Gene

KWMTBOMO12678

Pre Gene Modal

BGIBMGA001590

Annotation

PREDICTED:_OTU_domain-containing_protein_7B-like_[Bombyx_mori]

Location

Bomo_Chr21(+):11435553-11462307      View in EpiBrowser

Full name

Proteasome endopeptidase complex      

Location in the cell

Nuclear   Reliability : 1.794

CDS

ATGGTGATGGAAGCAGATCCGATAGCCGAAAAACGAAATGACGAGAGAGTGCACAGTGCGCCTTTGAAGGCAAGGGCGGGCGGTGACGTCATGGGAGAGCGTTCAGTCGATACTTTGGACATGGCCTTCACGGGACCTTCAAATTTAGTGCTCACACCAGCCCCGGAATGTCGGAAACTGTCCCGTGGCATTTCCCGGGCCACAGATAACGAAGGCCTGGTGTGGGCGTTACGTAACAACACAGACCCGGAGCCAAGCACGCTAAGCTCCGATCACATACTGCTCCTACCGGATATAACGGTTTACCCGCCGGATTTCAGAACATTCTTGGAGAAGGACTTACTAGAGACAGCCACTTTGGTCACATTAGAGACGGCAAATATATTGAACTGGTGGTGCCACGGCCGGGTGCCGGGTGCTCCTCGACTGCTGCCACTAGCGACGTCAGGAGACGGGAACTGCTTACCTCATGCGGCGTCATTAGCGGCCTACGGCTTCCACGACAGATTGCTCGCTTTGAGGACCAAAGTACAGGCTCTACTGTCCGGGGAATACGGCGAAACTATAACGAACGCGATCCGGCGTCGCTGGCGCTGGTCTGAGAGCGCGTCGCTGTGCGCGGCGGGGCTGGTCCCGTCGGAGGGCGAGTGGGCGCGCGAGTGGCGCGAGGCGGTGGCGGCGGCGGCCCCCACCCCCCGCGCCCCGCACCCGCAGCACGCGCCGCACTACACCGGGCTGGACGCGCTGCACGTGCTCGCGCTCGCGCACGTCATGCGGCGCCCGGTGCTCGTGTTCGCCGACGTCGCTCTCAGGGATTACCACGGTGACCCGATAGCGCCGATCCCGTTCGGGGGCGTCTATCTGCCGTTGGAACTGGACCCGGCGCAGTGCAGCCGCGCGCCCGTGCTGCTGGCCTACGACGCGGGACACTTCTCCGCGCTGGTCCCCTGCGAGCCCCTGCCCGCCGCCGGGGCCCGAGTGCCGCTCGAAGACAGCGCTGGCAACCCTATGCCGATCAGGTTCAGTGTAGATCCAGGCGAAGACTTCCGCTGGGACGTGGAGCACGATCAAAAAGTTATCAACAACCTCCTCCCGGATGAATACGAGAGATCCGCCATGCTGGCTGCTTATTTAGACCTCGAGAGGGTTGAATGCGTAACGCAGAATCAACCCCCCGAAGAGCTAAGACGATCGCTGGACGCACTGTCGACTAAAAGCTCGAAACAATTAAATTCTGTCGCCAAACAGTTTGGCAGCATCGGCAGGTCTATGAGCAGTAAGATAAAGAAGAATTTCGGGTCCATGGCCAAACTGACTGGCAAGAGCAGCGGCAGTCAAAGTAATCCTGAAGAGAGCTTGGTGCGGAGGCAGTCGACGTGCGAGGTGCTCTGTTGCAGGGTGCTAGCCGCAAGAGCACCTGTGCAAGAAGAAATGGTCAAAAACTATCTCAACGAAGCATGGACGGGGTACACCGCGGAAAAGAACCGCAAGGAAGCGTCGCCCTGCGAGCCCGGGCAGCCGCGGTACGGCACCGGCAAGTCGCAGTTCTACGCGGAGGCGGACCGCGCGGCGCACGAGCTGGCCCGCAGCCACGCCGCGCGCTCGGGCCGCCCCGCCGCCGACCGCACGCTCTACCTGTCCCGGTCAACGTTCTACGTCGACCGCCCGCCCTCCCCGCGCCCCTGCCGCGCGCCCCTCTGCGCCTACTACGGCAGCCCCGCCAACGACGACTACTGCTCGAGGTGTGCGAAACTGCAGTGA

Protein

MVMEADPIAEKRNDERVHSAPLKARAGGDVMGERSVDTLDMAFTGPSNLVLTPAPECRKLSRGISRATDNEGLVWALRNNTDPEPSTLSSDHILLLPDITVYPPDFRTFLEKDLLETATLVTLETANILNWWCHGRVPGAPRLLPLATSGDGNCLPHAASLAAYGFHDRLLALRTKVQALLSGEYGETITNAIRRRWRWSESASLCAAGLVPSEGEWAREWREAVAAAAPTPRAPHPQHAPHYTGLDALHVLALAHVMRRPVLVFADVALRDYHGDPIAPIPFGGVYLPLELDPAQCSRAPVLLAYDAGHFSALVPCEPLPAAGARVPLEDSAGNPMPIRFSVDPGEDFRWDVEHDQKVINNLLPDEYERSAMLAAYLDLERVECVTQNQPPEELRRSLDALSTKSSKQLNSVAKQFGSIGRSMSSKIKKNFGSMAKLTGKSSGSQSNPEESLVRRQSTCEVLCCRVLAARAPVQEEMVKNYLNEAWTGYTAEKNRKEASPCEPGQPRYGTGKSQFYAEADRAAHELARSHAARSGRPAADRTLYLSRSTFYVDRPPSPRPCRAPLCAYYGSPANDDYCSRCAKLQ

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Similarity

Belongs to the peptidase T1A family.

Uniprot

A0A2A4JQ31   A0A212F7A1   A0A2H1VDW9   A0A3S2PKT0   H9IWF8   A0A194QDR2   + More
A0A194REC3   A0A2H1WSX5   A0A088AV33   A0A2A3ESQ1   A0A0L7R7P8   E2ARU1   F4WE71   A0A154NZA4   A0A0J7P029   A0A151IRT1   A0A151JYJ9   A0A1B6DXN3   A0A1B6ITD5   A0A158NZ45   T1IG62   A0A151I5L0   A0A151XJ64   A0A0M8ZRT6   A0A232ETT1   A0A023F3G1   A0A1B6L9T1   A0A195D1R1   E2BZH6   K7IXF6   A0A026VYT2   A0A3L8D6D3   A0A2R5LNF1   A0A1B6GRG3   A0A1J1HR17   T1IMA8   A0A2J7PM88   A0A2J7PMB6   A0A2P6KZL1   A0A1L8DLE2   A0A2H8TME0   A0A2S2PWK6   J9K7A3   A0A0A9XE76   A0A0K8TA28   A0A146LF34   A0A2M4BD17   U5ESB2   E0VS90   A0A224XD60   K1PEI7   A0A443QVX4   A0A2M4A3G7   A0A2M4A3N8   A0A2M4A3R6   B0XL42   Q177V0   A0A2M4A3H9   A0A1W4WNX4   A0A1W4WYM9   A0A1B6DAP4   A0A182GCR4   A0A0P5C9M8   A0A0P5B4F5   A0A182FBX5   A0A0P6G519   A0A0P5UE29   A0A0P5CUE2   A0A0N8C9Q9   A0A164RH57   A0A0N8CKI4   A0A0P5Z9K0   A0A1D1UIQ2   A0A210QDX1   A0A444SGE9   A0A0A9XWA0   E9HPY1   A0A2C9K1J1   A0A1W4WNX6   A0A433SL36   A0A0P5YNL5   A0A1B6EUU0   V4BIC9   A0A1S3CXX9   A0A3P9KTQ6   A0A3P9ICC1   A0A0B7ACJ6   A0A3Q0SLQ1   C3YQ63   V9KZM8   F6XXD7   A0A443SRW2   U3IG83   A0A3Q3QK01   A0A093BP81  

EC Number

3.4.25.1

Pubmed

22118469    19121390    26354079    20798317    21719571    21347285    + More
28648823    25474469    20075255    24508170    30249741    25401762    26823975    20566863    22992520    17510324    26483478    27649274    28812685    21292972    15562597    23254933    17554307    18563158    24402279    20431018    23749191   

EMBL

NWSH01000885    PCG73704.1    AGBW02009897    OWR49610.1    ODYU01002009    SOQ38981.1    + More
RSAL01000006    RVE54251.1    BABH01006538    BABH01006539    KQ459193    KPJ03105.1    KQ460325    KPJ15819.1    ODYU01010823    SOQ56163.1    KZ288192    PBC34246.1    KQ414638    KOC66859.1    GL442170    EFN63859.1    GL888102    EGI67509.1    KQ434778    KZC04394.1    LBMM01000591    KMQ98005.1    KQ981112    KYN09409.1    KQ981463    KYN41534.1    GEDC01006862    JAS30436.1    GECU01017524    JAS90182.1    ADTU01000044    ACPB03002700    KQ976425    KYM88084.1    KQ982074    KYQ60429.1    KQ435883    KOX69657.1    NNAY01002226    OXU21770.1    GBBI01002849    JAC15863.1    GEBQ01019517    JAT20460.1    KQ976956    KYN06807.1    GL451627    EFN78874.1    AAZX01004609    KK107558    EZA48963.1    QOIP01000012    RLU15992.1    GGLE01006898    MBY11024.1    GECZ01004748    JAS65021.1    CVRI01000009    CRK88657.1    JH431009    NEVH01024418    PNF17450.1    PNF17449.1    MWRG01003277    PRD31763.1    GFDF01006897    JAV07187.1    GFXV01003296    MBW15101.1    GGMS01000673    MBY69876.1    ABLF02036962    GBHO01031950    GBHO01025305    GBHO01020474    GBHO01020473    GBHO01020472    GBHO01020468    JAG11654.1    JAG18299.1    JAG23130.1    JAG23131.1    JAG23132.1    JAG23136.1    GBRD01003427    GBRD01003425    JAG62394.1    GDHC01011861    JAQ06768.1    GGFJ01001577    MBW50718.1    GANO01003328    JAB56543.1    DS235746    EEB16246.1    GFTR01006030    JAW10396.1    JH817065    EKC19988.1    NCKU01003630    RWS07153.1    GGFK01002045    MBW35366.1    GGFK01002044    MBW35365.1    GGFK01002041    MBW35362.1    DS234233    EDS33336.1    CH477371    EAT42418.1    GGFK01002055    MBW35376.1    GEDC01014633    JAS22665.1    JXUM01056332    JXUM01056333    JXUM01056334    KQ561906    KXJ77210.1    GDIP01189820    JAJ33582.1    GDIP01189821    JAJ33581.1    GDIQ01056990    JAN37747.1    GDIP01131529    JAL72185.1    GDIP01166522    JAJ56880.1    GDIQ01100987    JAL50739.1    LRGB01002190    KZS08649.1    GDIP01122775    JAL80939.1    GDIP01046942    JAM56773.1    BDGG01000001    GAU89321.1    NEDP02004063    OWF46954.1    SAUD01037832    RXG52475.1    GBHO01041403    GBHO01025303    GBHO01020476    GBHO01020475    GBHO01020471    GBRD01003428    GBRD01003426    GDHC01021837    JAG02201.1    JAG18301.1    JAG23128.1    JAG23129.1    JAG23133.1    JAG62393.1    JAP96791.1    GL732712    EFX66207.1    RQTK01001555    RUS69853.1    GDIP01055291    JAM48424.1    GECZ01028043    JAS41726.1    KB202719    ESO88369.1    HACG01030820    CEK77685.1    GG666540    EEN57567.1    JW871824    AFP04342.1    AAMC01074463    AAMC01074464    AAMC01074465    AAMC01074466    AAMC01074467    AAMC01074468    AAMC01074469    AAMC01074470    AAMC01074471    NCKV01000562    RWS30286.1    ADON01126987    KN126402    KFU89352.1   

Proteomes

UP000218220    UP000007151    UP000283053    UP000005204    UP000053268    UP000053240    + More
UP000005203    UP000242457    UP000053825    UP000000311    UP000007755    UP000076502    UP000036403    UP000078492    UP000078541    UP000005205    UP000015103    UP000078540    UP000075809    UP000053105    UP000215335    UP000078542    UP000008237    UP000002358    UP000053097    UP000279307    UP000183832    UP000235965    UP000007819    UP000009046    UP000005408    UP000285301    UP000002320    UP000008820    UP000192223    UP000069940    UP000249989    UP000069272    UP000076858    UP000186922    UP000242188    UP000288706    UP000000305    UP000076420    UP000271974    UP000030746    UP000079169    UP000265180    UP000265200    UP000261340    UP000001554    UP000008143    UP000288716    UP000016666    UP000261600   

PRIDE

H9IWF8   

Pfam

PF02338   OTU        + More
PF01754   zf-A20
PF00227   Proteasome
PF00096   zf-C2H2
PF00651   BTB
PF10584   Proteasome_A_N
PF00134   Cyclin_N
PF16899   Cyclin_C_2

Interpro

IPR003323   OTU_dom        + More
IPR002653   Znf_A20       
IPR013087   Znf_C2H2_type       
IPR011333   SKP1/BTB/POZ_sf       
IPR036236   Znf_C2H2_sf       
IPR023332   Proteasome_alpha-type       
IPR000210   BTB/POZ_dom       
IPR001353   Proteasome_sua/b       
IPR000426   Proteasome_asu_N       
IPR016050   Proteasome_bsu_CS       
IPR029055   Ntn_hydrolases_N       
IPR009060   UBA-like_sf       
IPR038765   Papain-like_cys_pep_sf       
IPR033477   Cezanne-2       
IPR006671   Cyclin_N       
IPR031658   Cyclin_C_2       
IPR013763   Cyclin-like       
IPR036915   Cyclin-like_sf       

SUPFAM

SSF54695   SSF54695        + More
SSF56235   SSF56235       
SSF57667   SSF57667       
SSF46934   SSF46934       
SSF54001   SSF54001       
SSF47954   SSF47954       

Gene 3D

3.60.20.10    

CDD

cd00043  CYCLIN

ProteinModelPortal

A0A2A4JQ31   A0A212F7A1   A0A2H1VDW9   A0A3S2PKT0   H9IWF8   A0A194QDR2   + More
A0A194REC3   A0A2H1WSX5   A0A088AV33   A0A2A3ESQ1   A0A0L7R7P8   E2ARU1   F4WE71   A0A154NZA4   A0A0J7P029   A0A151IRT1   A0A151JYJ9   A0A1B6DXN3   A0A1B6ITD5   A0A158NZ45   T1IG62   A0A151I5L0   A0A151XJ64   A0A0M8ZRT6   A0A232ETT1   A0A023F3G1   A0A1B6L9T1   A0A195D1R1   E2BZH6   K7IXF6   A0A026VYT2   A0A3L8D6D3   A0A2R5LNF1   A0A1B6GRG3   A0A1J1HR17   T1IMA8   A0A2J7PM88   A0A2J7PMB6   A0A2P6KZL1   A0A1L8DLE2   A0A2H8TME0   A0A2S2PWK6   J9K7A3   A0A0A9XE76   A0A0K8TA28   A0A146LF34   A0A2M4BD17   U5ESB2   E0VS90   A0A224XD60   K1PEI7   A0A443QVX4   A0A2M4A3G7   A0A2M4A3N8   A0A2M4A3R6   B0XL42   Q177V0   A0A2M4A3H9   A0A1W4WNX4   A0A1W4WYM9   A0A1B6DAP4   A0A182GCR4   A0A0P5C9M8   A0A0P5B4F5   A0A182FBX5   A0A0P6G519   A0A0P5UE29   A0A0P5CUE2   A0A0N8C9Q9   A0A164RH57   A0A0N8CKI4   A0A0P5Z9K0   A0A1D1UIQ2   A0A210QDX1   A0A444SGE9   A0A0A9XWA0   E9HPY1   A0A2C9K1J1   A0A1W4WNX6   A0A433SL36   A0A0P5YNL5   A0A1B6EUU0   V4BIC9   A0A1S3CXX9   A0A3P9KTQ6   A0A3P9ICC1   A0A0B7ACJ6   A0A3Q0SLQ1   C3YQ63   V9KZM8   F6XXD7   A0A443SRW2   U3IG83   A0A3Q3QK01   A0A093BP81  

PDB

5LRW     E-value=3.36978e-47,     Score=477

KEGG

101745728    K11860 OTU domain-containing protein 7 [EC:3.4.19.12] | (RefSeq) OTU domain-containing protein 7B-li

GO

GO:0008270   GO:0003677   GO:0004298   GO:0005634   GO:0005737   GO:0019773   GO:0003676   GO:0006511   GO:0016301   GO:0004843   GO:0035871   GO:0070530   GO:0071108   GO:0071947   GO:0070536   GO:0043124   GO:0006355   GO:0042132   GO:0042578   GO:0044249   GO:0006428   GO:0000049   GO:0006508   GO:0016286  

PANTHER

PTHR13367:SF9  

Subcellular location

Nucleus  

Length:

586

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000560000000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00050

outside

1  -  586

 

 

Pi

24.951754

Theta

25.13815

Tajima's D

-0.606794

CLR

0.874747

CSRT

0.219489025548723

Interpretation

Uncertain