Gene

KWMTBOMO12670

Pre Gene Modal

BGIBMGA001401

Annotation

PREDICTED:_NAD-dependent_protein_deacetylase_Sirt6_[Plutella_xylostella]

Location

Bomo_Chr21(-):11144558-11152682      View in EpiBrowser

Full name

NAD-dependent protein deacetylase Sirt6      

Alternative Name

Regulatory protein SIR2 homolog 6
SIR2-like protein 6

Location in the cell

Cytoplasmic   Reliability : 2.277 Nuclear   Reliability : 1.749

CDS

ATGTCTTGCAATTATGCAGAAGGACTATCACCTTATGAAAACAAAGGTATACTAGGAGTCCCAGAGAAATTTGATTCAAATGACAAACTGAACCAGAAATGTGTACTCTTGGCTCAACTTGTGAAAGATAGTAAACATATTGTTGTCCACACTGGAGCTGGCATAAGTACTTCTGCGGGTATTCCAGACTTTAGAGGGCCAAATGGAGTGTGGACTTTAGAGAAGGAAGGTAAAAAGCCAACCATCAATGTATCATTTGCTGATGCACAACCCACAAAAACCCATATGATTTTAAAAAAGTTGGTTGAAATAAAAAAACTTAAATACATTGTGAGTCAAAACATTGACGGACTTCATCTCAAGTCTGGTGTCCCAAGAAAATTCTTAGCTGAACTACATGGAAATATGTTTATTGATGAATGTAACATCTGCAAGAGACAGTTTGTCCGTAGCAGTCCTGTCGAAACTGTAGGCAAGAAATGCAGTGGTGTGCCTTGTGCAGCTCACCATGTGACGGGTAGACCTTGCCGTGGTAGATTATATGACGGAGTGCTTGACTGGGAGCATAGCTTGCCTGAAAATGATTTGCTAATGGCAGAATGGCATTCAAGTATTGCAGACTTGAGCATATGTCTAGGTACAACACTTCAAATAGTACCAAGTGGTAATTTACCACTAGAGACTATTAAATATGGTGGAAAGTTAGTTATTTGCAACCTACAACCAACAAAACATGACAATAAAGCTGATCTCCTAATAAATTATTATGTAGATGATGTACTTGAGAAAGTAATGGACATCTTAGGAATTGAAATCCCCAGTTATAATGAATCTGAGAACCCCATGAAATTTGCAGAAACAGCTATTATTGACTGGTCAATAGACAGAAAAGATGTCTTAGCTTTAGAAAAGACATTCAAATCAAAATGCAAAGGAGTTAAAAAGAAACGAATATTAATAAAAACAAAAAGATTTACCAGTAATGCCAATGATATTGAAAAATCAAAAATGATCAAATTAGAAGTTAAGGAAGAGAATGAAACTAAAGACTGGCCATTGAAACCTTCGGATCAAGAATTTATAATTGATCAAAAGGGTTCTATTGTGTCTTGA

Protein

MSCNYAEGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPTKTHMILKKLVEIKKLKYIVSQNIDGLHLKSGVPRKFLAELHGNMFIDECNICKRQFVRSSPVETVGKKCSGVPCAAHHVTGRPCRGRLYDGVLDWEHSLPENDLLMAEWHSSIADLSICLGTTLQIVPSGNLPLETIKYGGKLVICNLQPTKHDNKADLLINYYVDDVLEKVMDILGIEIPSYNESENPMKFAETAIIDWSIDRKDVLALEKTFKSKCKGVKKKRILIKTKRFTSNANDIEKSKMIKLEVKEENETKDWPLKPSDQEFIIDQKGSIVS

Description

NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span.

Catalytic Activity

H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Cofactor

Zn(2+)

Similarity

Belongs to the sirtuin family. Class IV subfamily.
Belongs to the universal ribosomal protein uL22 family.

Keywords

Complete proteome   Hydrolase   Metal-binding   NAD   Reference proteome   Zinc  

Feature

chain  NAD-dependent protein deacetylase Sirt6

Uniprot

H9IVX0   A0A2A4IZK5   A0A2H1VR05   A0A212F7K9   A0A194REA8   A0A194QCC3   + More
A0A437BUW4   D6W9J7   K7IVH1   E2BAH7   A0A2J7PC12   A0A2J7PC17   A0A154PCL6   A0A0P4VU52   B4JPZ6   A0A0L7R8F1   A0A195EQL6   A0A088AIY8   A0A158NQL6   A0A026W6E6   A0A151XAX5   A0A1I8P496   B4LVC5   F4WKH3   A0A1B6GGY3   A0A1B6L1N7   A0A195BR04   A0A1B0EZ10   A0A347ZJH1   A0A195DI37   A0A1Y9IVF5   B4MUC7   A0A1B6K2Q4   A0A1B6I1F0   E2AN21   A0A1Y1KC95   B4KHR8   A0A1B0CHX5   A0A0R3NRG2   A0A023F1X0   B3LW04   A0A182TFJ6   A0A1C7CZT1   A0A1I8JVJ4   A0A1I8JTF3   Q7PXL0   A0A182LW30   A0A1I8JW60   A0A1Y9HEZ3   A0A2A3E4V8   A0A0L0C8M7   A0A232EZW5   B3P1P7   A0A0A1XA58   Q16PZ4   A0A1B6CB19   A0A1S4FTB4   A0A182S7X0   A0A1Y9H9L0   A0A240PPS8   A0A224XN22   A0A1W4UK10   B4PKN2   A0A1I8NCI0   A0A0K8USI3   A0A069DSU1   A0A1Y9G9J4   A0A034VXN7   A0A240PMX2   Q9VH08   B4HJ75   A0A0M4E8J5   A0A182YGA4   A0A0V0G6Z7   A0A3B0JHK7   A0A1Y9H398   A0A336LIU6   A0A336K0Y7   W5J661   W8AG47   B4QV96   A0A3R7Q068   A0A0K8TLQ7   E0VRL7   A0A1A9VUJ7   A0A1A9YMF0   A0A1A9W8Q5   A0A1A9ZKS0   A0A1B0BDH8   A0A1B0G8R3   A0A2R7VWG6   N6UN31   U4UFK1   A0A3B0JH01   U4TUL2   A0A0A9Z7B5   N6TUQ0   A0A0A9ZCQ7   A0A0A9Z9M5   A0A0P4W8L8  

EC Number

3.5.1.-

Pubmed

19121390    22118469    26354079    18362917    19820115    20075255    + More
20798317    27129103    17994087    21347285    24508170    30249741    21719571    28004739    15632085    25474469    20966253    12364791    14747013    17210077    26108605    28648823    25830018    17510324    17550304    25315136    26334808    25348373    10731132    12537572    17159295    25244985    20920257    23761445    24495485    26369729    20566863    23537049    25401762   

EMBL

BABH01006508    BABH01006509    BABH01006510    NWSH01004755    PCG64704.1    ODYU01003897    + More
SOQ43227.1    AGBW02009859    OWR49724.1    KQ460325    KPJ15804.1    KQ459193    KPJ03117.1    RSAL01000006    RVE54262.1    KQ971312    EEZ98502.1    GL446730    EFN87309.1    NEVH01027073    PNF13869.1    PNF13871.1    KQ434874    KZC09669.1    GDKW01003252    JAI53343.1    CH916372    EDV98976.1    KQ414632    KOC67162.1    KQ982021    KYN30570.1    ADTU01023390    KK107405    QOIP01000014    EZA51196.1    RLU14917.1    KQ982335    KYQ57531.1    CH940649    EDW63304.1    GL888199    EGI65311.1    GECZ01008067    JAS61702.1    GEBQ01022355    JAT17622.1    KQ976419    KYM89286.1    AJVK01007422    FX985739    BBA84477.1    KQ980824    KYN12506.1    CH963857    EDW76053.1    GECU01001954    JAT05753.1    GECU01036617    GECU01026964    GECU01022868    GECU01006688    JAS71089.1    JAS80742.1    JAS84838.1    JAT01019.1    GL441034    EFN65179.1    GEZM01088551    JAV58108.1    CH933807    EDW13355.1    AJWK01012834    AJWK01012835    CH379059    KRT03758.1    GBBI01003175    JAC15537.1    CH902617    EDV41537.1    APCN01000875    AAAB01008987    EAA00841.3    AXCM01005015    KZ288372    PBC26730.1    JRES01000749    KNC28793.1    NNAY01001524    OXU23698.1    CH954181    EDV49646.1    GBXI01006295    JAD07997.1    CH477768    EAT36439.1    GEDC01026664    JAS10634.1    AXCN02000207    GFTR01005218    JAW11208.1    CM000160    EDW96791.1    GDHF01022846    JAI29468.1    GBGD01002098    JAC86791.1    GAKP01012659    JAC46293.1    AE014297    BT126234    CH480815    EDW42747.1    CP012523    ALC39277.1    GECL01002644    JAP03480.1    OUUW01000006    SPP81675.1    UFQS01000011    UFQT01000011    SSW97149.1    SSX17535.1    SSW97148.1    SSX17534.1    ADMH02002026    ETN59902.1    GAMC01019275    JAB87280.1    CM000364    EDX13502.1    MG491309    QCYY01003131    AZI71012.1    ROT65169.1    GDAI01002306    JAI15297.1    DS235478    EEB16023.1    JXJN01012501    CCAG010000303    KK854098    PTY11241.1    APGK01016464    KB739858    ENN82101.1    KB632093    ERL88695.1    SPP81674.1    KB630484    ERL83623.1    GBHO01002507    JAG41097.1    APGK01017821    KB740053    ENN81803.1    GBHO01002506    JAG41098.1    GBHO01002505    JAG41099.1    GDRN01081144    JAI62065.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    + More
UP000007266    UP000002358    UP000008237    UP000235965    UP000076502    UP000001070    UP000053825    UP000078541    UP000005203    UP000005205    UP000053097    UP000279307    UP000075809    UP000095300    UP000008792    UP000007755    UP000078540    UP000092462    UP000078492    UP000075920    UP000007798    UP000000311    UP000009192    UP000092461    UP000001819    UP000007801    UP000075902    UP000075882    UP000075903    UP000075840    UP000007062    UP000075883    UP000076407    UP000075900    UP000242457    UP000037069    UP000215335    UP000008711    UP000008820    UP000075901    UP000075886    UP000075885    UP000192221    UP000002282    UP000095301    UP000069272    UP000075881    UP000000803    UP000001292    UP000092553    UP000076408    UP000268350    UP000075884    UP000000673    UP000000304    UP000283509    UP000009046    UP000078200    UP000092443    UP000091820    UP000092445    UP000092460    UP000092444    UP000019118    UP000030742   

PRIDE

H9IVX0    Q9VH08   

Pfam

PF02146   SIR2        + More
PF00237   Ribosomal_L22

Interpro

IPR029035   DHS-like_NAD/FAD-binding_dom        + More
IPR003000   Sirtuin       
IPR026590   Ssirtuin_cat_dom       
IPR018260   Ribosomal_L22/L17_CS       
IPR005721   Ribosomal_L22/L17_euk/arc       
IPR036394   Ribosomal_L22/L17_sf       
IPR001063   Ribosomal_L22       

SUPFAM

SSF52467   SSF52467        + More
SSF54843   SSF54843       

Gene 3D

3.90.470.10    

CDD

cd00336  Ribosomal_L22

ProteinModelPortal

H9IVX0   A0A2A4IZK5   A0A2H1VR05   A0A212F7K9   A0A194REA8   A0A194QCC3   + More
A0A437BUW4   D6W9J7   K7IVH1   E2BAH7   A0A2J7PC12   A0A2J7PC17   A0A154PCL6   A0A0P4VU52   B4JPZ6   A0A0L7R8F1   A0A195EQL6   A0A088AIY8   A0A158NQL6   A0A026W6E6   A0A151XAX5   A0A1I8P496   B4LVC5   F4WKH3   A0A1B6GGY3   A0A1B6L1N7   A0A195BR04   A0A1B0EZ10   A0A347ZJH1   A0A195DI37   A0A1Y9IVF5   B4MUC7   A0A1B6K2Q4   A0A1B6I1F0   E2AN21   A0A1Y1KC95   B4KHR8   A0A1B0CHX5   A0A0R3NRG2   A0A023F1X0   B3LW04   A0A182TFJ6   A0A1C7CZT1   A0A1I8JVJ4   A0A1I8JTF3   Q7PXL0   A0A182LW30   A0A1I8JW60   A0A1Y9HEZ3   A0A2A3E4V8   A0A0L0C8M7   A0A232EZW5   B3P1P7   A0A0A1XA58   Q16PZ4   A0A1B6CB19   A0A1S4FTB4   A0A182S7X0   A0A1Y9H9L0   A0A240PPS8   A0A224XN22   A0A1W4UK10   B4PKN2   A0A1I8NCI0   A0A0K8USI3   A0A069DSU1   A0A1Y9G9J4   A0A034VXN7   A0A240PMX2   Q9VH08   B4HJ75   A0A0M4E8J5   A0A182YGA4   A0A0V0G6Z7   A0A3B0JHK7   A0A1Y9H398   A0A336LIU6   A0A336K0Y7   W5J661   W8AG47   B4QV96   A0A3R7Q068   A0A0K8TLQ7   E0VRL7   A0A1A9VUJ7   A0A1A9YMF0   A0A1A9W8Q5   A0A1A9ZKS0   A0A1B0BDH8   A0A1B0G8R3   A0A2R7VWG6   N6UN31   U4UFK1   A0A3B0JH01   U4TUL2   A0A0A9Z7B5   N6TUQ0   A0A0A9ZCQ7   A0A0A9Z9M5   A0A0P4W8L8  

PDB

3ZG6     E-value=9.61199e-86,     Score=807

KEGG

101745097    K11416 mono-ADP-ribosyltransferase sirtuin 6 [EC:2.4.2.31] | (RefSeq) NAD-dependent protein deacetyl

GO

GO:0070403   GO:0000122   GO:0004407   GO:0070932   GO:0005634   GO:0046969   GO:0005724   GO:0016740   GO:0046872   GO:0031937   GO:0008340   GO:0016575   GO:0003735   GO:0006412   GO:0015934  

Length:

370

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.003

Exp number, first 60 AAs:

0.00117

Total prob of N-in:

0.00830

outside

1  -  370

 

 

Pi

11.066635

Theta

3.865061

Tajima's D

-1.523534

CLR

16.890825

CSRT

0.0517474126293685

Interpretation

Uncertain