Gene

KWMTBOMO12654

Pre Gene Modal

BGIBMGA001573

Annotation

cytochrome_P450_Cyp6AU1_[Bombyx_mori]

Location

Bomo_Chr21(+):10357715-10363089      View in EpiBrowser

Full name

Cytochrome P450 6B4       + More
Cytochrome P450 6B1      
Cytochrome P450 6B5      
Cytochrome P450 6B7      
Cytochrome P450 6B6      
Cytochrome P450 6B3      
Cytochrome P450 6B2      

Alternative Name

CYP6B4v1/CYP6B4v2
CYPVIB4
CYP6B1v1/CYP6B1v2/CYP6B1v3
CYPVIB1
CYP6B5v1
CYPVIB5
CYPVIB7
CYPVIB6
CYP6B3v1/CYP6B3v2
CYPVIB3
CYPVIB2

Location in the cell

Cytoplasmic   Reliability : 1.44 PlasmaMembrane   Reliability : 1.723

CDS

ATGCTCACGGCTTACCTCCTGTATGTGTTCGCTTCAATAGTGGTGTTAATTTATTTTTATCTCAATAATAAATACAAATATTGGAAAAATAAAAACATAGCCGGTCCGGAGCCGGAATTTTTGTTTGGGAATTTGAAGGAAAGCTTCCACAGGAGGAAGCATATCGCGACCGTCTTCAAGGAGATATACGATCAGTACCCCGATGAGAAGGTAGTGGGAATGTTCAGAATGACATCTCCTACGTTGATAGTGCGCGACTTGGACATTGTCAAACAGATAATGATCAAAGACTATGCCAAGTTCAACGAGAGAGGCATTAAGTTCAGCAAGGAAGGGCTCGGAGACAACCTGTTCCATGCTGATGCTGACGCTTGGAAAGCGGTAAGAAGCCACCTGACGCCGATGTTTAGTTCGGGAAAATTAAAGAACATGGTGAGGGTGTTGTCGCAAACGGGAGACCGGTTTGTGGACCACGTCACCAACGAAGTTCGCTTGCGACCCGAACAAGAGCTCGTATCCCTGTTCCTCAAGTACAACATCGCGACTATAATGGCTTGCAGCTTCAGCATGGAAACCGATATCAACGACATGCAAGTATATGAGATGCTCAACGTTGCTGTCTTCGAAAACAGCTACATCAGCGAATTGGATATGGTGTTCCCGGGAATTCTGAGGAAAACGAACCGATCGATTTTCGGGCCGACCGTCAACAATTTCTGCTATGAGATTGTCGAATTTATTAAAAACGAAAGGAACGGAAAGCCAGCCAACAGAAACGACATGATGGATATGCTGTTAGGTGTCAATTGTGATAAATTAAAAATGAAAAATGGCAGCGAAGATTTTGTTGAAATCACCGAGCATGTGATGGCTGGACAAGTGTTTGTCTTCTTTGCAGCCGGGTACGTTAATAATACGATCACGCTGACATTCTCTCTGTACCATTTGGCGAAAGATCAAAGCATTCAAGAAAGGTTAATGAGGGAAATAGAGACGGTGCTGGAAAACCATAACAACGTATTGACTCTTGAAGCGATTAACGAGATGAGTTACTTGGAGATGATATTTCTCGAAACCTTGAGGATGCACCCGACAACGAACACACTCCAACGCTCTGCTTTAGAAGATTACACGATACCTGGGACGGACATAGAGATCGAAAAGGGCACATTAGTGCTCATACCCCCCTTGGCTTTTCATCACGACGAGAAAATTTACCCTGAACCTGAGAAGTTTGATCCTGAAAGATTTTCCGTAGAGAATCACAAGAGCCGGCATGCTTGTGCGTTTTTGTCTTTCGGAATCGGCCCACGGACCTGTATAGGCATCAGATTAGCGAAATTACAATACAAAGTTTGCATGGTCAAGTTCCTAACGAAGTATCGAGTGGCGCCGTCTACGAGAACGAAGGATGCGTACAAGATTGATCCCCTAAGGACGGCTTTGGAACCTGAAGGAGGCGTTTATGTTGATATACTACCAAGATCTTAA

Protein

MLTAYLLYVFASIVVLIYFYLNNKYKYWKNKNIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS

Catalytic Activity

an alkane + O2 + reduced [NADPH--hemoprotein reductase] = a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Keywords

Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase   Polymorphism   Direct protein sequencing  

Feature

chain  Cytochrome P450 6B4

Uniprot

H9IWE2   A5JM35   A9QW16   A0A0L7LMR7   A0A0N0PCS4   A0A0N1IGJ6   + More
A0A194Q8F3   A0A194Q3U9   A0A0N0PD61   A0A194RD81   A0A194RE57   A0A0L7LIR5   D5L0M3   Q95WV9   A0A194RDS3   Q95WX2   A0A0L7L798   Q95WW0   Q95WW3   A0A0L7LI72   Q95WW8   Q95WW6   Q95WW4   A0A194RD41   Q95WX3   Q95WX0   D5L0M4   Q27902   Q95WX1   A0A194QG84   I4DJQ1   A0A194RD46   Q95WW9   A0A0K8TV66   A0A194QGD5   J7FJ23   C9E6M9   Q95WW5   D0VFI8   A0A0N1INS4   Q95WW7   A0A194Q8W8   A0A194Q2X4   A0A248QEF7   A0A194QG28   D2KQK5   Q8T7V2   A0A0K8TV82   Q04552   Q9U079   Q8MXC0   Q6J663   A0A0K0YD48   Q6PY59   A0A194QG65   A0A2A4IYM7   Q2HY58   A0A2H1VWR0   A0A2H1VHP3   Q2HY55   D2KQK6   Q508A7   Q2XTF1   Q8T7V1   Q95WW2   Q508A8   Q8MXC1   A0A0N0PBN2   B8YDH7   Q2HY56   A0A068F0Y2   A0A194QHT5   J7FIT2   A0A0N1IEY2   A1XNB6   Q95036   D7R771   O61387   A0A194QM16   A0A2A4J099   A0A194Q6S4   A0A0K0YD41   A0A068EVL4   Q8MXB9   A1XNB7   A0A0K8TV67   A0A2A4IYZ9   A0A0N1I9Z9   A0A0K8TVQ3   Q95031   A0A2A4JMY4   Q2XTF2   Q27756   Q27664   A0A0K8TVR2   A0A068EU78   A0A0N1IJW8   I4DJG2   A0A194Q2B9   A0A194RII2  

EC Number

1.14.14.1

Pubmed

19121390    26227816    26354079    19909380    11483436    9219364    + More
22651552    26017144    22984814    22391394    28881445    25547988    11804803    1279697    8065937    10646973    17257205    22689565    16984951    8901557    9753767    8589841    8541882   

EMBL

BABH01006444    AK343200    BAM73886.1    EF547546    ABQ42340.1    EU273878    + More
ABX64441.1    JTDY01000544    KOB76727.1    KQ460457    KPJ14658.1    KPJ14657.1    KQ459564    KPI99685.1    KPI99684.1    KPJ14656.1    KQ460397    KPJ15235.1    KQ460325    KPJ15754.1    JTDY01001023    KOB75101.1    GU731528    ADE05578.1    AF280622    AAK69504.1    KPJ15757.1    AF278602    AAK69478.1    JTDY01002464    KOB71358.1    AF280621    AAK69503.1    AF280618    AAK69500.1    KOB75100.1    AF280613    AAK69495.1    AF280615    AAK69497.1    AF280617    AAK69499.1    KPJ15753.1    AF278601    AAK69477.1    AF278604    AAK69480.1    GU731529    ADE05579.1    U47059    U65489    AF278603    AAK69479.1    KQ458981    KPJ04502.1    AK401519    BAM18141.1    KPJ15758.1    AF280612    AAK69494.1    GCVX01000052    JAI18178.1    KPJ04479.1    JX310076    AFP20587.1    GQ465039    JN862817    ACV88721.2    AEV46849.1    AF280616    AAK69498.1    GU074517    ACY41036.1    KQ460882    KPJ11487.1    AF280614    AAK69496.1    KQ459337    KPJ01420.1    KPI99688.1    KX443429    ASO98004.1    KPJ04503.1    GU263827    ADA68173.1    AF285186    AAL89656.1    GCVX01000059    JAI18171.1    M80828    M83117    Z29624    U05037    AF102263    AAF06102.1    AF285830    AAM90317.1    AY593871    DQ458470    DQ497428    HM042304    KM016749    AAT36350.1    ABE60887.1    ABF50223.2    ADH82408.1    AID54901.1    KR095602    AKS48890.1    AY571335    AAT01211.1    KPJ04482.1    NWSH01004601    PCG64861.1    DQ365694    DQ365695    DQ365696    ABC96862.1    ABC96863.1    ABC96864.1    ODYU01004908    SOQ45265.1    ODYU01002604    SOQ40326.1    DQ365698    ABC96866.1    GU263828    ADA68174.1    AY950637    AAY21921.1    DQ252325    ABB58823.1    AF285829    AAL93212.1    AF280619    AAK69501.1    AY950636    AAY21920.1    AF285828    AAM90316.1    KPJ11505.1    FJ524855    KX443427    ACL77781.1    ASO98002.1    DQ365697    ABC96865.1    KM016748    AID54900.1    KPJ04500.1    JX310079    AFP20590.1    KQ460423    KPJ14819.1    ABE60886.1    U65490    HM042303    ADH82407.1    AF031468    KPJ04501.1    PCG64860.1    KQ459386    KPJ01238.1    KR095601    AKS48889.1    KM016746    AID54898.1    AF285831    AAM90318.1    ABE60885.1    GCVX01000074    JAI18156.1    PCG64859.1    KPJ14659.1    GCVX01000085    JAI18145.1    U64800    NWSH01001009    PCG73146.1    DQ252324    ABB58822.1    U25819    U65488    U18085    GCVX01000075    JAI18155.1    KM016747    AID54899.1    KQ459762    KPJ20118.1    AK401430    BAM18052.1    KPI99686.1    KPJ15756.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000053268    UP000218220   

PRIDE

H9IWE2    A5JM35    O61387    Q2XTF2    Q27756   

Pfam

PF00067   p450

Interpro

IPR001128   Cyt_P450        + More
IPR017972   Cyt_P450_CS       
IPR002401   Cyt_P450_E_grp-I       
IPR036396   Cyt_P450_sf       
IPR002403   Cyt_P450_E_grp-IV       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

H9IWE2   A5JM35   A9QW16   A0A0L7LMR7   A0A0N0PCS4   A0A0N1IGJ6   + More
A0A194Q8F3   A0A194Q3U9   A0A0N0PD61   A0A194RD81   A0A194RE57   A0A0L7LIR5   D5L0M3   Q95WV9   A0A194RDS3   Q95WX2   A0A0L7L798   Q95WW0   Q95WW3   A0A0L7LI72   Q95WW8   Q95WW6   Q95WW4   A0A194RD41   Q95WX3   Q95WX0   D5L0M4   Q27902   Q95WX1   A0A194QG84   I4DJQ1   A0A194RD46   Q95WW9   A0A0K8TV66   A0A194QGD5   J7FJ23   C9E6M9   Q95WW5   D0VFI8   A0A0N1INS4   Q95WW7   A0A194Q8W8   A0A194Q2X4   A0A248QEF7   A0A194QG28   D2KQK5   Q8T7V2   A0A0K8TV82   Q04552   Q9U079   Q8MXC0   Q6J663   A0A0K0YD48   Q6PY59   A0A194QG65   A0A2A4IYM7   Q2HY58   A0A2H1VWR0   A0A2H1VHP3   Q2HY55   D2KQK6   Q508A7   Q2XTF1   Q8T7V1   Q95WW2   Q508A8   Q8MXC1   A0A0N0PBN2   B8YDH7   Q2HY56   A0A068F0Y2   A0A194QHT5   J7FIT2   A0A0N1IEY2   A1XNB6   Q95036   D7R771   O61387   A0A194QM16   A0A2A4J099   A0A194Q6S4   A0A0K0YD41   A0A068EVL4   Q8MXB9   A1XNB7   A0A0K8TV67   A0A2A4IYZ9   A0A0N1I9Z9   A0A0K8TVQ3   Q95031   A0A2A4JMY4   Q2XTF2   Q27756   Q27664   A0A0K8TVR2   A0A068EU78   A0A0N1IJW8   I4DJG2   A0A194Q2B9   A0A194RII2  

PDB

6MJM     E-value=5.93641e-51,     Score=508

KEGG

100127026    K14999 cytochrome P450 family 6 [EC:1.14.-.-] | (RefSeq) Cyp6au1; cytochrome P450 Cyp6AU1

GO

GO:0004497   GO:0020037   GO:0016021   GO:0016705   GO:0005506   GO:0070330   GO:0005789   GO:0009165   GO:0009156   GO:0044249   GO:0006428   GO:0000049   GO:0006508   GO:0016286   GO:0055114  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

496

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

40.8783

Exp number, first 60 AAs:

18.50572

Total prob of N-in:

0.02641

POSSIBLE N-term signal

sequence

outside

1  -  3

TMhelix

4  -  21

inside

22  -  294

TMhelix

295  -  317

outside

318  -  496

 

 

Pi

182.008468

Theta

163.506474

Tajima's D

0.123834

CLR

0.047735

CSRT

0.404729763511824

Interpretation

Uncertain