AXCN02001208    GFDF01003787    JAV10297.1    AXCM01001303    ATLV01019177    KE525264    KFB43899.1    AXCP01001861    AAAB01008799    EAA03664.4    APCN01001981    KX833970    ASW21098.1    GDHF01008207    GDHF01002042    JAI44107.1    JAI50272.1    GAMC01003188    JAC03368.1    JXJN01004286    CCAG010002237    EZ423517    ADD19793.1    JRES01001582    KNC21734.1    UFQS01000097    UFQT01000097    SSW99391.1    SSX19771.1    SSW99392.1    SSX19772.1    SSW99390.1    SSX19770.1    GALA01000761    JAA94091.1    CH477837    EAT35784.1    GAPW01004744    GEHC01000769    JAC08854.1    JAV46876.1    GEZM01058185    JAV71813.1    GANO01000619    JAB59252.1    SSW99389.1    SSX19769.1    LJIG01022888    KRT78212.1    GFDL01014039    JAV21006.1    DS231918    EDS26252.1    KZ288192    PBC34190.1    AAZX01004436    PYGN01000262    PSN49787.1    GBXI01006564    GBXI01000025    JAD07728.1    JAD14267.1    GBYB01014677    GBYB01014678    GBYB01014679    JAG84444.1    JAG84445.1    JAG84446.1    KQ435883    KOX69747.1    ADMH02002017    GGFL01001270    ETN59979.1    MBW65448.1    KR075835    ALE20554.1    GGFK01007833    MBW41154.1    GAMD01000600    JAB00991.1    KK854327    PTY14693.1    GL435766    EFN72630.1    KQ434926    KZC11693.1    GGFM01007305    MBW28056.1    KQ977661    KYN00688.1    GL888932    EGI57316.1    KQ976540    KYM81242.1    KQ981673    KYN38231.1    ADTU01011108    GL453160    EFN76426.1    KQ980581    KYN15412.1    GL770679    EFZ10058.1    QOIP01000004    RLU23626.1    KK853392    KDR07913.1    KQ971312    EEZ98533.1    KQ414934    KOC59296.1    CVRI01000064    CRL05543.1    GFTR01003164    JAW13262.1    GDKW01000511    JAI56084.1    GBBI01002217    JAC16495.1    ACPB03012299    GBGD01003096    JAC85793.1    KY198393    ATJ26462.1    KY198390    ATJ26459.1    KY198391    ATJ26460.1    KY198389    ATJ26458.1    KY198392    ATJ26461.1    KY198394    KY198395    KY198396    KY198397    KY198398    CH940650    ATJ26463.1    ATJ26464.1    ATJ26465.1    ATJ26466.1    ATJ26467.1    KRF82977.1    EDW66895.1    CM000160    EDW96662.1    AF186649    CM000364    AY459550    AAF15515.1    CH480815    EDW42877.1    M16429    M16123    M16428    K01960    AF186648    AE014297    AY089541    AY094888    X73219    AF186650    AAF15516.1    CH954181    EDV49774.1    CH902617    EDV44355.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000283053    UP000095301    + More
UP000075884    UP000075886    UP000095300    UP000076408    UP000075883    UP000075885    UP000075901    UP000075903    UP000075902    UP000075920    UP000030765    UP000076407    UP000075880    UP000075882    UP000007062    UP000075840    UP000192223    UP000092443    UP000092460    UP000092445    UP000092444    UP000037069    UP000008820    UP000075900    UP000002320    UP000242457    UP000005203    UP000002358    UP000245037    UP000053105    UP000000673    UP000069272    UP000000311    UP000076502    UP000078542    UP000007755    UP000078540    UP000078541    UP000005205    UP000008237    UP000078492    UP000279307    UP000027135    UP000007266    UP000053825    UP000183832    UP000015103    UP000079169    UP000008792    UP000002282    UP000000304    UP000001292    UP000000803    UP000008711    UP000007801   

PRIDE

Q5KT36    B4LY29    B4PUP5    P83831    B4HKC7    P08646    + More
P83832    B3NZR4    B3M185   

Pfam

PF00071   Ras        + More
PF00004   AAA
PF08542   Rep_fac_C

Interpro

IPR001806   Small_GTPase        + More
IPR027417   P-loop_NTPase       
IPR020849   Small_GTPase_Ras-type       
IPR005225   Small_GTP-bd_dom       
IPR003593   AAA+_ATPase       
IPR008921   DNA_pol3_clamp-load_cplx_C       
IPR013748   Rep_factorC_C       
IPR003959   ATPase_AAA_core       

SUPFAM

SSF52540   SSF52540        + More
SSF48019   SSF48019       

ProteinModelPortal

Q5KT36   A0A212FCP0   A0A0N1I665   E1AXG7   A0A0K8TML9   A0A2W1BNR1   + More
A0A2A4JWG2   A0A2H1V4W3   A0A437AWZ2   A0A1L8EGY4   T1PFW1   A0A034VYK3   A0A182NMS1   A0A182QRH8   A0A1I8PYA8   A0A1L8DV36   A0A182Y4M9   A0A182LW57   A0A182NZF6   A0A182TCM6   A0A182VM02   A0A182TSC9   A0A182VRX6   A0A084W105   A0A182X368   A0A182IR05   A0A182LQJ2   Q7QK91   A0A182HZJ5   A0A286RSD1   A0A1W4X007   A0A0K8WGR4   W8BVW0   A0A1A9XU59   A0A1B0AVL1   A0A1B0A3K2   D3TQ15   A0A0L0BR78   A0A336LS28   A0A336K696   A0A336LPE2   T1DIT9   Q16N58   A0A023EJ57   A0A1Y1LDW3   U5EY41   A0A336K410   A0A182RH15   A0A0T6AT07   A0A1Q3F0D0   B0WFI4   A0A2A3ER73   A0A088AUS1   K7IUG8   A0A2P8YZW3   A0A0A1XAM4   A0A0C9QIW7   A0A0M8ZRZ6   W5JB40   A0A182FAZ6   A0A0M4N074   A0A2M4AK70   T1DRK1   A0A2R7W4P7   E2A1F7   A0A154PIR6   A0A2M3ZHN1   A0A151IGY0   F4X8P7   A0A195BAI3   A0A195FCW5   A0A158NBH4   E2C6M4   A0A195DRH7   E9JAU0   A0A3L8DTG8   A0A067QHD4   D6W9R1   A0A0L7QL89   A0A1J1IZH1   A0A224XXJ8   A0A0P4VLU4   A0A023F5P8   T1HWY3   A0A069DNZ5   A0A1S3CVU8   A0A291NZI5   A0A291NZD2   A0A291NZB1   A0A291NZ71   A0A291NZJ7   A0A0Q9WNG4   B4LY29   B4PUP5   P83831   B4HKC7   P08646   P83832   B3NZR4   B3M185  

PDB

5USJ     E-value=5.77696e-71,     Score=676

KEGG

692520    K07827 GTPase KRas | (RefSeq) Ras1, Bras1; ras-like protein 1

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04137    Mitophagy - animal - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)
04214    Apoptosis - fly - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0005525   GO:0016020   GO:0007165   GO:0003924   GO:0007265   GO:0019003   GO:0005886   GO:0007173   GO:0003677   GO:0006260   GO:0005524   GO:0036335   GO:0008340   GO:0046534   GO:0009267   GO:0002168   GO:0008293   GO:0048865   GO:0007455   GO:0010629   GO:0072089   GO:0007479   GO:0043703   GO:0072002   GO:0007430   GO:0008594   GO:0040014   GO:0048010   GO:0007395   GO:0035088   GO:0060438   GO:0051607   GO:0007427   GO:0007474   GO:0045500   GO:0030381   GO:0035208   GO:2001234   GO:0070374   GO:0007362   GO:0007422   GO:0016242   GO:0035169   GO:0008586   GO:0016318   GO:0007298   GO:0000165   GO:0008543   GO:0007309   GO:0001710   GO:0046673   GO:0007426   GO:0045793   GO:0048626   GO:1904263   GO:0035099   GO:0035170   GO:0001709   GO:0008361   GO:0040008   GO:0007465   GO:0007369   GO:0007391   GO:0008283   GO:0046530   GO:0007552   GO:0042981   GO:0007472   GO:0007476   GO:0007623   GO:0043066   GO:0008284   GO:0048749   GO:0048863   GO:0010507   GO:0042461   GO:0007264   GO:0005515   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

PANTHER

PTHR24070  

Subcellular location

Cell membrane  

Length:

192

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.59425

Exp number, first 60 AAs:

0.57744

Total prob of N-in:

0.11669

outside

1  -  192

 

 

Pi

3.858139

Theta

15.655732

Tajima's D

-0.990226

CLR

0.509741

CSRT

0.138843057847108

Interpretation

Uncertain