Gene

KWMTBOMO12673  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001581

Annotation

mortality_factor_4-like_[Bombyx_mori]

Location

Bomo_Chr21(+):11197863-11201814      View in EpiBrowser

Full name

Mortality factor 4-like protein 1      

Alternative Name

MORF-related gene 15 protein
Transcription factor-like protein MRG15

Location in the cell

Nuclear   Reliability : 2.803

CDS

ATGGCACCAAAGTTAAAATTTGCTGAAGGTGAAAAAGTGCTATGTTTCCACGGACCGCTAATTTATGAAGCAAAATGTTTAAAAAGCTCAGTTACAAAGGACAAACACGTGAGGTATCTTATTCATTACGCGGGATGGAACAAAAATTGGGATGAATGGGTGCCTGAAAGCCGTGTTCTGAAGTACAATGAAGCAAATGTACAAAGGCAGAAAGAAGTCCAAAGAGCTCATTCCGCACAACCAACTAAAACTAAGAAAACTCCCGCAAAGGGTAGGAAATCTGATGCAGCAGTTGCTGCAACTACTCCAGCTAGAGAAGAATCAAGAGCATCTACCCCTGCGAGTAGTACTCAAGTAAAAGAGTCCGATAGTACACCAGCTCCCGCAAAAACAACTAAAACTCAGAGTAAAGATACACCTGCTGATTCTGGATCTGATCAACCTAAAAAAAAACGAGGACGTCTAGACTTGTCAATAGAATCCGAAGAGCAATACCTAGCAAAAGTAGAAGTTAAGATCAAAATACCCGAAGAACTGAAGGTTTGGCTCGTTGACGACTGGGACGTGATCACAAGGCAACAGAAGTTAGCTATTTTACCAGCAAAATTAACCGTTAGTCAAATAGTGGATAATTATTTGGCTTTCAAGAAATCTAGCAAGTCTCACAACCAGGCTAAGGAGTCTGTGCTGGTCGACATCACGGAGGGGATCAAGGAGTACTTCAACGCGACCCTGGGCTCTCAGCTGCTGTACAAGTTCGAGAGGCCGCAGTACAGCGAGATACTGCAGGAGTATCCCGACACCCCGATGTCTCAGGTGTACGGCGCCGTTCACTTGCTGCGGTTGTTCGCGAAAATGGGTCCGATGCTGGCGTACACGGCGCTCGACGAGAAGTCGCTCCACCACGTGTTGTCGCACATCCAGGACTTCTTGAAGTACATGGTGACGAACAGATCGACGCTTTTCAATTTACAAGATTACGGCAACGCCACGCCTGAATATCATAGGAAAATACAGTAA

Protein

MAPKLKFAEGEKVLCFHGPLIYEAKCLKSSVTKDKHVRYLIHYAGWNKNWDEWVPESRVLKYNEANVQRQKEVQRAHSAQPTKTKKTPAKGRKSDAAVAATTPAREESRASTPASSTQVKESDSTPAPAKTTKTQSKDTPADSGSDQPKKKRGRLDLSIESEEQYLAKVEVKIKIPEELKVWLVDDWDVITRQQKLAILPAKLTVSQIVDNYLAFKKSSKSHNQAKESVLVDITEGIKEYFNATLGSQLLYKFERPQYSEILQEYPDTPMSQVYGAVHLLRLFAKMGPMLAYTALDEKSLHHVLSHIQDFLKYMVTNRSTLFNLQDYGNATPEYHRKIQ

Description

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity).

Subunit

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and MYST1. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1 Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2 (By similarity). Forms a complex with MSL1 and NUPR1 (By similarity).

Keywords

Acetylation   Chromatin regulator   Complete proteome   DNA damage   DNA recombination   DNA repair   Growth regulation   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Mortality factor 4-like protein 1

Uniprot

C0RWX3   D2CFU1   A0A2H1V4I3   A0A3S2NR87   A0A212F7N0   A0A2A4JLU1   + More
H9IWF0   A0A1E1W7X3   A0A194RDY0   D6X4Z1   A0A1B0CA64   A0A1Y1K0I5   A0A1L8DX22   A0A1W4WW15   A0A1B0D930   A0A0T6AU28   N6U421   A0A067QMG4   U4UJT0   A0A2J7PYK0   K7INA4   A0A1S4F309   Q17H69   T1JFS7   A0A0K8TKA6   A0A182G1X2   A0A336JXP7   D3TMU9   A0A1B0A4M3   A0A2R5LJP8   A0A1S3JZQ1   A0A023FYY3   L7M4F0   A0A131YRJ9   E2AEL6   A0A3B3CLW0   A0A0N1ITD9   A0A1E1XGG8   Q4SLW2   A0A087ZV33   L7M497   A0A131XC26   E0VRN1   A0A3Q1JH87   A0A3B5BB72   A0A1A8KFU2   A0A1A8BF94   A0A1A8FIU4   A0A3Q3FKW2   A0A1A7XIZ7   A0A1U8DGY5   U3ES96   A0A2D4GVU2   A0A1E1XBF6   A0A131YMM3   A0A3B1JAG6   I3KEC6   A0A218UD67   M3ZN35   A0A147B2Z9   A0A401SXI8   A0A1A8AT52   A0A3B4YIF7   A0A3B4TXQ0   A0A151I2S5   A0A158NB17   H2UNL2   F4WCY1   F1P0X1   H2L9L3   A0A3Q1AIK8   A0A3B3XHV4   A0A226PDY9   A0A3B4UZM9   A0A1A8S1X2   A0A1A8N4U5   V9KRP2   A0A3B4GD74   A0A3Q2X9F4   I3KEC5   A0A087XUK5   A0A3Q3LGK4   Q6AYU1   A0A1V4JDW1   A0A3P8TY52   A0A3B5AXA2   A0A3B3BPL3   A0A3Q2TT47   Q3UBK1   A0A2K6EWU1   A0A2I4BN03   A0A3P9AQW6   A0A3P8PXN9   A0A0F7ZCZ0   A0A0K8RZB4   A0A3P9ILX2   A0A452DY88   A0A2Y9JZY4   K7GQW8  

Pubmed

22118469    19121390    26354079    18362917    19820115    28004739    + More
23537049    24845553    20075255    17510324    26369729    26483478    20353571    25576852    26830274    20798317    29451363    28503490    15496914    28049606    20566863    23915248    25329095    25186727    23542700    30297745    21347285    21551351    21719571    15592404    17554307    24621616    24402279    15489334    10349636    11042159    11076861    11217851    12466851    16141073    25727380    30723633   

EMBL

DQ888173    ABJ99463.1    DQ888172    ABJ99462.1    ODYU01000608    SOQ35686.1    + More
RSAL01000006    RVE54257.1    AGBW02009859    OWR49728.1    NWSH01001152    PCG72370.1    BABH01006514    BABH01006515    GDQN01007966    GDQN01001709    JAT83088.1    JAT89345.1    KQ460325    KPJ15807.1    KQ971381    EEZ97599.1    AJWK01003334    GEZM01100705    JAV52816.1    GFDF01003083    JAV11001.1    AJVK01012886    AJVK01012887    LJIG01022808    KRT78610.1    APGK01043667    APGK01043668    KB741015    ENN75371.1    KK853168    KDR10375.1    KB632237    ERL90441.1    NEVH01020346    PNF21421.1    CH477252    EAT46022.1    JH432185    GDAI01002939    JAI14664.1    JXUM01138081    KQ568678    KXJ68922.1    UFQS01000006    UFQT01000006    SSW96981.1    SSX17368.1    CCAG010007751    EZ422751    ADD19027.1    GGLE01005646    MBY09772.1    GBBL01001415    JAC25905.1    GACK01007060    JAA57974.1    GEDV01008036    JAP80521.1    GL438870    EFN68091.1    KQ435830    KOX71724.1    GFAC01000823    JAT98365.1    CAAE01014555    CAF98370.1    GACK01007061    JAA57973.1    GEFH01004669    JAP63912.1    DS235478    EEB16037.1    HAED01015848    HAEE01010484    SBR30534.1    HADZ01001214    HAEA01009000    SBP65155.1    HAEB01012164    HAEC01007701    SBQ58691.1    HADW01016568    HADX01009538    SBP17968.1    GAEP01000943    JAB53878.1    IACJ01150835    LAA63854.1    GFAC01002595    JAT96593.1    GEDV01008034    JAP80523.1    AERX01005350    MUZQ01000419    OWK51616.1    GCES01001169    JAR85154.1    BEZZ01000665    GCC35105.1    HADY01019832    HAEJ01013392    SBP58317.1    KQ976523    KYM82016.1    ADTU01010746    GL888074    EGI67962.1    AADN05000047    AWGT02000098    OXB77607.1    HAEH01020931    HAEI01012749    SBS11553.1    HAEF01013363    HAEG01000857    SBR64110.1    JW868911    AFP01429.1    AYCK01006720    BC078910    LSYS01007908    OPJ70280.1    AK150925    BAE29963.1    GBEX01002041    JAI12519.1    GBKC01002162    GBKD01001302    JAG43908.1    JAG46316.1    LWLT01000019    AEMK02000056    DQIR01208430    DQIR01238113    HDB63907.1   

Proteomes

UP000283053    UP000007151    UP000218220    UP000005204    UP000053240    UP000007266    + More
UP000092461    UP000192223    UP000092462    UP000019118    UP000027135    UP000030742    UP000235965    UP000002358    UP000008820    UP000069940    UP000249989    UP000092444    UP000092445    UP000085678    UP000000311    UP000261560    UP000053105    UP000007303    UP000005203    UP000009046    UP000265040    UP000261400    UP000261660    UP000189705    UP000018467    UP000005207    UP000197619    UP000002852    UP000265000    UP000287033    UP000261360    UP000261420    UP000078540    UP000005205    UP000005226    UP000007755    UP000000539    UP000001038    UP000257160    UP000261480    UP000198419    UP000261460    UP000264840    UP000028760    UP000261640    UP000002494    UP000190648    UP000265080    UP000233160    UP000192220    UP000265160    UP000265100    UP000265200    UP000291000    UP000248482    UP000008227   

PRIDE

C0RWX3    D2CFU1    H9IWF0    Q6AYU1    K7GQW8   

Pfam

PF11717   Tudor-knot        + More
PF05712   MRG

Interpro

IPR016197   Chromo-like_dom_sf        + More
IPR008676   MRG       
IPR025995   Tudor-knot       
IPR038011   MRG15       
IPR000953   Chromo/chromo_shadow_dom       
IPR026541   MRG_dom       
IPR038217   MRG_C_sf       

SUPFAM

SSF54160   SSF54160       

Gene 3D

1.10.274.30    

CDD

cd00024  CHROMO

ProteinModelPortal

C0RWX3   D2CFU1   A0A2H1V4I3   A0A3S2NR87   A0A212F7N0   A0A2A4JLU1   + More
H9IWF0   A0A1E1W7X3   A0A194RDY0   D6X4Z1   A0A1B0CA64   A0A1Y1K0I5   A0A1L8DX22   A0A1W4WW15   A0A1B0D930   A0A0T6AU28   N6U421   A0A067QMG4   U4UJT0   A0A2J7PYK0   K7INA4   A0A1S4F309   Q17H69   T1JFS7   A0A0K8TKA6   A0A182G1X2   A0A336JXP7   D3TMU9   A0A1B0A4M3   A0A2R5LJP8   A0A1S3JZQ1   A0A023FYY3   L7M4F0   A0A131YRJ9   E2AEL6   A0A3B3CLW0   A0A0N1ITD9   A0A1E1XGG8   Q4SLW2   A0A087ZV33   L7M497   A0A131XC26   E0VRN1   A0A3Q1JH87   A0A3B5BB72   A0A1A8KFU2   A0A1A8BF94   A0A1A8FIU4   A0A3Q3FKW2   A0A1A7XIZ7   A0A1U8DGY5   U3ES96   A0A2D4GVU2   A0A1E1XBF6   A0A131YMM3   A0A3B1JAG6   I3KEC6   A0A218UD67   M3ZN35   A0A147B2Z9   A0A401SXI8   A0A1A8AT52   A0A3B4YIF7   A0A3B4TXQ0   A0A151I2S5   A0A158NB17   H2UNL2   F4WCY1   F1P0X1   H2L9L3   A0A3Q1AIK8   A0A3B3XHV4   A0A226PDY9   A0A3B4UZM9   A0A1A8S1X2   A0A1A8N4U5   V9KRP2   A0A3B4GD74   A0A3Q2X9F4   I3KEC5   A0A087XUK5   A0A3Q3LGK4   Q6AYU1   A0A1V4JDW1   A0A3P8TY52   A0A3B5AXA2   A0A3B3BPL3   A0A3Q2TT47   Q3UBK1   A0A2K6EWU1   A0A2I4BN03   A0A3P9AQW6   A0A3P8PXN9   A0A0F7ZCZ0   A0A0K8RZB4   A0A3P9ILX2   A0A452DY88   A0A2Y9JZY4   K7GQW8  

PDB

2AQL     E-value=3.7523e-54,     Score=534

KEGG

100271910    K11339 mortality factor 4-like protein 1 | (RefSeq) mrg; mortality factor 4-like

GO

GO:0006355   GO:0006325   GO:0016580   GO:0035267   GO:0043968   GO:0016575   GO:0000123   GO:0006342   GO:0043967   GO:0016573   GO:0016740   GO:0005634   GO:0047485   GO:0016607   GO:0000724   GO:0040008   GO:0042132   GO:0042578   GO:0044249   GO:0006428   GO:0000049   GO:0006508   GO:0016286  

PANTHER

PTHR10880   PTHR10880:SF29  

Subcellular location

Nucleus  

Length:

339

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01062

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.00854

outside

1  -  339

 

 

Pi

6.431593

Theta

13.953894

Tajima's D

-1.783294

CLR

1.092956

CSRT

0.0263486825658717

Interpretation

Uncertain