Gene

KWMTBOMO12608  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001550

Annotation

cyclin_dependent_kinase_7_[Bombyx_mori]

Location

Bomo_Chr21(+):9223630-9229380      View in EpiBrowser

Full name

5-demethoxyubiquinone hydroxylase, mitochondrial      

Alternative Name

Ubiquinone biosynthesis monooxygenase COQ7

Location in the cell

Cytoplasmic   Reliability : 2.821

CDS

ATGGAAGAACCAACTTTACGATATGAAAAAATTGACTTTTTGGGCGAAGGACAGTTTGCAACTGTGTACAAAGCAAAGGATGCAAAAACAGACAAAATTGTTGCTGTGAAGAAAATTAAGATAGGATCACGTCTCGAAGCTCAAGACGGAATTAATAGAACTGCTCTTAGAGAAATTAAACTGTTACAGGAACTGCAGCATATAAATCTAATTGGATTATTGGATGTATTCGGACAGAAATCAAATGTGTCGCTGGTGTTTGACTTTATGGATACAGACTTAGAAATAATAATAAAGGACAATACTATTGTACTTACCCCAGCTAATGTTAAGGCATACATGATAATGACTTTGAAAGGCTTAGAATATTTACATCAGAATTGGATATTACACAGGGACTTAAAACCTAATAATTTGCTAATAAATAGAGAAGGTATTTTGAAAATTGGTGACTTTGGTTTAGCCAAGGCTTTTGGATCACCGACAAGAATAAACACACATCAAGTTGTTACGAGATGGTATAGAGCTCCAGAACTACTATTTGGAGCGAGGCAGTATGGAACGGGTGTGGATATGTGGGCTGTTGGATGTATTTTAGCAGAATTGCTTTTAAGAGTTCCATTTTTACCTGGCGAATCAGACTTAGATCAGCTCTCTAGGATATTCCAAGTGTTCGGAACACCAACAGAAGAAAACTGGCCTGGTATGAAGACTCTCACAGATTATGTGCAATTCAAGCTGTTTCCCGCTCAAGAACTACGGCATATATTCAGTGCGGCGTCTGAAGATCTTATATTTTTATTGGAGAGCCTTTTAGCTCTGTACCCGCCAAATCGATGTGATTGCACGCAGGCCTTGCAAATGGCGTATTTTAGTAGTAAACCGGCGCCATCGGTCGGCCCTAAGTTACCGATGCCTTCGAATATTTCAAAACTAGAGGTGGAAAAGCCGTCTTTGAAAAGAAAACTCCTGGACAACATTGATGGAGGCTCACTAGCGAAAAGACTACAATTTTAA

Protein

MEEPTLRYEKIDFLGEGQFATVYKAKDAKTDKIVAVKKIKIGSRLEAQDGINRTALREIKLLQELQHINLIGLLDVFGQKSNVSLVFDFMDTDLEIIIKDNTIVLTPANVKAYMIMTLKGLEYLHQNWILHRDLKPNNLLINREGILKIGDFGLAKAFGSPTRINTHQVVTRWYRAPELLFGARQYGTGVDMWAVGCILAELLLRVPFLPGESDLDQLSRIFQVFGTPTEENWPGMKTLTDYVQFKLFPAQELRHIFSAASEDLIFLLESLLALYPPNRCDCTQALQMAYFSSKPAPSVGPKLPMPSNISKLEVEKPSLKRKLLDNIDGGSLAKRLQF

Description

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.

Cofactor

Fe cation

Subunit

Component of a multi-subunit COQ enzyme complex.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the COQ7 family.

Uniprot

D2IGZ5   A0A2A4JS25   A0A2H1WGK9   A0A212ERP3   A0A437AZQ4   A0A194REQ2   + More
A0A194Q2Y9   A0A1B0F0B8   A0A0L7RFB6   A0A1B0GHP7   A0A2M4APA7   A0A2A3EPS7   A0A182J7P2   A0A026W571   A0A182M1P6   A0A195C061   W5JKY1   A0A182LEE4   A0A182WNQ3   A0A2M4BR83   A0A182XAK0   A0A182NYJ1   A0A182VEZ7   A0A2C9GR36   Q7QCI5   E2C4A3   A0A154PQ01   A0A158NID1   A0A151WMN4   A0A182QLS0   F4W4X2   A0A1L8DX23   A0A151JU81   A0A2M4BTH5   A0A084W754   A0A195EE39   A0A1Q3G1L3   W8AGV1   A0A182GNR8   A0A0K8V215   A0A034V527   Q17MG8   D6WG89   A0A0P5ZEC1   A0A0P5ZUG2   A0A0N8D2R0   A0A0P6HHT5   A0A0P6B975   A0A0P5MDB6   A0A0P5H4E2   A0A0P5SNG4   A0A1W4WAH6   A0A0P5Q4T2   A0A0N8EFA6   A0A0P5Y4I0   A0A0P5LFP2   A0A0P5HDZ8   A0A0P6DBR3   A0A0P5XKM2   N6UM52   E9J0U2   A0A0P6G1D0   E9GU99   A0A1A9VNF7   A0A2J7PNW7   A0A1A9XKH4   A0A1I8MG47   A0A1B0AFD5   A0A0L7KUR3   E0VRJ7   A0A1B0FQ97   A0A1B6IAJ4   A0A1B0BU00   T1PIH4   A0A1I8NNT0   A0A0L0C3H5   A0A067QPA9   K7IUM2   A0A1B6F7B2   A0A232EW41   A0A1Y1LSB0   A0A0P5MKB7   A0A0P4W0N4   T1I5M8   A0A0N8DY57   A0A069DSJ5   B4NU19   A0A1J1HG45   Q24216   A0A023F975   B4I0R4   A0A0A9WBF2   A0A146L1G3   A0A1A9WIE6   A0A0B7AXP2   A0A2J7PNY0   B4L1F1   R4G4T3   B3MRQ7   B4PZS1  

EC Number

1.14.13.-

Pubmed

19121390    22118469    26354079    24508170    20920257    23761445    + More
20966253    12364791    14747013    17210077    20798317    21347285    21719571    24438588    24495485    26483478    25348373    17510324    18362917    19820115    23537049    21282665    21292972    25315136    26227816    20566863    26108605    24845553    20075255    28648823    28004739    27129103    26334808    17994087    9450931    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25474469    25401762    26823975    17550304   

EMBL

BABH01006346    BABH01006347    GQ250577    ACT83402.2    NWSH01000780    PCG74273.1    + More
ODYU01008504    SOQ52167.1    AGBW02012992    OWR44124.1    RSAL01000244    RVE43593.1    KQ460325    KPJ15770.1    KQ459564    KPI99703.1    AJVK01008652    KQ414606    KOC69523.1    AJWK01005404    GGFK01009304    MBW42625.1    KZ288195    PBC33793.1    KK107447    EZA50766.1    AXCM01002903    KQ978501    KYM93556.1    ADMH02000875    ETN64796.1    GGFJ01006454    MBW55595.1    APCN01000266    AAAB01008859    EAA07668.3    GL452434    EFN77236.1    KQ435030    KZC13986.1    ADTU01016497    KQ982934    KYQ49134.1    AXCN02001467    GL887575    EGI70758.1    GFDF01003081    JAV11003.1    KQ981875    KYN33998.1    GGFJ01007162    MBW56303.1    ATLV01021109    KE525312    KFB46048.1    KQ979074    KYN23067.1    GFDL01001369    JAV33676.1    GAMC01021678    JAB84877.1    JXUM01077051    KQ562984    KXJ74709.1    GDHF01019337    JAI32977.1    GAKP01021746    GAKP01021745    JAC37207.1    CH477206    EAT47870.1    KQ971328    EFA00961.1    GDIP01044914    JAM58801.1    GDIP01038950    LRGB01002384    JAM64765.1    KZS07948.1    GDIP01074567    JAM29148.1    GDIQ01042626    JAN52111.1    GDIP01018478    JAM85237.1    GDIQ01165589    JAK86136.1    GDIQ01232260    JAK19465.1    GDIP01137547    JAL66167.1    GDIQ01119400    JAL32326.1    GDIQ01032420    JAN62317.1    GDIP01063109    JAM40606.1    GDIQ01171878    JAK79847.1    GDIQ01228215    JAK23510.1    GDIQ01080411    JAN14326.1    GDIQ01170512    GDIP01070713    JAK81213.1    JAM33002.1    APGK01018009    KB740064    KB632165    ENN81756.1    ERL89283.1    GL767538    EFZ13601.1    GDIQ01039982    JAN54755.1    GL732565    EFX77011.1    NEVH01023281    PNF18037.1    JTDY01005635    KOB66801.1    DS235478    EEB16003.1    CCAG010006701    GECU01023831    GECU01023768    JAS83875.1    JAS83938.1    JXJN01020422    KA648464    AFP63093.1    JRES01001043    KNC25999.1    KK853171    KDR10310.1    AAZX01004382    GECZ01023631    JAS46138.1    NNAY01001918    OXU22572.1    GEZM01049766    JAV75861.1    GDIQ01158039    JAK93686.1    GDKW01001332    JAI55263.1    ACPB03003573    GDIQ01080412    JAN14325.1    GBGD01002019    JAC86870.1    CH983523    EDX16466.1    CVRI01000002    CRK86959.1    U56661    AE014298    BT022155    AAC47856.1    AAF46016.1    AAY51550.1    GBBI01000661    JAC18051.1    CH480819    EDW53095.1    GBHO01038868    GBHO01005565    GBRD01002459    GDHC01015607    JAG04736.1    JAG38039.1    JAG63362.1    JAQ03022.1    GDHC01017919    JAQ00710.1    HACG01038537    CEK85402.1    PNF18038.1    CH933810    EDW06672.1    GAHY01001090    JAA76420.1    CH902622    EDV34462.1    CM000162    EDX01138.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    + More
UP000092462    UP000053825    UP000092461    UP000242457    UP000075880    UP000053097    UP000075883    UP000078542    UP000000673    UP000075882    UP000075920    UP000076407    UP000075884    UP000075903    UP000075840    UP000007062    UP000008237    UP000076502    UP000005205    UP000075809    UP000075886    UP000007755    UP000078541    UP000030765    UP000078492    UP000069940    UP000249989    UP000008820    UP000007266    UP000076858    UP000192223    UP000019118    UP000030742    UP000000305    UP000078200    UP000235965    UP000092443    UP000095301    UP000092445    UP000037510    UP000009046    UP000092444    UP000092460    UP000095300    UP000037069    UP000027135    UP000002358    UP000215335    UP000015103    UP000000304    UP000183832    UP000000803    UP000001292    UP000091820    UP000009192    UP000007801    UP000002282   

PRIDE

D2IGZ5    Q24216   

Pfam

PF00069   Pkinase        + More
PF03232   COQ7

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR000719   Prot_kinase_dom       
IPR037770   CDK7       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR002291   Phosph_kin_gamma       
IPR009078   Ferritin-like_SF       
IPR011566   Ubq_synth_Coq7       

SUPFAM

SSF56112   SSF56112        + More
SSF47240   SSF47240       

CDD

cd01042  DMQH

ProteinModelPortal

D2IGZ5   A0A2A4JS25   A0A2H1WGK9   A0A212ERP3   A0A437AZQ4   A0A194REQ2   + More
A0A194Q2Y9   A0A1B0F0B8   A0A0L7RFB6   A0A1B0GHP7   A0A2M4APA7   A0A2A3EPS7   A0A182J7P2   A0A026W571   A0A182M1P6   A0A195C061   W5JKY1   A0A182LEE4   A0A182WNQ3   A0A2M4BR83   A0A182XAK0   A0A182NYJ1   A0A182VEZ7   A0A2C9GR36   Q7QCI5   E2C4A3   A0A154PQ01   A0A158NID1   A0A151WMN4   A0A182QLS0   F4W4X2   A0A1L8DX23   A0A151JU81   A0A2M4BTH5   A0A084W754   A0A195EE39   A0A1Q3G1L3   W8AGV1   A0A182GNR8   A0A0K8V215   A0A034V527   Q17MG8   D6WG89   A0A0P5ZEC1   A0A0P5ZUG2   A0A0N8D2R0   A0A0P6HHT5   A0A0P6B975   A0A0P5MDB6   A0A0P5H4E2   A0A0P5SNG4   A0A1W4WAH6   A0A0P5Q4T2   A0A0N8EFA6   A0A0P5Y4I0   A0A0P5LFP2   A0A0P5HDZ8   A0A0P6DBR3   A0A0P5XKM2   N6UM52   E9J0U2   A0A0P6G1D0   E9GU99   A0A1A9VNF7   A0A2J7PNW7   A0A1A9XKH4   A0A1I8MG47   A0A1B0AFD5   A0A0L7KUR3   E0VRJ7   A0A1B0FQ97   A0A1B6IAJ4   A0A1B0BU00   T1PIH4   A0A1I8NNT0   A0A0L0C3H5   A0A067QPA9   K7IUM2   A0A1B6F7B2   A0A232EW41   A0A1Y1LSB0   A0A0P5MKB7   A0A0P4W0N4   T1I5M8   A0A0N8DY57   A0A069DSJ5   B4NU19   A0A1J1HG45   Q24216   A0A023F975   B4I0R4   A0A0A9WBF2   A0A146L1G3   A0A1A9WIE6   A0A0B7AXP2   A0A2J7PNY0   B4L1F1   R4G4T3   B3MRQ7   B4PZS1  

PDB

6O9L     E-value=8.26893e-134,     Score=1221

KEGG

100379321    K02202 cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] | (RefSeq) Cdk7; cyclin dependent kinase 7

PATHWAY

03022    Basal transcription factors - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)

GO

GO:0008353   GO:0070985   GO:0005524   GO:0005516   GO:0005978   GO:0004689   GO:0005964   GO:0051301   GO:0016021   GO:0045944   GO:0004693   GO:0005634   GO:0005737   GO:0006468   GO:0016709   GO:0006744   GO:0031314   GO:0046872   GO:0012501   GO:0001111   GO:0005730   GO:0000079   GO:0000278   GO:0005654   GO:0032806   GO:0006366   GO:0005675   GO:0004674   GO:0004672   GO:0004713   GO:0030286   GO:0008270   GO:0016787   GO:0004190   GO:0006508   GO:0016286  

PANTHER

PTHR24056:SF375  

Subcellular location

Mitochondrion inner membrane  

Length:

338

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07258

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02462

outside

1  -  338

 

 

Pi

149.331943

Theta

166.069166

Tajima's D

-0.447208

CLR

0.585222

CSRT

0.254637268136593

Interpretation

Uncertain