Gene

KWMTBOMO12569

Annotation

endonuclease-reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr21(-):7550605-7552443      View in EpiBrowser

Full name

Integrin beta       + More
Guanylate cyclase      

Location in the cell

Cytoplasmic   Reliability : 1.594 Mitochondrial   Reliability : 1.996

CDS

ATGAAGAAACGAATAGAACGAAACAAAGGCTCCAAGGTGTTCGCGAGAGATTTGTCTCTTGGGAAAAGCCAGTTGACAAGACTGAAGATCGATGATGGCAGGATCATTTCGTCCAAGCCTGAGCTTTTGAGAGAGGTCGAGAAGTTCTATGGACAGCTATACACATCTACTCGACAACCCGTGGAATATCTAGCAAAGGATCCAAGAGCTAGATTAGTCCGACACTATACCGAAGATATCCCCGACATCAGCCTGTGCGAGATTAGAATGGCTCTCAAGCAACTTAAGGACAACAAGGCACCGGGCGAGGATGGAATTACCGTCGAACTTCTGAAGGCGGGTGGAAAACCAGTCCTTCGGGCCCTACAAAATTTATTTAATTCCGTCATTCTCGATGGGAATGTGCCCCTGGCATGGACCAGAAGTGTGGTGGTACTGTTCTTCAAAAAGGGTGACAATACTCGTTTGAAGAATTATAGACCCATCTCACTTCTGAGTCATGTCTATAAGTTGTTCTCGAGAGTTATTACGAACCGTCTCGCGCGCAGGTTTGATGACTTCCAGCCACCCGAACAAGCCGGTTTCCGAAAAGGCTATAGTACCGTAGACCACATTCATACGTTGCGGCAGATTGTACAAAAGACCGAGGAATATAACCTGCCGCTTTGCTTAGCATTTGTGGACTACGAGAAAGCCTTTGATTCGATTGAAACCTGGGCCGTGTTACAGTCTCTCCAACGGTGCCAAATTGATTATCGGTATATCGAAGTGTTGAGGTGTTTGTATGAAAACGCTACTATGTCAGTCCGAGTACAGGACCGGGCTTCAGAACCTATCCTTCTGCAGCGGGGCGTGAGGCAAGGAGATGTTATTTCTCCGAAACTATTTACCGCTGCGCTGGAAGATGTTTTCAAAGTTCTGGACTGGAAAGGACTAGGCATCAACATAAACGGCGAGTACATAACTCACCTTCGGTTCGCCGATGATATTGTGATTATGGCCGAGACCATGGAGGACCTCAGTACAATGCTCAAAGACCTCAGTAGGGCTTCTATCCGAGTGGGTCTAAATATGAACAAAGAAAAAACAAAAATTATGTTGAATGCTCATGTAGCGCCCACTCCAGTAAAGATCGGAGGCTCTACGCTCGAAGTTGTTGACGAGTATATTTACCTGGGACACACTGTCCAGCTAGGTAAGTCCAACTTCGAAAAAGAGGTCAACCGTCGAATCCAGCTCGGATGGGCAGCGTTCGGAAAGCTACGTAAAATCTTCTCATCACAAATACCACAGTGTCTCAAGACGAAAGTCTTTGACCAGTGTGTGTTGCCAGTGATGACATATGGCACTGAGACGTGGTCGCTCACAATGGGCCTTATGAGAAGGCTCAAGGTCACCCAAAGAGCAATGGAGAGGGCTATGCTCGGAGTTTCCCTGCGAGACCAAATCAGAAATGAGGAGATTCGCAGGAAAACCATGGTAACCGACATAGCCCAAAGGATTGCGACACTGAAGTGGCAGTGGGCAGGACACATTGCTCGCGGAACAGATGGCCGTTGGGGCCAGAAGGTTCTTGAGTGA

Protein

MKKRIERNKGSKVFARDLSLGKSQLTRLKIDDGRIISSKPELLREVEKFYGQLYTSTRQPVEYLAKDPRARLVRHYTEDIPDISLCEIRMALKQLKDNKAPGEDGITVELLKAGGKPVLRALQNLFNSVILDGNVPLAWTRSVVVLFFKKGDNTRLKNYRPISLLSHVYKLFSRVITNRLARRFDDFQPPEQAGFRKGYSTVDHIHTLRQIVQKTEEYNLPLCLAFVDYEKAFDSIETWAVLQSLQRCQIDYRYIEVLRCLYENATMSVRVQDRASEPILLQRGVRQGDVISPKLFTAALEDVFKVLDWKGLGININGEYITHLRFADDIVIMAETMEDLSTMLKDLSRASIRVGLNMNKEKTKIMLNAHVAPTPVKIGGSTLEVVDEYIYLGHTVQLGKSNFEKEVNRRIQLGWAAFGKLRKIFSSQIPQCLKTKVFDQCVLPVMTYGTETWSLTMGLMRRLKVTQRAMERAMLGVSLRDQIRNEEIRRKTMVTDIAQRIATLKWQWAGHIARGTDGRWGQKVLE

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Similarity

Belongs to the integrin beta chain family.

Feature

chain  Integrin beta

Uniprot

D7F164   A0A437BHD1   D7F158   D7F159   A0A3S2TAR4   D7F157   + More
A0A3S2KX72   D7F166   D7F165   D7F160   A4KWF2   A4KWG0   A0A2W1BMB6   A0A437B0R4   A0A2G8JFM9   A0A2W1BLC9   A0A2G8K4F2   W4YXJ0   A0A0K0FAW8   W4YXJ1   A0A0N5C0B1   A0A2W1BZV1   D7F177   A0A2H1VS24   A0A2W1B5F8   A0A2W1BCS2   A0A016RYK0   A0A016RXU5   A0A016VV56   A0A016V7H3   A0A2W1BDX2   D7F176   A0A016WPY4   A0A016T8K4   A0A016WCB8   A0A023EXV2   A0A016ULU9   A0A016U784   A0A016S403   A0A069DZM5   A0A2G8L2C7   A0A016SGC3   A0A023GMF8   A0A2H1VY30   A0A016SX67   A0A069DX96   D7F179   A0A016UMK7   A0A0R3Q573   A0A023EWU8   A0A1E1X2U1   A0A016S1D2   A0A016TIA8   A0A016TNH6   A0A016TNS4   A0A016TNL1   A0A016TMT8   A0A016THC6   D7F178   A0A0P4VWD0   A0A016T590   A0A016T7J7   A0A016SSP6   A0A016VEC1   A0A016UWI5   A0A016UTS3   A0A016VCD9   A0A016WEQ1   A0A016UGM6   A0A016VCK8   A0A016VRX3   A0A016TXK2   A0A016VGM4   A0A016VBB9   A0A016VCU3   A0A016VN75   A0A016TH80   A0A016VBP7   A0A016S5A1   A0A016S795   A0A016WA79   A0A016WVQ3   A0A016UEM0   A0A016SPR9   A0A016VMK8   A0A016RUR3   A0A016WKT9   A0A016UUF2   A0A016T5Z1   A0A016VVN3   A0A016US53   A0A016T636   A0A016S5B2   A0A016UN79  

EC Number

4.6.1.2

Pubmed

20470440    17360547    28756777    29023486    25730766    25474469    + More
26334808    28503490    27129103   

EMBL

FJ265549    ADI61817.1    RSAL01000057    RVE49824.1    FJ265543    ADI61811.1    + More
FJ265544    ADI61812.1    RSAL01002362    RVE40503.1    FJ265542    ADI61810.1    RSAL01002130    RVE40575.1    FJ265551    ADI61819.1    FJ265550    ADI61818.1    FJ265545    ADI61813.1    EF113398    EF113401    ABO45231.1    EF113402    ABO45239.1    KZ150072    PZC74016.1    RSAL01000220    RVE44071.1    MRZV01002136    PIK34564.1    KZ149985    PZC75698.1    MRZV01000899    PIK42833.1    AAGJ04050748    AAGJ04144474    KZ149907    PZC78256.1    FJ265562    ADI61830.1    ODYU01004088    SOQ43598.1    KZ150317    PZC71439.1    KZ150485    PZC70710.1    JARK01001677    EYB83167.1    EYB83168.1    JARK01001340    EYC31295.1    JARK01001351    EYC23395.1    KZ150108    PZC73382.1    FJ265561    ADI61829.1    JARK01000173    EYC41342.1    JARK01001462    EYB98997.1    JARK01000388    EYC37469.1    GBBI01004876    JAC13836.1    JARK01001370    EYC16150.1    JARK01001389    EYC11015.1    JARK01001639    EYB85201.1    GBGD01000380    JAC88509.1    MRZV01000249    PIK54411.1    JARK01001568    EYB89432.1    GBBM01001358    JAC34060.1    ODYU01004982    SOQ45402.1    JARK01001500    JARK01001343    EYB95040.1    EYC28825.1    GBGD01000453    JAC88436.1    FJ265564    ADI61832.1    EYC16151.1    UZAG01000503    VDO08661.1    GBBI01004877    JAC13835.1    GFAC01005640    JAT93548.1    JARK01001655    EYB84321.1    JARK01001434    EYC02684.1    JARK01001424    EYC04315.1    EYC04317.1    EYC04316.1    EYC04314.1    JARK01001438    EYC02111.1    FJ265563    ADI61831.1    GDKW01001596    JAI54999.1    JARK01001473    EYB97806.1    JARK01001736    JARK01001379    JARK01001338    EYB80775.1    EYB98943.1    EYC13646.1    EYC33347.1    JARK01001517    EYB93530.1    JARK01001348    EYC25048.1    JARK01001362    EYC18843.1    EYC18844.1    EYC25050.1    JARK01000347    EYC38051.1    JARK01001378    EYC13977.1    EYC25145.1    JARK01001341    EYC29807.1    JARK01001406    EYC07496.1    JARK01001346    EYC26784.1    JARK01001349    EYC24735.1    EYC25046.1    JARK01001344    EYC28218.1    EYC02012.1    EYC25049.1    JARK01001630    EYB85641.1    JARK01001621    EYB86109.1    JARK01000460    EYC36749.1    JARK01000077    EYC43894.1    JARK01001380    EYC13322.1    JARK01001531    EYB92324.1    EYC28635.1    JARK01001711    EYB81734.1    JARK01000248    EYC39628.1    JARK01001361    EYC19034.1    JARK01001470    JARK01000204    EYB98082.1    EYC40602.1    EYC30828.1    JARK01001365    EYC18010.1    EYB98081.1    EYC40601.1    JARK01001626    EYB85833.1    EYC16376.1   

Proteomes

UP000283053    UP000230750    UP000007110    UP000035680    UP000046392    UP000024635    + More
UP000050602   

PRIDE

D7F164    D7F158    D7F159    D7F157    D7F166    D7F165    + More
D7F160    D7F177    D7F176    D7F179    D7F178   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF00362   Integrin_beta
PF01826   TIL
PF13520   AA_permease_2
PF01094   ANF_receptor
PF07714   Pkinase_Tyr
PF00211   Guanylate_cyc

Interpro

IPR000477   RT_dom        + More
IPR036691   Endo/exonu/phosph_ase_sf       
IPR005135   Endo/exonuclease/phosphatase       
IPR032695   Integrin_dom_sf       
IPR036465   vWFA_dom_sf       
IPR015812   Integrin_bsu       
IPR002035   VWF_A       
IPR002369   Integrin_bsu_VWA       
IPR036084   Ser_inhib-like_sf       
IPR002919   TIL_dom       
IPR020846   MFS_dom       
IPR002293   AA/rel_permease1       
IPR001828   ANF_lig-bd_rcpt       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR011009   Kinase-like_dom_sf       
IPR001170   ANPR/GUC       
IPR001054   A/G_cyclase       
IPR028082   Peripla_BP_I       
IPR000719   Prot_kinase_dom       
IPR029787   Nucleotide_cyclase       
IPR029052   Metallo-depent_PP-like       

SUPFAM

SSF56219   SSF56219        + More
SSF53300   SSF53300       
SSF69179   SSF69179       
SSF57567   SSF57567       
SSF53822   SSF53822       
SSF55073   SSF55073       
SSF56112   SSF56112       

Gene 3D

3.60.10.10     3.40.50.410     3.30.70.1230     3.60.21.10    

CDD

cd06174  MFS

ProteinModelPortal

D7F164   A0A437BHD1   D7F158   D7F159   A0A3S2TAR4   D7F157   + More
A0A3S2KX72   D7F166   D7F165   D7F160   A4KWF2   A4KWG0   A0A2W1BMB6   A0A437B0R4   A0A2G8JFM9   A0A2W1BLC9   A0A2G8K4F2   W4YXJ0   A0A0K0FAW8   W4YXJ1   A0A0N5C0B1   A0A2W1BZV1   D7F177   A0A2H1VS24   A0A2W1B5F8   A0A2W1BCS2   A0A016RYK0   A0A016RXU5   A0A016VV56   A0A016V7H3   A0A2W1BDX2   D7F176   A0A016WPY4   A0A016T8K4   A0A016WCB8   A0A023EXV2   A0A016ULU9   A0A016U784   A0A016S403   A0A069DZM5   A0A2G8L2C7   A0A016SGC3   A0A023GMF8   A0A2H1VY30   A0A016SX67   A0A069DX96   D7F179   A0A016UMK7   A0A0R3Q573   A0A023EWU8   A0A1E1X2U1   A0A016S1D2   A0A016TIA8   A0A016TNH6   A0A016TNS4   A0A016TNL1   A0A016TMT8   A0A016THC6   D7F178   A0A0P4VWD0   A0A016T590   A0A016T7J7   A0A016SSP6   A0A016VEC1   A0A016UWI5   A0A016UTS3   A0A016VCD9   A0A016WEQ1   A0A016UGM6   A0A016VCK8   A0A016VRX3   A0A016TXK2   A0A016VGM4   A0A016VBB9   A0A016VCU3   A0A016VN75   A0A016TH80   A0A016VBP7   A0A016S5A1   A0A016S795   A0A016WA79   A0A016WVQ3   A0A016UEM0   A0A016SPR9   A0A016VMK8   A0A016RUR3   A0A016WKT9   A0A016UUF2   A0A016T5Z1   A0A016VVN3   A0A016US53   A0A016T636   A0A016S5B2   A0A016UN79  

PDB

6AR3     E-value=1.39492e-06,     Score=126

KEGG

100158253    K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta | (RefSeq) Pi3k60, pi3k; phosph

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0003964   GO:0004519   GO:0005524   GO:0004672   GO:0004383   GO:0016021   GO:0035556  

PANTHER

PTHR10082  

Subcellular location

Membrane  

Length:

526

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32212

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02900

outside

1  -  526

 

 

Pi

56.608941

Theta

70.658686

Tajima's D

-0.727472

CLR

2.657042

CSRT

0.189690515474226

Interpretation

Uncertain