Gene

KWMTBOMO12584  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001539

Annotation

PREDICTED:_G_kinase-anchoring_protein_1-like_[Papilio_xuthus]

Location

Bomo_Chr21(+):8466086-8470890      View in EpiBrowser

Full name

G kinase-anchoring protein 1      

Alternative Name

cGMP-dependent protein kinase-anchoring protein of 42 kDa

Location in the cell

Nuclear   Reliability : 4.547

CDS

ATGGCTGCTCTTGTCGTACAATCTCGTTTTGCTGGTCTAATGATAGAAGATGATGATCACCCAACAAATAGCGATGAACAAAAACATAAAAAAGCCAAAACTAATTCTGCCAAAAAATCAGAACTTCTGAAGAAACCCAAAAACAATAATAACAACAACAACAACTGTAAAACTCAGTCAGCTGGTAAGAAGAAGAAGACTAAACTTGGTGAATCTACTGAAGCACAATGGGCACAATGGAAACAAAAAGATGAAGAAATGGTTGATGGCAATTTTGAATCTGAACTCCATCAGGCTATTCTTTTGTCTAAACTGGATTATGAAGAGAAGAAAGATGTATATAAACAATTGAAAAAGGATGTTGATGCAGCAAACAAAGTTGCAGAAGTTTCTCGTAATGTTAAGAAGTTGAAGAAGAAAAATGTGATGTGTCTGGAGCAGTTCAACGGCATTGTGAATTCTACTGAAAATAGTGATGTAAAATTTAATCATAATACAGAAGACGAAAAGAATTCTACTGATGATGACAAGATTCCCGAAAAAGATACACAATTTTTTGAACGAGTGAAAATAGAGACGAAAGATGCATTAATAAGAAACAAAATAAAAGAAAGAATCCACAATAGATTGACCGATGAAGTTATAACTAAAATTCAGTTTAATGAAACTTTAGAGAAGAAAGATAAAGAAATTGAAAGTTTAAAAGAAGAAGTATTAAAATTAAAACAGGAATTGTTAACAGTCAAGTCTAGGAATAAGAAGCTATGTAGTATACTAGGACAGGGTGAAATGAGAGATAAAGCAGAGGTATTAGTAGAAGTGGAGCGACTGAACTCCGTACAAGCTGAATTAACTGCAGAAATAGCTACGTTACACTCAGAGTTAGAAAAGGAGCGATCTAAAAACACAGATCCAAGAGCTAAAGACAAGAAAAATTCAACAAAAAAGAAAAAGATAAGATTTGACGTTTCTTCGGAGGCTGTCGTCACAAAAGAATCTGGTGCAGGGAATGTATGA

Protein

MAALVVQSRFAGLMIEDDDHPTNSDEQKHKKAKTNSAKKSELLKKPKNNNNNNNNCKTQSAGKKKKTKLGESTEAQWAQWKQKDEEMVDGNFESELHQAILLSKLDYEEKKDVYKQLKKDVDAANKVAEVSRNVKKLKKKNVMCLEQFNGIVNSTENSDVKFNHNTEDEKNSTDDDKIPEKDTQFFERVKIETKDALIRNKIKERIHNRLTDEVITKIQFNETLEKKDKEIESLKEEVLKLKQELLTVKSRNKKLCSILGQGEMRDKAEVLVEVERLNSVQAELTAEIATLHSELEKERSKNTDPRAKDKKNSTKKKKIRFDVSSEAVVTKESGAGNV

Description

Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.
May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.

Subunit

Interacts with PRKG1 (PubMed:10671526). Interacts with IRS1 (PubMed:25586176).
Interacts with PRKG1 and IRS1.

Similarity

Belongs to the GKAP1 family.

Keywords

Coiled coil   Complete proteome   Golgi apparatus   Phosphoprotein   Reference proteome  

Feature

chain  G kinase-anchoring protein 1

Uniprot

H9IWA8   A0A2A4K2T3   A0A437B2N3   A0A194PZC7   A0A212EWN7   S4P788   + More
A0A2H1VVD9   A0A1E1W9Y7   A0A194RPQ7   A0A1W4W9A0   A0A151WSR8   A0A195D9R5   E2BLS5   A0A195BVI8   F4WXL2   A0A195FRQ0   A0A0J7NUA6   A0A310SPC8   A0A158NUX9   A0A1B6K3T7   A0A195CPR9   A0A131X7H1   A0A1B6G0M9   A0A131Z0T7   A0A1E1XHU1   A0A0C9SE07   L7M819   G3MLM0   A0A224Y3I6   E9IDB2   A0A1Y1MGQ4   A0A1Y1MGE4   A0A1Y1MGI7   A0A0C9R5H4   A0A2C9M5A3   A0A1S3HFE3   A0A2R5L5K0   A0A182PJ50   A0A2T7NDN6   A0A232F2U1   A0A1Z5LI92   U5EVW3   N6UT87   A7UVR1   A0A182ULC2   A0A182NQU9   A0A182VNG9   A0A1U7R0E7   W5M2G5   W5M2F0   G3IAS7   A0A182X9A2   G1K9X6   A0A293N3S2   A0A293LTX2   V3ZAY7   A0A3B3YAP3   A0A096M6N3   Q9JMB0   Q5XIG5   F6ZMD6   A0A182RSG1   A0A2K5IEA4   A0A182L8G6   A0A3B3W1H7   A0A182JWI2   Q6NWC9   A0A3Q7RP87   A0A250XZE8  

Pubmed

19121390    26354079    22118469    23622113    20798317    21719571    + More
21347285    28049606    26830274    28503490    26131772    25576852    22216098    28797301    21282665    28004739    15562597    28648823    28528879    23537049    12364791    14747013    17210077    26319212    21804562    23254933    10671526    15489334    16141072    15028281    21183079    25586176    22673903    18464734    20966253    28087693   

EMBL

BABH01006274    NWSH01000211    PCG78359.1    RSAL01000188    RVE44757.1    KQ459585    + More
KPI98398.1    AGBW02011934    OWR45893.1    GAIX01006496    JAA86064.1    ODYU01004672    SOQ44805.1    GDQN01007234    JAT83820.1    KQ459896    KPJ19389.1    KQ982769    KYQ50920.1    KQ981082    KYN09607.1    GL449036    EFN83409.1    KQ976401    KYM92639.1    GL888425    EGI61082.1    KQ981335    KYN42589.1    LBMM01001620    KMQ95990.1    KQ762031    OAD56360.1    ADTU01026819    GECU01001584    JAT06123.1    KQ977444    KYN02738.1    GEFH01005057    JAP63524.1    GECZ01013772    JAS55997.1    GEDV01004481    JAP84076.1    GFAC01000415    JAT98773.1    GBZX01001507    JAG91233.1    GACK01005726    JAA59308.1    JO842771    AEO34388.1    GFPF01000980    MAA12126.1    GL762454    EFZ21377.1    GEZM01032203    GEZM01032202    JAV84771.1    GEZM01032200    JAV84774.1    GEZM01032201    JAV84773.1    GBYB01011559    JAG81326.1    GGLE01000627    MBY04753.1    PZQS01000013    PVD19290.1    NNAY01001119    OXU25074.1    GFJQ02000102    JAW06868.1    GANO01001699    JAB58172.1    APGK01017227    KB739998    KB631984    ENN81967.1    ERL87655.1    AAAB01008987    EDO63285.1    AHAT01012658    JH001748    EGW07098.1    GFWV01023047    MAA47774.1    GFWV01012198    MAA36927.1    KB202752    ESO88158.1    AYCK01002926    AB033130    BC052347    AK016588    BC083717    BC054663    BC067639    BC095240    GFFV01003214    JAV36731.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    + More
UP000192223    UP000075809    UP000078492    UP000008237    UP000078540    UP000007755    UP000078541    UP000036403    UP000005205    UP000078542    UP000076420    UP000085678    UP000075885    UP000245119    UP000215335    UP000019118    UP000030742    UP000007062    UP000075902    UP000075884    UP000075903    UP000189706    UP000018468    UP000001075    UP000076407    UP000001646    UP000030746    UP000261480    UP000028760    UP000000589    UP000002494    UP000002279    UP000075900    UP000233080    UP000075882    UP000261500    UP000075881    UP000000437    UP000286640   

PRIDE

H9IWA8    L7M819    G3MLM0    G3IAS7    Q9JMB0    Q5XIG5    + More

Interpro

IPR026109   GKAP1        + More
IPR003903   UIM_dom       

ProteinModelPortal

H9IWA8   A0A2A4K2T3   A0A437B2N3   A0A194PZC7   A0A212EWN7   S4P788   + More
A0A2H1VVD9   A0A1E1W9Y7   A0A194RPQ7   A0A1W4W9A0   A0A151WSR8   A0A195D9R5   E2BLS5   A0A195BVI8   F4WXL2   A0A195FRQ0   A0A0J7NUA6   A0A310SPC8   A0A158NUX9   A0A1B6K3T7   A0A195CPR9   A0A131X7H1   A0A1B6G0M9   A0A131Z0T7   A0A1E1XHU1   A0A0C9SE07   L7M819   G3MLM0   A0A224Y3I6   E9IDB2   A0A1Y1MGQ4   A0A1Y1MGE4   A0A1Y1MGI7   A0A0C9R5H4   A0A2C9M5A3   A0A1S3HFE3   A0A2R5L5K0   A0A182PJ50   A0A2T7NDN6   A0A232F2U1   A0A1Z5LI92   U5EVW3   N6UT87   A7UVR1   A0A182ULC2   A0A182NQU9   A0A182VNG9   A0A1U7R0E7   W5M2G5   W5M2F0   G3IAS7   A0A182X9A2   G1K9X6   A0A293N3S2   A0A293LTX2   V3ZAY7   A0A3B3YAP3   A0A096M6N3   Q9JMB0   Q5XIG5   F6ZMD6   A0A182RSG1   A0A2K5IEA4   A0A182L8G6   A0A3B3W1H7   A0A182JWI2   Q6NWC9   A0A3Q7RP87   A0A250XZE8  

KEGG

101737958    no KO assigned | (RefSeq) G kinase-anchoring protein 1-like

GO

GO:0007165   GO:0005794   GO:0016301   GO:0016021   GO:0046628   GO:0042802   GO:0007199   GO:0006355   GO:0033588   GO:0015269   GO:0015074   GO:0004190   GO:0006508   GO:0016286  

PANTHER

PTHR14899  

Subcellular location

Golgi apparatus  

Length:

338

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01145

outside

1  -  338

 

 

Pi

314.00891

Theta

216.933029

Tajima's D

0.905616

CLR

0.014221

CSRT

0.628268586570671

Interpretation

Uncertain