Gene

KWMTBOMO12676

Pre Gene Modal

BGIBMGA001398

Annotation

PREDICTED:_tumor_necrosis_factor?_alpha-induced_protein_8-like_protein_2_A_[Bombyx_mori]

Location

Bomo_Chr21(-):11339894-11346442      View in EpiBrowser

Full name

Tumor necrosis factor, alpha-induced protein 8-like protein 2 A      

Location in the cell

Cytoplasmic   Reliability : 1.413 Mitochondrial   Reliability : 1.221 Nuclear   Reliability : 1.123

CDS

ATGTCAATTAGTGCGACAGATATAACGCTCTACGAAGCAAAAATTAACCGTCTTTTTCCCACGATCGATGTGCAATATTTATCGCCGGCAACGGAGGGCGGCGCGTGGTGCGCTCGCGACATCTCCCTCCGCGCCCAGAAGAAGTTCCTGTCGAGGGTCGGAGGGAACAGCAGCGCGCGTGCCCTGGTCTTGGACGAGCATGCCGCTAAACTACTCGATCAGTTTCTGATCGTCCTGAGGGAGCGAGTCGAAAAACGTGAAGCAGAAAAACTGGTAAAACACGTCATCAAATCAGCAGTTAAGCTGGGAGTGTTACGGCGACACTCGCAGCTGTCCGCAGCGGACGACCGAGCCCTTGAAGCTTTCAGATCCAAATTCCACACCGTGTTGATGGCGGTGGTGTCTTTCTGTGAAGTGGAATTCTCGTACGACCGTGGCTTCCTGCAGGACGCGCTGCGCGATTCACACCAATCGCTCAAGTCGGTTGTAGAACGTCACCTCTCAGACAAGTCTGTGTCCAGGCTCGCTGGAGTGTTCGCTCTCGCATCCCGAGGTGAGTTGCTCGATTCGCTCTTCTCCGGCCAAGTTGACGAGGACGTCCTCAAACTGTCGAGGATGCTACGCAAGGAACTCGATCGGGGCCTGCTTTAA

Protein

MSISATDITLYEAKINRLFPTIDVQYLSPATEGGAWCARDISLRAQKKFLSRVGGNSSARALVLDEHAAKLLDQFLIVLRERVEKREAEKLVKHVIKSAVKLGVLRRHSQLSAADDRALEAFRSKFHTVLMAVVSFCEVEFSYDRGFLQDALRDSHQSLKSVVERHLSDKSVSRLAGVFALASRGELLDSLFSGQVDEDVLKLSRMLRKELDRGLL

Description

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Similarity

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.

Keywords

Complete proteome   Immunity   Innate immunity   Reference proteome  

Feature

chain  Tumor necrosis factor, alpha-induced protein 8-like protein 2 A

Uniprot

H9IVW7   A0A194RDA2   A0A194QI30   A0A2A4JQI2   A0A3S2NLW0   A0A2H1V9S5   + More
A0A0L7LKH1   A0A1B6ESN0   A0A1B6HSU3   A0A1B6MQL5   D6WCZ3   A0A0A9WCY8   A0A0V0G5W4   T1I973   A0A224XQA3   A0A023F3K5   A0A069DWU4   A0A1B6D751   X2KNR9   N6U278   A0A067R6M6   K1QZA7   A0A0L8I9W0   A0A2J7PZT9   A0A2J7PZT4   A0A2R5LCY3   W4YC83   A0A293MFN3   A0A2C9JUA1   V4CMK7   T1JFQ3   A0A183ITY3   A0A210QGU1   A0A0N0BHI1   A0A310S8I5   A0A443SJ81   A0A2T7NF64   A0A433TDD0   V9IDU3   A0A182N660   A0A1J1INI3   A0A0L7RGB5   A0A154P0K7   A0A2A3ER78   A0A088AKR0   A0A1Y1MV65   A0A2S2QMZ8   A0A0N8A4G0   A0A162PK07   A0A3M6UXI6   A0A1E1XLP3   Q1ECV8   E9G2H5   K4GGR4   R7VLX8   A0A2U3VNC5   T1END6   A0A2B4SDD2   K4G5F9   K4FSE1   J9JTY8   A0A131Y770   H0VV25   H3AUI2   F7BRR0   A0A1E1WXM1   A7SGA8   A0A286Y1F8   A0A1L8F4R6   A0A3P9A9Y7   A0A452J211   A0A1S3IUH9   A0A452J229   A0A0P6JDU1   A0A195BZV0   G5AX61   A0A195EMT8   E9ID89   A0A1B0D7J9   A0A0F7Z4Q4   A0A3Q0HI87   A0A2K6GPK0   C3YNR0   F4WRV9   A0A195FMM6   A0A2K6GPI9   A0A3N0Y082   K4FUZ5   A0A158NEK6   K7GJ11   A0A2K6GPK5   A0A1W7RCC4   A0A452FX72   W5Q5A1   A0A195BWP7   A0A452FY01   A0A3P8Z8G7   A0A2K6GPM1   A0A131XBZ2  

Pubmed

19121390    26354079    26227816    18362917    19820115    25401762    + More
25474469    26334808    23537049    24845553    22992520    15562597    23254933    28812685    28004739    30382153    29209593    23594743    21292972    23056606    21993624    9215903    18464734    28503490    17615350    27762356    25069045    28562605    21993625    21282665    18563158    21719571    21347285    17381049    26358130    20809919    28049606   

EMBL

BABH01006529    BABH01006530    KQ460325    KPJ15818.1    KQ459193    KPJ03106.1    + More
NWSH01000885    PCG73703.1    RSAL01000006    RVE54252.1    ODYU01001420    SOQ37579.1    JTDY01000774    KOB75930.1    GECZ01028803    JAS40966.1    GECU01029991    JAS77715.1    GEBQ01001792    JAT38185.1    KQ971311    EEZ99081.2    GBHO01037985    JAG05619.1    GECL01002668    JAP03456.1    ACPB03003211    GFTR01003172    JAW13254.1    GBBI01003268    JAC15444.1    GBGD01003085    JAC85804.1    GEDC01028418    GEDC01020434    GEDC01015903    JAS08880.1    JAS16864.1    JAS21395.1    KJ123770    AHN82531.1    APGK01052688    APGK01052689    KB741213    KB631874    ENN72657.1    ERL86881.1    KK852852    KDR15042.1    JH818926    EKC36499.1    KQ416196    KOF98232.1    NEVH01020332    PNF21846.1    PNF21847.1    GGLE01003081    MBY07207.1    AAGJ04113077    AAGJ04113078    GFWV01014220    MAA38949.1    KB199952    ESP03590.1    JH432185    UZAM01010302    VDP11801.1    NEDP02003748    OWF47936.1    KQ435750    KOX76262.1    KQ764626    OAD54464.1    NCKV01001919    RWS27570.1    PZQS01000013    PVD19801.1    RQTK01000450    RUS79444.1    JR039765    AEY58832.1    CVRI01000056    CRL01789.1    KQ414599    KOC69771.1    KQ434791    KZC05391.1    KZ288195    PBC33772.1    GEZM01023377    JAV88420.1    GGMS01009924    MBY79127.1    GDIP01183457    JAJ39945.1    LRGB01000507    KZS18911.1    RCHS01000537    RMX58299.1    GFAA01003291    JAU00144.1    CU571385    BC117652    GL732530    EFX86251.1    JX207168    AFM85482.1    AMQN01003728    KB291800    ELU18646.1    AMQM01000151    KB095811    ESO12377.1    LSMT01000123    PFX26567.1    JX208607    AFM86921.1    JX052357    AFK10585.1    ABLF02040576    GEFM01001860    JAP73936.1    AAKN02023111    AAKN02023112    AFYH01073884    AAPN01215247    AAPN01215248    AAPN01215249    AAPN01215250    AAPN01215251    GFAC01007460    JAT91728.1    DS469651    EDO37213.1    CM004481    OCT66559.1    GEBF01001074    JAO02559.1    KQ978501    KYM93438.1    JH167376    EHB01622.1    KQ978625    KYN29595.1    GL762454    EFZ21380.1    AJVK01026966    GBEX01003638    JAI10922.1    GG666535    EEN58020.1    GL888292    EGI63116.1    KQ981490    KYN41194.1    RJVU01056109    ROK64933.1    JX053261    AFK11489.1    ADTU01013480    AGCU01162090    AGCU01162091    AGCU01162092    AGCU01162093    GDAY02002676    JAV48791.1    LWLT01000008    AMGL01092261    KQ976401    KYM92386.1    GEFH01004444    JAP64137.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000283053    UP000037510    + More
UP000007266    UP000015103    UP000019118    UP000030742    UP000027135    UP000005408    UP000053454    UP000235965    UP000007110    UP000076420    UP000030746    UP000050793    UP000242188    UP000053105    UP000288716    UP000245119    UP000271974    UP000075884    UP000183832    UP000053825    UP000076502    UP000242457    UP000005203    UP000076858    UP000275408    UP000000437    UP000000305    UP000014760    UP000245340    UP000015101    UP000225706    UP000007819    UP000005447    UP000008672    UP000002279    UP000001593    UP000186698    UP000265140    UP000291020    UP000085678    UP000078542    UP000006813    UP000078492    UP000092462    UP000189705    UP000233160    UP000001554    UP000007755    UP000078541    UP000005205    UP000007267    UP000291000    UP000002356    UP000078540   

PRIDE

H9IVW7   

Pfam

PF05527   DUF758

Interpro

IPR008477   TNFAIP8-like        + More
IPR038355   TNFAIP8_sf       

Gene 3D

1.20.1440.160    

ProteinModelPortal

H9IVW7   A0A194RDA2   A0A194QI30   A0A2A4JQI2   A0A3S2NLW0   A0A2H1V9S5   + More
A0A0L7LKH1   A0A1B6ESN0   A0A1B6HSU3   A0A1B6MQL5   D6WCZ3   A0A0A9WCY8   A0A0V0G5W4   T1I973   A0A224XQA3   A0A023F3K5   A0A069DWU4   A0A1B6D751   X2KNR9   N6U278   A0A067R6M6   K1QZA7   A0A0L8I9W0   A0A2J7PZT9   A0A2J7PZT4   A0A2R5LCY3   W4YC83   A0A293MFN3   A0A2C9JUA1   V4CMK7   T1JFQ3   A0A183ITY3   A0A210QGU1   A0A0N0BHI1   A0A310S8I5   A0A443SJ81   A0A2T7NF64   A0A433TDD0   V9IDU3   A0A182N660   A0A1J1INI3   A0A0L7RGB5   A0A154P0K7   A0A2A3ER78   A0A088AKR0   A0A1Y1MV65   A0A2S2QMZ8   A0A0N8A4G0   A0A162PK07   A0A3M6UXI6   A0A1E1XLP3   Q1ECV8   E9G2H5   K4GGR4   R7VLX8   A0A2U3VNC5   T1END6   A0A2B4SDD2   K4G5F9   K4FSE1   J9JTY8   A0A131Y770   H0VV25   H3AUI2   F7BRR0   A0A1E1WXM1   A7SGA8   A0A286Y1F8   A0A1L8F4R6   A0A3P9A9Y7   A0A452J211   A0A1S3IUH9   A0A452J229   A0A0P6JDU1   A0A195BZV0   G5AX61   A0A195EMT8   E9ID89   A0A1B0D7J9   A0A0F7Z4Q4   A0A3Q0HI87   A0A2K6GPK0   C3YNR0   F4WRV9   A0A195FMM6   A0A2K6GPI9   A0A3N0Y082   K4FUZ5   A0A158NEK6   K7GJ11   A0A2K6GPK5   A0A1W7RCC4   A0A452FX72   W5Q5A1   A0A195BWP7   A0A452FY01   A0A3P8Z8G7   A0A2K6GPM1   A0A131XBZ2  

PDB

5JXD     E-value=6.19275e-21,     Score=245

KEGG

101745578    no KO assigned | (RefSeq) tumor necrosis factor, alpha-induced protein 8-like protein 2 A

GO

GO:0042981   GO:0005737   GO:0045087   GO:0005654   GO:0043065   GO:0043027  

PANTHER

PTHR12757  

Length:

216

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01937

Exp number, first 60 AAs:

0.00095

Total prob of N-in:

0.06105

outside

1  -  216

 

 

Pi

26.843222

Theta

22.639564

Tajima's D

0.462313

CLR

2.68859

CSRT

0.507174641267937

Interpretation

Uncertain