Gene

KWMTBOMO12603

Pre Gene Modal

BGIBMGA001428

Annotation

PREDICTED:_ADAM_17-like_protease_[Bombyx_mori]

Location

Bomo_Chr21(-):9136500-9149829      View in EpiBrowser

Full name

ADAM 17-like protease      

Location in the cell

Nuclear   Reliability : 2.262

CDS

ATGAAGATATTCGTACTACCTGTATTAACAATTTTGTTTGTTTTAGGACATTGTTCTATACACCATAATTTGAAATATTTTGAGACAATACACGCGTCGAGTTTGTCCCATAGTATTGTCAAGCGTGGTGCAAAACTTTCTAATCATCCCTATAATACGATAAAGGAGGTTCGCTTCAAGACCTTGGGAAAAGACTTTCGATTGATATTACACCCTCAGAGTTCTGTTTTGCATTCCAATTTTAAAGCCTACTCTGTTGATGCTGATGGTAAAGAGACTACTGTGCATGTTGATCGTGAGAATTTCTTCACTGGCAGAGTATTTGGAGAAACAAAATCAGATGTTAAGTTACATATGGAAGATGGTGTAATGACAGGAATCATACATACACCTGATGAAACATATCATGTGGAGCCGTCCTGGCGACATCTGCCTGATTTAGATGGGAAGAGCATGATCACTTATCGTTCTTCTGATATTCGGTACAGTTGGGCTGGTGATGCAATTCCCAACAAACCACGGGTTTGTGGTTATGTTAAAGAGGGAAAAGAATTGGAAGACGACAGTGATGATGTACAAGAAGAATATGATATCGAATTGAAGCATGAACAGCTTGAAAAAGAAAAGTATTTGGACCAAACAAACTCATACCATCCAGCTAATGAAGCTGACACAAGTAATGATGGTCCTAAAAAGAGGACTAAGAGACAGAGTGATTATGAATATACACCAACAAAAACAAGATGTCCCCTATTACTTGTGGCTGACTATAGATTCTTTCAAGAAATGGGAGCTAGCAACACCAAAACTACCATTAGTTATTTGATAAGTCTAATTGATCGTGTGCATAAAATTTATAATGATACTCTGTGGCAGGATAGGCAGGATATGGATGGATTTAAAGGCATGGGGTTTGTAATTAAAAAGATATTGGTACATTCTGAACCTACACGAGTCCGAGGAGGAGAGGCTCATTATAATATGGTGCGTGAGAAATGGGATGTTCGGAATTTGCTTGAGGTGTTCAGTCGAGAATATTCACACAAAGACTTCTGTTTGGCTCACTTATTTACTGACCTTAAATTCGAAGGCGGCATCTTAGGTTTAGCCTATGTCGGTTCGCCGCGTAGAAATTCAGTCGGTGGTATATGCACCCCAGAATATTTCAAGAACGGATATACGTTATATTTGAACTCTGGCCTGAGTTCGTCCCGGAATCATTACGGGCAGCGCGTGATCACCCGGGAGGCGGACCTGGTGACGGCGCACGAGTTCGGCCACAACTGGGGCTCCGAGCACGACCCCGACGTGGCCGAGTGCTCGCCGGCCGCCAGCCAGGGGGGCTCCTACCTCATGTACACCTACAGCGTCAGCGGGTACGACGTCAACAACAAGAGATTTTCACCGTGCAGCCTAAGATCTATCAGAAAAGTGTTGCAGGCCAAATCTGGCAGATGTTTCTCTGAACCGGAGGAGAGTTTTTGTGGAAATCTTCGTGTCGAAGGAGGAGAGGAATGCGACGCTGGCCTGCTTGGTACTGAAGACAATGATATGTGCTGCGATAAGAATTGTAAATTGAGAAAAAATCAAGGCGCTGTCTGCAGCGACAAGAACTCCCCGTGCTGCGCCGGCTGTGTATTCGCGCCGCCCGGGCTCGTGTGCCGCGAGGCCGCGCACTCCGCCTGCGAGGGGGAGGCCATCTGCAACGGAGCCTCCGCCGACTGCCCCAAGGCGCCCGCCATCGCGGACGAGCACGAGTGCGCGGAGCGGGGCCGGTGCCGCAACGGCACGTGCATGCCGTACTGCGAGACGCAGGGGATGCACAGCTGCATGTGCGATATAGTCGCCGATGCCTGTAAACGTTGCTGCCGAAAGAGTTTAAACAAAACATGTTTTCCAGTCGCCCATAACGATATTTTGCCCGATGGAACTCCTTGTATACAAGGTTTTTGCAATAAGGGAGTATGTGAGAAGACAATACAAGACGTGGTCGAACGTTTCTGGGACATCATAGAGGACATTAACATAAACAATGTGCTGGGCTTCCTCCGGGACAACATCGTGGGAGTGGTCGTACTCGTCACTGCCTTCATATGGATACCTGCCAGTTGTGTTATTAGCTATGTTGATCGTCGACGTCAGCGTCAGCATCAGAAGTATTTGGAGTGGGAGAGGCAACATGATCTGATTCATCCGTCGTCACCGAGAAAAGTTATACACACACGATTACCGAAACAGAAACCTCCGGGAATTAAATCTGCCATACAAGGCAGCAGTCAACTGTAG

Protein

MKIFVLPVLTILFVLGHCSIHHNLKYFETIHASSLSHSIVKRGAKLSNHPYNTIKEVRFKTLGKDFRLILHPQSSVLHSNFKAYSVDADGKETTVHVDRENFFTGRVFGETKSDVKLHMEDGVMTGIIHTPDETYHVEPSWRHLPDLDGKSMITYRSSDIRYSWAGDAIPNKPRVCGYVKEGKELEDDSDDVQEEYDIELKHEQLEKEKYLDQTNSYHPANEADTSNDGPKKRTKRQSDYEYTPTKTRCPLLLVADYRFFQEMGASNTKTTISYLISLIDRVHKIYNDTLWQDRQDMDGFKGMGFVIKKILVHSEPTRVRGGEAHYNMVREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDVAECSPAASQGGSYLMYTYSVSGYDVNNKRFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGGEECDAGLLGTEDNDMCCDKNCKLRKNQGAVCSDKNSPCCAGCVFAPPGLVCREAAHSACEGEAICNGASADCPKAPAIADEHECAERGRCRNGTCMPYCETQGMHSCMCDIVADACKRCCRKSLNKTCFPVAHNDILPDGTPCIQGFCNKGVCEKTIQDVVERFWDIIEDININNVLGFLRDNIVGVVVLVTAFIWIPASCVISYVDRRRQRQHQKYLEWERQHDLIHPSSPRKVIHTRLPKQKPPGIKSAIQGSSQL

Cofactor

Zn(2+)

Keywords

Alternative splicing   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Membrane   Metal-binding   Metalloprotease   Protease   Reference proteome   Signal   Transmembrane   Transmembrane helix   Zinc   Zymogen  

Feature

chain  ADAM 17-like protease
splice variant  In isoform B.

Uniprot

A0A2A4JRN8   A0A2H1VDH4   A0A212ERJ3   A0A194QCC1   A0A182Y773   Q7QC01   + More
A0A182RYF5   A0A182HT89   A0A182VL03   A0A182PA53   A0A182F8C3   A0A182M7E4   A0A182W2W1   A0A182UEZ4   A0A182XIA2   A0A084W1N1   H9IVZ7   A0A182QEW5   W5JMW2   W8C0V8   A0A1I8M7C9   Q17E69   A0A1I8PUR0   A0A1B0AVD5   A0A034VSK8   A0A1A9YBN5   A0A0L0C6N9   A0A182NA78   A0A0K8W128   A0A336K6Z0   A0A0A1WRC0   A0A0K8V8I8   B4PL54   B4HZJ6   Q9VAC5   A0A1B0CSK0   A0A1W4UCA3   A0A182JMQ5   B3P809   B3LYW6   A0A3B0JZI9   B5DXC1   A0A151IFR3   A0A182KBE5   F4WB07   A0A2J7RJQ9   A0A158NRA3   A0A1A9WB29   A0A1Y1KAL7   A0A151IU71   A0A2A3EBN5   A0A1J1HIY7   B4JS92   A0A1B6D7E4   B4KC41   B4NK15   A0A0M4F503   A0A088ANI2   A0A0L7RGH9   K7IYX9   A0A195FJN4   B4MBA9   A0A232F7R2   A0A1Y1KAC3   A0A1A9ZM89   A0A0M8ZQR2   A0A1B0GEV1   T1HTT3   A0A026W8S0   B0WF95   E2BLC9   B4GNG8   E9IRZ3   A0A336LT71   E2A0G3   U4UWS6   A0A1B0D0W8   D6W9R5   A0A1B6DXH2   A0A1B6LAR2   A0A067QSA9   J9JIY4   A0A0A9XMC2   A0A224X8E8   E0VA01   A0A182G137   N6T965   A0A336LPF6   A0A0K2TMX9   E9G5W0   A0A0P5NR73   A0A3R7PZN4   A0A0P6FJX0   A0A0P5HUB5   A0A0V0GBJ1   A0A0P5E9K8   A0A162R8V1   A0A0P5IL95   A0A0P6FP73   A0A0P6EKT7  

EC Number

3.4.24.-

Pubmed

22118469    26354079    25244985    12364791    14747013    17210077    + More
24438588    19121390    20920257    23761445    24495485    25315136    17510324    25348373    26108605    25830018    17994087    17550304    10731132    12537572    15632085    21719571    21347285    28004739    20075255    28648823    24508170    30249741    20798317    21282665    23537049    18362917    19820115    24845553    25401762    20566863    26483478    21292972   

EMBL

NWSH01000780    PCG74284.1    ODYU01001967    SOQ38888.1    AGBW02012992    OWR44118.1    + More
KQ459193    KPJ03069.1    AAAB01008859    EAA08066.5    APCN01000423    AXCM01000066    ATLV01019399    KE525269    KFB44125.1    BABH01006334    BABH01006335    BABH01006336    BABH01006337    BABH01006338    BABH01006339    BABH01006340    BABH01006341    AXCN02000218    ADMH02000650    ETN65446.1    GAMC01001243    JAC05313.1    CH477285    EAT44750.1    JXJN01004199    JXJN01004200    GAKP01012681    GAKP01012664    JAC46271.1    JRES01000835    KNC27901.1    GDHF01007530    JAI44784.1    UFQS01000097    UFQT01000097    SSW99408.1    SSX19788.1    GBXI01013106    JAD01186.1    GDHF01019781    GDHF01017123    JAI32533.1    JAI35191.1    CM000160    EDW99039.1    CH480819    EDW53453.1    AY212802    AY525768    AE014297    AY061030    BT003184    AJWK01026149    CH954182    EDV53136.1    CH902617    EDV44082.1    OUUW01000005    SPP80930.1    CM000070    EDY67486.2    KQ977771    KYM99996.1    GL888056    EGI68627.1    NEVH01002990    PNF41049.1    ADTU01023838    GEZM01087879    JAV58424.1    KQ980970    KYN10938.1    KZ288292    PBC29147.1    CVRI01000006    CRK87999.1    CH916373    EDV94632.1    GEDC01015691    JAS21607.1    CH933806    EDW16914.1    CH964272    EDW84017.1    CP012526    ALC46532.1    KQ414596    KOC69965.1    KQ981522    KYN40576.1    CH940656    EDW58380.2    NNAY01000791    OXU26488.1    GEZM01087880    JAV58423.1    KQ436008    KOX67619.1    CCAG010012590    ACPB03009762    KK107390    QOIP01000007    EZA51424.1    RLU20425.1    DS231916    EDS26112.1    GL449017    EFN83481.1    CH479186    EDW39294.1    GL765283    EFZ16703.1    SSW99409.1    SSX19789.1    GL435586    EFN73100.1    KB632399    ERL94730.1    AJVK01021750    AJVK01021751    KQ971312    EEZ98535.2    GEDC01006926    JAS30372.1    GEBQ01019180    JAT20797.1    KK853016    KDR12487.1    ABLF02022098    ABLF02022102    GBHO01025349    GBHO01025348    JAG18255.1    JAG18256.1    GFTR01007821    JAW08605.1    DS235002    EEB10207.1    JXUM01135890    KQ568348    KXJ69034.1    APGK01039066    KB740967    ENN76784.1    SSW99410.1    SSX19790.1    HACA01009606    CDW26967.1    GL732533    EFX84833.1    GDIQ01246047    GDIQ01138927    GDIQ01120681    JAL12799.1    QCYY01000856    ROT82229.1    GDIQ01056301    JAN38436.1    GDIQ01224937    JAK26788.1    GECL01000880    JAP05244.1    GDIP01146279    JAJ77123.1    LRGB01000220    KZS20319.1    GDIQ01212637    JAK39088.1    GDIQ01056360    JAN38377.1    GDIQ01061154    JAN33583.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000076408    UP000007062    UP000075900    + More
UP000075840    UP000075903    UP000075885    UP000069272    UP000075883    UP000075920    UP000075902    UP000076407    UP000030765    UP000005204    UP000075886    UP000000673    UP000095301    UP000008820    UP000095300    UP000092460    UP000092443    UP000037069    UP000075884    UP000002282    UP000001292    UP000000803    UP000092461    UP000192221    UP000075880    UP000008711    UP000007801    UP000268350    UP000001819    UP000078542    UP000075881    UP000007755    UP000235965    UP000005205    UP000091820    UP000078492    UP000242457    UP000183832    UP000001070    UP000009192    UP000007798    UP000092553    UP000005203    UP000053825    UP000002358    UP000078541    UP000008792    UP000215335    UP000092445    UP000053105    UP000092444    UP000015103    UP000053097    UP000279307    UP000002320    UP000008237    UP000008744    UP000000311    UP000030742    UP000092462    UP000007266    UP000027135    UP000007819    UP000009046    UP000069940    UP000249989    UP000019118    UP000000305    UP000283509    UP000076858   

PRIDE

H9IVZ7    Q9VAC5   

Pfam

PF00200   Disintegrin        + More
PF16698   ADAM17_MPD
PF01562   Pep_M12B_propep
PF06423   GWT1

Interpro

IPR001590   Peptidase_M12B        + More
IPR024079   MetalloPept_cat_dom_sf       
IPR001762   Disintegrin_dom       
IPR002870   Peptidase_M12B_N       
IPR034025   ADAM10_ADAM17       
IPR036436   Disintegrin_dom_sf       
IPR032029   ADAM17_MPD       
IPR009447   PIGW/GWT1       

SUPFAM

SSF57552   SSF57552       

Gene 3D

3.40.390.10     4.10.70.10    

CDD

cd04270  ZnMc_TACE_like
cd14246  ADAM17_MPD

ProteinModelPortal

A0A2A4JRN8   A0A2H1VDH4   A0A212ERJ3   A0A194QCC1   A0A182Y773   Q7QC01   + More
A0A182RYF5   A0A182HT89   A0A182VL03   A0A182PA53   A0A182F8C3   A0A182M7E4   A0A182W2W1   A0A182UEZ4   A0A182XIA2   A0A084W1N1   H9IVZ7   A0A182QEW5   W5JMW2   W8C0V8   A0A1I8M7C9   Q17E69   A0A1I8PUR0   A0A1B0AVD5   A0A034VSK8   A0A1A9YBN5   A0A0L0C6N9   A0A182NA78   A0A0K8W128   A0A336K6Z0   A0A0A1WRC0   A0A0K8V8I8   B4PL54   B4HZJ6   Q9VAC5   A0A1B0CSK0   A0A1W4UCA3   A0A182JMQ5   B3P809   B3LYW6   A0A3B0JZI9   B5DXC1   A0A151IFR3   A0A182KBE5   F4WB07   A0A2J7RJQ9   A0A158NRA3   A0A1A9WB29   A0A1Y1KAL7   A0A151IU71   A0A2A3EBN5   A0A1J1HIY7   B4JS92   A0A1B6D7E4   B4KC41   B4NK15   A0A0M4F503   A0A088ANI2   A0A0L7RGH9   K7IYX9   A0A195FJN4   B4MBA9   A0A232F7R2   A0A1Y1KAC3   A0A1A9ZM89   A0A0M8ZQR2   A0A1B0GEV1   T1HTT3   A0A026W8S0   B0WF95   E2BLC9   B4GNG8   E9IRZ3   A0A336LT71   E2A0G3   U4UWS6   A0A1B0D0W8   D6W9R5   A0A1B6DXH2   A0A1B6LAR2   A0A067QSA9   J9JIY4   A0A0A9XMC2   A0A224X8E8   E0VA01   A0A182G137   N6T965   A0A336LPF6   A0A0K2TMX9   E9G5W0   A0A0P5NR73   A0A3R7PZN4   A0A0P6FJX0   A0A0P5HUB5   A0A0V0GBJ1   A0A0P5E9K8   A0A162R8V1   A0A0P5IL95   A0A0P6FP73   A0A0P6EKT7  

PDB

3G42     E-value=1.75529e-71,     Score=687

KEGG

101742406    K06059 disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86] | (RefSeq) ADAM

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0004222   GO:0007220   GO:0007219   GO:0006509   GO:0046872   GO:0006506   GO:0016746   GO:0007229   GO:0008237   GO:0006508   GO:0007018   GO:0030286   GO:0008270   GO:0016787   GO:0004190   GO:0016286  

Subcellular location

Membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.961555

 

 

Length:

761

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

24.64556

Exp number, first 60 AAs:

1.8368

Total prob of N-in:

0.09363

outside

1  -  686

TMhelix

687  -  709

inside

710  -  761

 

 

Pi

310.781805

Theta

171.492806

Tajima's D

3.260882

CLR

0.297325

CSRT

0.989050547472626

Interpretation

Uncertain