Gene
KWMTBOMO12602 Validated by peptides from experiments
Pre Gene Modal
BGIBMGA001546
Annotation
PREDICTED:_dynein_heavy_chain?_cytoplasmic_[Amyelois_transitella]
Full name
Dynein heavy chain, cytoplasmic
+ More
Cytoplasmic dynein 1 heavy chain 1
Dynein heavy chain 2, axonemal
Dynein heavy chain-like protein MAL7P1.162
Dynein-1-alpha heavy chain, flagellar inner arm I1 complex
Cytoplasmic dynein 2 heavy chain 1
Dynein heavy chain 6, axonemal
Dynein heavy chain 10, axonemal
Dynein heavy chain 1, axonemal
Dynein heavy chain 17, axonemal
Dynein heavy chain 8, axonemal
Dynein heavy chain 7, axonemal
Dynein gamma chain, flagellar outer arm
Dynein beta chain, flagellar outer arm
Dynein heavy chain 3, axonemal
Dynein alpha chain, flagellar outer arm
Dynein-1-beta heavy chain, flagellar inner arm I1 complex
Dynein heavy chain 5, axonemal
Dynein heavy chain domain-containing protein 1
Cytoplasmic dynein 1 heavy chain 1
Dynein heavy chain 2, axonemal
Dynein heavy chain-like protein MAL7P1.162
Dynein-1-alpha heavy chain, flagellar inner arm I1 complex
Cytoplasmic dynein 2 heavy chain 1
Dynein heavy chain 6, axonemal
Dynein heavy chain 10, axonemal
Dynein heavy chain 1, axonemal
Dynein heavy chain 17, axonemal
Dynein heavy chain 8, axonemal
Dynein heavy chain 7, axonemal
Dynein gamma chain, flagellar outer arm
Dynein beta chain, flagellar outer arm
Dynein heavy chain 3, axonemal
Dynein alpha chain, flagellar outer arm
Dynein-1-beta heavy chain, flagellar inner arm I1 complex
Dynein heavy chain 5, axonemal
Dynein heavy chain domain-containing protein 1
Alternative Name
Dynein heavy chain, cytosolic
Cytoplasmic dynein heavy chain 1
MAP 1C
Ropy-1
DHC08
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
1-alpha DHC
Dynein-1, subspecies f
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Dynein heavy chain isotype 1B
Axonemal beta dynein heavy chain 6
Ciliary dynein heavy chain 6
Dynein heavy chain domain-containing protein 3
Axonemal beta dynein heavy chain 10
Ciliary dynein heavy chain 10
Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
Heat shock regulated protein 1
hDHC7
mDHC7
Axonemal beta dynein heavy chain 17
Ciliary dynein heavy chain 17
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
Axonemal beta dynein heavy chain 7
Axonemal dynein heavy chain b
Ciliary dynein heavy chain 7
Dynein-like protein 7
Axonemal beta dynein heavy chain 3
Ciliary dynein heavy chain 3
Dnahc3-b
DHC alpha
1-beta DHC
Dynein-like protein 4
Axonemal beta dynein heavy chain 5
Ciliary dynein heavy chain 5
Dynein heavy chain domain 1-like protein
Protein CCDC35
Cytoplasmic dynein heavy chain 1
MAP 1C
Ropy-1
DHC08
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
1-alpha DHC
Dynein-1, subspecies f
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Dynein heavy chain isotype 1B
Axonemal beta dynein heavy chain 6
Ciliary dynein heavy chain 6
Dynein heavy chain domain-containing protein 3
Axonemal beta dynein heavy chain 10
Ciliary dynein heavy chain 10
Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
Heat shock regulated protein 1
hDHC7
mDHC7
Axonemal beta dynein heavy chain 17
Ciliary dynein heavy chain 17
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
Axonemal beta dynein heavy chain 7
Axonemal dynein heavy chain b
Ciliary dynein heavy chain 7
Dynein-like protein 7
Axonemal beta dynein heavy chain 3
Ciliary dynein heavy chain 3
Dnahc3-b
DHC alpha
1-beta DHC
Dynein-like protein 4
Axonemal beta dynein heavy chain 5
Ciliary dynein heavy chain 5
Dynein heavy chain domain 1-like protein
Protein CCDC35
Location in the cell
Cytoplasmic Reliability : 2.359
Sequence
CDS
ATGTTATATGCTGTTCACAGGCCAAATCAAATTCTGGCCACAGAGCCTTGTAACTTTTTTATTGTACAATATCCACAATCGAAGTGCAGTAGTATTTCGACGGTACGAGATCTGCCTCCCGTCGCCGGCTCCATCATTTGGGCGAAGCAGATTGATCACCAGCTCACTGCTTATTTAAAAAGAGTTGAAGATGTTCTTGGTAAAGGCTGGGAAAATCATATTGAAGGGCAGAAGTTGAAGGCAGACGGTGACAGTTTCCGACTGAAATTAGATACTCAAGAAGTATTCGACGATTGGGCTCGTAAGGTTCAACAACGTAACCTGGGTGTATCGGGACGAATCTTCGCGATCGACTCAGTGCGTGCCCGGTCCAGCAAGACTGGCACAATCCTCAAACTGAAAGTTAACTTTCTGCCGGAAATCATCACTCTATACAAGGAAGTGCGTAATTTAAAGAACCTAGGGTTCAGAGTGCCGTTAGCCATTGTGAACAAGGCTCATCAAGCTAATCAACTGTACCCGTTCGCCATTTCATTGATTGAAAGTGTACGCACTTACGAGCGCACTCTCGAAAAGATTCGTGATAAGGCATCCATCATCCCGCTGGTGGCTGGTCTGAGGCGCGACGTTCTCAACCAGGTGTCCGAAGGCATGGCTCTCGTATGGGAATCCTACAAACTTGATCCATATGTACAGAAATTGAGTGAAGTCGTGCTACTATTCCAAGAGAAAGTTGAAGATTTACTTGCGGTCGAAGAACAAATCTCGGTGGATGTGAGATCGCTCGAGACCTGCCCATACTCGGCTCAAAGCCTGGCCGACATTTTGAGTCGCCTGCAGCGCGCCATCGACGATCTGTCCTTGAGGCAGTACAGCAACTTGCATCTATGGGTGCAACGCTTAGACGAAGAGGTTGAAAAGAGTCTCGCAGCCCGTCTGCAGGCCGGTGTCGAAGCCTGGACTGGCGCCTTGCTAGGGAAGAGCCATGAGCTTGACCTATCGATGGATACTTATTCTCCTGCTGAACCTACCCACAAACCCGGAGGCGAACCCCAGATCGCCCGCGTGGTCCACGAGGTGCGCATTACGAATCAACAAATGTATTTATTCCCGTCTTTGGAAGAAGCTCGCTTCCAACTGATGAGGCAGATGTTTGCGTGGCAGGCCATCGTCACCAGCCTGCACAGACTGCAGAGCACCAGGTACCAAGTTGGAGTTGCTCGAGCTCAAACAGCCACCTACAGGAACCTACTGACCAAGCTTCCTGGAGGATCCGCACCCCTCGAAAAAGCTTACGATGCGATTGAAAAGAAGATATTTGAAGTTCGCGAATACGTCGACGAATGGCTGCGTTATCAAGCCCTTTGGGACTTACAACCGGAAAGCTTGTATGGACGTCTCGGGGAAGATATCACTTTGTGGATTAAGTGTTTGAATGACATCAAGAAATCTCGTACCACGTTCGACACATCCGACACTCGGCGTGAATACGGGCCGGTGGTTATCGACTTCGCCCGCGTGCAGAGCAAGGTGGCTCTCAAGTACGACGCCTGGCACAAGGAGGTGCTCGGCAAGTTCGGGGCACTGCTCGGCGGGGAAATGGTCCAGTTCCACTCCAAACTCTCCAAGTCGCGTAGCCAACTAGAACAACAGACTATCGAAGCGGCATCTACTAGTGACGCAGTGTCTCTCATTACCTACGTGCAACAGTTGAAGAGAGAAGTCTTGGCTTGGGAAAAGCAAGTCGATATTTACAGGGAAGCCCAACGTATTCTAGAACGGCAACGATTCCAATTCCCAGCTCAATGGCTCCACGTCGACAATATCGATGGAGAATGGAGTGCATTCAATGAGATAATGCGTAGAAAGGATTCTTCTATACAGACCCAGGTTGCATCACTACAACAAAAGATCGTAGCTGAAGACAAAGCTGTTGAAACCCGCACTCTGGAGTTCCTCACCGAATGGGAACGCAATAAGCCGACAGACGGATCCACCCGGCCTGAAGATGCGCTGTCGAGACTACAGGCTATGGAAACTAGGTACACCAGGCTGAAGGACGAAAGAGATAATGTCGCTAAAGCTAAAGAAGCTCTGGAGCTGCACGATACTGGAAGCTCGATTAATAACGAACGCATGACGGTCGTACTTGAGGAACTGCAAGATCTACGAGGCGTGTGGTCATCGCTCAGCAAAATCTGGACACAAATTGATGATATCAGAGAGAAACCTTGGCTTTCCGTACAGCCCAGAAAACTCAGGCAACAGCTGGAGGCTATGCTGAATGAGCTGAAAGAACTGCCAGCTCGTCTGCGTATGTACGACAGCTATGAATTCGTTCGGAAATTACTTCAGTCTTATACCAAGGTCAACATGTTAATTGTGGAATTAAAATCGGATGCTCTTAAAGAACGTCATTGGCGTCAACTGTGCCGAGCTCTCAAAGTGGATTGGTCTTTATCCGAACTGACTCTAGGACAAGTGTGGGATGCTGATCTTCTCCACAACGAACATACAGTTAAAGATGTCGTTCTTGTCGCTCAAGGAGAAATGGCACTTGAAGAATTCTTGAAACAGGTCCGTGAGTCGTGGCAGAGCTACGAGTTAGATCTGATTAACTATCAGAATAAATGCAAGATTATTCGTGGATGGGATGATCTCTTTAACAAAGTAAAGGAGCACATCAACAGTGTTGCTGCAATGAAACTTTCTCCCTATTATAAGGTGTTTGAAGAAGAAGCTCTTACTTGGGAGGAGAAACTAAATCGTATTAACGCTCTATTTGACGTATGGATCGACGTACAACGGCGATGGGTGTATCTGGAAGGTATCTTCAGTGGATCTGCTGACATCAAGACTTTGCTACCCGTTGAAACAAGTCGTTTCCAGAGCATTAGCTCCGAATTCCTTGGCTTGATGAAAAAAGTTTCCAAGTCTCCCATGGTCATGGACGTGTTGAATATTCCTGGTGTTCAAAGATCTTTAGAACGTTTGGCTGATTTATTGGGAAAAATACAAAAGGCGCTCGGTGAATATCTGGAGCGGGAGAGAAGCAGCTTTCCTCGATTCTATTTCGTGGGTGATGAAGATCTCCTCGAGATCATTGGTAACAGCAAGAACATAGCGCGTCTACAGAAACACTTTAAGAAAATGTTTGCTGGGGTTTCAGCTATTATTCTAAACGAAGACAATACCATCATCAACGGAATCGCTTCAAGGGAAGGAGAAGAGGTTTACTTCACAGCCCCTGTTTCAACAATAGAAAATCCAAAAATCAACTCATGGTTGTCGATGGTTGAGCGTGAAATGCGAGTCACGTTAGCTTGCAGACTGAAGGACGCGGTTGGCGATGTCAAACAATTCAAAGACGGCAATGTCGACCCTCTGAAGTTTATCGAATGGTGTGATAAGTATCAGGCTCAAATAGTTGTGCTAGCGGCTCAGATCCTCTGGTCCGAGGATGTAGAGGCAGCGCTCGTTAATGGGGGCGGAGATGGATTGAAACGCGTACTGGCTCATGTTGAAAATATGCTGAACATACTTGCTGACTCTGTTTTGCAAGAACAACCCCCGCTTAGAAGAAGGAAACTTGAACATTTGATCAACGAATTCGTTCACAAGCGTACGGTGACTCGTCGTCTGATCGCTTCGGGCGTGAACAGCCCGCGCTCGTTTGATTGGCTGTACGAGATGCGTTTCTATTTCGATCCAAGGAATAACGACGTGCTGCAACAACTGACAATACATATGGCCAACGCTAAATTCCTGTATGGCTTTGAATATTTGGGTGTTCAAGATCGTCTAGTACAAACTCCGTTGACGGATCGATGCTATCTCACCATGACGCAAGCGCTGGAAGCTCGCCTGGGTGGATCACCTTTTGGGCCGGCTGGTACCGGTAAAACGGAGTCTGTAAAAGCTTTGGGTAATCAACTCGGTCGCTTCGTGTTGGTCTTCAACTGCGATGAAACCTTCGACTTCCAGGCCATGGGCCGTATCTTCGTCGGTCTATGCCAGGTCGGTGCCTGGGGTTGTTTCGACGAATTCAATCGTCTCGAAGAAAGAATGCTGTCTGCTGTATCTCAACAAGTTCAGACAATCCAGGAGGCTCTCAAAAGCCACCAAGAAGGGGACAATACTAGTAAATCGATTACAGTGGAGCTGGTAGGTAAACAAGTCCGCGTATCGCAAGACATGGCGATCTTCATTACCATGAACCCTGGTTACGCTGGACGCTCAAACTTGCCCGATAATTTGAAGAAGCTATTCCGAAGCTTGGCTATGACGACCCCGGACAGGCAACTCATCGCCGAAGTCATGTTGTTCAGTCAGGGATTCCGAACTGCTGAGAAGCTGGCCTGCAAAATTGTACCATTCTTTAAACTGTGTGATGAACAACTGTCGAACCAATCTCACTACGATTTCGGTTTGCGAGCACTCAAGTCAGTGCTTGTATCTGCTGGTAATGTGAAACGTGATCGCATACAGAAGATAAAGGAGACATTAGCTGAACGAGGACAAGAAGTGCCCGACGAAGCATCTATTGCAGAATCGCTGCCCGAACAAGATATTCTAATTCAATCTGTCTGCGAGACAATGGTCCCGAAACTGGTAGCAGAGGATATTCCATTGCTTTTCTCACTGCTTAACGACGTATTCCCAAATGTGGGGTACACTAGAGCCGAAATGACTGGTTTGAAGAACGAAATTCGGGCAGTTTGCGCTGAAGAATTTTTGGTTTGTGGTGAAGCTGACGAACAAGGCTCCACTTGGATGGACAAGGTACTGCAACTATACCAAATCTGCAAGCTAAATCATGGCTTGATGATGGTCGGGCCATCGGGCAGCGGTAAATCTACCGCATGGCGGGTACTACTTAAAGCTTTGGAGAGATTTGAAGGCGTTGAAGGTGTTGCCCACGTGATCGATCCAAAAGCGATGTCAAAGGAAACTTTATATGGTGTTCTCGATCCAAACACACGTGAATGGACTGATGGTCTCTTCACACATATATTAAGGAAAATAATTGATAACGTACGAGGTGAGATCAACAAACGCCAATGGATTATATTCGACGGTGACGTCGATCCCGAGTGGGTCGAGAACTTGAACTCTGTACTGGACGACAACAAGCTCCTCACTCTGCCAAACGGTGAACGTCTATCGCTGCCTCCGAATGTCAGAATCATGTTTGAGGTACAAGACTTGAAATACGCAACGCTTGCTACAGTGTCTCGTTGCGGTATGGTTTGGTTCTCGCAAGACGTCCTTACAACTGAGATGATCTTCGAAAATTATCTGATGAGATTGAAAAATATTCCTTTGGAAGATGGTGAGGAGGATTCGTTCAGTATTGTCATGGCTGCACCTACACCCGGTAGTGAACAGAATGTCACTGAAAATATCCTGTCACCCGCTTTACAAACGCAGCGTGACGTGGCGGCTATACTACAACCACTTTTCTTTGGCGACGGTCTCGTGGTCAAATGTCTCGAAAGAGCTGCATCCCTCGATCACATAATGGACTTCACTCGGCATCGAGCTCTGTCTTCGCTGCACTCTATGCTTAATCGAGGTGTTAGGAATATACTGGGATACAATCGACAACATCCGGACTTCCCCATCACAAACGAGCAATTAGAAGCCTACATACCGAAATGGCTGGTATATTCTTTACTATGGTCATTTGCTGGTGACGCGAAATTGAAGGATCGCAATGAACTCGGTGATTTCATACGATCAGCCAGCACAATGCTGCTACCCAATTGCGGACCCAATCAACACATTATCGATTTTGAGGTTAGCGTGACCGGAGAATGGGTTCCGTGGTCCGCGAAAGTACCACAAATCGAAGTTGAAACTCACAAAGTTGCTGCACCTGACGTTGTCGTTCCTACCTTGGACACAGTGCGTCACGAAGCCTTGCTTTATACTTGGCTTGCCGAACATAAACCTTTGGTTCTGTGCGGTCCCCCCGGCTCCGGGAAGACAATGACCCTGTTCTCTGCGCTCCGAGCGCTGCCCGACATGGAGGTGGTGGGGTTGAACTTCTCGTCCGCCACGACACCGGAGCTGCTGCTGAAAACATTCGATCACTACTGCGAGTACAGGAAGACTCCGAACGGCGTTGTGCTTGCTCCGGTGCAGCTCGGAAAATGGTTGGTTTTGTTTTGTGATGAAATTAACTTACCTGACATGGATCAATACGGTACCCAGCGAGTCATTTCTTTCTTGCGTCAACTTCTTGAACACAAGGGCTTCTATCGAGCAAGCGACCATTCCTGGGTACATCTGGAGCGCATACAGTTCGTTGGAGCTTGCAATCCGCCTACGGACCCTGGAAGAAAGCCACTCTCACATCGTCTATTAAGACACGTGCCCGTTATTTACGTCGACTACCCCGGAGAAATGTCCCTAGAACAGATCTACGGCACGTTCACCCGCGCCATGCTCCGTATGCAGCCGGCCCTGCGCGGATACGCTGAGCCGCTTACTCAAGCGATGGTGAAATTATACCTCGCTTCTCAAGAACGATTCACTCAGGATATGCAGCCGCACTATGTGTATTCCCCCCGTGAGATGACCCGATGGGTTAGAGGAATATGCGAAGCTATAAGGCCTTTGGACAATTTGACTGTAGAAGGTCTGGTAAGGCTGTGGGCGCACGAGGCTCTGCGGCTATTCCAAGATCGTTTGGTAGATGATGTTGAGAGACAATGGACGGATGAAAACATCGATACTGTAGCCATGCGATTCTTCCCCGGTATCAATAGAGAACAAGCTCTGGCCCGTCCAATACTTTACAGTAATTGGTTGAGCAAAGATTATGTGCCAGTCTTACGAGACCAACTTCGAGAATACGTGAAAGCGAGATTGAAGGTGTTCTATGAAGAAGAATTAGACGTTCCGTTAGTGTTGTTCGATGAAGTCCTGGACCACGTACTGCGTATCGATCGTATATTCCGACAGCCGCAGGGACATCTGCTACTCATCGGAGTGTCCGGAGCGGGAAAGACAACTCTGAGTCGTTTCGTCGCTTGGATGAACGGACTCAGCATTTTCCAAATCAAGGTTCACAACAAATACACTGGTGCTGACTTCGACGAAGACCTTCGCTCGGTTCTTCGTCGCGCTGGATGTAGAGACGAAAAAGTCGCCTTCATATTAGATGAGTCTAACGTACTGGACAGCGGATTCCTTGAAAGAATGAACACGCTACTCGCTAATGGAGAGGTGCCTGGGTTATTTGAAGGTGATGAATTTTCCGCACTCATGACCCAATGTAAGGAAGGTGCCCAACGCGAGGGTTTGATGCTAGATTCGAATGACGAGCTTTACAAATGGTTCACGAGCCAGGTGATGCGCAACTTGCACGTAGTGTTCACAATGAACCCGTCCTCGGAGGGCTTGAAGGACCGAGCCGCGACATCTCCTGCTCTGTTCAACCGATGCGTGCTTAACTGGTTCGGAGACTGGAGCGACGGAGCTTTGTTCCAAGTGGGTAAAGAGTTCACGAGCCGCATGGACCTGGAGTCTGCCGAGTACGTGCCGCCCGCGGAGTTCCCGGCGGCGTGCGGCGAGGTGGGCGCGGCGCCGGCGCACCGCGAGGCCGTGGTCAACGCCTGCGTGTACGTGCACCAGACGCTGCACCAGGCCAACGCCAGGCTCGCCAAGCGCGCCAACAGGACCATGGCCATCACGCCCAGGCATTATTTGGACTTTATCCAACAAATGGTTAAGCTTTACGCCGAAAAACGTGCCGACCTGGAGGAGCAGCAGCTTCACTTGAACGTGGGTCTCGGTAAGATTGCCGAAACCGTCGAGCAGGTCGAGGAGATGCAGAAGAGCTTAGCGGTCAAATCTCAGGAACTGCAAGCCAAGAACGAGGCCGCCAATGCGAAGTTGCGGCAAATGGTGAAGGACCAACAGGAAGCTGAAAAGAAAAAGGTCGAGAGCCAGGAAATTCAGGTCGCTTTGGAGAAACAAACCAAGGAGATCGAGGCCAAGCGAAGGGACGTGATGGCGGACCTCGCACAAGTGGAACCAGCCGTTATCGAAGCGCAAAACGCGGTGAAATCTATAAAGAAGCAGCATTTGGTCGAAGTGAGGTCTATGGGCAACCCGCCGGCGATAGTGAAGGTGGCCCTCGAATCTATTTGCCTGCTGCTGGGCGAGAACGCAACCGATTGGAAGGCGATCCGGGCGGTCATCATGCGGGAGAACTTCATCAATAGCATCGTCTCCAATTTCTCGACGGAGGACATAACTGACGACGTACGTGAGAAAATGAGGACCAGGTACCTCAGCAACCCCGATTACAACTTCGAAAAAGTGAACCGTGCCAGTATGGCATGCGGTCCTATGGTCAAATGGGCGATTGCTCAGATTGAATATGCTGACATGTTGAAACGGGTAGAGCCTCTGCGTAACGAGCTCCAAGCCCTCGAGGACCAGGCTCAGAGCAACGTCACGGCCGGCAACGAAGTGCGCGAACTTATTGCTCAGCTGGAGAAATCGATCGCTTCGTACAAAGAAGAGTACGCTCAACTAATCAGTCAAGCGCAGGCCATCAAGACCGACCTCGAAAATGTACAAGCTAAGGTGGACAGATCTATCGCTCTCCTGAAGAGCTTAGTGATCGAACGTGAGCGTTGGGAGTCCAGCTCGGAGACGTTCCGTTCACAAATGAGCACTATCGTCGGCGACGTGCTCCTTTCAGCAGCTTTCATCGCTTACGGAGGATACTTCGATCAACATTATCGTCAAAATCTATTTACGACATGGACCAATCACCTTGCGGCGGCCAACATACGGTACAGAGCGGACATAGCGCGCACGGAGTACCTCAGCAACCCCGACGAGAGACTGCGCTGGCAAGCTAACGCCCTGCCTACTGACGAACTATGCGTTGAAAATGCAATTATGCTCAGGCGCTTCAACCGCTACCCGCTGATCATAGATCCGTCCGGACAAGCAACGGAATTCATAATGCGCGAATTCAAAGAACGTAAAATCACTAAAACATCTTTCCTTGATGATTCCTTCCGGAAGAACTTGGAATCGGCACTCCGTTTCGGAAACCCCTTACTTGTACAGGACGTTGAGAACTACGATCCTATTCTAAATCCGGTATTAAACCGAGAGCTGCGTCGCACGGGCGGCCGCGTGCTGATCACGCTCGGAGACCAGGACATCGATCTAAGTCCGTCATTCGTCATCTTCCTCAGTACAAGAGATCCGACTGTGGAGTTCCCTCCGGACATGTGCTCGCGAGTGACGTTCGTTAACTTCACCGTCACCCGCTCGTCGCTGCAGTCGCAGTGTCTGCACAGAGTACTCAAGGCGGAGCGACCTGACATCGACGCCAAGCGATCCGACTTACTCAAACTGCAAGGCGAATTCCACCTCCGTTTACGTCAACTTGAAAAGTCGCTTCTACAAGCTCTCAACGACGCTAAAGGAAAGATCTTGGATGATGACTCTGTAATCGCGACATTGGAAACCTTGAAGAAGGAAGCCGATGATATTGGACAAAAGGTTGAAGAAACTGATAAAGTGATTGCTGAGATAGAGACTGTGAGTCAGCAGTACTTACCGTTATCACAAGCATGCAGCAGCATCTACTTCACAATGGATTCCCTCAACCAGATCCACTTCTTGTATCAATACTCGTTGAAGATGTTCCTGGACATATTCAGCTCCGTGCTGATATGTCCGTTGCTGAACGGCGTTACCGACTATACGGCGAGGCTTAAAATCATTACCGAAGAACTGTTCGCGGTCGTGTATGAGCGTGTAGCCCGTGGTATGTTGCACACGGACAGACTCACTTTCGCGCTGCTGCTGTGCCGCATACATCTGAAGGGCACGGGAGCCGAGGATACCCTAGAGCAGTCGTTCCCGGTGTTCTTGCGAGGCAAGGAAGGGTTCGTCTCTCAGACTGCGCCTTCGGAACCGCTCACGCATCAGCAGCACGATGCCGCCGCCAGACTCAGTTCCAGGTTGGGAGTGTTCCGTCGTCTGCTGGAGAAGGCTGGCGAGCTGCCGGAGCTGTCGGCGTGGCTGTCGCAGGCGGCGCCCGAGCAGTGCGTGCCCACGCTGTGGGACTCCGAGCCCGCCGCGCCGCCCGCGCCGCACTCGCTCGCCATGTACCGCCTGCTGCTCATACAGGCGTTCCGACCAGACCGTGTGATCGCTGCGGCCACACAACTAGCAGCGGCTGTCCTCGGCGCCGGATTCATGGCTAAAGCAGAGACCGAGCTGGATCTCGCGTCCATTACCGAAACTCAACTGAACGCGACCACGCCGGCCATACTGTGCTCCGTGCCCGGATATGACGCTAGTGGTCGCGTGGATGATATGGCGACTGAATTGAACAAGCCTTTATCGAGTATCGCCATCGGATCTGCTGAAGGATTCAATCAAGCTGAGCGAGCGATTAACACTGCTTGCAAAACCGGACGCTGGGTGATGCTGAAGAACGTGCATCTCGCCCCGGTGTGGCTGGTGCAGCTGGAGAAGAAACTCCACTCGCTGCAACCCCACCCGAACTTCCGGCTGTTCCTCACGACGGAGATCAACCCGAAACTGCCGGTGAACCTGCTGCGGGCCGGACGAGTGCTGGTCTTCGAACCGCCACCCGGCATCCGCGCTAACCTGCTCAGGACTTTTGTCACTGTACCGGCAGCTCGAATGATGAAACCACCATCAGAACGTGCCAGACTTTATTTCTTGCTGGCTTGGTTCCACGGTATTGTTCAGGAGCGTCTGCGCTACGTGCCGCTCGGCTGGGCCAAGTACTACGAGTTCAACGAGTCGGACCTGCGCGTCGCGTGCGATACTCTCGACACGTGGATCGACGCCACTGCCATGGGCCGAACCAATCTTCCTCCCGAGAAAGTGCCGTGGGAAGCTTTAGTTACGCTTCTGTCACAATGTATATACGGAGGGAAAATTGACAACTTGTTCGACCAACGTCTGCTGCAGTCGTTCCTGTCCAAACTGTTCACGCCTAAATCGTTTGAAGCCGATTTCGCCCTTGTAGCTAATGTTGATGGGGCTACTGGCAATCAGCGTCACATCACGATGCCCGACGGTAACCGTCGTGACAACTTCCTGAAATGGATCGAAGAACTATCGGATCGACAAACACCGTCCTGGCTCGGACTACCCAACAACGCTGAGAAGGTGCTGCTGACTACACAAGGCAGCGACCTTGTATCGAAATTATTGAAAATGCAACAACTTGAAGATGAAGAAGAGCTGGCCTATAGTGCTGCCACTCAGGACAACGACGCCAGTTCGGTTGTACTTGGTGATGGCAGACCTGCCTGGATGAAAATTTTACATCAAACAGCAGCGAACTGGCTGCAACTACTGCCTAAAGAACTTCCGACTCTTCGCCGTACAGTGGAGAATATCAAAGATCCTTTGTACCGGTTCTTCGAACGTGAGGTCGCTGCCGGAGCGTCTCTGTTGCAGCAAGTACTGCACGATCTGCGCAACGTTATGTTAATTTGTCAGAGCGAAATGAAACAAACAAACGAGACTCGTGCGATGGTGGGGTCCCTGGTGCGCGGCATGCTGCCCGCCTCGTGGCGCCGCTACGCCGTGGCCCGCGGCTGCACGGTGCAGCAGTGGATCGGAGACTTTGCACAGAGGGTCACACAGCTGGCCGAGGTGGCAGATGCAGTCGCTGCTAAGAGGTTGCAGAATGTCCCAGTGTGGCTCGGTGGACTGCTGAACCCTGAAGCTTATATCACAGCTACCCGCCAATGCGTCGCACAAGCTAACTCGTGGTCTTTAGAAGAATTACATTTGCAGGTGACAATACCCGACCCCGGAACACCAACTGAGAATGCTCAAACTGAATGGTCGTTCTCTGTAACTGGTTTAAAACTGCAGGGAGCCACTGTCAAAGGAAATCGGTTATTACTGACAAACACTATCATGGTAGACCTGCCGCTGACTGTGCTCACTTGGGTTCGCGGTCCGGAGCCCGCGTCCAATTCTCACACGCTGACTCTCCCCGTGTACCTGAATAGCGCCCGCACGGAGCTGCTGTTCACGGTGCGGCTGCCCGTCGCGCCCGGACAGGAACCGCACGCGTTCTACGAGCGAGGAGTCGCCCTGCTCACTTCTACTGCTCTCAACTAA
Protein
MLYAVHRPNQILATEPCNFFIVQYPQSKCSSISTVRDLPPVAGSIIWAKQIDHQLTAYLKRVEDVLGKGWENHIEGQKLKADGDSFRLKLDTQEVFDDWARKVQQRNLGVSGRIFAIDSVRARSSKTGTILKLKVNFLPEIITLYKEVRNLKNLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTLEKIRDKASIIPLVAGLRRDVLNQVSEGMALVWESYKLDPYVQKLSEVVLLFQEKVEDLLAVEEQISVDVRSLETCPYSAQSLADILSRLQRAIDDLSLRQYSNLHLWVQRLDEEVEKSLAARLQAGVEAWTGALLGKSHELDLSMDTYSPAEPTHKPGGEPQIARVVHEVRITNQQMYLFPSLEEARFQLMRQMFAWQAIVTSLHRLQSTRYQVGVARAQTATYRNLLTKLPGGSAPLEKAYDAIEKKIFEVREYVDEWLRYQALWDLQPESLYGRLGEDITLWIKCLNDIKKSRTTFDTSDTRREYGPVVIDFARVQSKVALKYDAWHKEVLGKFGALLGGEMVQFHSKLSKSRSQLEQQTIEAASTSDAVSLITYVQQLKREVLAWEKQVDIYREAQRILERQRFQFPAQWLHVDNIDGEWSAFNEIMRRKDSSIQTQVASLQQKIVAEDKAVETRTLEFLTEWERNKPTDGSTRPEDALSRLQAMETRYTRLKDERDNVAKAKEALELHDTGSSINNERMTVVLEELQDLRGVWSSLSKIWTQIDDIREKPWLSVQPRKLRQQLEAMLNELKELPARLRMYDSYEFVRKLLQSYTKVNMLIVELKSDALKERHWRQLCRALKVDWSLSELTLGQVWDADLLHNEHTVKDVVLVAQGEMALEEFLKQVRESWQSYELDLINYQNKCKIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWIDVQRRWVYLEGIFSGSADIKTLLPVETSRFQSISSEFLGLMKKVSKSPMVMDVLNIPGVQRSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFAGVSAIILNEDNTIINGIASREGEEVYFTAPVSTIENPKINSWLSMVEREMRVTLACRLKDAVGDVKQFKDGNVDPLKFIEWCDKYQAQIVVLAAQILWSEDVEAALVNGGGDGLKRVLAHVENMLNILADSVLQEQPPLRRRKLEHLINEFVHKRTVTRRLIASGVNSPRSFDWLYEMRFYFDPRNNDVLQQLTIHMANAKFLYGFEYLGVQDRLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQTIQEALKSHQEGDNTSKSITVELVGKQVRVSQDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTTPDRQLIAEVMLFSQGFRTAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLVSAGNVKRDRIQKIKETLAERGQEVPDEASIAESLPEQDILIQSVCETMVPKLVAEDIPLLFSLLNDVFPNVGYTRAEMTGLKNEIRAVCAEEFLVCGEADEQGSTWMDKVLQLYQICKLNHGLMMVGPSGSGKSTAWRVLLKALERFEGVEGVAHVIDPKAMSKETLYGVLDPNTREWTDGLFTHILRKIIDNVRGEINKRQWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSQDVLTTEMIFENYLMRLKNIPLEDGEEDSFSIVMAAPTPGSEQNVTENILSPALQTQRDVAAILQPLFFGDGLVVKCLERAASLDHIMDFTRHRALSSLHSMLNRGVRNILGYNRQHPDFPITNEQLEAYIPKWLVYSLLWSFAGDAKLKDRNELGDFIRSASTMLLPNCGPNQHIIDFEVSVTGEWVPWSAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLAPVQLGKWLVLFCDEINLPDMDQYGTQRVISFLRQLLEHKGFYRASDHSWVHLERIQFVGACNPPTDPGRKPLSHRLLRHVPVIYVDYPGEMSLEQIYGTFTRAMLRMQPALRGYAEPLTQAMVKLYLASQERFTQDMQPHYVYSPREMTRWVRGICEAIRPLDNLTVEGLVRLWAHEALRLFQDRLVDDVERQWTDENIDTVAMRFFPGINREQALARPILYSNWLSKDYVPVLRDQLREYVKARLKVFYEEELDVPLVLFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTGADFDEDLRSVLRRAGCRDEKVAFILDESNVLDSGFLERMNTLLANGEVPGLFEGDEFSALMTQCKEGAQREGLMLDSNDELYKWFTSQVMRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSDGALFQVGKEFTSRMDLESAEYVPPAEFPAACGEVGAAPAHREAVVNACVYVHQTLHQANARLAKRANRTMAITPRHYLDFIQQMVKLYAEKRADLEEQQLHLNVGLGKIAETVEQVEEMQKSLAVKSQELQAKNEAANAKLRQMVKDQQEAEKKKVESQEIQVALEKQTKEIEAKRRDVMADLAQVEPAVIEAQNAVKSIKKQHLVEVRSMGNPPAIVKVALESICLLLGENATDWKAIRAVIMRENFINSIVSNFSTEDITDDVREKMRTRYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLRNELQALEDQAQSNVTAGNEVRELIAQLEKSIASYKEEYAQLISQAQAIKTDLENVQAKVDRSIALLKSLVIERERWESSSETFRSQMSTIVGDVLLSAAFIAYGGYFDQHYRQNLFTTWTNHLAAANIRYRADIARTEYLSNPDERLRWQANALPTDELCVENAIMLRRFNRYPLIIDPSGQATEFIMREFKERKITKTSFLDDSFRKNLESALRFGNPLLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDMCSRVTFVNFTVTRSSLQSQCLHRVLKAERPDIDAKRSDLLKLQGEFHLRLRQLEKSLLQALNDAKGKILDDDSVIATLETLKKEADDIGQKVEETDKVIAEIETVSQQYLPLSQACSSIYFTMDSLNQIHFLYQYSLKMFLDIFSSVLICPLLNGVTDYTARLKIITEELFAVVYERVARGMLHTDRLTFALLLCRIHLKGTGAEDTLEQSFPVFLRGKEGFVSQTAPSEPLTHQQHDAAARLSSRLGVFRRLLEKAGELPELSAWLSQAAPEQCVPTLWDSEPAAPPAPHSLAMYRLLLIQAFRPDRVIAAATQLAAAVLGAGFMAKAETELDLASITETQLNATTPAILCSVPGYDASGRVDDMATELNKPLSSIAIGSAEGFNQAERAINTACKTGRWVMLKNVHLAPVWLVQLEKKLHSLQPHPNFRLFLTTEINPKLPVNLLRAGRVLVFEPPPGIRANLLRTFVTVPAARMMKPPSERARLYFLLAWFHGIVQERLRYVPLGWAKYYEFNESDLRVACDTLDTWIDATAMGRTNLPPEKVPWEALVTLLSQCIYGGKIDNLFDQRLLQSFLSKLFTPKSFEADFALVANVDGATGNQRHITMPDGNRRDNFLKWIEELSDRQTPSWLGLPNNAEKVLLTTQGSDLVSKLLKMQQLEDEEELAYSAATQDNDASSVVLGDGRPAWMKILHQTAANWLQLLPKELPTLRRTVENIKDPLYRFFEREVAAGASLLQQVLHDLRNVMLICQSEMKQTNETRAMVGSLVRGMLPASWRRYAVARGCTVQQWIGDFAQRVTQLAEVADAVAAKRLQNVPVWLGGLLNPEAYITATRQCVAQANSWSLEELHLQVTIPDPGTPTENAQTEWSFSVTGLKLQGATVKGNRLLLTNTIMVDLPLTVLTWVRGPEPASNSHTLTLPVYLNSARTELLFTVRLPVAPGQEPHAFYERGVALLTSTALN
Summary
Description
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression.
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron (PubMed:20510931). This function may involve the regulation of dynein by pct-1 and/or cdk-5 (PubMed:20510931). Involved in the formation of synapses in the dorsal region during synaptic remodeling of DD motor neurons (PubMed:21609829). Required for anterograde trafficking of dense-core vesicles in the DB motor neuron dendrites (PubMed:22699897). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). May play a role in the pairing of homologous chromosomes during meiosis (PubMed:26483555).
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.
Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805).
Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity).
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase.
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression.
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron (PubMed:20510931). This function may involve the regulation of dynein by pct-1 and/or cdk-5 (PubMed:20510931). Involved in the formation of synapses in the dorsal region during synaptic remodeling of DD motor neurons (PubMed:21609829). Required for anterograde trafficking of dense-core vesicles in the DB motor neuron dendrites (PubMed:22699897). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). May play a role in the pairing of homologous chromosomes during meiosis (PubMed:26483555).
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.
Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805).
Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity).
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase.
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.
Subunit
Consists of at least two heavy chains and a number of intermediate and light chains.
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (By similarity). Interacts with BICD2 (PubMed:25512093).
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (By similarity). Interacts with BICD2 (PubMed:22956769).
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer (PubMed:2140361). Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (PubMed:10893223). Interacts with BICD2 (By similarity).
The dynein complex consists of at least two heavy chains and a number of intermediate and light chains. Interacts with DYN3.
The I1 inner arm complex (also known as the f dynein complex) is a two-headed isoform composed of two heavy chains (1-alpha and 1-beta), three intermediate chains and three light chains. I1 occupies a specific position proximal to the first radial spoke and repeats every 96 nm along the length of the axoneme.
The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.
The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.
Consists of at least 3 heavy chains (alpha, beta and gamma), 2 intermediate chains and 8 light chains.
Interacts with DNAL1 (By similarity). Consists of at least two heavy chains and a number of intermediate and light chains.
Interacts with DNAL1 (PubMed:21496787). Consists of at least two heavy chains and a number of intermediate and light chains.
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (By similarity). Interacts with BICD2 (PubMed:25512093).
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (By similarity). Interacts with BICD2 (PubMed:22956769).
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer (PubMed:2140361). Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (PubMed:10893223). Interacts with BICD2 (By similarity).
The dynein complex consists of at least two heavy chains and a number of intermediate and light chains. Interacts with DYN3.
The I1 inner arm complex (also known as the f dynein complex) is a two-headed isoform composed of two heavy chains (1-alpha and 1-beta), three intermediate chains and three light chains. I1 occupies a specific position proximal to the first radial spoke and repeats every 96 nm along the length of the axoneme.
The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.
The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.
Consists of at least 3 heavy chains (alpha, beta and gamma), 2 intermediate chains and 8 light chains.
Interacts with DNAL1 (By similarity). Consists of at least two heavy chains and a number of intermediate and light chains.
Interacts with DNAL1 (PubMed:21496787). Consists of at least two heavy chains and a number of intermediate and light chains.
Miscellaneous
Present with 195 molecules/cell in log phase SD medium.
Mice homozygous for Dync2h1 null alleles die at approximately 12.5 dpc with abnormal brain morphology, frequent heart-looping and occasionally with polysyndactily. Cilia have abnormal morphology.
Mice homozygous for Dync2h1 null alleles die at approximately 12.5 dpc with abnormal brain morphology, frequent heart-looping and occasionally with polysyndactily. Cilia have abnormal morphology.
Similarity
Belongs to the dynein heavy chain family.
Keywords
Alternative splicing
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Dynein
Microtubule
Motor protein
Nucleotide-binding
Reference proteome
Repeat
3D-structure
Acetylation
Cell cycle
Cell division
Charcot-Marie-Tooth disease
Disease mutation
Mental retardation
Mitosis
Neurodegeneration
Neuropathy
Phosphoprotein
Polymorphism
Transport
Neurogenesis
Karyogamy
Cell projection
Cilium
TPR repeat
Merozoite
Flagellum
Cell membrane
Ciliopathy
Developmental protein
Membrane
RNA editing
Glycoprotein
Kartagener syndrome
Primary ciliary dyskinesia
Kelch repeat
Direct protein sequencing
Feature
chain Dynein heavy chain, cytoplasmic
splice variant In isoform C.
sequence variant Found in a patient with spinal muscular atrophy; unknown pathological significance.
splice variant In isoform C.
sequence variant Found in a patient with spinal muscular atrophy; unknown pathological significance.
Uniprot
P37276.2
Q14204.5
Q9JHU4.2
P38650.1
Q19020.1
P34036.2
+ More
P78716.1 P45443.1 P45444.2 Q27171.1 Q9C1M7.1 P36022.1 P0C6F1.1 Q8IBG1.2 Q9SMH3.1 Q8NCM8.4 Q9C0G6.3 Q9P225.3 Q8IVF4.4 Q9P2D7.5 E9Q8T7.1 Q69Z23.2 Q96JB1.2 Q91XQ0.2 Q63170.2 Q39575.1 Q39565.1 Q8BW94.2 O13290.1 Q8TD57.1 Q39610.2 Q9MBF8.1 Q9JJ79.1 Q45VK7.1 Q8VHE6.2 Q8TE73.3 M0R8U1.1 Q96M86.2
P78716.1 P45443.1 P45444.2 Q27171.1 Q9C1M7.1 P36022.1 P0C6F1.1 Q8IBG1.2 Q9SMH3.1 Q8NCM8.4 Q9C0G6.3 Q9P225.3 Q8IVF4.4 Q9P2D7.5 E9Q8T7.1 Q69Z23.2 Q96JB1.2 Q91XQ0.2 Q63170.2 Q39575.1 Q39565.1 Q8BW94.2 O13290.1 Q8TD57.1 Q39610.2 Q9MBF8.1 Q9JJ79.1 Q45VK7.1 Q8VHE6.2 Q8TE73.3 M0R8U1.1 Q96M86.2
Pubmed
8089180
10731132
12537572
8186464
12537569
9205841
+ More
8666668 8227145 15489334 14654843 17081983 18669648 19690332 19608861 20068231 21269460 22223895 23186163 24275569 25944712 27462074 21076407 21820100 22368300 22847149 22459677 23033978 23603762 25512093 24307404 25484024 26846447 28193117 19468303 12730604 18034455 21183079 22956769 23806337 7690137 7684232 2140361 10893223 8674131 9851916 16996038 20510931 20005871 20599902 21205795 21609829 22699897 26483555 27697906 27864381 1469051 12097910 15875012 7866389 7929559 12712197 8134356 16372000 19146970 8589455 8056840 11181180 15001715 23749448 8248224 8196765 24374639 8234262 14562095 14562106 15642746 9373155 16141072 12368864 12368867 17653272 10459015 8889521 2957507 2137128 9008712 9247642 16554811 14702039 8186465 17974005 12056414 16440056 21211617 19361615 19442771 22499340 23456818 15815621 8812413 11175280 11214970 28206990 10819331 16625196 9256245 20835228 16541075 19159218 10718198 16641997 24360805 25927852 27798045 28552195 29449551 11371505 19131326 15368895 12297094 14574404 18691976 16959974 10602986 16054618 15057822 7657712 8741840 7516341 8006077 10366596 11859360 10493829 9186009 10888669 10069812 12432068 8832411 9450951 11907264 16061793 16229832 11912187 11788826 15269178 11062149 10997877 21496787 16627867 25186273 12693554 12975309
8666668 8227145 15489334 14654843 17081983 18669648 19690332 19608861 20068231 21269460 22223895 23186163 24275569 25944712 27462074 21076407 21820100 22368300 22847149 22459677 23033978 23603762 25512093 24307404 25484024 26846447 28193117 19468303 12730604 18034455 21183079 22956769 23806337 7690137 7684232 2140361 10893223 8674131 9851916 16996038 20510931 20005871 20599902 21205795 21609829 22699897 26483555 27697906 27864381 1469051 12097910 15875012 7866389 7929559 12712197 8134356 16372000 19146970 8589455 8056840 11181180 15001715 23749448 8248224 8196765 24374639 8234262 14562095 14562106 15642746 9373155 16141072 12368864 12368867 17653272 10459015 8889521 2957507 2137128 9008712 9247642 16554811 14702039 8186465 17974005 12056414 16440056 21211617 19361615 19442771 22499340 23456818 15815621 8812413 11175280 11214970 28206990 10819331 16625196 9256245 20835228 16541075 19159218 10718198 16641997 24360805 25927852 27798045 28552195 29449551 11371505 19131326 15368895 12297094 14574404 18691976 16959974 10602986 16054618 15057822 7657712 8741840 7516341 8006077 10366596 11859360 10493829 9186009 10888669 10069812 12432068 8832411 9450951 11907264 16061793 16229832 11912187 11788826 15269178 11062149 10997877 21496787 16627867 25186273 12693554 12975309
EMBL
L23195
AE014296
L25122
AY051501
AB002323
AB290157
+ More
AY682080 U53530 L23958 BC021297 AY004877 AC152827 D13896 L08505 L33260 BX284601 Z15124 AAFI02000014 U84215 L31504 CM002239 U03904 AACD01000004 BN001308 U20449 L17132 AF287477 AE016816 Z21877 L15626 Z28279 BK006944 AL596125 AL731687 Z83813 AK029791 AL844506 AJ243806 U61364 AB231765 AB231766 AP000817 AP001486 AP002829 AP002961 AP003382 AP003461 AK021818 AK095579 AK125524 AK131453 U53531 U20552 Z83800 BX538093 AB082528 AK027182 AK094676 AL512706 AC010087 AC096770 AC098975 AC109827 CH471053 BC015442 BC104884 BC113424 BC117259 BC143666 U61736 AJ132086 AB051484 AB040936 AK128517 AK292607 AC025335 AC087388 BC034225 U83570 AC079315 AC117503 AK095581 AK125475 AK125796 AB095937 AJ132089 AB037831 AK023766 AK074130 AK125990 AB290163 AC092045 KF459588 AJ132083 AJ132094 U61738 Z83804 U83571 AY221994 AL117428 AK053204 AC108416 CH466573 BC023155 Z83815 AL591204 AL591433 Z83807 AK173343 AF356519 AL034345 AL035555 AL035690 AL353700 AL391415 Z83806 AJ132091 AF356520 AF356521 AF356522 AF356523 AF363577 AF342999 AC165951 AC165962 AC166166 AC174471 AF117305 Z83817 AK133238 AABR03068169 AABR03068266 AABR03068762 AABR03068958 AABR03068975 AABR03069173 AABR03069339 AABR03069471 AABR03070154 AABR03071231 AABR03071501 AABR03071646 AABR03071706 AABR03071857 AABR03072256 D26498 U32180 U15303 U02963 AC122853 AC131702 Z83816 BC051401 AK053178 AB006784 CU329670 AF494040 AK056509 CH471228 AJ132085 AJ132092 Z83805 U83574 BC019878 AL096732 AC002394 L26049 AJ242523 AJ242524 AJ242525 AJ132799 AB041881 U61748 D26495 DQ104402 AK014500 AK032860 AK045978 AK046538 AK083433 AK084796 AC155908 CT010499 AY452064 AY452065 AY452066 AY452067 Z83809 AK173324 AF466704 AC131997 AC154880 AK052643 AY045575 AY049075 U61735 AB046823 AK026756 AABR07008948 AK057314 AK093028 BC111765 BC117301 BC117303 AC009796 AC084337 CH471064 AK074178 AL137619 AY358770
AY682080 U53530 L23958 BC021297 AY004877 AC152827 D13896 L08505 L33260 BX284601 Z15124 AAFI02000014 U84215 L31504 CM002239 U03904 AACD01000004 BN001308 U20449 L17132 AF287477 AE016816 Z21877 L15626 Z28279 BK006944 AL596125 AL731687 Z83813 AK029791 AL844506 AJ243806 U61364 AB231765 AB231766 AP000817 AP001486 AP002829 AP002961 AP003382 AP003461 AK021818 AK095579 AK125524 AK131453 U53531 U20552 Z83800 BX538093 AB082528 AK027182 AK094676 AL512706 AC010087 AC096770 AC098975 AC109827 CH471053 BC015442 BC104884 BC113424 BC117259 BC143666 U61736 AJ132086 AB051484 AB040936 AK128517 AK292607 AC025335 AC087388 BC034225 U83570 AC079315 AC117503 AK095581 AK125475 AK125796 AB095937 AJ132089 AB037831 AK023766 AK074130 AK125990 AB290163 AC092045 KF459588 AJ132083 AJ132094 U61738 Z83804 U83571 AY221994 AL117428 AK053204 AC108416 CH466573 BC023155 Z83815 AL591204 AL591433 Z83807 AK173343 AF356519 AL034345 AL035555 AL035690 AL353700 AL391415 Z83806 AJ132091 AF356520 AF356521 AF356522 AF356523 AF363577 AF342999 AC165951 AC165962 AC166166 AC174471 AF117305 Z83817 AK133238 AABR03068169 AABR03068266 AABR03068762 AABR03068958 AABR03068975 AABR03069173 AABR03069339 AABR03069471 AABR03070154 AABR03071231 AABR03071501 AABR03071646 AABR03071706 AABR03071857 AABR03072256 D26498 U32180 U15303 U02963 AC122853 AC131702 Z83816 BC051401 AK053178 AB006784 CU329670 AF494040 AK056509 CH471228 AJ132085 AJ132092 Z83805 U83574 BC019878 AL096732 AC002394 L26049 AJ242523 AJ242524 AJ242525 AJ132799 AB041881 U61748 D26495 DQ104402 AK014500 AK032860 AK045978 AK046538 AK083433 AK084796 AC155908 CT010499 AY452064 AY452065 AY452066 AY452067 Z83809 AK173324 AF466704 AC131997 AC154880 AK052643 AY045575 AY049075 U61735 AB046823 AK026756 AABR07008948 AK057314 AK093028 BC111765 BC117301 BC117303 AC009796 AC084337 CH471064 AK074178 AL137619 AY358770
Proteomes
PRIDE
Pfam
Interpro
IPR024317
Dynein_heavy_chain_D4_dom
+ More
IPR024743 Dynein_HC_stalk
IPR027417 P-loop_NTPase
IPR042222 Dynein_2_N
IPR035706 AAA_9
IPR035699 AAA_6
IPR041658 AAA_lid_11
IPR041228 Dynein_C
IPR042228 Dynein_2_C
IPR041466 Dynein_AAA5_ext
IPR003593 AAA+_ATPase
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR042219 AAA_lid_11_sf
IPR013594 Dynein_heavy_dom-1
IPR041589 DNAH3_AAA_lid_1
IPR026983 DHC_fam
IPR026975 DNAH1
IPR002048 EF_hand_dom
IPR018247 EF_Hand_1_Ca_BS
IPR011043 Gal_Oxase/kelch_b-propeller
IPR017868 Filamin/ABP280_repeat-like
IPR011498 Kelch_2
IPR001736 PLipase_D/transphosphatidylase
IPR014756 Ig_E-set
IPR015915 Kelch-typ_b-propeller
IPR002909 IPT_dom
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR024743 Dynein_HC_stalk
IPR027417 P-loop_NTPase
IPR042222 Dynein_2_N
IPR035706 AAA_9
IPR035699 AAA_6
IPR041658 AAA_lid_11
IPR041228 Dynein_C
IPR042228 Dynein_2_C
IPR041466 Dynein_AAA5_ext
IPR003593 AAA+_ATPase
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR042219 AAA_lid_11_sf
IPR013594 Dynein_heavy_dom-1
IPR041589 DNAH3_AAA_lid_1
IPR026983 DHC_fam
IPR026975 DNAH1
IPR002048 EF_hand_dom
IPR018247 EF_Hand_1_Ca_BS
IPR011043 Gal_Oxase/kelch_b-propeller
IPR017868 Filamin/ABP280_repeat-like
IPR011498 Kelch_2
IPR001736 PLipase_D/transphosphatidylase
IPR014756 Ig_E-set
IPR015915 Kelch-typ_b-propeller
IPR002909 IPT_dom
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
ProteinModelPortal
P37276.2
Q14204.5
Q9JHU4.2
P38650.1
Q19020.1
P34036.2
+ More
P78716.1 P45443.1 P45444.2 Q27171.1 Q9C1M7.1 P36022.1 P0C6F1.1 Q8IBG1.2 Q9SMH3.1 Q8NCM8.4 Q9C0G6.3 Q9P225.3 Q8IVF4.4 Q9P2D7.5 E9Q8T7.1 Q69Z23.2 Q96JB1.2 Q91XQ0.2 Q63170.2 Q39575.1 Q39565.1 Q8BW94.2 O13290.1 Q8TD57.1 Q39610.2 Q9MBF8.1 Q9JJ79.1 Q45VK7.1 Q8VHE6.2 Q8TE73.3 M0R8U1.1 Q96M86.2
P78716.1 P45443.1 P45444.2 Q27171.1 Q9C1M7.1 P36022.1 P0C6F1.1 Q8IBG1.2 Q9SMH3.1 Q8NCM8.4 Q9C0G6.3 Q9P225.3 Q8IVF4.4 Q9P2D7.5 E9Q8T7.1 Q69Z23.2 Q96JB1.2 Q91XQ0.2 Q63170.2 Q39575.1 Q39565.1 Q8BW94.2 O13290.1 Q8TD57.1 Q39610.2 Q9MBF8.1 Q9JJ79.1 Q45VK7.1 Q8VHE6.2 Q8TE73.3 M0R8U1.1 Q96M86.2
PDB
5NUG
E-value=0,
Score=15190
Ontologies
GO
GO:0098958
GO:0048813
GO:0007098
GO:0045169
GO:0007298
GO:0005794
GO:0005938
GO:0042623
GO:0005868
GO:0007052
GO:0007018
GO:0007312
GO:0007405
GO:0045198
GO:0050658
GO:0008090
GO:0016319
GO:0040001
GO:0005737
GO:0007051
GO:0030723
GO:0035149
GO:0051959
GO:0030286
GO:0034501
GO:0030071
GO:0008088
GO:0051237
GO:0005875
GO:0045505
GO:0051683
GO:0048477
GO:0008569
GO:0048134
GO:0007282
GO:0051642
GO:0035011
GO:1904115
GO:1904801
GO:0006886
GO:0046604
GO:0045197
GO:0007279
GO:0000776
GO:0005874
GO:0007349
GO:0045478
GO:0007294
GO:0040003
GO:0000278
GO:0034063
GO:0003777
GO:1990904
GO:0048311
GO:0008298
GO:0005524
GO:0007097
GO:0097711
GO:0070062
GO:0051301
GO:0090235
GO:0032388
GO:0072382
GO:0005881
GO:0051293
GO:0043312
GO:0060236
GO:0120162
GO:0010389
GO:0030175
GO:0045503
GO:0035578
GO:0000086
GO:1905832
GO:0005829
GO:0033962
GO:0005813
GO:0019886
GO:0003723
GO:0016020
GO:0006888
GO:0031122
GO:0005576
GO:0030424
GO:0003341
GO:0043025
GO:0005635
GO:0002177
GO:1905243
GO:1990090
GO:0007286
GO:0005819
GO:1990048
GO:0051296
GO:1902473
GO:0000922
GO:1904811
GO:0051932
GO:0048814
GO:0045202
GO:0048489
GO:0051661
GO:0016322
GO:0015631
GO:0016887
GO:0030139
GO:0043273
GO:0036186
GO:0061474
GO:0090382
GO:0090307
GO:0042803
GO:0008017
GO:0030428
GO:0070789
GO:0001411
GO:0047496
GO:0005816
GO:0000132
GO:0000741
GO:0000070
GO:0000235
GO:0030473
GO:0031514
GO:0005930
GO:0036156
GO:0036159
GO:0060294
GO:1905515
GO:0005886
GO:0035721
GO:0007368
GO:0061512
GO:0009953
GO:0005929
GO:0030326
GO:0060271
GO:0060976
GO:0003774
GO:0045880
GO:0097542
GO:0007030
GO:0021522
GO:0016485
GO:0045177
GO:0030900
GO:0035735
GO:0060285
GO:0005858
GO:0030317
GO:0003351
GO:0036126
GO:0007288
GO:0036157
GO:0036158
GO:0097228
GO:0005509
GO:0030030
GO:0051315
GO:0000742
GO:0035974
GO:0007129
GO:0030981
GO:1990758
GO:0030989
GO:1990574
GO:0007275
GO:0007507
GO:0030182
GO:0097729
GO:0021670
GO:0008270
GO:0016787
GO:0004190
GO:0006508
GO:0016286
PANTHER
Topology
Subcellular location
Cell projection
Cilium
Flagellum
Cytoplasm
Cytoskeleton
Flagellum axoneme
Cilium axoneme Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (PubMed:8666668). With evidence from 4 publications.
Cell membrane Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (PubMed:8666668). With evidence from 4 publications.
Microtubule organizing center
Spindle pole body
Length:
4051
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.146560000000001
Exp number, first 60 AAs:
0.00034
Total prob of N-in:
0.00006
outside
1 - 4051
Population Genetic Test Statistics
Pi
315.867514
Theta
181.587511
Tajima's D
2.32987
CLR
0.341134
CSRT
0.926803659817009
Interpretation
Uncertain
