Gene

KWMTBOMO12610  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001426

Annotation

putative_tubulin_tyrosine_ligase-like_family?_member_6_[Danaus_plexippus]

Location

Bomo_Chr21(-):9237563-9238829      View in EpiBrowser

Full name

Tubulin polyglutamylase TTLL6       + More
Tubulin polyglutamylase TTLL13P      

Alternative Name

Tubulin--tyrosine ligase-like protein 6
Tubulin tyrosine ligase-like family member 13 pseudogene
Tubulin--tyrosine ligase-like protein 13

Location in the cell

Mitochondrial   Reliability : 2.114

CDS

ATGGTTCTGCGGTGGTTCCATAGATCACAAATAACAATTTGTCTTGCAAATTGCCGATATGAGTCAATAAGAAAGGTCGCCAGTGCGTTCGGTATGAGGGAGGTTTCCGAAGAAGACGCTTGGAATTTCTATTGGACTGATATGAGTGTGTCTGTCGAAAGGGCGAAGGAAATGAAAAGGTTTCAGCGCATAAATCATTATCCGGGAATGCTTGAGATCTGCAGAAAAGATCTCCTAGCTCGCAATTTGAACAGGATGCAGAAAATTTATCCGAAGGATTATAATTTCTTTCCCAAAACTTGGTGTCTTCCTGCAGACTTCGGGGAAGCTCTGAATTACAGCAAAACGCGTAAAAATAAAACTTTTATAATAAAACCGGAATGCGGGAGTCAAGGACGTGGCATATATTTAACAAAATCTTTGAAAGACATCAAACCTTCCGACAAACTTATTTGTCAGGTATATCTATCAAAACCATTTCTGGTCGATGGTTACAAGTTTGACATACGAGTATACACTCTCATTACGTCGTGTGACCCATTAAGAATATTTGTCTACAACGAAGGACTAGTCAGATTCGCAACGAGCAGATACGCCGATCCGAATGCTAATAATACCACTAATCAGAACCTACGTGTATGA

Protein

MVLRWFHRSQITICLANCRYESIRKVASAFGMREVSEEDAWNFYWTDMSVSVERAKEMKRFQRINHYPGMLEICRKDLLARNLNRMQKIYPKDYNFFPKTWCLPADFGEALNYSKTRKNKTFIIKPECGSQGRGIYLTKSLKDIKPSDKLICQVYLSKPFLVDGYKFDIRVYTLITSCDPLRIFVYNEGLVRFATSRYADPNANNTTNQNLRV

Description

Polyglutamylase which preferentially modifies alpha-tubulin (PubMed:17499049, PubMed:21074048). Mediates tubulin polyglutamylation in cilia (PubMed:22246503). Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (PubMed:17499049, PubMed:21074048). Generates long side-chains (PubMed:20530212). Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS (PubMed:26829768).
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

Subunit

Found in a complex with CEP41.

Similarity

Belongs to the tubulin--tyrosine ligase family.

Keywords

Alternative splicing   ATP-binding   Cell projection   Cilium   Complete proteome   Cytoplasm   Cytoskeleton   Ligase   Microtubule   Nucleotide-binding   Reference proteome   Coiled coil   Polymorphism  

Feature

chain  Tubulin polyglutamylase TTLL6
splice variant  In isoform 2.
sequence variant  In dbSNP:rs12912620.

Uniprot

A0A3S2N7L2   A0A2A4JR28   A0A2A4JQJ6   A0A2H1WGG6   A0A2A4JS85   A0A212ERJ6   + More
A0A194Q3X0   A0A194RIJ8   H9IVZ5   A0A0C9QYC9   E2A1U6   A0A0C9RFB5   A0A0C9PW20   D6W9Z2   A0A195FKX7   A0A026X1L0   E9J688   A0A088AUZ2   A0A2A3E625   A0A0L7QL04   A0A1Y1L213   A0A154PIM7   A0A1W4X3Y3   A0A195C9G5   A0A151X9N4   A0A0M8ZTP0   A0A067RUE1   E2B8S8   A0A1B6J9U1   A0A1B6BYI8   A0A151J3A7   A0A158NC37   A0A195BG04   A0A3L8DS56   A0A0C9QPW3   A0A1B6GVF2   A0A2P8YAE9   A0A2J7QZ67   A0A1B6D2B6   T1IDB6   A0A2C9JJI2   A0A2C9JJJ6   A0A2C9JJI9   A0A224XKK0   A0A1B6CU34   A0A2C9JJH7   A0A2C9JJH5   F4WHY8   L8IV73   K7FG17   T1FYK2   A4Q9E8   A7SPH2   D3ZJ17   A0A3S0ZT01   A0A2Y9K1C8   G3SS89   M3YV65   A0A091FXC0   A0A1U7RHU3   G1LEF0   H0X0N3   A0A182KD59   H2NVI8   A0A091SW39   A0A182STE0   U3F8Q7   W5NDA3   W5PA15   K1QHS9   A0A2Y9DNM6   D2HCY5   A0A2Y9K0S3   H0VY84   A0A182QLK3   A0A1S3WEB4   M3W3S4   G1KFB6   H0V4X7   G3WBT3   G1T8E3   A0A096P437   A0A384BWJ2   A0A2U3VK53   A0A1U7TKQ8   A0A1S3WK46   A6NNM8-2   A0A2U3YCR6   H9GCF0   A0A3Q7X3K8   G1PP77   A0A2U4AHW6   A0A2K6QYG1   A0A2J8W948   G3IHT2   A0A2K6MGF4   A0A091TT66   A0A3M6U143   A0A087VS31  

EC Number

6.-.-.-

Pubmed

22118469    26354079    19121390    20798317    18362917    19820115    + More
24508170    21282665    28004739    24845553    21347285    30249741    29403074    15562597    21719571    22751099    17381049    23254933    17499049    16141072    19468303    15489334    21074048    20530212    22246503    26829768    17615350    15057822    28071753    20010809    25243066    20809919    22992520    21993624    17975172    21709235    14702039    16572171    25959773    21881562    25362486    21804562    30382153   

EMBL

RSAL01000244    RVE43595.1    NWSH01000780    PCG74269.1    PCG74271.1    ODYU01008504    + More
SOQ52168.1    PCG74270.1    AGBW02012992    OWR44126.1    KQ459564    KPI99704.1    KQ460325    KPJ15771.1    BABH01006347    BABH01006348    GBYB01005687    JAG75454.1    GL435806    EFN72585.1    GBYB01005686    JAG75453.1    GBYB01005683    JAG75450.1    KQ971312    EEZ98564.1    KQ981491    KYN41001.1    KK107036    EZA61973.1    GL768230    EFZ11676.1    KZ288356    PBC27213.1    KQ414934    KOC59302.1    GEZM01066955    JAV67624.1    KQ434926    KZC11699.1    KQ978068    KYM97504.1    KQ982373    KYQ57087.1    KQ435883    KOX69756.1    KK852460    KDR23459.1    GL446373    EFN87900.1    GECU01011742    JAS95964.1    GEDC01030965    JAS06333.1    KQ980286    KYN16940.1    ADTU01011441    ADTU01011442    KQ976500    KYM83112.1    QOIP01000004    RLU23275.1    GBYB01005684    GBYB01005685    JAG75451.1    JAG75452.1    GECZ01026054    GECZ01003335    JAS43715.1    JAS66434.1    PYGN01000760    PSN41134.1    NEVH01009073    PNF33878.1    GEDC01027434    GEDC01017461    JAS09864.1    JAS19837.1    ACPB03006091    ACPB03006092    GFTR01007763    JAW08663.1    GEDC01020370    JAS16928.1    GL888170    EGI66217.1    JH880613    ELR60311.1    AGCU01067912    AGCU01067913    AGCU01067914    AMQM01000776    KB096742    ESO02029.1    AM690749    AK077033    AK145771    AL603682    BC132203    BC138058    BC145131    AAI32204.1    BAC36577.1    BAE26641.1    CAM84326.1    DS469733    EDO34389.1    AABR07030389    RQTK01000307    RUS82032.1    AEYP01062120    AEYP01062121    KL447470    KFO73779.1    ACTA01171998    ACTA01179996    ACTA01187994    AAQR03183173    AAQR03183174    AAQR03183175    ABGA01084711    ABGA01084712    ABGA01084713    ABGA01084714    ABGA01084715    ABGA01084716    ABGA01084717    KK487850    KFQ62543.1    GAMP01000726    JAB52029.1    AHAT01004844    AMGL01018462    AMGL01018463    JH818005    EKC21166.1    GL192700    EFB25918.1    AAKN02016024    AXCN02001464    AANG04002993    AEFK01006231    AHZZ02010084    AK127965    AC091167    CH471101    BC036668    AAPE02037671    NDHI03003397    PNJ66304.1    JH002857    EGW06015.1    KK463667    KFQ80598.1    RCHS01002420    RMX47403.1    KL503450    KFO15423.1   

Proteomes

UP000283053    UP000218220    UP000007151    UP000053268    UP000053240    UP000005204    + More
UP000000311    UP000007266    UP000078541    UP000053097    UP000005203    UP000242457    UP000053825    UP000076502    UP000192223    UP000078542    UP000075809    UP000053105    UP000027135    UP000008237    UP000078492    UP000005205    UP000078540    UP000279307    UP000245037    UP000235965    UP000015103    UP000076420    UP000007755    UP000007267    UP000015101    UP000000589    UP000001593    UP000002494    UP000271974    UP000248482    UP000007646    UP000000715    UP000053760    UP000189706    UP000008912    UP000005225    UP000075881    UP000001595    UP000075901    UP000018468    UP000002356    UP000005408    UP000248480    UP000005447    UP000075886    UP000079721    UP000011712    UP000001646    UP000007648    UP000001811    UP000028761    UP000261680    UP000245340    UP000189704    UP000005640    UP000245341    UP000286642    UP000001074    UP000245320    UP000233200    UP000001075    UP000233180    UP000275408   

PRIDE

H9IVZ5    A4Q9E8    D3ZJ17    A6NNM8    G3IHT2   

Pfam

PF03133   TTL        + More
PF01266   DAO

Interpro

IPR013815   ATP_grasp_subdomain_1        + More
IPR004344   TTL/TTLL_fam       
IPR027754   TTLL6       
IPR006181   D-amino_acid_oxidase_CS       
IPR006076   FAD-dep_OxRdtase       

Gene 3D

3.30.1490.20    

ProteinModelPortal

A0A3S2N7L2   A0A2A4JR28   A0A2A4JQJ6   A0A2H1WGG6   A0A2A4JS85   A0A212ERJ6   + More
A0A194Q3X0   A0A194RIJ8   H9IVZ5   A0A0C9QYC9   E2A1U6   A0A0C9RFB5   A0A0C9PW20   D6W9Z2   A0A195FKX7   A0A026X1L0   E9J688   A0A088AUZ2   A0A2A3E625   A0A0L7QL04   A0A1Y1L213   A0A154PIM7   A0A1W4X3Y3   A0A195C9G5   A0A151X9N4   A0A0M8ZTP0   A0A067RUE1   E2B8S8   A0A1B6J9U1   A0A1B6BYI8   A0A151J3A7   A0A158NC37   A0A195BG04   A0A3L8DS56   A0A0C9QPW3   A0A1B6GVF2   A0A2P8YAE9   A0A2J7QZ67   A0A1B6D2B6   T1IDB6   A0A2C9JJI2   A0A2C9JJJ6   A0A2C9JJI9   A0A224XKK0   A0A1B6CU34   A0A2C9JJH7   A0A2C9JJH5   F4WHY8   L8IV73   K7FG17   T1FYK2   A4Q9E8   A7SPH2   D3ZJ17   A0A3S0ZT01   A0A2Y9K1C8   G3SS89   M3YV65   A0A091FXC0   A0A1U7RHU3   G1LEF0   H0X0N3   A0A182KD59   H2NVI8   A0A091SW39   A0A182STE0   U3F8Q7   W5NDA3   W5PA15   K1QHS9   A0A2Y9DNM6   D2HCY5   A0A2Y9K0S3   H0VY84   A0A182QLK3   A0A1S3WEB4   M3W3S4   G1KFB6   H0V4X7   G3WBT3   G1T8E3   A0A096P437   A0A384BWJ2   A0A2U3VK53   A0A1U7TKQ8   A0A1S3WK46   A6NNM8-2   A0A2U3YCR6   H9GCF0   A0A3Q7X3K8   G1PP77   A0A2U4AHW6   A0A2K6QYG1   A0A2J8W948   G3IHT2   A0A2K6MGF4   A0A091TT66   A0A3M6U143   A0A087VS31  

PDB

4YLS     E-value=6.60579e-50,     Score=495

KEGG

101740464    K16582 tubulin polyglutamylase TTLL6/13 [EC:6.-.-.-] | (RefSeq) tubulin polyglutamylase TTLL13-like

GO

GO:0006464   GO:0005524   GO:0016874   GO:0003884   GO:0003353   GO:0051013   GO:0018095   GO:0001578   GO:0036064   GO:0015631   GO:0070739   GO:0005874   GO:0005737   GO:0005829   GO:0006468   GO:0004713   GO:0030286   GO:0008270   GO:0016787   GO:0004190   GO:0006508   GO:0016286  

PANTHER

PTHR12241:SF96  

Subcellular location

Cell projection   CEP41 is required for its transport between the basal body and the cilium.   With evidence from 2 publications.
Cilium   CEP41 is required for its transport between the basal body and the cilium.   With evidence from 2 publications.
Cytoplasm   CEP41 is required for its transport between the basal body and the cilium.   With evidence from 2 publications.
Cytoskeleton   CEP41 is required for its transport between the basal body and the cilium.   With evidence from 2 publications.
Cilium basal body   CEP41 is required for its transport between the basal body and the cilium.   With evidence from 2 publications.

Length:

213

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01257

Exp number, first 60 AAs:

0.00058

Total prob of N-in:

0.11095

outside

1  -  213

 

 

Pi

175.372004

Theta

177.266085

Tajima's D

-0.04165

CLR

0

CSRT

0.35653217339133

Interpretation

Uncertain