Gene

KWMTBOMO12625

Pre Gene Modal

BGIBMGA001557

Annotation

PREDICTED:_voltage-gated_sodium_channel_alpha_subunit_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr21(+):9555794-9579782      View in EpiBrowser

Full name

Sodium channel protein      

Location in the cell

PlasmaMembrane   Reliability : 4.593

CDS

ATGTCCCTACGTAGCGACCCCTTCCAGGACTCGGTGAGCACTCAGCCCGCGCACAAGCCCACCGCCACCGACACGCACGACTCCGCACGACGGCCGAGGAAGGTCAGCATGGCGTCTTTATCATTGCCTGGTTCTCCATTCAATTTGCGCCGTGGTTCACGTGGATCTCATCAGATGGCTCTGAGACCTAACGGTAGACCGAGATATCCTCCCGGAGGGGATCGGAAGCCACTGGTTTTGTCTACGTACCTCGATGCACAGGAACACCTGCCTTATGCTGATGACTCGAACGCTGTCACACCGATGTCTGAAGAAAATGGTGCTATCATCATCCCAGTTTATTATGCTAATTTAGGATCCCGACATTCTTCATACACGTCTCATCAGTCACGTTTGTCTTACACGTCTCACGGGGACTTGTTGGGCGGAGGGAAAGCTCAAACTAAGGAAGCTAGATTACGCGGCAGGTCCGCTTCTAGGAACCACAGTGTGACATCACAACCTCACGCCTATCCCTTACCTAGACAAGACTCCTCGCTAGCATCTAGACCCCTTAGAGAATATGAAGTAAGTACGACTGAGTGCACAGACGAAGCTGGAAAAGTTCTGAAACCATCAAGCGATAATCCGTTCATAGAATCGTCACAGCAGCCTAACGTAGTGGATATGAGAGACGTAATGGTATTAAATGAAATCATTGAACAGGCTGGACGTCAGAGTCGGGCGAGCGAACAAAACGTGTCAGTGTACTACTTCCCAACAGCCGAAGACGATGAAGATGGACCCACATTTAAGGAGAAACTACTCGATTGTCTAATGAAAGGAATAGACTTCTTCTGTGTGTGGGACTGTTGCTGGTTGTGGCTCGAGTTCCAAAAATACGTAGCGCTGTTGGTGTTCGATCCATTCGTCGAGTTGTTCATCACGCTCTGTATTGTTGTAAATACACTATTTATGGCTCTGGACCATCATAACATGGATAAAGACATGGACAAAGCGTTAAAAAGCGGCAATTATTTCTTCACGGCGACATTCGGCATAGAAGCAACACTAAAATTAATAGCAATGAGCCCGAAATATTATTTCCAAGAGGGATGGAATATTTTTGATTTCATTATTGTGGCCTTATCACTGCTTGAATTGGGGCTTGAGGGTGTTCAGGGTTTGTCGGTATTACGATCGTTTCGTTTGCTTCGAGTATTCAAATTGGCAAAGTCATGGCCGACTCTTAATTTACTCATCTCTATAATGGGTAGGACAATGGGTGCCTTGGGCAACCTGACCTTCGTATTGTGCATCATTATTTTCATATTTGCGGTGATGGGTATGCAACTGTTCGGAAAAAATTATGTCGATTACGTAGACCGGTTTCCTGATGGGGACCTTCCTCGGTGGAACTTCACGGATTTTATGCACAGTTTTATGATCGTATTCCGAGTGCTATGCGGAGAATGGATAGAAAGCATGTGGGATTGTATGTTGGTTGGAGATGTATCTTGCATACCATTTTTCTTGGCAACCGTCGTTATCGGAAACCTTGTGGTACTGAATCTCTTCTTAGCCCTGTTGCTCTCCAATTTTGGTTCCTCGAGCTTATCAACCCCAACAGCTGATCAAGACACGAACAAAATCGCGGAGGCTTTCAATAGAATATCGAGGTTCATTGACTGGATAAAACGGAACGTCGCAGACTTCCTCAAGCTACTGAAAAACAAACTCACCAATCAGATAGCTATACACGCGCCCGGCTTAAAAGCCGCTTTGTGTGGTCGCTGTGTCTCCTCAGAGCGGGTCGACAACGAATTAGAACTAGGAACTGACCTCGATGACGCCGTACTCTATAAAGACAAGAAACTCAAAGATCAAGTCGAAGTGGCTATCGGAGATGGAATGGAATTCACAATACCAGGTGACAATAAATACAAAAAAGGTAAAATTTTGATGAATAACATAAATGCAATAACAGATAATCACAGGGACAATAGATTAGACTGTGAACTGAATCATCATGGATATCCTATTCAGGATGACGACACTATAAGTCAAAAATCTTACGGTAGTCACAAAATAAGATCATTCAAGGATGAAAGCCACAAAGGATCGGCCGATACGATAGATGGAGAAGAAAAGAAAGATGCAAGCAAAGAAGAACTTGGACTTGAAGAAGAATTGATTGAGGAAGACGAAGAGGGCAAACTTGATGGTACTTTAGGTAAAACGGATATAAAAGTAGGGGCCGATGAAGACGTTGTTGATGATACACCAGCCGATTGTTGTCCGGAGCAATGCTATCAAAAGTTTCCATTTCTTGCTGGAGACGACGACTCGCCTTTTTGGCAAGGCTGGGGCACTCTTCGGCTCAAAACGTTCAAACTCATTGAAAACACTTACTTTGAGACTGCAGTTATTACCATGATTTTACTGAGTAGTTTAGCATTGGCTTTAGAAGACGTACATTTACCACACCGTCCAATACTTCAAGACATTCTTTATTACATGGATCGTATCTTCACTGTTATATTCTTCATTGAGATGTTGATCAAGTGGCTTGCTCTCGGATTCCAAAAATATTTTACTAATGCTTGGTGCTGGCTTGATTTCATCATTGTGATGGTCTCGCTTATAAACTTCGTAGCGGCGCTTTGTGGTGCCGGAGGCATTCAGGCGTTCAAAACGATGAGAACACTGCGCGCACTGCGCCCGCTCAGAGCCATGAGCCGCATGCAGGGCATGAGGGTTGTTGTGAACGCCCTGGTACAGGCAATTCCATCCATCTTCAACGTACTCCTTGTATGTCTAATATTCTGGCTCATCTTCGCCATTATGGGTGTCCAGCTCTTTGCAGGAAAATACTTTAAGTGCGTTGATATGAATCACACCACTCTAAGCCACGAAATCATTCCGGATAAAAATGCATGCACCTTAGAAAACTATACATGGGAAAATTCACCAATGAACTTTGATCACGTGGGTAAAGCGTATTTATGTCTCTTCCAAGTGGCAACATTCAAAGGCTGGATCCAAATTATGAACGATGCAATTGACTCTAGGGAGGTGGGACGTCAGCCGATTCGAGAAACTAACATATACATGTACCTTTACTTTGTGTTCTTCATTATATTCGGTTCATTCTTCACTCTCAATCTGTTTATCGGAGTGATCATCGACAACTTCAACGAACAGAAAAAGAAAGCCGGGGGCAGTCTCGAAATGTTCATGACTGAAGATCAAAAGAAATACTATAACGCCATGAAGAAAATGGGTTCTAAAAAGCCTTTGAAAGCGATTCCAAGACCAAGGTGGCGACCACAAGCAATCGTGTTCGAGATAGTCACTGACAAGAAGTTTGACATGATTATCATGTTGTTCATTGGATTAAACATGCTCACGATGACATTGGACCACTACCAACAGTCGGAAACGTTTAGCGCCGTCCTCGACTATCTCAATATGATATTCATAGTGATATTTAGTTCAGAGTGCCTATTGAAAATATTCGCCTTACGTTATCACTATTTTGTTGAACCATGGAATCTTTTCGATTTCGTCGTAGTTATGTTTTCTATTCTTAGCTTGGTGCTCAGTGACATTATAGAAAAATATTTTGTATCTCCTACGCTACTAAGAGTGGTGCGAGTAGCAAAAGTTGGTCGAGTCCTTCGACTCGTGAAAGGCGCTAAAGGGATACGAACGTTGTTGTTCGCTTTGGCTATGTCGCTGCCGGCTTTGTTCAATATTTGCCTACTCTTGTTCCTGGTCATGTTTATTTTTGCCATATTCGGCATGTCATTCTTCATGCACGTTAAAGACAAAGGTGGTCTGGACGACGTGTATAACTTCAAAACATTCGTGCAGAGTATGATTTTACTGTTCCAGATGTCAACGTCTGCCGGTTGGGATGGAGTTTTAGATGGTATTATAAATGAGGAAGAATGTGATCTTCCCGACAACGAACGAGGATCGCCAGGAAACTGTGGCTCTGCAACCATAGGCATAACTTACCTACTATCATACCTTGTCATTTCTTTTCTCATCGTCATCAACATGTACATCGCCGTCATTCTCGAGAATTACTCTCAGGCAACAGAAGACGTGCAGGAAGGATTGACAGATGACGACTACGACATGTACTACGAAATCTGGCAGCGGTTCGACCCGGACGGTAGTCAGTACATTAGATACGATCAGCTCTCAGATTTCCTTGACGTCTTGGAACCGCCATTACAAATCCACAAACCTAACAAATACAAAATTATATCGATGGACATACCGATATGTCGCGGCGACATGATGTTCTGCGTCGACATTCTCGACGCACTGACGAAAGATTTCTTCGCTCGAAAAGGGAATCCCATTGAGGAGACGGGTGATTTGGAAGTGGGTCGTCCTGAAGAAGCGGGCTACGAGCCAGTGTCGTCGACGCTGTGGCGGCAGCGCGAGGAGTACTGTGCGCGACTGATACAGCACGCGTGGCGACGGCATCGGCGTGCACACGAGGAGCCCGAAGTGGGCGGCGGAGCGGAGGGTGCAGCCACGGCCGTGTTGCTGGACGCCGTGACTCCTAACGGTCACCGCGTGGTTCTGCAGGAAGCGACCCATAAGAAGAAGCAGATCGCTGTTGCCTAA

Protein

MSLRSDPFQDSVSTQPAHKPTATDTHDSARRPRKVSMASLSLPGSPFNLRRGSRGSHQMALRPNGRPRYPPGGDRKPLVLSTYLDAQEHLPYADDSNAVTPMSEENGAIIIPVYYANLGSRHSSYTSHQSRLSYTSHGDLLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEAGKVLKPSSDNPFIESSQQPNVVDMRDVMVLNEIIEQAGRQSRASEQNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYFFTATFGIEATLKLIAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPGLKAALCGRCVSSERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYKKGKILMNNINAITDNHRDNRLDCELNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKGSADTIDGEEKKDASKEELGLEEELIEEDEEGKLDGTLGKTDIKVGADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQHAWRRHRRAHEEPEVGGGAEGAATAVLLDAVTPNGHRVVLQEATHKKKQIAVA

Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Similarity

Belongs to the sodium channel (TC 1.A.1.10) family.

Uniprot

B6SDJ2   C9D7C6   A0A2A4J016   A0A2A4J0G0   A0A1W6DWE6   A0A1C9EFC4   + More
A0A437BUZ8   A0A1C9EFB6   A0A194Q2B4   A0A1W6DWG8   A0A385I6P5   A0A223FQL2   A0A1C9EFB3   A0A1C9EFB5   A0A1C9EFA5   A0A0D3R104   A0A0D3R0X6   A0A0D3R179   A0A1W6DWU7   A0A1C9EFA8   B3GEF9   B3GEF8   B3GEG2   B3GEG0   A5A2M4   M4T8I8   A0A1C9EFB8   D7PI27   A0PAE6   A0PAE8   A0PAE5   A0PAE7   A0A1I8JVS3   A0A3F2YSL1   A0A182WAV2   A0A182UN78   A0A182QPX9   A0A240PKX8   Q177V3   A5I843   A0A1Y9HTT7   Q6DLT3   Q7PJH0   A0A182NN78   A0A182R2V3   C3RTM1   A0A1Z1EDE6   C3RTM2   C3RTM3   A0A084W1B1   A0A2C9GUI5   A0A1B0CRI1   Q94584   A0A0Q5T4F0   A0A0Q5TK02   A0A1Y9HT44   M9MS92   A0A0Q5T4G4   A0A0Q5TJV3   A0A1W4VVP3   A0A1W4VWK9   A0A1S4GMH9   M9MSE6   A0A0Q5TB65   M9MSA3   A0A0Q9XNV8   A0A0Q9XPD4   A0A1Y9HTN3   A7UUW1   A0A0Q9XEI2   A0A0Q9XQX6   A0A0Q9XH42   A0A0Q5TJ83   A0A0Q5T4D7   A0A0Q9XEI1   A0A1W4VWJ2   A0A1W4VIA0   A0A1W4VUZ0   Q5TPQ2   A5I9E7   A0A0Q9WBL3   A0A1W4VVN8   M1U7W8   A0A0Q5TK41   A0A0Q5T4U7   A0A182FLR9   A0A0Q9WM53   A0A0Q5TH18   A0A0Q9WBR5   A0A1A9XBN8   A0A182IMT4   A0A1W4VIF6   A0A0Q9WP78   A0A1W4VWH3   A0A0Q9XSV4   A0A0Q9XSY1   A0A0Q9XF06   A0A0Q9XS98   A0A0Q9XPM9   A0A0Q9XEI4  

Pubmed

18996195    26354079    20362057    17098165    18615615    17510324    + More
17433068    12364791    14747013    17210077    19171193    28422157    24438588    10380099    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    23821746   

EMBL

EU822499    ACJ09096.1    GQ202023    ACV87001.1    NWSH01004601    PCG64864.1    + More
PCG64863.1    KY247121    ARK07244.1    KU739063    AON96184.1    RSAL01000006    RVE54292.1    KU739061    AON96182.1    KQ459564    KPI99681.1    KY247120    ARK07243.1    MG674159    AXY66618.1    MF461351    AST11482.1    KU739060    AON96181.1    KU739062    AON96183.1    KU739057    AON96178.1    KM027335    AJR27944.1    KM027337    AJR27946.1    KM027336    AJR27945.1    KX824114    ARK07242.1    KU739058    AON96179.1    EU688971    ACD80425.1    EU688970    ACD80424.1    EU688974    ACD80428.1    EU688972    ACD80426.1    EF521818    ABP96886.1    KC342959    AGH70334.1    KU739064    AON96185.1    GU574730    ADF80418.1    AB265177    BAF37094.2    AB265178    BAF37096.2    BAF37093.2    BAF37095.2    APCN01006994    APCN01006995    APCN01006996    APCN01006997    APCN01006998    APCN01006999    APCN01007000    APCN01007001    APCN01007002    APCN01007003    AXCN02001896    CH477371    EAT42414.1    AM422833    CAM12801.1    AAAB01008968    AY663385    AAT69681.1    EAA43760.4    EU399179    KY747529    ACB37022.1    ARM35695.1    KY747530    ARM35696.1    EU399180    ACB37023.1    EU399181    ACB37024.1    ATLV01019251    ATLV01019252    ATLV01019253    ATLV01019254    KE525266    KFB44005.1    AXCM01000653    AJWK01024813    AF072493    AH006308    AAC26517.1    CH954180    KQS30188.1    KQS30154.1    AE014298    ADV37717.1    KQS30210.1    KQS30150.1    ADV37713.1    KQS30209.1    ADV37730.1    CH933811    KRG06980.1    KRG06994.1    EDO63520.1    KRG06992.1    KRG06961.1    KRG06985.1    KQS30212.1    KQS30195.1    KRG06988.1    EAL39442.3    BN001092    CAM31894.1    CH940651    KRF82108.1    KC107440    AGG53064.1    KQS30186.1    KQS30175.1    KRF82116.1    KQS30151.1    KRF82089.1    KRF82128.1    KRG06979.1    KRG06995.1    KRG06973.1    KRG06968.1    KRG06958.1    KRG06955.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000076407    UP000075840    UP000075920    + More
UP000075903    UP000075886    UP000075885    UP000008820    UP000007062    UP000075884    UP000075900    UP000030765    UP000075883    UP000092461    UP000008711    UP000000803    UP000192221    UP000009192    UP000008792    UP000069272    UP000092443    UP000075880   

PRIDE

B6SDJ2    C9D7C6    B3GEF8    A5A2M4   

Pfam

PF00520   Ion_trans        + More
PF11933   Na_trans_cytopl
PF06512   Na_trans_assoc

Interpro

IPR005821   Ion_trans_dom        + More
IPR001696   Na_channel_asu       
IPR027359   Volt_channel_dom_sf       
IPR002048   EF_hand_dom       
IPR010526   Na_trans_assoc       
IPR024583   Na_trans_cytopl       

Gene 3D

1.20.120.350    

ProteinModelPortal

B6SDJ2   C9D7C6   A0A2A4J016   A0A2A4J0G0   A0A1W6DWE6   A0A1C9EFC4   + More
A0A437BUZ8   A0A1C9EFB6   A0A194Q2B4   A0A1W6DWG8   A0A385I6P5   A0A223FQL2   A0A1C9EFB3   A0A1C9EFB5   A0A1C9EFA5   A0A0D3R104   A0A0D3R0X6   A0A0D3R179   A0A1W6DWU7   A0A1C9EFA8   B3GEF9   B3GEF8   B3GEG2   B3GEG0   A5A2M4   M4T8I8   A0A1C9EFB8   D7PI27   A0PAE6   A0PAE8   A0PAE5   A0PAE7   A0A1I8JVS3   A0A3F2YSL1   A0A182WAV2   A0A182UN78   A0A182QPX9   A0A240PKX8   Q177V3   A5I843   A0A1Y9HTT7   Q6DLT3   Q7PJH0   A0A182NN78   A0A182R2V3   C3RTM1   A0A1Z1EDE6   C3RTM2   C3RTM3   A0A084W1B1   A0A2C9GUI5   A0A1B0CRI1   Q94584   A0A0Q5T4F0   A0A0Q5TK02   A0A1Y9HT44   M9MS92   A0A0Q5T4G4   A0A0Q5TJV3   A0A1W4VVP3   A0A1W4VWK9   A0A1S4GMH9   M9MSE6   A0A0Q5TB65   M9MSA3   A0A0Q9XNV8   A0A0Q9XPD4   A0A1Y9HTN3   A7UUW1   A0A0Q9XEI2   A0A0Q9XQX6   A0A0Q9XH42   A0A0Q5TJ83   A0A0Q5T4D7   A0A0Q9XEI1   A0A1W4VWJ2   A0A1W4VIA0   A0A1W4VUZ0   Q5TPQ2   A5I9E7   A0A0Q9WBL3   A0A1W4VVN8   M1U7W8   A0A0Q5TK41   A0A0Q5T4U7   A0A182FLR9   A0A0Q9WM53   A0A0Q5TH18   A0A0Q9WBR5   A0A1A9XBN8   A0A182IMT4   A0A1W4VIF6   A0A0Q9WP78   A0A1W4VWH3   A0A0Q9XSV4   A0A0Q9XSY1   A0A0Q9XF06   A0A0Q9XS98   A0A0Q9XPM9   A0A0Q9XEI4  

PDB

6J8E     E-value=0,     Score=2763

KEGG

100101199    K04834 voltage-gated sodium channel type II alpha | (RefSeq) Nav, PARA; voltage-gated sodium channel

GO

GO:0005248   GO:0034765   GO:0005244   GO:0001518   GO:0005509   GO:0019228   GO:0005886   GO:0086010   GO:0035725   GO:0006814   GO:0005216   GO:0006811   GO:0016020   GO:0004190   GO:0006508   GO:0016286   GO:0055085  

Subcellular location

Cell membrane  

Length:

1541

Number of predicted TMHs:

17

Exp number of AAs in TMHs:

351.63733

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.01495

outside

1  -  298

TMhelix

299  -  321

inside

322  -  333

TMhelix

334  -  356

outside

357  -  370

TMhelix

371  -  393

inside

394  -  422

TMhelix

423  -  445

outside

446  -  464

TMhelix

465  -  482

inside

483  -  502

TMhelix

503  -  525

outside

526  -  795

TMhelix

796  -  815

inside

816  -  835

TMhelix

836  -  853

outside

854  -  867

TMhelix

868  -  890

inside

891  -  924

TMhelix

925  -  947

outside

948  -  1032

TMhelix

1033  -  1055

inside

1056  -  1115

TMhelix

1116  -  1133

outside

1134  -  1147

TMhelix

1148  -  1170

inside

1171  -  1176

TMhelix

1177  -  1199

outside

1200  -  1241

TMhelix

1242  -  1264

inside

1265  -  1276

TMhelix

1277  -  1299

outside

1300  -  1329

TMhelix

1330  -  1352

inside

1353  -  1541

 

 

Pi

175.900515

Theta

164.427401

Tajima's D

-1.208557

CLR

1.616072

CSRT

0.102894855257237

Interpretation

Uncertain