Gene

KWMTBOMO12671  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001579

Annotation

hypothetical_protein_KGM_04775_[Danaus_plexippus]

Location

Bomo_Chr21(+):11157823-11176996      View in EpiBrowser

Full name

Nuclear cap-binding protein subunit 1      

Alternative Name

80 kDa nuclear cap-binding protein

Location in the cell

Cytoplasmic   Reliability : 1.61 Nuclear   Reliability : 1.655

CDS

ATGAACCGTCGTAGAGGACATGATGATGAAGAAGGATATGAACGCCTCCATCGGAAAAGGCGTCGTGTATCTGAAAACCAAGAAATCGAGGATCGCTTAGAGTCCTTAATTTTAAGAGTTGGCGAAAAAAGTAGTTCCAGTTTGGAGAGTAACCTAGAAGGATTAGCAAGTGTACTGGAAGCCGATTTGAGTACCTTTAGAGTTAAAATACTACGGATACTAACGGATTGTGCTATCCGCATGCCCGAGAAATGTACAATCTATGCAACTCTTGTTGGTTTGTTGAATGCAAAGAATTATAACTTTGGTGGAGAATTTGTTGATTACATAGTAAAAACCTTTAAAGAAAATCTTAAAGTCGGGAAATGGAATGCTGCTAGGTATTGTCTAAGGTTCATTGCGGACTTGGTGAACTGTCACGTATTGGCTGCTTCATCATTGCTGACTTTATTAGAGACATTAGTAGATTCTGCTAATGAAGATGGAGTACCTCACGTCAGAAGGGATTGGTTTGTATTTGCGGTGCTGTCAGCATTACCTTGGGTTGGTCGGGAGTTGTATGAAAAGAAGGAATCTCAATTAGATCACTTACTTGTGACTATAGAGGTTTTCTTGAATAAACGGAGTAAGAAACATTGGCCAGCCTTAAAGGTGTGGTCGGCTGATTCACCTCATTTACAAGAAGAATATTTGGATTGCCTCTGGTCTCAGATAAAGAAGTTGAAACAAGACAATTGGTCAGAGAAACATATTCCAAGGCCATATCTTGCCTTTGACTCTATTCTTTGTGAAGCTTTACAACACACACTTCCTGCCATTCAGCCACCACCCCATAATGACACTGATACTTATCCAATGCCTCGGGTTATATTCCGTATGTTTGACTACACAGACTGTCCAGACGGACCAGTTTTGCCTGGAGTGCACTCTATAGAGAGATTCTTGATAGAAGAACATTTGCACAATATTATTGAGACATATCATTTAGAACGTAAAGAATGTGCTGCTCAACTCCTCTGCTTTCCTTACAAAGCCAAAATTCCTCTGGAATATTGCATAGTTGAGGTGATATTTGCTGAATTATTTAATTTGCCAAAACCAAGGTATTTGGAGATATGTTATGGTTCAATATTAATTGAACTTTGCAAGCTTCAGCCATCAACAATGCCACAGGTTCTAGCTCAAGCTACTGAAATTTTGTTCATGAGGATTGACACCATGAATGTTGCTTGCTTTGACAGGTTTGCGAACTGGTTTGCCTACCATTTGAGCAACTTCCAGTACAGATGGTCATGGGAAGATTGGGAGGCGTGTCTCCAATTAGATCCTGAACATCCAAAACCCAGGTTTATCAGAGAGGTCCTCGGAAAATGTCTAAGGCTATCTTACCACCAAAGAATCAAAGACATGGTCCCAGAGTCGTTTGCATCATTTGTGCCACCCAAGCCTGAACCAATCTACAAGTATTCCATGGAAGGTGCAGCTGCTCTACCCGGCACCGAAGCCGCCCATCAGCTCGTTGTATTCGTGCGTAACAAGTGCACACCCGAAGAAGCCTTGAACGTTCTCCGCGACCTACCGAACCCCCTCAAGGAGGGCGAACAAACGGCCAACCAGCCGACCGCGTACAACCCCCTGAAAATCGACGTCTTCGTGCAGACCCTGCTGAATCTCGGCAGCAAGAGCATTTCGCACAGTTTCGCTGCGATCTCGAAGTTTCATTACGTTTTTAAGATCTTAGCCGAGTCTGAGGAGGCGCAGATATGCATCCTCCGCAACGTGTGGGAGCTGTGGCAGCGACACCCGCAGATGGTCTGCGTGCTCATCGACAAGATGCTCAAGACTCAGATCGTCGAGTGCAGCGCCGTCGCCACGTGGCTCTTCTCGAAGGAGATGGCGCCCTACTTCACGCACGGCTGCCTCTGGGAGATGCTGCATCTGACCATCGACAAAATGAACAAGCACGTGTCGAAGCTCAGTGCAGAACTCCAGGAAGCCCGCGAAGCATTAGCGAGAGCGGACTCGAGCAGTTCGGATTCTGAAGATGAGAACAGTAAGAAGAAGAAAGACCAGGACAAGCCTACTGAAGAGGCGGTCGAGCGTATGGAGGAGCGCCTGGAAGCTGCACATATGGACCAGAAGCGGCTCTTCCTGATCGTGTTCCAGCGGTTCATCATGATCCTCTCGGAGCATCTCGTCCGCTGTGATACAGACGCACGGGACCCTCACACGCACTGGTACCGCGCCACGCTGCACCGCCTCACGCAGGTCTTCCTCATCCACCACGAGCAAGTCCAGAAGTACAGCAGCACGCTGGAGACGCTGCTGTTCACGCAGGACCTGGACCCTCACATACTGGACGTGTTCCACCAGTTCGTGGCGCTGACCGCGTGA

Protein

MNRRRGHDDEEGYERLHRKRRRVSENQEIEDRLESLILRVGEKSSSSLESNLEGLASVLEADLSTFRVKILRILTDCAIRMPEKCTIYATLVGLLNAKNYNFGGEFVDYIVKTFKENLKVGKWNAARYCLRFIADLVNCHVLAASSLLTLLETLVDSANEDGVPHVRRDWFVFAVLSALPWVGRELYEKKESQLDHLLVTIEVFLNKRSKKHWPALKVWSADSPHLQEEYLDCLWSQIKKLKQDNWSEKHIPRPYLAFDSILCEALQHTLPAIQPPPHNDTDTYPMPRVIFRMFDYTDCPDGPVLPGVHSIERFLIEEHLHNIIETYHLERKECAAQLLCFPYKAKIPLEYCIVEVIFAELFNLPKPRYLEICYGSILIELCKLQPSTMPQVLAQATEILFMRIDTMNVACFDRFANWFAYHLSNFQYRWSWEDWEACLQLDPEHPKPRFIREVLGKCLRLSYHQRIKDMVPESFASFVPPKPEPIYKYSMEGAAALPGTEAAHQLVVFVRNKCTPEEALNVLRDLPNPLKEGEQTANQPTAYNPLKIDVFVQTLLNLGSKSISHSFAAISKFHYVFKILAESEEAQICILRNVWELWQRHPQMVCVLIDKMLKTQIVECSAVATWLFSKEMAPYFTHGCLWEMLHLTIDKMNKHVSKLSAELQEAREALARADSSSSDSEDENSKKKKDQDKPTEEAVERMEERLEAAHMDQKRLFLIVFQRFIMILSEHLVRCDTDARDPHTHWYRATLHRLTQVFLIHHEQVQKYSSTLETLLFTQDLDPHILDVFHQFVALTA

Description

Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure.
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).

Subunit

Component of the nuclear cap-binding complex (CBC), a heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-capped RNA.

Similarity

Belongs to the NCBP1 family.

Keywords

Complete proteome   mRNA capping   mRNA processing   mRNA splicing   Nucleus   Phosphoprotein   RNA-mediated gene silencing   Reference proteome  

Feature

chain  Nuclear cap-binding protein subunit 1

Uniprot

A0A212F7L2   A0A1E1WTD0   A0A1W4WJ55   A0A2J7QT07   A0A1Y1NG62   A0A067R587   + More
A0A1L8DGY9   W8C9N4   A0A0K8VTP5   A0A034VCV5   A0A0A1XET0   A0A088A145   A0A2A3EN24   A0A0L0CL87   A0A154PSU0   U5ENC9   K7IVH0   A0A0C9QS52   A0A232EZH0   T1PBD2   A0A1B0FFF1   E2BW56   A0A1J1I559   B4Q034   E2QD75   Q7K4N3   A0A1A9UGF8   A0A1W4UII4   A0A1Q3G0V8   B4I0W6   E2AC77   B3NU52   Q29G82   B4GW22   A0A026WWH0   B3MS75   Q16UN6   B4NC41   A0A3B0K2Q4   A0A1B0AEE3   A0A2M4BER4   B4JM29   A0A2K6VB37   A0A1B6GIC9   A0A1Y9J003   A0A3F2YUX2   Q7PX35   A0A2M4ACE7   E9J6J3   A0A084W0C9   A0A1I8Q2I0   A0A151IDL5   A0A0M4EZ67   B4L2J8   A0A158NPN5   A0A1B6MGN0   T1HND5   A0A195AT54   A0A069DZJ7   A0A195EM70   A0A0V0G7W0   A0A151WJ36   A0A195ESJ1   A0A0K8SUQ8   A0A0A9Y0R4   E0VJH5   R4WPV5   B4M7T6   A0A1B6MND2   A0A2M4A8G5   A0A0P4ZZK2   A0A0P4YLU7   A0A0P5QC32   A0A0N8BQK0   A0A0P5Q311   A0A0P5UWS2   A0A0P5IV70   A0A0P4Y749   A0A0P5UVF2   A0A0P5CUS9   A0A0P5PXK4   A0A0P5J859   E9HSG0   A0A0P5HNA5   A0A0P5XJ99   A0A0P5AHK1   A0A0P6FRJ1   A0A0P5TYH9   A0A0N8CLF2   A0A0P5RTI7   A0A0N8AVH8   A0A0P5AVK3   A0A1S3JU09   A0A1S3CX94   A0A1S3KF50   A0A0P4W2Q8   A0A3R7PXP8   T1JMW3   A0A0P5V436  

Pubmed

22118469    28004739    24845553    24495485    25348373    25830018    + More
26108605    20075255    28648823    25315136    20798317    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    10731137    18327897    19632183    15632085    24508170    30249741    17510324    20920257    20966253    12364791    21282665    24438588    21347285    26334808    25401762    20566863    23691247    21292972   

EMBL

AGBW02009859    OWR49725.1    GDQN01000968    JAT90086.1    NEVH01011205    PNF31707.1    + More
GEZM01007587    JAV95076.1    KK852693    KDR18321.1    GFDF01008371    JAV05713.1    GAMC01002014    JAC04542.1    GDHF01010091    JAI42223.1    GAKP01017827    GAKP01017821    GAKP01017818    JAC41131.1    GBXI01005294    JAD08998.1    KZ288215    PBC32662.1    JRES01000333    KNC32219.1    KQ435127    KZC14827.1    GANO01000645    JAB59226.1    GBYB01006574    GBYB01006582    JAG76341.1    JAG76349.1    NNAY01001524    OXU23693.1    KA646071    AFP60700.1    CCAG010001650    GL451091    EFN80088.1    CVRI01000041    CRK95416.1    CM000162    AE014298    AAF45970.1    AJ238970    AY051796    AL031766    GFDL01001618    JAV33427.1    CH480819    GL438428    EFN68971.1    CH954180    CH379064    CH479193    KK107105    QOIP01000011    EZA59474.1    RLU17043.1    CH902622    CH477617    CH964239    OUUW01000003    SPP77678.1    GGFJ01002167    MBW51308.1    CH916371    GGFL01004464    MBW68642.1    GECZ01007592    JAS62177.1    AAAB01008987    GGFK01005130    MBW38451.1    GL768276    EFZ11562.1    ATLV01019117    KE525262    KFB43673.1    KQ977926    KYM98786.1    CP012528    ALC49405.1    CH933810    ADTU01022666    GEBQ01004870    JAT35107.1    ACPB03015037    KQ976745    KYM75403.1    GBGD01000520    JAC88369.1    KQ978730    KYN28974.1    GECL01002324    JAP03800.1    KQ983049    KYQ47868.1    KQ981986    KYN31215.1    GBRD01008814    JAG57007.1    GBHO01017825    GBHO01017824    GBRD01008813    JAG25779.1    JAG25780.1    JAG57008.1    DS235222    EEB13531.1    AK417706    BAN20921.1    CH940653    GEBQ01002521    JAT37456.1    GGFK01003738    MBW37059.1    GDIP01207677    JAJ15725.1    GDIP01225967    JAI97434.1    GDIQ01122828    JAL28898.1    GDIQ01154659    JAK97066.1    GDIQ01120223    JAL31503.1    GDIP01107732    JAL95982.1    GDIP01193373    GDIQ01247427    GDIQ01208788    GDIP01053303    LRGB01000024    JAJ30029.1    JAK42937.1    KZS21632.1    GDIP01235423    JAI87978.1    GDIP01107733    JAL95981.1    GDIP01166123    JAJ57279.1    GDIQ01122829    JAL28897.1    GDIQ01228688    JAK23037.1    GL732751    EFX65315.1    GDIQ01230933    JAK20792.1    GDIP01083538    JAM20177.1    GDIP01199430    JAJ23972.1    GDIQ01043701    JAN51036.1    GDIP01120230    JAL83484.1    GDIP01120231    JAL83483.1    GDIQ01105636    JAL46090.1    GDIQ01238835    JAK12890.1    GDIP01207676    JAJ15726.1    GDRN01096677    JAI59294.1    QCYY01001124    ROT80387.1    JH431845    GDIP01105077    JAL98637.1   

Proteomes

UP000007151    UP000192223    UP000235965    UP000027135    UP000005203    UP000242457    + More
UP000037069    UP000076502    UP000002358    UP000215335    UP000095301    UP000092444    UP000008237    UP000183832    UP000002282    UP000000803    UP000078200    UP000192221    UP000001292    UP000000311    UP000008711    UP000001819    UP000008744    UP000053097    UP000279307    UP000007801    UP000008820    UP000007798    UP000268350    UP000092445    UP000001070    UP000076407    UP000075882    UP000007062    UP000030765    UP000095300    UP000078542    UP000092553    UP000009192    UP000005205    UP000015103    UP000078540    UP000078492    UP000075809    UP000078541    UP000009046    UP000008792    UP000076858    UP000000305    UP000085678    UP000079169    UP000283509   

PRIDE

E2QD75    Q7K4N3    B3MS75    Q16UN6    Q7PX35   

Pfam

PF02854   MIF4G        + More
PF09090   MIF4G_like_2
PF09088   MIF4G_like
PF07690   MFS_1

Interpro

IPR016024   ARM-type_fold        + More
IPR015172   MIF4G-like_typ-1       
IPR015174   MIF4G-like_typ-2       
IPR027159   CBP80       
IPR016021   MIF4-like_sf       
IPR003890   MIF4G-like_typ-3       
IPR020846   MFS_dom       
IPR005829   Sugar_transporter_CS       
IPR011701   MFS       
IPR036259   MFS_trans_sf       
IPR001958   Tet-R_TetA/multi-R_MdtG       

SUPFAM

SSF48371   SSF48371        + More
SSF103473   SSF103473       

Gene 3D

1.25.40.180    

CDD

cd06174  MFS

ProteinModelPortal

A0A212F7L2   A0A1E1WTD0   A0A1W4WJ55   A0A2J7QT07   A0A1Y1NG62   A0A067R587   + More
A0A1L8DGY9   W8C9N4   A0A0K8VTP5   A0A034VCV5   A0A0A1XET0   A0A088A145   A0A2A3EN24   A0A0L0CL87   A0A154PSU0   U5ENC9   K7IVH0   A0A0C9QS52   A0A232EZH0   T1PBD2   A0A1B0FFF1   E2BW56   A0A1J1I559   B4Q034   E2QD75   Q7K4N3   A0A1A9UGF8   A0A1W4UII4   A0A1Q3G0V8   B4I0W6   E2AC77   B3NU52   Q29G82   B4GW22   A0A026WWH0   B3MS75   Q16UN6   B4NC41   A0A3B0K2Q4   A0A1B0AEE3   A0A2M4BER4   B4JM29   A0A2K6VB37   A0A1B6GIC9   A0A1Y9J003   A0A3F2YUX2   Q7PX35   A0A2M4ACE7   E9J6J3   A0A084W0C9   A0A1I8Q2I0   A0A151IDL5   A0A0M4EZ67   B4L2J8   A0A158NPN5   A0A1B6MGN0   T1HND5   A0A195AT54   A0A069DZJ7   A0A195EM70   A0A0V0G7W0   A0A151WJ36   A0A195ESJ1   A0A0K8SUQ8   A0A0A9Y0R4   E0VJH5   R4WPV5   B4M7T6   A0A1B6MND2   A0A2M4A8G5   A0A0P4ZZK2   A0A0P4YLU7   A0A0P5QC32   A0A0N8BQK0   A0A0P5Q311   A0A0P5UWS2   A0A0P5IV70   A0A0P4Y749   A0A0P5UVF2   A0A0P5CUS9   A0A0P5PXK4   A0A0P5J859   E9HSG0   A0A0P5HNA5   A0A0P5XJ99   A0A0P5AHK1   A0A0P6FRJ1   A0A0P5TYH9   A0A0N8CLF2   A0A0P5RTI7   A0A0N8AVH8   A0A0P5AVK3   A0A1S3JU09   A0A1S3CX94   A0A1S3KF50   A0A0P4W2Q8   A0A3R7PXP8   T1JMW3   A0A0P5V436  

PDB

3FEY     E-value=0,     Score=2251

KEGG

101745390    K12882 nuclear cap-binding protein subunit 1 | (RefSeq) nuclear cap-binding protein subunit 1

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)
03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0051028   GO:0045292   GO:0000339   GO:0005846   GO:0006370   GO:0005634   GO:0031053   GO:0030422   GO:0045071   GO:0071013   GO:0000398   GO:0035195   GO:0071011   GO:0016246   GO:0031047   GO:0000184   GO:0005845   GO:0016021   GO:0055085   GO:0005215   GO:0005488   GO:0016070   GO:0003723   GO:0005515   GO:0009156   GO:0044249   GO:0006428   GO:0000049   GO:0006508   GO:0016286  

PANTHER

PTHR12412  

Subcellular location

Nucleus  

Length:

797

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.706989999999997

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03243

outside

1  -  797

 

 

Pi

4.163488

Theta

15.510418

Tajima's D

-1.592739

CLR

1.873816

CSRT

0.0492475376231188

Interpretation

Uncertain