Gene

KWMTBOMO12631  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001415

Annotation

PREDICTED:_uncharacterized_protein_LOC103519968_isoform_X3_[Diaphorina_citri]

Location

Bomo_Chr21(-):9714493-9718163      View in EpiBrowser

Full name

Polyubiquitin-A       + More
Polyubiquitin-C      
Polyubiquitin      

Location in the cell

Nuclear   Reliability : 1.911

CDS

ATGCAGATTTTTGTAAAAACTCTCACTGGTAAAACCATAACATTAGAAGTCGAAGCATCCGACACCATAGAAAATGTAAAAGCAAAAATTCAAGACAAAGAGGGCATTCCTCCAGATCAGCAGCGACTGATTTTCGCTGGGAAACAACTTGAAGACGGACGGACATTATCCGATTACAATATTCAAAAAGAATCTACTCTCCATTTGGTATTACGTCTGAGAGGTGGAATGCAGATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATTGAGAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATCTTTGCGGGCAAACAGCTTGAAGATGGCCGTACATTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTGTTACGTCTCAGAGGTGGCATGCAGATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATTGAGAATGTGAAAGCAAAGATTCAGGACAAAGAGGGAATTCCTCCGGATCAGCAGCGGTTGATCTTTGCGGGCAAACAGCTTGAAGATGGCCGTACACTATCCGACTACAACATCCAGAAAGAATCTACTCTGCACTTGGTTTTGAGACTGCGTGGTGGCATGCAGATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATCGAAAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATCTTTGCGGGCAAACAGCTTGAAGATGGTCGTACACTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTATTACGTCTCAGAGGTGGCATGCAGATCTTTGTGAAAACACTTACCGGTAAAACCATCACATTGGAAGTTGAAGCATCTGACACCATCGAAAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATTTTTGCTGGCAAACAGCTTGAAGATGGTCGTACATTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTGTTACGTCTCAGAGGTGGCATGCAAATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATTGAAAATGTGAAAGCAAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATTTTTGCGGGCAAACAGCTTGAAGATGGCCGTACATTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTGTTACGTCTCAGAGGTGGAATGCAGATTTTTGTGAAAACACTTACCGGTAAAACCATCACATTGGAAGTTGAAGCATCTGACACCATCGAAAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATTTTTGCTGGCAAACAGCTTGAAGATGGTCGTACATTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTTTTGAGACTGCGTGGTGGCATGCAAATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATAGAAAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATTTTTGCGGGCAAACAGCTTGAAGATGGTCGTACATTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTGCTACGTCTCAGAGGTGGAATGCAGATTTTTGTGAAAACACTTACCGGTAAAACCATCACATTGGAAGTTGAAGCATCTGACACCATCGAAAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATTTTTGCGGGCAAACAGCTTGAAGATGGTCGTACATTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTTTTGAGACTGCGTGGTGGCATGCAGATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATTGAGAATGTGAAAGCCAAGATTCAGGATAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATCTTTGCGGGCAAACAGCTTGAAGATGGTCGTACACTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTATTACGTCTCAGAGGTGGCATGCAAATCTTTGTGAAAACACTTACCGGTAAAACCATCACGCTAGAAGTTGAAGCATCTGACACCATTGAGAATGTGAAAGCCAAGATTCAGGATAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATCTTTGCAGGCAAACAGCTTGAAGATGGTCGTACACTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTTTTGAGACTGCGTGGTGGCATGCAGATCTTTGTGAAAACACTTACCGGTAAAACCATCACACTAGAAGTTGAAGCATCTGACACCATTGAGAATGTGAAAGCCAAGATTCAGGATAAAGAGGGAATTCCCCCAGATCAGCAGCGATTGATCTTTGCAGGCAAACAGCTTGAAGATGGTCGTACACTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTGTTACGTCTCAGAGGTGGAATGCAGATTTTTGTGAAAACACTTACCGGTAAAACCATCACATTGGAAGTTGAAGCATCTGACACCATCGAAAATGTGAAAGCCAAAATTCAGGACAAAGAGGGAATTCCTCCGGATCAGCAGCGATTGATCTTTGCGGGGAAACAGCTTGAAGACGGCCGTACACTATCTGACTACAACATCCAGAAAGAATCTACTCTGCATTTGGTTTTGAGACTGCGTGGTGGCATGCAGATCTTTGTCAAAACACTTACCGGTAAAACCATCACATTGGAAGTTGAAGCATCTGACACCATCGAAAATGTGAAAGCCAAGATTCAGGACAAAGAGGGAATTCCTCCGGATCAGCAGCGATTGATCTTTGCGGGCAAACAGCTTGAAGATGGCCGTACACTATCTGACTACAACATCCAGAAAGAATCTACTTTACATTTGGTTTTGAGACTCCGTGGTGGCATGTAG

Protein

MQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGM

Description

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

Miscellaneous

In C.elegans ubiquitin is encoded by 2 different genes. ubq-2 gene codes for a single copy of ubiquitin fused to the ribosomal proteins L40. ubq-1 gene codes for a polyubiquitin precursor with exact head to tail repeats.
For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.
Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

Similarity

Belongs to the ubiquitin family.

Keywords

Complete proteome   Cytoplasm   Isopeptide bond   Nucleus   Reference proteome   Repeat   Ubl conjugation   3D-structure   ADP-ribosylation   Direct protein sequencing   Phosphoprotein  

Feature

chain  Ubiquitin

Uniprot

A0A3Q0JF84   Q59EM9   Q8MSM5   A0A182G3H1   F7IUE6   A0A2C9GG42   + More
B0W973   A0A2V2XAK1   A0A2V2WXM7   A0A3L6KU91   A4HFB9   A0A381MWQ8   A0A3Q8IL40   A0A0V0UP34   O35080   A0A3L8DNX1   A0A310SL57   B4KXU3   A0A3R7Q158   A4HPM0   A0A3Q3DDY5   A0A3P8PAX2   A0A2V2UI66   G0V1P8   H9IVY4   K7JAJ3   G0MLK4   Q9XXZ6   E3LYQ5   A0A0L7REF9   A0A0Q9XB42   A0A161N0S0   B4HTV7   A0A2C9F3G2   A0A2V2URT3   A0A3Q0FBI2   F6H5Z7   A0A1X6NST7   O35079   A0A026WRG4   P0CG71   E0VZ82   A0A3P3ZIW3   B3NFZ3   A0A0R1DX86   A0A423TTK6   B3M7Z7   A0A2J8MCK3   A0A069DWK5   A0A3B5PX76   A0A2N9FRA3   T1FVF6   A0A0N5DTJ2   A0A072UMK2   Q4Q165   A0A2R6WG48   A0A0V0TBY2   A4HU11   Q63429   F1LML2   A0A2H2I3C6   A0A088AKW7   A8X7Y8   A0A0Q5U353   A0A3Q1HML6   A0A2A4JQD5   A0A0P5J9N1   A4V1F9   B4PH74   P0CG69   A0A1W3JG08   Q17E99   A0A0N8P0W8   A0A0P5ZXS3   P0CG61   P0CG64   E9GJF3   A0A0P5AM28   A0A0P6HH73   A0A2V2XAL8   A0A3P9JTM9   A0A3Q3FL84   A0A0P5AT03   H2M983   A0A0P5B0K3   A0A1U8J3Y2   A0A0B1PSR6   Q41067   A0A224XJ55   A0A3P9ME82   W1Q8J4   A0A085M187   A0A2G5CKP2   A0A1D2N8C3  

Pubmed

26483478    12364791    14747013    17210077    17510324    29708484    + More
17572675    30409989    9504932    30249741    17994087    18057021    22038252    22331916    19121390    20075255    25384727    17721507    24508170    2538720    9851916    2839490    20566863    17550304    26334808    23542700    23254933    22089132    24767513    16020728    8018730    15489334    8031840    15057822    14624247    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    2463465    14745543    21292972    17554307    25893780    24279325    24929829    27289101   

EMBL

AB209782    BAD93019.1    AY118702    AAM50562.1    JXUM01141442    KQ569246    + More
KXJ68707.1    AAAB01008987    EAL38503.3    DS231862    EDS39770.1    PRFC01000016    PWV17888.1    PRFC01000046    PWV12995.1    QSBY01000011    RHW67705.1    CADA01000041    CAM39530.1    UINB01000036    SUZ46748.1    CP029535    AYU83724.1    JYDN01000241    KRX52531.1    AB003732    BAA23488.1    QOIP01000006    RLU22134.1    KQ764626    OAD54467.1    CH933809    EDW17615.1    KRG05643.1    QCYY01003020    ROT65878.1    FR799010    CAM44128.1    PRFA01000275    PWU83895.1    HE575324    CCC95569.1    BABH01006376    AAZX01001755    GL379800    EGT35653.1    AB021974    BAA76676.1    DS268419    EFO86690.1    KQ414611    KOC69219.1    KRG05644.1    GEMB01002637    JAS00552.1    CH480817    EDW50378.1    AEMK02000096    PRFA01000138    PWU85926.1    FN595241    CCB47636.1    KV919117    OSX71664.1    AB003731    BAA23487.1    KK107128    EZA58281.1    M23433    FO081045    M21321    DS235850    EEB18688.1    LS997634    SYZ70200.1    CH954178    EDV50822.2    CM000159    KRK01102.1    QCYY01001188    ROT79785.1    CH902618    EDV39905.1    KPU78285.1    NBAG03000260    PNI57239.1    PNI57240.1    PNI57242.1    PNI57243.1    PNI57244.1    PNI57246.1    GBGD01000471    JAC88418.1    OIVN01001092    SPC89743.1    AMQM01007187    KB097579    ESN94006.1    CM001220    KEH31009.1    FR796432    CAJ09316.1    KZ772766    PTQ32829.1    JYDJ01000365    KRX36432.1    FR796441    CAM65917.2    D17296    BC103477    AC113658    HE601284    CAP28749.2    KQS43535.1    NWSH01000780    PCG74275.1    GDIQ01209048    JAK42677.1    AE014296    AAS64964.1    AGB94078.1    EDW93311.2    KRK01103.1    M33013    M33015    M33122    M22428    CH477284    EAT44779.1    KPU78284.1    GDIP01150781    GDIP01037838    JAM65877.1    AB089616    AB089614    GL732547    EFX80447.1    GDIP01196884    JAJ26518.1    GDIQ01028301    JAN66436.1    PWV17890.1    GDIP01194525    JAJ28877.1    GDIP01195771    JAJ27631.1    KN538398    KHJ43005.1    X98063    CAA66667.1    GFTR01007936    JAW08490.1    AEOI02000010    ESW96372.1    KL363245    KL367480    KFD50983.1    KFD71912.1    KZ305064    PIA31856.1    LJIJ01000159    ODN01335.1   

Proteomes

UP000079169    UP000069940    UP000249989    UP000007062    UP000002320    UP000007258    + More
UP000274082    UP000054681    UP000279307    UP000009192    UP000283509    UP000264820    UP000265100    UP000005204    UP000002358    UP000008068    UP000008281    UP000053825    UP000001292    UP000008227    UP000087766    UP000009183    UP000053097    UP000001940    UP000009046    UP000008711    UP000002282    UP000007801    UP000002852    UP000015101    UP000046395    UP000002051    UP000000542    UP000055048    UP000008153    UP000002494    UP000005237    UP000005203    UP000008549    UP000265040    UP000218220    UP000000803    UP000008820    UP000002277    UP000000305    UP000265200    UP000261660    UP000001038    UP000189702    UP000265180    UP000008673    UP000230069    UP000094527   

PRIDE

Q59EM9    Q8MSM5    O35080    H9IVY4    Q9XXZ6    O35079    + More
P0CG71    Q63429    F1LML2    A0A088AKW7    A4V1F9    P0CG69    P0CG61    P0CG64   

Pfam

PF00240   ubiquitin        + More
PF01020   Ribosomal_L40e

Interpro

IPR029071   Ubiquitin-like_domsf        + More
IPR019954   Ubiquitin_CS       
IPR019956   Ubiquitin       
IPR000626   Ubiquitin_dom       
IPR011332   Ribosomal_zn-bd       
IPR038587   L40e_sf       
IPR001975   Ribosomal_L40e       

SUPFAM

SSF54236   SSF54236        + More
SSF57829   SSF57829       

Gene 3D

2.20.28.70    

ProteinModelPortal

A0A3Q0JF84   Q59EM9   Q8MSM5   A0A182G3H1   F7IUE6   A0A2C9GG42   + More
B0W973   A0A2V2XAK1   A0A2V2WXM7   A0A3L6KU91   A4HFB9   A0A381MWQ8   A0A3Q8IL40   A0A0V0UP34   O35080   A0A3L8DNX1   A0A310SL57   B4KXU3   A0A3R7Q158   A4HPM0   A0A3Q3DDY5   A0A3P8PAX2   A0A2V2UI66   G0V1P8   H9IVY4   K7JAJ3   G0MLK4   Q9XXZ6   E3LYQ5   A0A0L7REF9   A0A0Q9XB42   A0A161N0S0   B4HTV7   A0A2C9F3G2   A0A2V2URT3   A0A3Q0FBI2   F6H5Z7   A0A1X6NST7   O35079   A0A026WRG4   P0CG71   E0VZ82   A0A3P3ZIW3   B3NFZ3   A0A0R1DX86   A0A423TTK6   B3M7Z7   A0A2J8MCK3   A0A069DWK5   A0A3B5PX76   A0A2N9FRA3   T1FVF6   A0A0N5DTJ2   A0A072UMK2   Q4Q165   A0A2R6WG48   A0A0V0TBY2   A4HU11   Q63429   F1LML2   A0A2H2I3C6   A0A088AKW7   A8X7Y8   A0A0Q5U353   A0A3Q1HML6   A0A2A4JQD5   A0A0P5J9N1   A4V1F9   B4PH74   P0CG69   A0A1W3JG08   Q17E99   A0A0N8P0W8   A0A0P5ZXS3   P0CG61   P0CG64   E9GJF3   A0A0P5AM28   A0A0P6HH73   A0A2V2XAL8   A0A3P9JTM9   A0A3Q3FL84   A0A0P5AT03   H2M983   A0A0P5B0K3   A0A1U8J3Y2   A0A0B1PSR6   Q41067   A0A224XJ55   A0A3P9ME82   W1Q8J4   A0A085M187   A0A2G5CKP2   A0A1D2N8C3  

PDB

5B83     E-value=1.31811e-145,     Score=1328

KEGG

101742698    K08770 ubiquitin C | (RefSeq) polyubiquitin-A

GO

GO:0019941   GO:0031386   GO:0005737   GO:0005634   GO:0031625   GO:0016567   GO:0003735   GO:0005840   GO:0006412   GO:0006914   GO:0035096   GO:0002020   GO:0016021   GO:0006511   GO:0005829   GO:0005654   GO:0005515   GO:0005524   GO:0006418   GO:0004822   GO:0006428   GO:0000049   GO:0006508   GO:0016286  

Subcellular location

Cytoplasm  
Nucleus  

Length:

1065

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00035

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00001

outside

1  -  1065

 

 

Pi

81.134893

Theta

164.876936

Tajima's D

-1.573771

CLR

5.300741

CSRT

0.0516974151292435

Interpretation

Uncertain