Gene

KWMTBOMO12583

Pre Gene Modal

BGIBMGA001436

Annotation

PREDICTED:_leucine-rich_repeat_protein_1_[Plutella_xylostella]

Location

Bomo_Chr21(-):8461507-8463695      View in EpiBrowser

Full name

Leucine-rich repeat protein 1      

Alternative Name

4-1BB-mediated-signaling molecule
4-1BBlrr
LRR-repeat protein 1
Peptidylprolyl isomerase-like 5

Location in the cell

Extracellular   Reliability : 1.735

CDS

ATGGCCAACTTGTCTGAACTACATTTAGCAAACAATCAACTTGGTGTAAGAGGAGTAGTTGATTGGCGTTGGTTACTAGGACCTCAGATTACAAAAACTTTAAAATTATTAGATCTCACTAGTAATAAATTGGGACATCTTCCAAAAGCCATTTGGAAACTAGAAAAATTGGTAACCCTAAAAGCAAATGATAATATGATTTCAAGACTACCTGCAACTATTGGACGCATTTCCACGTTAAGATATTTCACAATCTCTAGCAATGAACTGCAATCTTTGCCATGTAGCCTAATGCAATGTAGACTGGAATACATTGACATATCCTCAAATAAATTTGACAACAAGCAAAATAATTCTACGTCAGATCAATATTCTCCGTGGCAATTTTATGTCGGAAGTTTAGTACATCTTAGTGCAAAAATAATATTAAAACATAAAATACATTATGCATCCAACATAATTCCCTGGACACTTGTTGAGTTTCTGGACAATGCTAACATGTGTGTGTGTGGAGCACCAGTAGTAAATTACACACATTCAATAAATAAAGAATATGACCTCAAAGACTATTTTAGAACTGTAGTTTTTAATAACAATCTCAGTGTGGTTGAATTTGAGTGCTATTTTTGCTCACCCAAGTGTTTCCTAAAACATTAG

Protein

MANLSELHLANNQLGVRGVVDWRWLLGPQITKTLKLLDLTSNKLGHLPKAIWKLEKLVTLKANDNMISRLPATIGRISTLRYFTISSNELQSLPCSLMQCRLEYIDISSNKFDNKQNNSTSDQYSPWQFYVGSLVHLSAKIILKHKIHYASNIIPWTLVEFLDNANMCVCGAPVVNYTHSINKEYDLKDYFRTVVFNNNLSVVEFECYFCSPKCFLKH

Description

May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subunit

Interacts with the cytoplasmic domain of TNFRSF9. Component of the probable ECS(LRR1) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and LRR1. Interacts with CUL2, RBX1, ELOB and ELOC.

Keywords

Alternative splicing   Complete proteome   Leucine-rich repeat   Polymorphism   Reference proteome   Repeat   Ubl conjugation pathway  

Feature

chain  Leucine-rich repeat protein 1
splice variant  In isoform 2.
sequence variant  In dbSNP:rs17121605.

Uniprot

H9IW05   A0A2A4K3W5   A0A194Q4U4   A0A3S2LE53   A0A212EWM4   A0A194RQ00   + More
A0A2H1VLW0   A0A0L7LRC7   S4PB46   A0A0C9PX45   A0A2A3E750   A0A154PPU4   A0A232EKD9   A0A0T6BFC1   D6WTS9   K7J1K9   A0A0L0C8R2   N6TQT3   U4UIW4   A0A1Y1MNK0   A0A1A9WZU5   A0A2J7RIX6   A0A1I8MC35   E2C6Q4   A0A1B0B8Y0   A0A1A9UTK6   A0A1B0FK91   A0A1A9Y5R8   A0A1A9ZPW7   A0A0N0BG93   A0A151WVY8   A0A067RED3   A0A182G3B1   G3VCB4   A0A1B6JYR3   K1PE70   A0A1B6HA38   A0A401PX57   A0A026VSH3   A0A195EBV8   A0A034W797   A0A1S3EUT6   A0A023EZ12   A0A182URA7   I3M8W2   A0A0K8W005   F6SP71   A0A1B0D5S6   A0A1B6H0U5   A0A401S4L6   A0A151IM93   E9ILT8   A0A2K6GNS9   A0A286XRL5   Q0IEE8   A0A2K5IBL3   A7S7S6   A0A0A1WQM5   D3ZE86   G5BW64   E1ZZ28   G1RMR8   A0A0G2KDW9   W8BN63   W5N046   A0A146KPM5   A0A2K5XAR6   A0A0A9YMT3   Q96L50   A0A182U610   A0A2R9B8G0   H2Q888   A0A1W4WA27   A0A1D5QNU9   W5JNV3   H0X8L9   A0A2T7NZR4   A0A096NUT2   G7MXP6   Q6NYX1   K9KAR3   A0A1A6GE12   G3R676   H9Z559   G7PA70   A0A2K6DGN5   A0A2K6PBC2   A0A2K5PL81   A0A2K6UZE3   A0A2K6KAU6   A0A2K5NQ99   A0A2K6PBA1   F7HCJ4   G2HFU2   A0A2K5DGF9   F4WNH6   L5JYG2   A0A182MTC1   A0A0D9RRX6  

Pubmed

19121390    26354079    22118469    26227816    23622113    28648823    + More
18362917    19820115    20075255    26108605    23537049    28004739    25315136    20798317    24845553    26483478    21709235    22992520    30297745    24508170    30249741    25348373    25474469    17495919    21282665    21993624    17510324    17615350    25830018    15057822    15632090    21993625    23594743    24495485    26823975    25401762    11804328    14702039    15489334    15601820    22722832    16136131    17431167    20920257    23761445    22002653    22398555    25319552    25362486    21484476    21719571    23258410   

EMBL

BABH01006274    NWSH01000211    PCG78360.1    KQ459585    KPI98430.1    RSAL01000188    + More
RVE44756.1    AGBW02011934    OWR45892.1    KQ459896    KPJ19390.1    ODYU01003259    SOQ41776.1    JTDY01000265    KOB78005.1    GAIX01006117    JAA86443.1    GBYB01006078    JAG75845.1    KZ288347    PBC27577.1    KQ435012    KZC13767.1    NNAY01003809    OXU18827.1    LJIG01000903    KRT86037.1    KQ971352    EFA06739.1    JRES01000842    KNC27784.1    APGK01002320    APGK01058328    KB741288    KB734730    ENN70671.1    ENN83517.1    KB632322    ERL92338.1    GEZM01027712    JAV86638.1    NEVH01003023    PNF40776.1    GL453161    EFN76366.1    JXJN01010105    CCAG010009529    KQ435789    KOX74442.1    KQ982706    KYQ51851.1    KK852747    KDR17246.1    JXUM01141261    KQ569212    KXJ68717.1    AEFK01043639    GECU01003386    JAT04321.1    JH816535    EKC22182.1    GECU01036247    JAS71459.1    BFAA01011634    GCB77727.1    KK108417    QOIP01000014    EZA46708.1    RLU14723.1    KQ979074    KYN22710.1    GAKP01008368    JAC50584.1    GBBI01004746    JAC13966.1    AGTP01067343    GDHF01007893    JAI44421.1    AJVK01025572    AJVK01025573    GECZ01001476    JAS68293.1    BEZZ01000084    GCC25328.1    KQ977063    KYN06000.1    GL764129    EFZ18507.1    AAKN02027600    CH477695    EAT37151.1    DS469594    EDO40291.1    GBXI01013341    JAD00951.1    AABR07064716    CH473947    EDM03499.1    JH172194    GEBF01003014    EHB13524.1    JAO00619.1    GL435281    EFN73547.1    ADFV01039962    ADFV01039963    ADFV01039964    ADFV01039965    ADFV01039966    CABZ01079358    CABZ01101914    GAMC01004065    JAC02491.1    AHAT01003708    GDHC01021659    JAP96969.1    GBHO01011196    GBRD01002126    JAG32408.1    JAG63695.1    AY052405    BX248298    AK293156    CH471078    BC030142    BC093697    BC112241    BC139921    AJFE02112253    AJFE02112254    AJFE02112255    AJFE02112256    AJFE02112257    AJFE02112258    AACZ04059603    GABC01006043    GABF01004597    GABD01007302    GABE01008924    NBAG03000214    JAA05295.1    JAA17548.1    JAA25798.1    JAA35815.1    PNI83274.1    JSUE03039692    JSUE03039693    ADMH02001019    ETN64429.1    AAQR03088013    AAQR03088014    PZQS01000008    PVD26660.1    AHZZ02032136    AHZZ02032137    AHZZ02032138    CM001259    EHH27854.1    BC066431    AAH66431.1    JL621978    AEP99538.1    LZPO01097182    OBS64486.1    CABD030092220    CABD030092221    JU474271    AFH31075.1    CM001282    EHH63595.1    AK305606    BAK62600.1    GL888237    EGI64169.1    KB031080    ELK03546.1    AXCM01001019    AQIB01058984   

Proteomes

UP000005204    UP000218220    UP000053268    UP000283053    UP000007151    UP000053240    + More
UP000037510    UP000242457    UP000076502    UP000215335    UP000007266    UP000002358    UP000037069    UP000019118    UP000030742    UP000091820    UP000235965    UP000095301    UP000008237    UP000092460    UP000078200    UP000092444    UP000092443    UP000092445    UP000053105    UP000075809    UP000027135    UP000069940    UP000249989    UP000007648    UP000005408    UP000288216    UP000053097    UP000279307    UP000078492    UP000081671    UP000075903    UP000005215    UP000002280    UP000092462    UP000287033    UP000078542    UP000233160    UP000005447    UP000008820    UP000233080    UP000001593    UP000002494    UP000006813    UP000000311    UP000001073    UP000000437    UP000018468    UP000233140    UP000005640    UP000075902    UP000240080    UP000002277    UP000192223    UP000006718    UP000000673    UP000005225    UP000245119    UP000028761    UP000092124    UP000001519    UP000009130    UP000233120    UP000233200    UP000233040    UP000233220    UP000233180    UP000233060    UP000008225    UP000233020    UP000007755    UP000010552    UP000075883    UP000029965   

PRIDE

H9IW05    D3ZE86    Q96L50   

Pfam

PF13855   LRR_8        + More
PF13516   LRR_6
PF12799   LRR_4
PF00560   LRR_1

Interpro

IPR032675   LRR_dom_sf        + More
IPR001611   Leu-rich_rpt       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR025875   Leu-rich_rpt_4       

Gene 3D

3.80.10.10    

ProteinModelPortal

H9IW05   A0A2A4K3W5   A0A194Q4U4   A0A3S2LE53   A0A212EWM4   A0A194RQ00   + More
A0A2H1VLW0   A0A0L7LRC7   S4PB46   A0A0C9PX45   A0A2A3E750   A0A154PPU4   A0A232EKD9   A0A0T6BFC1   D6WTS9   K7J1K9   A0A0L0C8R2   N6TQT3   U4UIW4   A0A1Y1MNK0   A0A1A9WZU5   A0A2J7RIX6   A0A1I8MC35   E2C6Q4   A0A1B0B8Y0   A0A1A9UTK6   A0A1B0FK91   A0A1A9Y5R8   A0A1A9ZPW7   A0A0N0BG93   A0A151WVY8   A0A067RED3   A0A182G3B1   G3VCB4   A0A1B6JYR3   K1PE70   A0A1B6HA38   A0A401PX57   A0A026VSH3   A0A195EBV8   A0A034W797   A0A1S3EUT6   A0A023EZ12   A0A182URA7   I3M8W2   A0A0K8W005   F6SP71   A0A1B0D5S6   A0A1B6H0U5   A0A401S4L6   A0A151IM93   E9ILT8   A0A2K6GNS9   A0A286XRL5   Q0IEE8   A0A2K5IBL3   A7S7S6   A0A0A1WQM5   D3ZE86   G5BW64   E1ZZ28   G1RMR8   A0A0G2KDW9   W8BN63   W5N046   A0A146KPM5   A0A2K5XAR6   A0A0A9YMT3   Q96L50   A0A182U610   A0A2R9B8G0   H2Q888   A0A1W4WA27   A0A1D5QNU9   W5JNV3   H0X8L9   A0A2T7NZR4   A0A096NUT2   G7MXP6   Q6NYX1   K9KAR3   A0A1A6GE12   G3R676   H9Z559   G7PA70   A0A2K6DGN5   A0A2K6PBC2   A0A2K5PL81   A0A2K6UZE3   A0A2K6KAU6   A0A2K5NQ99   A0A2K6PBA1   F7HCJ4   G2HFU2   A0A2K5DGF9   F4WNH6   L5JYG2   A0A182MTC1   A0A0D9RRX6  

PDB

4U06     E-value=1.76569e-07,     Score=129

KEGG

101737826    K10348 LRR-repeat protein 1 | (RefSeq) leucine-rich repeat protein 1

GO

GO:0016853   GO:0016567   GO:0005829   GO:0043687  

Length:

218

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0341

Exp number, first 60 AAs:

0.00062

Total prob of N-in:

0.02026

outside

1  -  218

 

 

Pi

213.113012

Theta

198.741727

Tajima's D

0.199723

CLR

0

CSRT

0.422728863556822

Interpretation

Uncertain