Gene

KWMTBOMO12741  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007194

Annotation

PREDICTED:_lon_protease_homolog?_mitochondrial_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr21(+):13589540-13594957      View in EpiBrowser

Full name

Lon protease homolog, mitochondrial       + More
Lon protease homolog      

Alternative Name

Lon protease-like protein
Mitochondrial ATP-dependent protease Lon
Serine protease 15

Location in the cell

Mitochondrial   Reliability : 1.814 Nuclear   Reliability : 1.859

CDS

ATGCATACAGCAAGTGTTCTGCTACGAAATTCGATACTTAATCCTAAATTGTGTTCGACACGGCTCTTGAATAATATAACTAGAATTGCATCACACAAACCGGTGCAAAGGTTGTCTAGTAGTTTACACAGATTTAGGGGTCCTCGGGTCTGTGGTCATATTGACAATTATTTATGTTCTTCCAAAGACTTAGGTTGTACACGATTATTTTCGACCGGGAATAAAGGTGATCCTCCAGAAGACGAACCGGAAATTAAAGACGAGACTCCTCTCTTTAGTAGTCAACTACCGGCAACGGTCGCTGTGCCGGAAGTATGGCCGCAAGTTCCAGTTATTGCCATTAATAGGAATCCAGTGTTTCCAAGATTCATTAAGTTAATTGAGATATCGAACCCAGCCCTAATTGATCTAATAAGGCGTAAAGTTAAACTCAATCAACCATATGTTGGTATATTCTTACGTAAGAAGGAAGATGAAAAATCTGACATTGTATCAAGCTTGGAAGATGTACATGAGGTGGGAGTATTTGCACAGATACACGAGATGCAAGATATGGATTACAAGCTGAGGCTCGTTGTGATGGCTCATCGTAGAATAAAAATCACAGGCCAGTTTGTTGAGGAAGAGGTTGAGACTGGTCCTGCAGAGTCCGATGCTGAGCGACGGAGGCGAAAATATCGTAACACAAGGAAGAAACCAGCTACTGATGCAGACAATGAGCCAAAGAAAGCACCCCCAGACCAGGTTCTGATGGTGAAGGTTGAGAATATGATGCACGAAAAGTTCCAGCAGACAGAGGAAGTCAAGGCTCTAACACAGGAAGTCATCAAGACAATTAGAGATATTATTAATTTGAATCCTTTGTATAGAGAGTCCCTTCACCACATGCTGGCCCAAGGTCAGAGGGTGATAGATAACCCGGTTTATCTAAGTGATCTTGGAGCAGCTCTCACCGGTGCTGAACCAGCCGAGTTACAAGCTATTCTGGAGGAAATGGATATACCAAAAAGATTGTTGATGTCTCTATCTCTACTGAAGAAGGAGTATGAACTGTCGAAACTGCAGCAGAAGATAGGCAAAGAAGTCGAAGAGAAAGTGAAACAGCAACACAGGAAATACATTTTACATGAACAACTTAAGGTAATAAAAAAGGAGTTGGGCCTGGAAAAAGACGATAAAGATGCCATCGGAGAGAAGTTCAGGGAGCGTCTGGCCGACAAGACGGTGCCTCAAGCCGTGCAAACCGTCATCGATGAAGAGCTCAACAAGCTGAACTTCTTGGAGGGACACAGTTCTGAGTTCAACGTAACACGGTGTTACCTGGACTGGTTGACCTCCCTCCCTTGGGGCATCACCTCTGAGGAAAACCTCAAGTTGGAAGATGCTCAAGTGATTTTAGACCAAGATCACTATGGCATGGAGGATATAAAGAAACGAATCCTCGAGTTCATTGCGGTCTCGCAGCTGAAGGGCACCACCCAAGGCAAGATACTGTGCTTCCATGGACCTCCAGGTGTAGGCAAGACCAGTATAGCCCGTTCGATAGCTCGTGCGCTGAACCGGCAGTACTTCAGGTTCTCCGTGGGCGGCATGACGGACGTGGCCGAGATCAAGGGTCACCGCAGGACGTACGTTGGCGCCATGCCGGGGAAAATCGTGCAGTGCCTCAAGAAAACCGGCACCGAAAACCCTCTGGTGCTGATCGATGAGGTCGATAAGATTGGCAATTGA

Protein

MHTASVLLRNSILNPKLCSTRLLNNITRIASHKPVQRLSSSLHRFRGPRVCGHIDNYLCSSKDLGCTRLFSTGNKGDPPEDEPEIKDETPLFSSQLPATVAVPEVWPQVPVIAINRNPVFPRFIKLIEISNPALIDLIRRKVKLNQPYVGIFLRKKEDEKSDIVSSLEDVHEVGVFAQIHEMQDMDYKLRLVVMAHRRIKITGQFVEEEVETGPAESDAERRRRKYRNTRKKPATDADNEPKKAPPDQVLMVKVENMMHEKFQQTEEVKALTQEVIKTIRDIINLNPLYRESLHHMLAQGQRVIDNPVYLSDLGAALTGAEPAELQAILEEMDIPKRLLMSLSLLKKEYELSKLQQKIGKEVEEKVKQQHRKYILHEQLKVIKKELGLEKDDKDAIGEKFRERLADKTVPQAVQTVIDEELNKLNFLEGHSSEFNVTRCYLDWLTSLPWGITSEENLKLEDAQVILDQDHYGMEDIKKRILEFIAVSQLKGTTQGKILCFHGPPGVGKTSIARSIARALNRQYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIVQCLKKTGTENPLVLIDEVDKIGN

Description

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.

Catalytic Activity

Hydrolysis of proteins in presence of ATP.

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.
Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.

Similarity

Belongs to the peptidase S16 family.
Belongs to the syntaxin family.

Uniprot

H9JCE9   A0A2H1V4Z6   A0A3S2LR09   A0A2A4JX53   A0A437ASC3   D6W9J3   + More
A0A1Y1L8P7   A0A2J7RJS7   A0A1Y1LG27   A0A1Q3FWQ0   A0A2J7RJT0   A0A0P4VU21   T1I5V3   A0A224XBA6   A0A182G8C0   Q176B8   A0A0V0G6L8   E0VJG4   A0A1Q3FX66   A0A069DWP6   A0A1B6H1P4   E2BX97   A0A2M4BCF8   A0A2M4BCG1   A0A1B6G104   A0A182PSC1   A0A2M4BCC6   A0A2M4A9L1   A0A182M6P9   A0A0A9X8U9   A0A146MED5   A0A2M4A9T4   A0A1J1IHL0   N6T429   A0A0K8S447   A0A023F4V0   A0A1L8DTV2   T1GQ42   U5EI28   A0A0P5BWA6   A0A0P6EWL4   A0A336LJN4   L7M609   A0A336LJ02   A0A131XEQ5   A0A131YMI1   L7LWL8   A0A336LK93   A0A336LNC7   E9GU95   A0A0P5EP01   A0A1E1X9V7   G3MF31   A0A0K8RH37   A0A293MW43   A0A147BHR5   A0A443SFI4   A0A131XUJ5   C3YBR1   A0A0N8EJ88   A0A3B4YRV0   A0A3Q3FGG8   A0A2U9C721   A0A3B4TTD5   W5M5N0   A0A3B3R0W5   W5LQB5   A0A0F8AL53   A0A2D0RT06   A0A1A8QRZ1   A0A1A8N0W2   A0A1A8RQ17   W5UDG1   A0A3Q1CR95   A0A2R5LM27   A0A091GFE7   A0A1A8SA98   A0A3P8TV30   A0A1A8HY04   A0A147AMM2   A0A1A8FVM3   A0A2U3Z2B4   A0A2U3Z2A0   A0A1A8GY32   A0A1A8ATA5   A0A3P8X199   A0A1A7Z3V2   A0A1A7WJF5   A0A2U3Z2B1   A0A1A8CAL4   H0YP48   A0A3Q3NBL3   A0A1A8DM21   A0A1S3FNI0   A0A3Q3NJE6   F6Z4A8   A0A1L8HXB6   A0A337S6C6   A0A2K6FHM2   M3WFV4  

EC Number

3.4.21.53
3.4.21.-

Pubmed

19121390    18362917    19820115    28004739    27129103    26483478    + More
17510324    20566863    26334808    20798317    25401762    26823975    23537049    25474469    25576852    28049606    26830274    21292972    28503490    22216098    29652888    18563158    29240929    25329095    25835551    23127152    24487278    20360741    20431018    27762356    17975172   

EMBL

BABH01031552    ODYU01000681    SOQ35869.1    RSAL01000317    RVE42591.1    NWSH01000508    + More
PCG75972.1    RSAL01001034    RVE40976.1    KQ971312    EEZ98145.1    GEZM01062187    JAV69964.1    NEVH01002988    PNF41086.1    GEZM01062185    JAV69967.1    GFDL01003036    JAV32009.1    PNF41087.1    GDKW01002263    JAI54332.1    ACPB03008304    GFTR01008212    JAW08214.1    JXUM01047603    JXUM01047604    JXUM01047605    JXUM01047606    JXUM01047607    JXUM01047608    JXUM01047609    JXUM01047610    KQ561527    KXJ78274.1    CH477391    EAT41940.1    GECL01002438    JAP03686.1    DS235222    EEB13520.1    GFDL01003032    JAV32013.1    GBGD01000421    JAC88468.1    GECZ01001202    JAS68567.1    GL451230    EFN79680.1    GGFJ01001562    MBW50703.1    GGFJ01001561    MBW50702.1    GECZ01013663    JAS56106.1    GGFJ01001563    MBW50704.1    GGFK01004175    MBW37496.1    AXCM01000213    GBHO01026487    JAG17117.1    GDHC01006234    GDHC01000471    JAQ12395.1    JAQ18158.1    GGFK01004243    MBW37564.1    CVRI01000052    CRK99707.1    APGK01044427    KB741026    ENN74914.1    GBRD01017766    JAG48061.1    GBBI01002669    JAC16043.1    GFDF01004359    JAV09725.1    CAQQ02064828    GANO01002794    JAB57077.1    GDIP01179614    JAJ43788.1    GDIQ01070439    JAN24298.1    UFQT01000027    SSX18110.1    GACK01009530    GACK01005303    JAA59731.1    SSX18114.1    GEFH01003896    JAP64685.1    GEDV01008907    JAP79650.1    GACK01009805    JAA55229.1    SSX18115.1    SSX18109.1    GL732565    EFX77013.1    GDIP01143675    JAJ79727.1    GFAC01003392    JAT95796.1    JO840482    AEO32099.1    GADI01003665    JAA70143.1    GFWV01020018    MAA44746.1    GEGO01005103    JAR90301.1    NCKV01002925    RWS26252.1    GEFM01006470    JAP69326.1    GG666497    EEN62418.1    GDIQ01021364    JAN73373.1    CP026254    AWP11526.1    AHAT01011189    KQ041835    KKF21860.1    HAEG01013836    SBR96023.1    HAEF01021250    SBR62409.1    HAEH01018511    SBS07797.1    JT412577    AHH39905.1    GGLE01006457    MBY10583.1    KL448126    KFO80688.1    HAEI01012399    SBS14868.1    HAED01003406    HAEE01012578    SBQ89378.1    GCES01006888    JAR79435.1    HAEB01016525    SBQ63052.1    HAEC01007292    SBQ75430.1    HADY01018985    HAEJ01006002    SBP57470.1    HADX01014804    SBP37036.1    HADW01004503    SBP05903.1    HADZ01012728    SBP76669.1    ABQF01053700    ABQF01053701    ABQF01053702    HAEA01006925    SBQ35405.1    AAMC01082495    CM004466    OCU00518.1    AANG04002859   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007266    UP000235965    UP000015103    + More
UP000069940    UP000249989    UP000008820    UP000009046    UP000008237    UP000075885    UP000075883    UP000183832    UP000019118    UP000015102    UP000000305    UP000288716    UP000001554    UP000261360    UP000264800    UP000246464    UP000261420    UP000018468    UP000261540    UP000018467    UP000221080    UP000257160    UP000053760    UP000265080    UP000245341    UP000265120    UP000007754    UP000261640    UP000081671    UP000008143    UP000186698    UP000011712    UP000233160   

PRIDE

H9JCE9    L7M609    L7LWL8    G3MF31   

Pfam

PF05362   Lon_C        + More
PF00004   AAA
PF02190   LON_substr_bdg
PF16124   RecQ_Zn_bind
PF00270   DEAD
PF00271   Helicase_C
PF05739   SNARE

Interpro

IPR008269   Lon_proteolytic        + More
IPR008268   Peptidase_S16_AS       
IPR027065   Lon_Prtase       
IPR003593   AAA+_ATPase       
IPR015947   PUA-like_sf       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR004815   Lon_bac/euk-typ       
IPR027503   Lonm_euk       
IPR003959   ATPase_AAA_core       
IPR027417   P-loop_NTPase       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR003111   Lon_substr-bd       
IPR004589   DNA_helicase_ATP-dep_RecQ       
IPR032284   RecQ_Zn-bd       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR000727   T_SNARE_dom       
IPR010989   SNARE       
IPR006012   Syntaxin/epimorphin_CS       
IPR001270   ClpA/B       

SUPFAM

SSF54211   SSF54211        + More
SSF88697   SSF88697       
SSF52540   SSF52540       
SSF47661   SSF47661       

Gene 3D

3.30.230.10    

CDD

cd00079  HELICc

ProteinModelPortal

H9JCE9   A0A2H1V4Z6   A0A3S2LR09   A0A2A4JX53   A0A437ASC3   D6W9J3   + More
A0A1Y1L8P7   A0A2J7RJS7   A0A1Y1LG27   A0A1Q3FWQ0   A0A2J7RJT0   A0A0P4VU21   T1I5V3   A0A224XBA6   A0A182G8C0   Q176B8   A0A0V0G6L8   E0VJG4   A0A1Q3FX66   A0A069DWP6   A0A1B6H1P4   E2BX97   A0A2M4BCF8   A0A2M4BCG1   A0A1B6G104   A0A182PSC1   A0A2M4BCC6   A0A2M4A9L1   A0A182M6P9   A0A0A9X8U9   A0A146MED5   A0A2M4A9T4   A0A1J1IHL0   N6T429   A0A0K8S447   A0A023F4V0   A0A1L8DTV2   T1GQ42   U5EI28   A0A0P5BWA6   A0A0P6EWL4   A0A336LJN4   L7M609   A0A336LJ02   A0A131XEQ5   A0A131YMI1   L7LWL8   A0A336LK93   A0A336LNC7   E9GU95   A0A0P5EP01   A0A1E1X9V7   G3MF31   A0A0K8RH37   A0A293MW43   A0A147BHR5   A0A443SFI4   A0A131XUJ5   C3YBR1   A0A0N8EJ88   A0A3B4YRV0   A0A3Q3FGG8   A0A2U9C721   A0A3B4TTD5   W5M5N0   A0A3B3R0W5   W5LQB5   A0A0F8AL53   A0A2D0RT06   A0A1A8QRZ1   A0A1A8N0W2   A0A1A8RQ17   W5UDG1   A0A3Q1CR95   A0A2R5LM27   A0A091GFE7   A0A1A8SA98   A0A3P8TV30   A0A1A8HY04   A0A147AMM2   A0A1A8FVM3   A0A2U3Z2B4   A0A2U3Z2A0   A0A1A8GY32   A0A1A8ATA5   A0A3P8X199   A0A1A7Z3V2   A0A1A7WJF5   A0A2U3Z2B1   A0A1A8CAL4   H0YP48   A0A3Q3NBL3   A0A1A8DM21   A0A1S3FNI0   A0A3Q3NJE6   F6Z4A8   A0A1L8HXB6   A0A337S6C6   A0A2K6FHM2   M3WFV4  

PDB

4YPN     E-value=1.00837e-48,     Score=490

KEGG

101738203    K08675 ATP-dependent Lon protease [EC:3.4.21.53] | (RefSeq) lon protease homolog, mitochondrial

GO

GO:0006515   GO:0004176   GO:0005524   GO:0051131   GO:0043565   GO:0004252   GO:0070407   GO:0005759   GO:0034599   GO:0007005   GO:0003697   GO:0008026   GO:0006310   GO:0030163   GO:0043531   GO:0051880   GO:0001018   GO:0042645   GO:0001666   GO:0003727   GO:0005829   GO:0070182   GO:0051260   GO:0005654   GO:0006508   GO:0004386   GO:0005515   GO:0003677   GO:0004003   GO:0005634   GO:0006289   GO:0016286  

PANTHER

PTHR43718  

Subcellular location

Mitochondrion matrix  

Length:

576

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00105

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.00095

outside

1  -  576

 

 

Pi

21.595765

Theta

19.038469

Tajima's D

0.355571

CLR

0.34409

CSRT

0.479226038698065

Interpretation

Uncertain