Gene

KWMTBOMO12624

Pre Gene Modal

BGIBMGA001557

Annotation

para_sodium_channel_alpha_subunit_variant_2_[Bombyx_mandarina]

Location

Bomo_Chr21(+):9544924-9553506      View in EpiBrowser

Full name

Sodium channel protein      

Location in the cell

PlasmaMembrane   Reliability : 4.278

CDS

ATGTCCGAGGACTTGGACTCGATCAGCGAGGAAGAACGAAGCTTGTTCCGACCCTTCACACGAGAGTCTCTGGCCGCAATCGAAGCCCGCATAGCTGAAGAGCATGCCAAGCAAAAAGAACTCGAGAAAAAACGAGCGGAAGGCGAGAACGATTTGGGGCGGACGAAAAAGAAAAAAGAAGTGCGTTACGATGATGAGGATGAGGACGAGGGTCCCCAGCCGGACGCTACCTTGGAGCAAGGTCTACCACTGCCGGTGCGCATGCAAGGGTCCTTCCCGCTCGAACTCGCCTCTACACCACTCGAGGACATCGACCCCTTCTACCACAATCAGACAACCTTCGTAGTTATAAGCAAGGGTAAAGATATCTTCAGATTTTCGGCGACAAATGCTCTGTGGATATTAGACCCATTTAATCCCATAAGAAGAGTGGCTATATACATATTGGTACATCCTTTGTTTTCGCTGTTCATTATTACGACAATCTTAGTGAATTGCATACTTATGATAATGCCTACAACGCCAACAGTTGAAAGTACTGAAGTTATCTTTACCGGGATCTACACGTTTGAATCAGCGGTGAAAGTAATGGCCAGGGGTTTTATACTACAGCCATTCACATACCTTAGAGATGCATGGAATTGGCTTGACTTCGTAGTTATAGCTTTAGCTTATGTGACGATGGGCATAGATCTCGGAAACCTAGCCGCTCTGAGAACGTTCAGGGTACTACGAGCGTTGAAGACTGTGGCCATAGTACCGGGCTTGAAGACGATCGTCGGTGCTGTTATAGAATCCGTGAAAAATCTCCGTGATGTAATAATTTTAACGATGTTTTCGCTGTCCGTATTCGCGTTGATGGGCCTACAGATTTACATGGGAGTTTTGACGCAGAAGTGTGTCAAAGTGTTCCCGGAGGACGGCTCTTGGGGTAACCTGACCGACGAGAACTGGGAGAGGTTTTGTCAGAACGAAACTAACTGGTATGGTGAAGGGGGTGATTATCCTTTATGCGGCAATTCATCAGGGGCAGGACAATGCGAACCGGGCTACGTTTGTCTTCAAGGCTTCGGTCCAAATCCAAACTACGGATATACAAGCTTTGACACCTTCGGTTGGGCATTTCTATCAGCTTTCCGTCTAATGACACAGGATTATTGGGAAAATCTCTATCAATTGGTCTTAAGATCAGCTGGCTCGTGGCACGTATTGTTTTTCGTAGTGATAATATTCCTGGGATCTTTTTATCTGGTGAACTTGATTTTGGCTATCGTCGCCATGTCATACGATGAGCTACAGAAGAAAGCCGAAGAAGAAGAACAAGCAGAAGAAGAAGCTTTACGGGTACAGAATTAG

Protein

MSEDLDSISEEERSLFRPFTRESLAAIEARIAEEHAKQKELEKKRAEGENDLGRTKKKKEVRYDDEDEDEGPQPDATLEQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQLVLRSAGSWHVLFFVVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEQAEEEALRVQN

Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Similarity

Belongs to the sodium channel (TC 1.A.1.10) family.

Uniprot

B3GEG0   B3GEF9   B3GEG1   B3GEF8   M4T8I8   A0A2H1W775   + More
A0A1W6DWG8   A0A2A4J0G0   A0A1W6DWE6   Q94584   B3GEG2   B6SDJ2   C9D7C6   A0PAE8   A0PAE5   A0PAE6   A0PAE7   A0A212FAU8   A0A194Q2B4   A0A437BUZ8   A0A385I6P5   D7PI27   H9IWC6   A0A0D3R0X6   A0A0D3R104   A0A0D3R179   A0A2Z0LQW5   A0A240PKX8   A0A1W4XDT2   A0A1W4X4D2   A0A182NN78   A5I843   A0A1Y9HUC2   A0A2C9GUI5   A0A1W4XF20   A0A1S4GMH9   A0A1W4XF15   A0A1W4X4A1   A0A1W4X4D7   A0A1W4X4A6   A0A182QPX9   M1U7W8   A0A089ZWV3   A4IJ23   C3RTM3   C3RTM2   A0A182R2V3   A0A182WAV2   C3RTM1   A0A1W6S2I3   A0A1Z1EDE6   A0A2H4UZ54   A0A2H4UZ66   A0A1W6S2F2   B3VUH6   B3VUH5   A0A2H4UZ64   B3VUH7   D3KSS9   A0A2H4UZ65   A0A2H4UZ81   A0A2H4UZ84   A0A2H4UZ74   A0A2H4UZ92   A0A2H4UZ83   A0A2H4UZ77   A0A2H4UZ78   A0A2H4UZ99   A0A182IMT4   D3KST0   A0A2H4UZ93   C9D7C5   A0A232F412   K7IZT8   A0A3G4YHM1   A0A087ZV49   M1FNL3   A0A2R2WUN8   A0A0M8ZWZ2   K7W9N3   M1FIX3   C9D7C7   A1XNB4   M1FL24   A0A154PNY2   A0A182FLR9   A0A2K6VB92   A0A0L7RG34   C9D7C8   A0A1W4XDT8   A0A1W4XF25   A0A1W4XER0   A0A1B6LXE7   A0A1W4VUZ6   A0A1W4VVN8   A0A146LU77   A0A1S4GLX0   A0A0A9W7M5   A0A0Q9XNU3   A0A0Q9XEI2  

Pubmed

10380099    18996195    17098165    18615615    22118469    26354079    + More
20362057    19121390    25652001    17433068    12364791    23821746    25166902    17257205    19171193    28422157    26202396    28648823    20075255    30397209    23139629    20920257    26823975    25401762    17994087   

EMBL

EU688972    ACD80426.1    EU688971    ACD80425.1    EU688973    ACD80427.1    + More
EU688970    ACD80424.1    KC342959    AGH70334.1    ODYU01006760    SOQ48897.1    KY247120    ARK07243.1    NWSH01004601    PCG64863.1    KY247121    ARK07244.1    AF072493    AH006308    AAC26517.1    EU688974    ACD80428.1    EU822499    ACJ09096.1    GQ202023    ACV87001.1    AB265178    BAF37096.2    AB265177    BAF37093.2    BAF37094.2    BAF37095.2    AGBW02009427    OWR50848.1    KQ459564    KPI99681.1    RSAL01000006    RVE54292.1    MG674159    AXY66618.1    GU574730    ADF80418.1    BABH01006366    BABH01006367    BABH01006368    KM027337    AJR27946.1    KM027335    AJR27944.1    KM027336    AJR27945.1    KJ699123    AJM87404.1    AM422833    CAM12801.1    AAAB01008968    AXCM01000653    AXCN02001896    KC107440    AGG53064.1    AB909019    BAP46858.1    BK005824    DAA05879.1    EU399181    ACB37024.1    EU399180    ACB37023.1    EU399179    KY747529    ACB37022.1    ARM35695.1    KY171977    ARO72115.1    KY747530    ARM35696.1    KY499805    AUA17903.1    KY499813    AUA17911.1    KY171978    ARO72116.1    EU817516    ACF04200.1    EU817515    ACF04199.1    KY499809    AUA17907.1    EU817517    ACF04201.1    AB453977    BAI77917.1    KY499808    KY499811    AUA17906.1    AUA17909.1    KY499806    AUA17904.1    KY499825    AUA17923.1    KY499818    AUA17916.1    KY499814    KY499817    AUA17912.1    AUA17915.1    KY499830    AUA17928.1    KY499822    AUA17920.1    KY499824    AUA17922.1    KY499827    AUA17925.1    AB453978    BAI77918.1    KY499826    AUA17924.1    GQ202022    KT455380    ACV87000.1    AMB38675.1    NNAY01001065    OXU25269.1    MG813771    AYV60955.1    JN695777    AFQ00696.1    KY123916    ARH02610.1    KQ435830    KOX71756.1    JX424548    AFW98420.1    JN695779    AFQ00698.1    GQ202024    ACV87002.1    DQ458470    ABE60888.1    JN695778    AFQ00697.1    KQ435007    KZC13595.1    KQ414598    KOC69810.1    GQ202025    ACV87003.1    GEBQ01011615    JAT28362.1    GDHC01008689    JAQ09940.1    GBHO01039810    JAG03794.1    CH933811    KRG06964.1    KRG06992.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000283053    UP000005204    UP000075885    + More
UP000192223    UP000075884    UP000075883    UP000075886    UP000075900    UP000075920    UP000075880    UP000215335    UP000002358    UP000005203    UP000053105    UP000076502    UP000069272    UP000053825    UP000192221    UP000009192   

PRIDE

B3GEF8    B6SDJ2    C9D7C6    H9IWC6    A4IJ23   

Pfam

PF00520   Ion_trans        + More
PF11933   Na_trans_cytopl
PF06512   Na_trans_assoc

Interpro

IPR005821   Ion_trans_dom        + More
IPR002048   EF_hand_dom       
IPR001696   Na_channel_asu       
IPR027359   Volt_channel_dom_sf       
IPR010526   Na_trans_assoc       
IPR024583   Na_trans_cytopl       

Gene 3D

1.20.120.350    

ProteinModelPortal

B3GEG0   B3GEF9   B3GEG1   B3GEF8   M4T8I8   A0A2H1W775   + More
A0A1W6DWG8   A0A2A4J0G0   A0A1W6DWE6   Q94584   B3GEG2   B6SDJ2   C9D7C6   A0PAE8   A0PAE5   A0PAE6   A0PAE7   A0A212FAU8   A0A194Q2B4   A0A437BUZ8   A0A385I6P5   D7PI27   H9IWC6   A0A0D3R0X6   A0A0D3R104   A0A0D3R179   A0A2Z0LQW5   A0A240PKX8   A0A1W4XDT2   A0A1W4X4D2   A0A182NN78   A5I843   A0A1Y9HUC2   A0A2C9GUI5   A0A1W4XF20   A0A1S4GMH9   A0A1W4XF15   A0A1W4X4A1   A0A1W4X4D7   A0A1W4X4A6   A0A182QPX9   M1U7W8   A0A089ZWV3   A4IJ23   C3RTM3   C3RTM2   A0A182R2V3   A0A182WAV2   C3RTM1   A0A1W6S2I3   A0A1Z1EDE6   A0A2H4UZ54   A0A2H4UZ66   A0A1W6S2F2   B3VUH6   B3VUH5   A0A2H4UZ64   B3VUH7   D3KSS9   A0A2H4UZ65   A0A2H4UZ81   A0A2H4UZ84   A0A2H4UZ74   A0A2H4UZ92   A0A2H4UZ83   A0A2H4UZ77   A0A2H4UZ78   A0A2H4UZ99   A0A182IMT4   D3KST0   A0A2H4UZ93   C9D7C5   A0A232F412   K7IZT8   A0A3G4YHM1   A0A087ZV49   M1FNL3   A0A2R2WUN8   A0A0M8ZWZ2   K7W9N3   M1FIX3   C9D7C7   A1XNB4   M1FL24   A0A154PNY2   A0A182FLR9   A0A2K6VB92   A0A0L7RG34   C9D7C8   A0A1W4XDT8   A0A1W4XF25   A0A1W4XER0   A0A1B6LXE7   A0A1W4VUZ6   A0A1W4VVN8   A0A146LU77   A0A1S4GLX0   A0A0A9W7M5   A0A0Q9XNU3   A0A0Q9XEI2  

PDB

6A95     E-value=1.54928e-139,     Score=1272

KEGG

100101199    K04834 voltage-gated sodium channel type II alpha | (RefSeq) Nav, PARA; voltage-gated sodium channel

GO

GO:0005244   GO:0005509   GO:0034765   GO:0001518   GO:0005248   GO:0019233   GO:0005216   GO:0016021   GO:0005272   GO:0006811   GO:0016020   GO:0005524   GO:0016459   GO:0000166   GO:0046872   GO:0004190   GO:0006508   GO:0016286   GO:0055085  

Subcellular location

Cell membrane  

Length:

451

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

122.42922

Exp number, first 60 AAs:

0

Total prob of N-in:

0.39465

outside

1  -  145

TMhelix

146  -  168

inside

169  -  180

TMhelix

181  -  203

outside

204  -  212

TMhelix

213  -  235

inside

236  -  241

TMhelix

242  -  264

outside

265  -  273

TMhelix

274  -  296

inside

297  -  402

TMhelix

403  -  425

outside

426  -  451

 

 

Pi

186.238437

Theta

180.832937

Tajima's D

-0.493077

CLR

2.068513

CSRT

0.243937803109845

Interpretation

Uncertain