Gene

KWMTBOMO12742  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007194

Annotation

PREDICTED:_lon_protease_homolog?_mitochondrial_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr21(+):13595930-13609018      View in EpiBrowser

Full name

Lon protease homolog, mitochondrial       + More
Lon protease homolog      

Location in the cell

Mitochondrial   Reliability : 2.069

CDS

ATGTCGGGGTACATCGCGGAGGAGAAACTGGCCATAGCGCAGCAGTACCTGGTGCCGACGGCACGGCAGAACTGTGGGCTCTCCCAGCAGCAGCTGGCGGTGTCGGAGCCGGCGCTGCTGGCGCTCGTGCGCTCCTACTGCCGCGAGAGCGGAGTCCGAAACCTGCAGAAGCACATTGAAAAGATAGCCCGCAAGGTGGCTTATAAAATAGTGAAGAAGGAAACGGAAGAGGTCAACGTCACGGAAGAGAACCTGTCGGATTTGGTCGGCAAGCCTAGCTTCAAGCACGACCGCATGTATGACGTCACCCCGCCCGGCGTCATCATGGGACTAGCCTGGACCGCTATGGGGGGCAGCACACTGTACATAGAGACTGCACTGAGGAATAGCACACAGGACGAGAAGTCGCCCTTCGGCTCGCTGGAGCTGACCGGCCACCTCGGGGACGTCATGAAGGAGTCCGCTCGCATCGCGCTCACCGTCGCTAGGAATTACCTCGCCACCCACCACCCTGACAATAAGTTCTTGAACACGAGCCACCTCCACCTGCACGTGCCGGAGGGCGCCACCCCGAAGGACGGGCCGTCGGCCGGGGTCACCATCACGTCGGCGCTGCTGTCGCTGGCTCTGGGCAGGGCTCCGCGGGCCGACCTCGCCATGACGGGGGAGGTGTCCCTCACCGGTCGGGTGCTGCCCGTCGGCGGCATCAAGGAGAAGATTATAGCCGCGAAACGCGTGGGCGTGAAGTGCGTGATCCTTCCGGAGGAGAACAGGCGGGACTACGAGGACCTGCAGTCCTTCATCAAGCAAGACATAGACGTGCACTTCGTCAGCACGTACGACGACGTGTTCAGGGTCGCCTTTGGAGAGCAGCAGATATTCGAGGCCGACCACTCATCCACATCGGAGCTTTAA

Protein

MSGYIAEEKLAIAQQYLVPTARQNCGLSQQQLAVSEPALLALVRSYCRESGVRNLQKHIEKIARKVAYKIVKKETEEVNVTEENLSDLVGKPSFKHDRMYDVTPPGVIMGLAWTAMGGSTLYIETALRNSTQDEKSPFGSLELTGHLGDVMKESARIALTVARNYLATHHPDNKFLNTSHLHLHVPEGATPKDGPSAGVTITSALLSLALGRAPRADLAMTGEVSLTGRVLPVGGIKEKIIAAKRVGVKCVILPEENRRDYEDLQSFIKQDIDVHFVSTYDDVFRVAFGEQQIFEADHSSTSEL

Description

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Catalytic Activity

Hydrolysis of proteins in presence of ATP.

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Similarity

Belongs to the peptidase S16 family.

Uniprot

H9JCE9   A0A2H1V4Z6   A0A194QM00   A0A2A4JX53   A0A3S2LR09   A0A212FCQ2   + More
A0A2J7RJS7   A0A2J7RJT0   A0A0N0PBV6   N6T429   A0A158NUV2   E0VJG4   A0A195B8I8   A0A1B6MLC6   A0A1B6MLV5   A0A1L8DTJ0   A0A1B6HV54   U5EI28   A0A151IHZ3   A0A067QTG5   E2AFM0   K7IWC8   A0A182U9Z5   A0A1Y1LEI3   B0WP21   Q176B8   A0A1B0GKA2   A0A2F0BEE6   A0A2M4BEK3   A0A232F8W0   A0A182G8C0   A0A182JXX0   A0A182PSC1   E2BX97   A0A0N1ITX4   A0A182NDM9   A0A195FVU6   A0A1L8DTV2   A0A182UWV5   A0A0J7NG97   A0A151WNM8   A0A182Q276   A0A1Q3FX66   A0A182T7M0   A0A1Q3FWQ0   A0A2M4BCF8   A0A1B6IB05   A0A1B6HJ87   A0A2M4BCG1   D6W9J3   F4WNM2   A0A1Y1L8P7   U4UB30   A0A0A9X8U9   A0A2M4BCC6   A0A0P4VU21   A0A1Y1LG27   A0A182LNA9   A0A0K8S447   T1I5V3   A0A146MED5   A0A2P4SSW0   A0A0V0G6L8   A0A182HXB1   A0A182JL79   A0A182FM56   A0A1S4H431   A0A069DWP6   A0A182X851   A0A2M4A9T4   A0A224XBA6   A0A2M4A9L1   A0A1B6BZM9   Q7QDW1   A0A182RJQ2   A0A026WSQ1   A0A3L8DH63   T1PPM5   A0A182M6P9   Q56A16   W5JW89   A0A182YIQ7   A0A1B6H1P4   A0A1B6G104   A0A310SD14   A0A0L7R5Z5   A0A084VDC5   A0A2A3EKF6   A0A183U0V4   A0A3P7EVZ7   A0A088A462   A0A336LJ53   A0A023F4V0   A0A1I8M1H4   A0A1I8M1H7   F1L992   A0A336LMV6   A0A2J8JRE1   A0A1U7SFG0   A0A1I8PJS4  

EC Number

3.4.21.53
3.4.21.-

Pubmed

19121390    26354079    22118469    23537049    21347285    20566863    + More
24845553    20798317    20075255    28004739    17510324    28648823    26483478    18362917    19820115    21719571    25401762    27129103    20966253    26823975    12364791    26334808    24508170    30249741    15489334    20920257    23761445    25244985    24438588    25474469    25315136    21685128   

EMBL

BABH01031552    ODYU01000681    SOQ35869.1    KQ458981    KPJ04481.1    NWSH01000508    + More
PCG75972.1    RSAL01000317    RVE42591.1    AGBW02009157    OWR51500.1    NEVH01002988    PNF41086.1    PNF41087.1    KQ460882    KPJ11486.1    APGK01044427    KB741026    ENN74914.1    ADTU01002868    ADTU01002869    DS235222    EEB13520.1    KQ976565    KYM80509.1    GEBQ01003263    JAT36714.1    GEBQ01003047    JAT36930.1    GFDF01004312    JAV09772.1    GECU01029180    JAS78526.1    GANO01002794    JAB57077.1    KQ977545    KYN02031.1    KK853510    KDR07078.1    GL439118    EFN67771.1    GEZM01062186    JAV69966.1    DS232018    EDS32048.1    CH477391    EAT41940.1    AJWK01028599    NTJE010156281    MBW01356.1    GGFJ01002334    MBW51475.1    NNAY01000634    OXU27284.1    JXUM01047603    JXUM01047604    JXUM01047605    JXUM01047606    JXUM01047607    JXUM01047608    JXUM01047609    JXUM01047610    KQ561527    KXJ78274.1    GL451230    EFN79680.1    KQ435728    KOX77752.1    KQ981215    KYN44546.1    GFDF01004359    JAV09725.1    LBMM01005390    KMQ91560.1    KQ982918    KYQ49295.1    AXCN02001747    GFDL01003032    JAV32013.1    GFDL01003036    JAV32009.1    GGFJ01001562    MBW50703.1    GECU01023582    JAS84124.1    GECU01032947    JAS74759.1    GGFJ01001561    MBW50702.1    KQ971312    EEZ98145.1    GL888237    EGI64215.1    GEZM01062187    JAV69964.1    KB631924    ERL87165.1    GBHO01026487    JAG17117.1    GGFJ01001563    MBW50704.1    GDKW01002263    JAI54332.1    GEZM01062185    JAV69967.1    GBRD01017766    JAG48061.1    ACPB03008304    GDHC01006234    GDHC01000471    JAQ12395.1    JAQ18158.1    PPHD01024931    POI27196.1    GECL01002438    JAP03686.1    APCN01005172    AAAB01008849    GBGD01000421    JAC88468.1    GGFK01004243    MBW37564.1    GFTR01008212    JAW08214.1    GGFK01004175    MBW37496.1    GEDC01030575    JAS06723.1    EAA07151.4    KK107109    EZA59062.1    QOIP01000008    RLU19522.1    KA650140    AFP64769.1    AXCM01000213    BC092212    AAH92212.1    ADMH02000098    ETN67828.1    GECZ01001202    JAS68567.1    GECZ01013663    JAS56106.1    KQ762962    OAD55184.1    KQ414648    KOC66312.1    ATLV01011253    KE524658    KFB35969.1    KZ288219    PBC32293.1    UYWY01001958    VDM27510.1    UFQT01000027    SSX18112.1    GBBI01002669    JAC16043.1    JI174384    ADY46696.1    SSX18111.1    NBAG03000432    PNI25343.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000283053    UP000007151    UP000235965    + More
UP000053240    UP000019118    UP000005205    UP000009046    UP000078540    UP000078542    UP000027135    UP000000311    UP000002358    UP000075902    UP000002320    UP000008820    UP000092461    UP000215335    UP000069940    UP000249989    UP000075881    UP000075885    UP000008237    UP000053105    UP000075884    UP000078541    UP000075903    UP000036403    UP000075809    UP000075886    UP000075901    UP000007266    UP000007755    UP000030742    UP000075882    UP000015103    UP000075840    UP000075880    UP000069272    UP000076407    UP000007062    UP000075900    UP000053097    UP000279307    UP000075883    UP000000673    UP000076408    UP000053825    UP000030765    UP000242457    UP000050794    UP000267007    UP000005203    UP000095301    UP000189705    UP000095300   

PRIDE

H9JCE9   

Pfam

PF05362   Lon_C        + More
PF00004   AAA
PF02190   LON_substr_bdg
PF01593   Amino_oxidase

Interpro

IPR008269   Lon_proteolytic        + More
IPR008268   Peptidase_S16_AS       
IPR027065   Lon_Prtase       
IPR003593   AAA+_ATPase       
IPR015947   PUA-like_sf       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR004815   Lon_bac/euk-typ       
IPR027503   Lonm_euk       
IPR003959   ATPase_AAA_core       
IPR027417   P-loop_NTPase       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR003111   Lon_substr-bd       
IPR004572   Protoporphyrinogen_oxidase       
IPR036188   FAD/NAD-bd_sf       
IPR002937   Amino_oxidase       

SUPFAM

SSF54211   SSF54211        + More
SSF88697   SSF88697       
SSF52540   SSF52540       
SSF51905   SSF51905       

Gene 3D

3.30.230.10     3.50.50.60    

ProteinModelPortal

H9JCE9   A0A2H1V4Z6   A0A194QM00   A0A2A4JX53   A0A3S2LR09   A0A212FCQ2   + More
A0A2J7RJS7   A0A2J7RJT0   A0A0N0PBV6   N6T429   A0A158NUV2   E0VJG4   A0A195B8I8   A0A1B6MLC6   A0A1B6MLV5   A0A1L8DTJ0   A0A1B6HV54   U5EI28   A0A151IHZ3   A0A067QTG5   E2AFM0   K7IWC8   A0A182U9Z5   A0A1Y1LEI3   B0WP21   Q176B8   A0A1B0GKA2   A0A2F0BEE6   A0A2M4BEK3   A0A232F8W0   A0A182G8C0   A0A182JXX0   A0A182PSC1   E2BX97   A0A0N1ITX4   A0A182NDM9   A0A195FVU6   A0A1L8DTV2   A0A182UWV5   A0A0J7NG97   A0A151WNM8   A0A182Q276   A0A1Q3FX66   A0A182T7M0   A0A1Q3FWQ0   A0A2M4BCF8   A0A1B6IB05   A0A1B6HJ87   A0A2M4BCG1   D6W9J3   F4WNM2   A0A1Y1L8P7   U4UB30   A0A0A9X8U9   A0A2M4BCC6   A0A0P4VU21   A0A1Y1LG27   A0A182LNA9   A0A0K8S447   T1I5V3   A0A146MED5   A0A2P4SSW0   A0A0V0G6L8   A0A182HXB1   A0A182JL79   A0A182FM56   A0A1S4H431   A0A069DWP6   A0A182X851   A0A2M4A9T4   A0A224XBA6   A0A2M4A9L1   A0A1B6BZM9   Q7QDW1   A0A182RJQ2   A0A026WSQ1   A0A3L8DH63   T1PPM5   A0A182M6P9   Q56A16   W5JW89   A0A182YIQ7   A0A1B6H1P4   A0A1B6G104   A0A310SD14   A0A0L7R5Z5   A0A084VDC5   A0A2A3EKF6   A0A183U0V4   A0A3P7EVZ7   A0A088A462   A0A336LJ53   A0A023F4V0   A0A1I8M1H4   A0A1I8M1H7   F1L992   A0A336LMV6   A0A2J8JRE1   A0A1U7SFG0   A0A1I8PJS4  

PDB

2X36     E-value=4.62426e-72,     Score=688

KEGG

101738203    K08675 ATP-dependent Lon protease [EC:3.4.21.53] | (RefSeq) lon protease homolog, mitochondrial

GO

GO:0006515   GO:0004176   GO:0005524   GO:0051131   GO:0043565   GO:0004252   GO:0070407   GO:0005759   GO:0034599   GO:0030163   GO:0016021   GO:0007005   GO:0003697   GO:0006779   GO:0004729   GO:0006508   GO:0004386   GO:0005515   GO:0003677   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

PANTHER

PTHR43718  

Subcellular location

Mitochondrion matrix  

Length:

304

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.98456

Exp number, first 60 AAs:

0.00033

Total prob of N-in:

0.03063

outside

1  -  304

 

 

Pi

18.464002

Theta

17.73133

Tajima's D

-0.808283

CLR

1.30122

CSRT

0.176041197940103

Interpretation

Uncertain